Transgenic mouse models of Alzheimer’s disease
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Many APP transgenic mouse models develop relevant AD-related Aβ pathology and exhibit cognitive impairment within 6 to 12 months of age.
“Though many APP transgenic mouse models have been shown to develop relevant AD-related Aβ pathology and exhibit cognitive impairment within 6 to 12 months of age [2-4]”
From Normal cognition in transgenic BRI2-Aβ mice (2013) · cites this paper as [2]
Table 2 reports Aβ plaque deposition by 6–12 months in several APP transgenic lines, and §4.2 reports cognitive impairment in Tg2576 mice from about 10 months. But §4.2 says several lines had not been behaviorally tested and cautions that apparent learning deficits in others were confounded. The paper therefore does not establish that many lines exhibited both pathology and cognitive impairment within 6–12 months (page numbers unavailable in our copy). (LLM, conf=0.88)
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Self-citation
- Authors
- Janus, C., Chishti, M. A., & Westaway, D.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Westaway, David
- ORCID
- Janus, Christopher
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 1502
- Issue
- 1
- Pages
- 63-75
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2170149943
- Cited by
- 101
- References
- 16
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, transgenic mouse model, amyloid-beta, tau protein, APP/PS1 mice, APP751
- MeSH terms
- Alzheimer Disease, Animals, Behavior, Animal, Cognition Disorders, Disease Models, Animal, Hippocampus, Membrane Proteins, Mice, Transgenic, Mutation, Peptide Fragments, Endopeptidases, Phenotype, Promoter Regions, Genetic, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, DNA, Complementary, Thy-1 Antigens, Transgenes, Mice, Amyloid Precursor Protein Secretases
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