Relationship of Mean Platelet Volume To MDD: A Retrospective Study.
Open accessAbstract
BACKGROUND: Results of numerous studies show that major depressive disorder (MDD) is associated with a chronic low-grade inflammation, but the underlying mechanism remains unclear. AIM: To compare the results of blood cell analysis of MDD patients with healthy controls, and explore the potential value of it as an indicator of immune-inflammation in MDD, especially the mean platelet volume. METHODS: 103 MDD patients and 106 healthy controls with matched age and gender were recruited. We collected peripheral blood samples from both groups and gathered basic data. For comparison of normally distributed data (age, body mass index, lymphocyte count, white blood cell count, red blood cell count, hematocrit, platelet count and mean corpuscular volume) between groups, single t-test were used; and for comparison of non-normally distributed data (Neutrophil count, neutrophil count, platelet/ lymphocyte ratio, hemoglobin, red blood cell distribution width, mean platelet volume, mean hemoglobin concentration, mean hemoglobin and platelet distribution width), we used Mann-Whitney U-test. RESULTS: >0.001). CONCLUSIONS: The results suggest that serum inflammatory response probably exists in people with MDD, and indicators of blood analysis especially mean platelet volume have a potential value as biomarker for inflammation.
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NLR, PLR, and MLR are inexpensive and easily acquired reproducible markers of systemic inflammation.
“Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are inexpensive and easily acquired reproducible markers of systemic inflammation (17–19), and are calculated from white blood cell counts.”
From Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis (2022) · cites this paper as [17]
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- Authors
- Cai, L., Xu, L., Wei, L., & Chen, W.
- Affiliations
- Sir Run Run Shaw Hospital (CN)
- Venue
- PubMed Central
- Publisher
- National Institutes of Health
- Published
- 2017-02-25
- Volume
- 29
- Issue
- 1
- Pages
- 21-29
- PMC
- PMC5518251
- OpenAlex
- W2946401909
- Cited by
- 54
- References
- 43
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 12 · 2021: 8 · 2020: 9 · 2019: 10
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc
- Locations
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- major depressive disorder, mean platelet volume, inflammation, inflammatory markers, platelet indices, red cell distribution width, platelet-to-lymphocyte ratio, hematological parameters
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