Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder and these days a lot of emphasis is given on the treatment of this disease using herbal medicines. The present study evaluates the neuroprotective effect of Withania somnifera (Ws) root extract on Parkinsonian mice. The mice were divided into three groups; the first group served as control, the second group was given maneb (MB) and paraquat (PQ) and the last group was administered MB-PQ along with Ws root extract for 3, 6 and 9 weeks. The behavioral studies showed a significant improvement in the motor movement patterns and gripping ability of Ws root extract exposed Parkinsonian mice. Tyrosine hydroxylase (TH) immunostaining was reduced in the substantia nigra of MB-PQ exposed mice, while Ws co-exposure restored TH immunostaining significantly. Additionally, our results also demonstrate generation of oxidative stress in the nigrostriatal region of MB-PQ exposed mice. There was a marked decline in the level of catalase and a simultaneous increase in the level of nitrite and lipid peroxidation in Parkinsonian mice. Thus, the Ws root extract have shown to counteract the pro-oxidants and their associated oxidative stress in the PD model studied here. Our results clearly indicate the usefulness of Ws root extract in providing protection against MB-PQ induced nigrostriatal dopaminergic neurodegeneration and marked improvement in the behavioral, anatomical and the biochemical deformities.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
No toxic signs or mortality were observed with 2000 mg/kg of WS root hydroalcoholic extract in Wistar rats.
“No toxic signs or mortality were observed with 2000 mg/kg of WS root hydroalcoholic extract (WSR) in Wistar rats [270].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [270]
Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
Colorimetric assay of catalase
Sinha, A. K. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90132-7 · Cited by 5,574 · see citing works
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works
Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149 · see citing works
Oxygen radicals and the nervous system
Halliwell, B. B., & Gutteridge, J. M. C. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90010-4 · Cited by 822 · see citing works
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803 · see citing works
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
Mishra, L. C., Singh, B. B., & Dagenais, S. (2000) · PubMed · Cited by 776 · see citing works
Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction
Granger, D. L., Taintor, R. R., Boockvar, K. S., & Hibbs, J. B. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68016-1 · Cited by 511 · see citing works
Thiruchelvam, M. J., Richfield, E. K., Baggs, R. B., Tank, A. W., & Cory‐Slechta, D. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09207.2000 · Cited by 471 · see citing works
Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss
Brooks, A. I., Chadwick, C. A., Gelbard, H. A., Cory‐Slechta, D. A., & Federoff, H. J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01192-5 · Cited by 425 · see citing works
Withania somnifera: an Indian ginseng
Kulkarni, S. K., & Dhir, A. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.011 · Cited by 416 · see citing works
Kale, M., Rathore, N., John, S., & Bhatnagar, D. (1999) · Toxicology Letters · doi:10.1016/s0378-4274(98)00399-3 · Cited by 413 · see citing works
Thiruchelvam, M. J., Brockel, B. J., Richfield, E. K., Baggs, R. B., & Cory‐Slechta, D. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02496-3 · Cited by 324 · see citing works
Uversky, V. N. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0937-z · Cited by 312 · see citing works
Bhattacharya, A., Ghosal, S., & Bhattacharya, S. K. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00309-3 · Cited by 288 · see citing works
Search for natural products related to regeneration of the neuronal network
Tohda, C., Kuboyama, T., & Komatsu, K. (2005) · Neurosignals · doi:10.1159/000085384 · Cited by 257 · see citing works
Zhang, J., Fitsanakis, V. A., Gu, G., Jing, D., Ao, M., Amarnath, V., & Montine, T. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01525.x · Cited by 238 · see citing works
