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Cited by 374

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

Open access
Yamaza, Takayoshi, Kentaro, Akiyama, Chen, Chider, Liu, Yi, Shi, Yufang, Gronthos, Stan, Wang, Songlin, Shi, Songtao·2010·Stem Cell Research & Therapy
DOI 10.1186/scrt5
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Abstract

Introduction: Stem cells from human exfoliated deciduous teeth (SHED) have been identified as a population of postnatal stem cells capable of differentiating into osteogenic and odontogenic cells, adipogenic cells, and neural cells. Herein we have characterized mesenchymal stem cell properties of SHED in comparison to human bone marrow mesenchymal stem cells (BMMSCs). Methods: We used in vitro stem cell analysis approaches, including flow cytometry, inductive differentiation, telomerase activity, and Western blot analysis to assess multipotent differentiation of SHED and in vivo implantation to assess tissue regeneration of SHED. In addition, we utilized systemic SHED transplantation to treat systemic lupus erythematosus (SLE)-like MRL/lpr mice. Results: We found that SHED are capable of differentiating into osteogenic and adipogenic cells, expressing mesenchymal surface molecules (STRO-1, CD146, SSEA4, CD73, CD105, and CD166), and activating multiple signaling pathways, including TGFβ, ERK, Akt, Wnt, and PDGF. Recently, BMMSCs were shown to possess an immunomodulatory function that leads to successful therapies for immune diseases. We examined the immunomodulatory properties of SHED in comparison to BMMSCs and found that SHED had significant effects on inhibiting T helper 17 (Th17) cells in vitro. Moreover, we found that SHED transplantation is capable of effectively reversing SLE-associated disorders in MRL/lpr mice. At the cellular level, SHED transplantation elevated the ratio of regulatory T cells (Tregs) via Th17 cells. Conclusions: These data suggest that SHED are an accessible and feasible mesenchymal stem cell source for treating immune disorders like SLE.

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Metadata

Authors
Yamaza, T., Kentaro, A., Chen, C., Liu, Y., Shi, Y., Gronthos, S., Wang, S., & Shi, S.
Venue
Stem Cell Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2010-03-15
Volume
1
Issue
1
Pages
5-5
ISSN
1757-6512 (ISSN-L)
DOI
10.1186/scrt5
OpenAlex
W1988477032
Cited by
374
References
41
FWCI
8.42
Type
journal article
Language
en
Open access
gold

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