The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
TLR agonists: our best frenemy in cancer immunotherapy
Open accessAbstract
Review on the ability of different TLR agonists to orchestrate antitumor immune responses, or promote tumor growth, underscoring the impact of choosing among TLR agonists when applying these therapies in the clinic. Various TLR agonists are currently under investigation in clinical trials for their ability to orchestrate antitumor immunity. The antitumor responses are largely attributed to their aptitude to stimulate APCs such as DCs which in turn, activate tumor-specific T cell responses. However, there is a potential for TLR signaling to occur on cells other than professional APCs that could negate antitumor responses or even worse, promote tumor growth. The impetus for this review is twofold. First, there is accumulating data demonstrating that the engagement of TLRs on different T cell subsets and different cancer types could promote tumor growth or conversely, contribute to antitumor responses. Second, the efficacy of TLR agonists as monotherapies to treat cancer patients has been limited. In this review, we discuss how TLR signaling within different T cell subsets and cancer cells can potentially impact the generation of antitumor responses. Based on evidence from preclinical models and clinical trials, we draw attention to several criteria that we believe must be considered when selecting TLR agonists for developing effective immunotherapeutic strategies against cancer.
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1 retracted
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Exploring the next generation of antibody–drug conjugates
Tsuchikama, K., Anami, Y., Ha, S. Y. Y., & Yamazaki, C. M. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00850-2 · Cited by 659
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Sameer, A. S., & Nissar, S. (2021) · BioMed Research International · doi:10.1155/2021/1157023 · Cited by 323
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs
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Metadata
- Authors
- Kaczanowska, S., Joseph, A. M., & Davila, E.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-03-08
- Volume
- 93
- Issue
- 6
- Pages
- 847-863
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2123662098
- Cited by
- 339
- References
- 179
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaczanowska, S., Joseph, A. M., & Davila, E. (2013). TLR agonists: our best frenemy in cancer immunotherapy. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.1012501
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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