A simple method to measure stride length as an index of nigrostriatal dysfunction in mice
Fernagut, P., Diguet, E., Labattu, B., & Tison, F. (2002) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00485-x · Cited by 214 · see citing works
Diffusion barriers evoked in the rat cortex by reactive astrogliosis
Roitbak, T., & Sykov�, E. (1999) · Glia · doi:10.1002/(sici)1098-1136(199910)28:1 · Cited by 208 · see citing works
Konar, A., Shah, N., Singh, R., Saxena, N., Kaul, S. C., Wadhwa, R., & Thakur, M. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027265 · Cited by 193 · see citing works
Limitations of Animal Models of Parkinson's Disease
Potashkin, J. A., Blume, S. R., & Runkle, N. K. (2010) · Parkinson s Disease · doi:10.4061/2011/658083 · Cited by 180 · see citing works
Association of l-DOPA with recovery following Ayurveda medication in Parkinson’s disease
Nagashayana, N., Sankarankutty, P., Nampoothiri, M. R. V., Mohan, P. K., & Mohanakumar, K. P. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00329-4 · Cited by 175 · see citing works
Mochizuki, H., Hayakawa, H., Migita, M., Shibata, M., Tanaka, R., Suzuki, A., Shimo-Nakanishi, Y., Urabe, T., YAMADA, M., Tamayose, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191107398 · Cited by 164 · see citing works
Rajasankar, S., Manivasagam, T., Venkatachalam, S., Prakash, S., Muthusamy, R., Krishnamurti, A., & Surendran, S. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.003 · Cited by 161 · see citing works
Zafar, K. S., Siddiqui, A., Sayeed, I., Ahmad, M., Salim, S., & Islam, F. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01531.x · Cited by 159 · see citing works
Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha
Kuboyama, T., Tohda, C., Zhao, J., Nakamura, N., Hattori, M., & Komatsu, K. (2002) · Neuroreport · doi:10.1097/00001756-200210070-00005 · Cited by 146 · see citing works
Tillerson, J. L., & Miller, G. W. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(02)00360-6 · Cited by 145 · see citing works
Peroxynitrite and drug-dependent toxicity
Denicola, A., & Radí, R. (2004) · Toxicology · doi:10.1016/j.tox.2004.11.023 · Cited by 145 · see citing works
A comparative pharmacological investigation of Ashwagandha and Ginseng
Grandhi, A., Mujumdar, A. M., & Patwardhan, B. (1994) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(94)01119-2 · Cited by 142 · see citing works
Cheng, Y., He, G., Mu, X. L., Zhang, T., Li, X., Hu, J., Xu, B., & Du, G. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.116 · Cited by 141 · see citing works
Rajasankar, S., Manivasagam, T., & Surendran, S. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.044 · Cited by 140 · see citing works
Developmental Pesticide Models of the Parkinson Disease Phenotype
Cory‐Slechta, D. A., Thiruchelvam, M. J., Barlow, B. K., & Richfield, E. K. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7570 · Cited by 132 · see citing works
Somayajulu‐Nitu, M., Sandhu, J. K., Cohen, J. S., Sikorska, M., Sridhar, T., Matei, A., Borowy‐Borowski, H., & Pandey, S. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-88 · Cited by 117 · see citing works
Xu, Q., Kanthasamy, A. G., & Reddy, M. B. (2011) · Parkinson s Disease · doi:10.4061/2011/431068 · Cited by 112 · see citing works
Kidd, P. M. (2000) · PubMed · Cited by 110 · see citing works
Singh, A. K., Tiwari, M. N., Upadhyay, G., Patel, D. K., Singh, D., Prakash, O., & Singh, M. P. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.018 · Cited by 110 · see citing works
Frequency-specific modulation of population-level frequency tuning in human auditory cortex
Okamoto, H., Stracke, H., Zwitserlood, P., Roberts, L. E., & Pantev, C. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-1 · Cited by 107 · see citing works
Neuroprotective Effects of Withania somnifera Dunal.: A Possible Mechanism
Bhatnagar, M., Sharma, D., & Salvi, M. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9987-7 · Cited by 95 · see citing works
Patel, S., Singh, V. K., Kumar, A., Gupta, Y. K., & Singh, M. P. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.060 · Cited by 95 · see citing works
Cost-Effectiveness of Immediate Specimen Adequacy Assessment of Thyroid Fine-Needle Aspirations
