Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression
Open accessAbstract
Abstract Background We annually monitored stable compensated cirrhosis (CC) patients to evaluate serial variation in blood serum, liver stiffness, and multiparametric magnetic resonance imaging (mpMRI) measures to provide reference change values (RCV) and sample size measures for future studies. Methods Patients were recruited from a prospectively followed CC cohort, with assessments at baseline and annually over three years. We report on blood markers, transient elastography liver stiffness measures (LSM) and noninvasive mpMRI (volume, T1 mapping, blood flow, perfusion) of the liver, spleen, kidneys, and heart in a stable CC group and a healthy volunteer (HV) group. Coefficient of variation over time (CoV T ) and RCV are reported, along with hazard ratio to assess disease progression. Sample size estimates to power future trials of cirrhosis regression on mpMRI are presented. Results Of 60 CC patients enrolled, 28 with stable CC were followed longitudinally and compared to 10 HVs. CoV T in mpMRI measures was comparable between CC and HV groups. CoV T of Enhanced Liver Fibrosis score was low (< 5%) compared to Fibrosis-4 index (17.9%) and Aspartate Aminotransferase-to-Platelet-Ratio Index (19.4%). A large CoV T (20.7%) and RCV (48.3%) were observed for LSM. CoV T and RCV were low for liver, spleen, and renal T1 values (CoV T < 5%, RCV < 8%) and volume (CoV T < 10%, RCV < 16%); haemodynamic measures were high (CoV T 12–25%, RCV 16–47%). Conclusions Evidence of low CoV T and RCV in multiorgan T1 values. RCV and sample size estimates are provided for future longitudinal multiorgan monitoring in CC patients. Trial registration ClinicalTrials.gov identifier: NCT02037867 , Registered: 05/01/2013.
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VCTE measurements are highly variable, with a coefficient of variation of up to 60% in those with cirrhosis.
“VCTE measurements are highly variable, 188 with a coef fi cient of variation of up to 60% in those with cirrhosis. 189”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [189]
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- Authors
- Bradley, C. R., Cox, E. F., Palaniyappan, N., Aithal, G. P., Francis, S. T., & Guha, I. N.
- Affiliations
- Nottingham University Hospitals NHS Trust (GB)
- Corresponding author
- Guha, Indra Neil
- ORCID
- Venue
- European Radiology Experimental
- Published
- 2022-10-24
- Volume
- 6
- Issue
- 1
- Pages
- 52-52
- ISSN
- 2509-9280 (ISSN-L)
- PMC
- PMC9588852
- OpenAlex
- W4307117565
- Cited by
- 8
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- European Radiology Experimental (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (publishedVersion, other-oa)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Academy of Medical Sciences (SGL024\1044)
- NIHR Nottingham Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- compensated cirrhosis, reference change value, longitudinal variation, liver stiffness, transient elastography, multiparametric MRI, T1 mapping, liver perfusion, spleen, renal perfusion, heart, enhanced liver fibrosis test, FIB-4, APRI, disease progression, sample size determination
- MeSH terms
- Aspartate Aminotransferases, Fibrosis, Humans, Liver Cirrhosis, Magnetic Resonance Imaging, Biomarkers, Disease Progression
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