Cited by 4,117Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchNutrition and Health in Aging

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The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

Blessed, G., Tomlinson, B. E., Roth, Martin·1968·British Journal of Psychiatry

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Abstract

The ageing of many populations in recent years has directed increasing attention to the social, medical and biological problems of senescence. The psychological changes associated with ageing occupy a central position in inquiries in this field. The expectation of mental disorder shows a steep increase with advancing chronological age, and beyond 75 years a large part of this increase is accounted for by disorders associated with degenerative changes in the central nervous system for which we lack remedies at the present time. Larsson et al . (1963) have estimated that the aggregate morbidity risk for these disorders up to the age of 70 is 0·4 per cent., up to age 75, 1·2 per cent. and up to age 80, 5 per cent. For higher ages estimates were probably less reliable, but the calculated risk up to the age of 90 was 5·2 per cent. In a survey of a random sample of elderly people aged 65 and over in the general population, Kay et al . (1964), found a total of 4·2 per cent. of elderly subjects to be suffering from senile dementia, 2·9 per cent. being mild cases. The condition is generally recognized as being a major cause of serious infirmity among the elderly in psychiatric, geriatric, general medical and community practice alike.

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Authors: Blessed, G., Tomlinson, B. E., & Roth, M.
Affiliations: Newcastle University (GB)
ORCID: Roth, Martin
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 1968-07
Volume: 114
Issue: 512
Pages: 797-811
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.114.512.797
OpenAlex: W2159529587
Cited by: 4,117
References: 22
Citations by year: 2026: 39 · 2025: 39 · 2024: 48 · 2023: 43 · 2022: 51 · 2021: 71 · 2020: 73 · 2019: 82 · 2018: 63 · 2017: 62 · 2016: 68 · 2015: 77 · 2014: 79 · 2013: 85 · 2012: 105
FWCI: 16.74
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 18109 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: dementia, senile dementia, brain aging, older adults, central nervous system degeneration, cognitive decline
MeSH terms: Aged, Aging, Cerebral Cortex, Delirium, Dementia, Depression, Female, Humans, Intelligence, Male, Personality, Psychological Tests

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The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

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