Eedes, C. R., & Wang, H. H. (2004) · American Journal of Clinical Pathology · doi:10.1309/xlndte289waqyk0y · Cited by 94 · see citing works
Schwarting, R. K. W., Bonatz, A. E., Carey, R. J., & Huston, J. P. (1991) · Brain Research · doi:10.1016/0006-8993(91)90170-z · Cited by 90 · see citing works
Gupta, S. P., Patel, S., Yadav, S., Singh, A. K., Singh, S. K., & Singh, M. P. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0176-5 · Cited by 90 · see citing works
Self-citationCost-Effectiveness of Immediate Specimen Adequacy Assessment of Thyroid Fine-Needle Aspirations
Eedes, C. R., & Wang, H. H. (2004) · American Journal of Clinical Pathology · doi:10.1309/xlnd-te28-9waq-yk0y · Cited by 89 · see citing works
Sadrzadeh, S. M. H., & Saffari, Y. (2004) · Pathology Patterns Reviews · doi:10.1309/ew0121lg9n3n1yl4 · Cited by 88 · see citing works
Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection
Mounsey, R. B., & Teismann, P. (2010) · Parkinson s Disease · doi:10.4061/2011/617472 · Cited by 82 · see citing works
Mohanasundari, M., Srinivasan, M. S., Sethupathy, S., & Sabesan, M. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.06.018 · Cited by 76 · see citing works
Koppula, S., Kumar, H., More, S. V., Kim, B., Kim, I. S., & Choi, D. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130810608 · Cited by 74 · see citing works
Yadav, S., Gupta, S. P., Srivastava, G., Srivastava, P. K., & Singh, M. P. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0682-0 · Cited by 66 · see citing works
Self-citationKumar, A., Ahmad, I., Shukla, S., Singh, B. K., Patel, D. K., Pandey, H. P., & Singh, C. (2010) · Free Radical Research · doi:10.3109/10715762.2010.492832 · Cited by 65 · see citing works
Ahmad, I., Kumar, A., Shukla, S., Pandey, H. P., & Singh, C. (2008) · Free Radical Research · doi:10.1080/10715760802513733 · Cited by 64 · see citing works
Singh, C., Ahmad, I., & Kumar, A. (2007) · PubMed · Cited by 54 · see citing works
Jagetia, G. C., Malagi, K., Baliga, M. S., Ponemone, V., & Veruva, R. R. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2004.10.971 · Cited by 53 · see citing works
Redox interactions of nitric oxide with dopamine and its derivatives
Antunes, F., Nunes, C., Laranjinha, J. A. N., & Cadenas, E. (2005) · Toxicology · doi:10.1016/j.tox.2004.11.033 · Cited by 53 · see citing works
Kumar, A., Bullard, R. L., Patel, P., Paslay, L. C., Singh, D., Bienkiewicz, E. A., Morgan, S. E., & Rangachari, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018759 · Cited by 51 · see citing works
Meningeal cells can communicate with astrocytes by calcium signaling
Grafstein, B., Liu, S., Cotrina, M. L., Goldman, S. A., & Nedergaard, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200001)47:1 · Cited by 50 · see citing works
Pisa, M. (1988) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(88)90038-3 · Cited by 44 · see citing works
Yadav, S., Dixit, A., Agrawal, S., Singh, A. K., Srivastava, G., Singh, A. K., Srivastava, P. K., Prakash, O., & Singh, M. P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8291-8 · Cited by 34 · see citing works
Self-citationAhmad, M., Yousuf, S., Khan, M. B., Ahmad, A. S., Saleem, S., Hoda, M. N., & Islam, F. (2006) · Human & Experimental Toxicology · doi:10.1191/0960327106ht635oa · Cited by 28 · see citing works
Singh, M. P., Patel, S., Dikshit, M., & Gupta, Y. K. (2006) · PubMed · Cited by 27 · see citing works
Surendran, S., Shihabuddin, L. S., Clarke, J. L., Taksir, T. V., Stewart, G. R., Parsons, G., Yang, W., Tyring, S. K., Michals‐Matalon, K., & Matalon, R. K. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.07.003 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Manoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8590578 · Cited by 523 · see citing works
Pharmacologic overview of Withania somnifera, the Indian Ginseng
Dar, N. J., Hamid, A., & Ahmad, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2012-1 · Cited by 391 · see citing works
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306 · see citing works
Advancement in the modelling and therapeutics of Parkinson’s disease
Nand, S., & Singh, P. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101752 · Cited by 213 · see citing works
