The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The role of calcium signaling in phagocytosis
Open accessAbstract
This review focuses on the sequence of cellular events leading to calcium signals critical for phagosome maturation. Immune cells kill microbes by engulfing them in a membrane-enclosed compartment, the phagosome. Phagocytosis is initiated when foreign particles bind to receptors on the membrane of phagocytes. The best-studied phagocytic receptors, those for Igs (FcγR) and for complement proteins (CR), activate PLC and PLD, resulting in the intracellular production of the Ca2+-mobilizing second messengers InsP3 and S1P, respectively. The ensuing release of Ca2+ from the ER activates SOCE channels in the plasma and/or phagosomal membrane, leading to sustained or oscillatory elevations in cytosolic Ca2+ concentration. Cytosolic Ca2+ elevations are required for efficient ingestion of foreign particles by some, but not all, phagocytic receptors and stringently control the subsequent steps involved in the maturation of phagosomes. Ca2+ is required for the solubilization of the actin meshwork that surrounds nascent phagosomes, for the fusion of phagosomes with granules containing lytic enzymes, and for the assembly and activation of the superoxide-generating NADPH oxidase complex. Furthermore, Ca2+ entry only occurs at physiological voltages and therefore, requires the activity of proton channels that counteract the depolarizing action of the phagocytic oxidase. The molecules that mediate Ca2+ ion flux across the phagosomal membrane are still unknown but likely include the ubiquitous SOCE channels and possibly other types of Ca2+ channels such as LGCC and VGCC. Understanding the molecular basis of the Ca2+ signals that control phagocytosis might provide new, therapeutic tools against pathogens that subvert phagocytic killing.
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Cites
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Cited by
ROS production in phagocytes: Why, when, and where?
Dupré-Crochet, S., Erard, M., & Nüβe, O. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012544 · Cited by 467
Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1211601 · Cited by 430
A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
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A role of PIEZO1 in iron metabolism in mice and humans
Ma, S., Dubin, A. E., Zhang, Y., Mousavi, S. A. R., Wang, Y., Coombs, A. M., Loud, M., Andolfo, I., & Patapoutian, A. (2021) · Cell · doi:10.1016/j.cell.2021.01.024 · Cited by 232
Kyrmizi, I., Ferreira, H., Carvalho, A., Figueroa, J. A. L., Zarmpas, P., Cunha, C., Akoumianaki, T., Stylianou, K., Deepe, G. S., Samonis, G., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0167-x · Cited by 96
Metadata
- Authors
- Nunes, P., & Demaurex, N.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04-16
- Volume
- 88
- Issue
- 1
- Pages
- 57-68
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2104180154
- Cited by
- 242
- References
- 12
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- green
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