The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats
Abstract
6-Hydroxydopamine (6-OHDA) is one of the most widely used rat models for Parkinson's disease. There is ample evidence in the literature that 6-OHDA elicits its toxic manifestations through oxidant stress. In the present study, we evaluated the anti-parkinsonian effects of Withania somnifera extract, which has been reported to have potent anti-oxidant, anti-peroxidative and free radical quenching properties in various diseased conditions. Rats were pretreated with 100, 200 and 300 mg/kg b.w. of the W. somnifera extract orally for 3 weeks. On day 21, 2 microL of 6-OHDA (10 microg in 0.1% in ascorbic acid-saline) was infused into the right striatum while sham operated group received 2 microL of the vehicle. Three weeks after 6-OHDA injections, rats were tested for neurobehavioral activity and were killed 5 weeks after lesioning for the estimation of lipidperoxidation, reduced glutathione content, activities of glutathione-S-transferase, glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase, catecholamine content, dopaminergic D2 receptor binding and tyrosine hydroxylase expression. W. somnifera extract was found to reverse all the parameters significantly in a dose-dependent manner. Thus, the study demonstrates that the extract of W. somnifera may be helpful in protecting the neuronal injury in Parkinson's disease.
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In the citing paper
“Ahmad et al. [9] reported dose-dependent reversal of the 6-OHDA induced neurotoxicity mainly due to the strong antioxidant properties of WS extract.”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [9]
In the citing paper
“| WS extract | Dose-dependent reversal of 6-OHDA | Rats | Increase in strong antioxidant property, | [9] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [9]
In the citing paper
“| WS extract | Dose-dependent reversal of 6-OHDA | Rats | Increase in strong antioxidant property, | [9] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [9]
In the citing paper
“| WS extract | Dose-dependent reversal of 6-OHDA | Rats | Increase in strong antioxidant property, | [9] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [9]
Citations
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Sorted by citations
Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
Rahal, A., Kumar, A., Singh, V., Yadav, B., Tiwari, R., Chakraborty, S., & Dhama, K. (2014) · BioMed Research International · doi:10.1155/2014/761264 · Cited by 1,806
Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine
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Metadata
- Authors
- Ahmad, M., Saleem, S., Ahmad, A. S., Ansari, M. A., Yousuf, S., Hoda, M. N., & Islam, F.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Islam, Fakhrul
- Venue
- Human & Experimental Toxicology
- Publisher
- SAGE Publications
- Published
- 2005-03
- Volume
- 24
- Issue
- 3
- Pages
- 137-147
- ISSN
- 0960-3271 (ISSN-L)
- 1477-0903
- OpenAlex
- W1977817564
- Cited by
- 227
- References
- 51
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 14 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 9 · 2017: 16 · 2016: 17 · 2015: 14 · 2014: 14 · 2013: 17 · 2012: 13
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human & Experimental Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Withania somnifera, ashwagandha extract, Parkinson's disease, 6-hydroxydopamine, neuroprotection, oxidative stress, striatum, antioxidant enzymes, lipid peroxidation, dopaminergic neurons, tyrosine hydroxylase, D2 receptor binding, catecholamines
- MeSH terms
- Animals, Behavior, Animal, Brain, Disease Models, Animal, Male, Plant Extracts, Oxidopamine, Rats, Wistar, Neuroprotective Agents, Parkinsonian Disorders, Withania, Rats
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