Prakash, J., Chouhan, S., Yadav, S. K., Westfall, S., Nand, S., & Singh, S. P. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1443-7 · Cited by 211 · see citing works
Self-citationMucuna pruriens reduces inducible nitric oxide synthase expression in Parkinsonian mice model
Yadav, S. K., Nand, S., & Singh, S. P. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.11.009 · Cited by 185 · see citing works
Self-citationPeterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160 · see citing works
Mandlik, D. S., & Namdeo, A. G. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1741484 · Cited by 149 · see citing works
Natural Withanolides in the Treatment of Chronic Diseases
White, P. T., Subramanian, C., Motiwala, H. F., & Cohen, M. S. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_14 · Cited by 139 · see citing works
Ashwagandha in brain disorders: A review of recent developments
Zahiruddin, S., Basist, P., Parveen, A., Parveen, R., Khan, W., Gaurav, G., & Ahmad, S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112876 · Cited by 150 · see citing works
Kuboyama, T., Tohda, C., & Komatsu, K. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00022 · Cited by 127 · see citing works
Neurodegenerative diseases and Withania somnifera (L.): An update
Dar, N. J., & Ahmad, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112769 · Cited by 123 · see citing works
Durg, S., Dhadde, S. B., Vandal, R., Shivakumar, B. S., & Charan, C. S. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12398 · Cited by 110 · see citing works
Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1049334 · Cited by 103 · see citing works
Birla, H., Keswani, C., Nand, S., Singh, S. S., Zahra, W., Dilnashin, H., Rathore, A. S., & Singh, S. P. (2019) · Behavioral and Brain Functions · doi:10.1186/s12993-019-0160-4 · Cited by 101 · see citing works
Self-citationYadav, S. K., Prakash, J., Chouhan, S., & Singh, S. P. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.03.015 · Cited by 89 · see citing works
Self-citationImportant medicinal herbs in Parkinson’s disease pharmacotherapy
Srivastav, S., Fatima, M., & Mondal, A. C. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.137 · Cited by 87 · see citing works
Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism
Limanaqi, F., Biagioni, F., Busceti, C. L., Ryskalin, L., Polzella, M., Frati, A., & Fornai, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133274 · Cited by 86 · see citing works
Yadav, S. K., Prakash, J., Chouhan, S., Westfall, S., Verma, M., Singh, T. D., & Singh, S. P. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.12.001 · Cited by 80 · see citing works
Self-citationProtein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders
Olloquequi, J., Cano, A. C., Sánchez‐López, E., Carrasco, M., Verdaguer, E., Fortuna, A. C., Folch, J., Bulló, M., Auladell, C., Camins, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113709 · Cited by 72 · see citing works
Colle, D., Farina, M., Ceccatelli, S., & Raciti, M. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9916-0 · Cited by 64 · see citing works
Rational use of Ashwagandha in Ayurveda (Traditional Indian Medicine) for health and healing
Joshi, V. K., & Joshi, A. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114101 · Cited by 65 · see citing works
Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024) · Plants · doi:10.3390/plants13060771 · Cited by 63 · see citing works
Role of Medicinal Plants against Neurodegenerative Diseases
Luthra, R., & Roy, A. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210211123539 · Cited by 56 · see citing works
Parkinson’s Disease: Exploring Different Animal Model Systems
Khan, E., Hasan, I., & Haque, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109088 · Cited by 53 · see citing works
Gupta, M., & Kaur, G. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2635-0 · Cited by 49 · see citing works
Ahmad, I., Kumar, D., & Patel, H. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1905553 · Cited by 49 · see citing works
Ravi, S. K., Ramesh, B. N., Mundugaru, R., & Vincent, B. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.01.008 · Cited by 47 · see citing works
Kosmopoulou, D., Lafara, M.-P., Adamantidi, T., Ofrydopoulou, A., Grabrucker, A. M., & Τσούπρας, Α. (2024) · Applied Sciences · doi:10.3390/app14156417 · Cited by 45 · see citing works
