The DOI matches its Crossref record; 258 of the 258 references it cites were found in a registry or an index.
Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation
Open accessAbstract
Extensive research in the past decade has identified innate immune recognition receptors and intracellular signaling pathways that culminate in inflammatory responses. Besides its role in cytoprotection, the importance of cell stress in inflammation and host defense against pathogens is emerging. Recent studies have shown that proteins in cellular stress responses, including the heat shock response, ER stress response, and DNA damage response, interact with and regulate signaling intermediates involved in the activation of innate and adaptive immune responses. The effect of such regulation by cell stress proteins may dictate the inflammatory profile of the immune response during infection and disease. In this review, we describe the regulation of innate immune cell activation by cell stress pathways, present detailed descriptions of the types of stress response proteins and their crosstalk with immune signaling intermediates that are essential in host defense, and illustrate the relevance of these interactions in diseases characteristic of aberrant immune responses, such as chronic inflammatory diseases, autoimmune disorders, and cancer. Understanding the crosstalk between cellular stress proteins and immune signaling may have translational implications for designing more effective regimens to treat immune disorders.
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Citations
Cites
1 retracted
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Cited by
Fever and the thermal regulation of immunity: the immune system feels the heat
Evans, S. S., Repasky, E. A., & Fisher, D. T. (2015) · Nature Reviews Immunology · doi:10.1038/nri3843 · Cited by 1,257
Air pollution and its effects on the immune system
Glencross, D. A., Ho, T.-R., Camiña, N., Hawrylowicz, C. M., & Pfeffer, P. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.179 · Cited by 726
Abuaita, B. H., Schultz, T. L., & O’Riordan, M. X. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.10.005 · Cited by 223
Peroxisome-mediated metabolism is required for immune response to microbial infection
Di Cara, F., Sheshachalam, A., Braverman, N. E., Rachubinski, R. A., & Simmonds, A. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.016 · Cited by 155
Jayawardena, T. U., Fernando, I. P. S., Lee, W. W., Sanjeewa, K. K. A., Kim, H.-S., Lee, D.-S., & Jeon, Y.-J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.105 · Cited by 95
Metadata
- Authors
- Muralidharan, S., & Mandrekar, P.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-29
- Volume
- 94
- Issue
- 6
- Pages
- 1167-1184
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2144315186
- Cited by
- 329
- References
- 258
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