Nadig, A. P. R., Huwaimel, B., Alobaida, A., Khafagy, E., Alotaibi, H. F., Moin, A., Lila, A. S. A., Suman, Sahyadri, M., & Krishna, K. L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113697 · Cited by 43 · see citing works
Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts
Wadhwa, R., Konar, A., & Kaul, S. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.001 · Cited by 43 · see citing works
Singh, B., Pandey, S., Yadav, S. K., Verma, R., Singh, S. P., & Mahdi, A. A. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.10.007 · Cited by 43 · see citing works
Self-citationJacquet, A. D. R., Timmers, M. A., Ma, S. Y., Thieme, A., McCabe, G. P., Vest, J. H. C., Lila, M. A., & Rochet, J. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.02.021 · Cited by 40 · see citing works
Plant-Derived Natural Products for Parkinson’s Disease Therapy
Sengupta, T. K., Vinayagam, J., Singh, R. P., Jaisankar, P., & Mohanakumar, K. P. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_23 · Cited by 39 · see citing works
Manchanda, S., Mishra, R., Singh, R., Kaur, T., & Kaur, G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9883-5 · Cited by 38 · see citing works
El‐Sayed, R. M., Abdelaziz, A. M., Zaki, H. F., & Rasheed, N. O. A. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109986 · Cited by 36 · see citing works
Bhatnagar, M., Goel, I., Roy, T., Shukla, S. D., & Khurana, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177254 · Cited by 32 · see citing works
Kaur, S., Chauhan, K., & Sachdeva, H. (2014) · Journal of Medical Microbiology · doi:10.1099/jmm.0.072694-0 · Cited by 31 · see citing works
Vegh, C., Wear, D., Okaj, I., Huggard, R., Culmone, L., Eren, Ş., Cohen, J. S., Rishi, A. K., & Pandey, S. (2021) · Antioxidants · doi:10.3390/antiox10040563 · Cited by 29 · see citing works
Yenisetti, S. C., Manjunath, M. J., & ., M. (2016) · Recent Patents on CNS Drug Discovery · doi:10.2174/1574889810666160615014106 · Cited by 29 · see citing works
Jacquet, A. D. R., Tambe, M. A., Ma, S. Y., McCabe, G. P., Vest, J. H. C., & Rochet, J. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.01.001 · Cited by 27 · see citing works
Su, Y., Mao, L., Wang, Q., Xu, X., Qin, P., Huang, H., Zhang, Y., Zhou, Y., & Yan, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1837278 · Cited by 26 · see citing works
Paraquat Induces Apoptosis through Cytochrome C Release and ERK Activation
Seo, H.-J., Choi, S. J., & Lee, J.-H. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.115 · Cited by 25 · see citing works
Experimental evidence and mechanism of action of some popular neuro-nutraceutical herbs
Kumar, A., Konar, A., Garg, S., Kaul, S. C., & Wadhwa, R. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105124 · Cited by 24 · see citing works
Mukherjee, S., Kumar, G., & Patnaik, R. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1709228 · Cited by 24 · see citing works
Possible Anti-Parkinson’s Disease Therapeutics From Nature: A Review
Dey, A., & De, J. N. (2015) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63460-3.00009-2 · Cited by 22 · see citing works
Coughlan, C. M., Walker, D. I., Lohr, K. M., Richardson, J. R., Saba, L. M., Caudle, W. M., Fritz, K. S., & Roede, J. R. (2015) · Parkinson s Disease · doi:10.1155/2015/812532 · Cited by 21 · see citing works
Mechanisms of Autoimmune Cell in DA Neuron Apoptosis of Parkinson’s Disease: Recent Advancement
Zheng, Z., Zhang, S., Zhang, H., Gao, Z., Wang, X., Liu, X., Cheng, X., Yao, L., & Lu, G. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7965433 · Cited by 20 · see citing works
Goyal, A., Gopika, S., Kumar, A., & Garabadu, D. (2022) · Current Drug Targets · doi:10.2174/1389450123666220316091734 · Cited by 19 · see citing works
Saadullah, M., Arif, S., Hussain, L., Asif, M., & Khurshid, U. (2022) · Dose-Response · doi:10.1177/15593258221125478 · Cited by 19 · see citing works
Togashi, K., Hasegawa, M., Nagai, J., Tonouchi, A., Masukawa, D., Hensley, K., Goshima, Y., & Ohshima, T. (2018) · Genes to Cells · doi:10.1111/gtc.12651 · Cited by 19 · see citing works
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease
Singla, R. K., Agarwal, T., He, X., & Shen, B. (2020) · Current Drug Targets · doi:10.2174/1389450121999201013155202 · Cited by 19 · see citing works
Network pharmacology of Withania somnifera against stress associated neurodegenerative diseases
Duyu, T., Khanal, P., Dey, Y. N., & Jha, S. K. (2021) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-020-00530-x · Cited by 18 · see citing works
Ayaz, M., Anwar, F., Saleem, U., Shahzadi, I., Ahmad, B., Mir, A., & Ismail, T. (2022) · ACS Omega · doi:10.1021/acsomega.2c00145 · Cited by 16 · see citing works
Iqbal, A., Anwar, F., Saleem, U., Khan, S. S., Karim, A., Ahmad, B., Gul, M., Iqbal, Z., & Ismail, T. (2022) · ACS Omega · doi:10.1021/acsomega.2c05500 · Cited by 16 · see citing works
Abnormal phosphorylation of protein tyrosine in neurodegenerative diseases
Shu, L., Du, C., & Zuo, Y. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad066 · Cited by 17 · see citing works
Optimization of Parkinson's disease therapy with plant extracts and nutrition’s evolving roles
Abolarin, P. O., Amin, A., Nafiu, A. B., Ogundele, O. M., & Owoyele, B. V. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.05.011 · Cited by 20 · see citing works
Withania somnifera shows ability to counter Parkinson's Disease: An Update
Singh, S. P. (2015) · SOJ Neurology · doi:10.15226/2374-6858/2/2/00120 · Cited by 14 · see citing works
Self-citationImproving medicinal crops through phytochemical perspective: Withania somnifera (Ashwagandha)
Srivastava, Y., & Sangwan, N. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818581-0.00017-6 · Cited by 14 · see citing works
Gupta, S. K., Bansal, R. N., Sodhi, S. P. S., Brar, G. K., & Malhotra, M. (2021) · Journal of Pre-Clinical and Clinical Research · doi:10.26444/jpccr/141582 · Cited by 14 · see citing works
RP-HPLC Analysis of Anti-Parkinson’s Drug l-DOPA Content in Mucuna Species from Indian Subcontinent
Patil, R., Aware, C. B., Gaikwad, S., Rajebhosale, M., Bapat, V. A., Yadav, S. R., & Jadhav, J. P. (2019) · Proceedings of the National Academy of Sciences India Section B Biological Sciences · doi:10.1007/s40011-018-01071-9 · Cited by 14 · see citing works
Self-citationPhytopharmaceuticals and Herbal Approaches to Target Neurodegenerative Disorders
Islam, A., Mishra, A., Ahsan, R., & Fareha, S. (2023) · Drug Research · doi:10.1055/a-2076-7939 · Cited by 13 · see citing works
Tonouchi, A., Nagai, J., Togashi, K., Goshima, Y., & Ohshima, T. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13617 · Cited by 12 · see citing works
Siddiqui, M. A., Farshori, N. N., Al-Oqail, M. M., Pant, A. B., & Al-Khedhairy, A. A. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03146-4 · Cited by 12 · see citing works
Phytochemicals in Parkinson’s Disease: a Pathway to Neuroprotection and Personalized Medicine
Das, S., Rajeswari, V. D., Venkatraman, G., & Ramanathan, G. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01607-z · Cited by 11 · see citing works
Extrapyramidal system neurotoxicity
Dorman, D. C. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62627-1.00012-3 · Cited by 11 · see citing works
Doke, R. R., Pansare, P. A., Sainani, S., Bhalchim, V., Rode, K., & Desai, S. (2021) · Journal of scientific research · doi:10.37398/jsr.2021.650119 · Cited by 8 · see citing works
Prakash, J., Yadav, S. K., Chouhan, S., Prakash, S., & Singh, S. P. (2013) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2013.411a2001 · Cited by 12 · see citing works
Self-citationKrishnan, M. (2023) · Bioinformation · doi:10.6026/97320630019729 · Cited by 12 · see citing works
Solid-state UV–MALDI–MS assay of transition metal dithiocarbamate fungicides
Ivanova, B. B., & Spiteller, M. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1837-0 · Cited by 10 · see citing works
Togashi, K., Hasegawa, M., Nagai, J., Kotaka, K., Yazawa, A., Takahashi, M., Masukawa, D., Goshima, Y., Hensley, K., & Ohshima, T. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116802 · Cited by 10 · see citing works
Phytomolecules from conventional to nano form: Next-generation approach for Parkinson’s disease
Pradhan, S. P., Tejaswani, P., Behera, A., & Sahu, P. K. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102136 · Cited by 9 · see citing works
The Roles of Calcium Ions in Parkinson’s Disease: Calcium Channel Inhibitors as a Novel Agents?
Alam, M. R., Raj, K., & Singh, S. (2022) · Journal of Molecular Pathology · doi:10.3390/jmp3040021 · Cited by 9 · see citing works
Self-citationBotany and Ethnopharmacological Potential of Ashwagandha
Pandian, A., Ashokkumar, K., Sekar, S., Sivakumar, P. S., Selvaraj, K. S. V., Karthik, M., & Hariprasath, L. (2020) · Journal of Current Opinion in Crop Science · doi:10.62773/jcocs.v1i1.16 · Cited by 8 · see citing works
Therapeutic potential of Indian traditional medicines in Parkinson’s disease
Sharma, S., Kochhar, K. P., Jain, S., Jayasundar, R., & Divya, M. R. (2021) · Annals of Phytomedicine An International Journal · doi:10.21276/ap.2021.10.2.34 · Cited by 7 · see citing works
Herbs treating Parkinson's disease
Ittiyavirah, S. P., & Hameed, J. (2014) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2014.08.003 · Cited by 8 · see citing works
Wang, J., Liu, Q.-T., Shen, D.-Y., Bai, J.-P., Hu, Y., Huang, Q., Yu, H., He, N.-N., Qin, X., & Lan, R. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117009 · Cited by 7 · see citing works
Saadullah, M., Sehar, A., Chauhdary, Z., Siddique, R., Tariq, H., Asif, M., Bukhari, S. A., & Sethi, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0311140 · Cited by 6 · see citing works
RetractedThe Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature
Elyasi, L., Rosenholm, J. M., Jesmi, F., & Jahanshahi, M. (2022) · Molecules · doi:10.3390/molecules27196189 · Cited by 6 · see citing works
Nand, S., Birla, H., Zahra, W., Singh, S. S., & Singh, S. P. (2018) · SOJ Neurology · Cited by 6 · see citing works
Self-citationParaquat-induced neurotoxicity: Mechanisms and potential therapies
Jahani, R., & Mohammadi, H. (2025) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2025.100258 · Cited by 5 · see citing works
Ma, J., Huang, C., Ma, K., Wu, Y., Li, B., & Sun, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7833 · Cited by 5 · see citing works
Nimbalwar, M. G. (2021) · International Journal for Research in Applied Science and Engineering Technology · doi:10.22214/ijraset.2021.37402 · Cited by 5 · see citing works
Exploring the neuro-ameliorative propensity of Withania somnifera—Indian ginseng
Muralidhara, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00012-0 · Cited by 5 · see citing works
Traditional Medicinal Plants of Sri Lanka and Their Derivatives of Benefit to the Nervous System
Perera, P. K., Meedeniya, A. C. B., & Chamikara, N. H. A. (2021) · Springer eBooks · doi:10.1007/978-981-33-4141-8_13 · Cited by 5 · see citing works
Shukla, S. D. (2025) · Academia Biology · doi:10.20935/acadbiol7925 · Cited by 4 · see citing works
Zebrafish models for studying central nervous system effects of Ayurvedic medicinal plants
Chakraborty, P., Pal, S., Galstyan, D. S., Petersen, E. V., Amstislavskaya, T. G., Kolesnikova, T. O., de Abreu, M. S., & Kalueff, A. V. (2025) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2025.101169 · Cited by 4 · see citing works
Nellore, J., Sahajan, A., Antony, D., Pauline, C., & Namasivayam, S. K. R. (2015) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 4 · see citing works
Zhaowei, L., Yong-ling, X., Jiajia, Y., & Yang, Z. R. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1233-7 · Cited by 4 · see citing works
Singh, R. H. (2018) · Springer eBooks · doi:10.1007/978-981-10-8291-7_16 · Cited by 4 · see citing works
An Overview of the Role of Medicinal Plants in Parkinson’s Disease: A Semi-Systematic Review
Haxhiu, H., Hoxha, M., Zela, I., & Zappacosta, B. (2025) · Biomedicines · doi:10.3390/biomedicines13082008 · Cited by 6 · see citing works
Swain, C. C., Prevoznik, S., Kalbus, J. A., Pokharel, D., Beligala, D. H., Jain, P., Reddy, M. V. S. R. R., Popovich, C., Russell, J. A., & Subramanian, T. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103433 · Cited by 3 · see citing works
Dolatabadi, S., Oskuei, S. R., Mehri, S., & Hosseinzadeh, H. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03795-8 · Cited by 4 · see citing works
Ahmed, M. M. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107549 · Cited by 3 · see citing works
Kamsala, R. V., Bhakshu, L. M., & Venkataraju, R. R. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-8158-5_16 · Cited by 3 · see citing works
Withania somnifera a journey from traditionalrejuvenator to anti-SARS-CoV-2 remedy
Ashokkumar, K., Pandian, A., Baskar, M., Karthik, M. N., Murugan, M., Semwal, R. B., & Semwal, D. K. (2023) · Herba Polonica · doi:10.5604/01.3001.0053.7210 · Cited by 4 · see citing works
Plants as a promising source for the treatment of parkinson disease: A systemic review
Subitsha, A. J., Khanam, S., & Sabu, S. (2021) · IP International Journal of Comprehensive and Advanced Pharmacology · doi:10.18231/j.ijcaap.2020.032 · Cited by 3 · see citing works
Vegh, C., Walach, G., Dube, K., Malakoti-Negad, N. J., Wear, D., Jayawardena, H., Patel, M. B., Polsinelli, A., Eren, Ş., Cohen, J. S., et al. (2026) · Biomedicine Hub · doi:10.1159/000550968 · Cited by 2 · see citing works
Parkinson's Disease: A Phytotherapeutic Prospective
Deka, B., Bhattacharjee, B., Shivavedi, N., Singh, G. K., Bhat, H. R., Ghosh, S. K., & Shakya, A. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815040197123010004 · Cited by 3 · see citing works
Posible contribución del paraquat al desarrollo de la enfermedad de Parkinson
Elena‐Real, C. A., Pasión-Galván, R., Pérez-Artés, M. R., Rodríguez, M. P., & Navarro, I. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 2 · see citing works
- Authors
- Prakash, J., Yadav, S. K., Chouhan, S., & Singh, S. P.
- Affiliations
- Banaras Hindu University (IN)
- Corresponding author
- Singh, Surya Pratap
- ORCID
- Singh, Surya Pratap
- Venue
- Neurochemical Research
- Published
- 2013-02-22
- Volume
- 38
- Issue
- 5
- Pages
- 972-980
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W2055407191
- Cited by
- 128
- References
- 59
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 11 · 2021: 15 · 2020: 13 · 2019: 5 · 2018: 7 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 5 · 2012: 1
- FWCI
- 21.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Withania somnifera, ashwagandha root extract, Parkinson's disease, maneb, paraquat, neuroprotection, oxidative stress, dopaminergic neuron loss, substantia nigra, tyrosine hydroxylase, nigrostriatal pathway, catalase, lipid peroxidation, motor behavior, herbal medicine
- MeSH terms
- Animals, Disease Models, Animal, Maneb, Paraquat, Plant Extracts, Plant Roots, Neuroprotective Agents, Parkinsonian Disorders, Withania, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
