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Cited by 4,117Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchNutrition and Health in Aging

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

Blessed, G., Tomlinson, B. E., Roth, Martin·1968·British Journal of Psychiatry
DOI 10.1192/bjp.114.512.797
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Abstract

The ageing of many populations in recent years has directed increasing attention to the social, medical and biological problems of senescence. The psychological changes associated with ageing occupy a central position in inquiries in this field. The expectation of mental disorder shows a steep increase with advancing chronological age, and beyond 75 years a large part of this increase is accounted for by disorders associated with degenerative changes in the central nervous system for which we lack remedies at the present time. Larsson et al . (1963) have estimated that the aggregate morbidity risk for these disorders up to the age of 70 is 0·4 per cent., up to age 75, 1·2 per cent. and up to age 80, 5 per cent. For higher ages estimates were probably less reliable, but the calculated risk up to the age of 90 was 5·2 per cent. In a survey of a random sample of elderly people aged 65 and over in the general population, Kay et al . (1964), found a total of 4·2 per cent. of elderly subjects to be suffering from senile dementia, 2·9 per cent. being mild cases. The condition is generally recognized as being a major cause of serious infirmity among the elderly in psychiatric, geriatric, general medical and community practice alike.

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Research works printed but not linked: 9

  1. Norris, 1955, “Outcome of mental breakdown in the elderly”, Brit. med. J., 675
  2. Gellerstedt, 1932–33, “Our knowledge of cerebral changes in normal involution of old age.”, Upsala Läk/Fören, Förh., 38, 193
  3. Arab, 1954, “Plaques séniles et artériosclérose cérébrale; absence de rapports de dépendance entre les deux processus; étude statistique”, Rev. Neurol., 91, 22
  4. Alzheimer, 1907, “On a peculiar disease of the cerebral cortex”, Allg. Z. Psychiat., 64, 146
  5. Simchowicz, 1910, “Histologische Studien über die senile Demenz”, Hist. histopath. Arb., 4, 267
  6. Sjgören H. , Sourander P. , and Svennerholm L. (1966). “Clinical, histological and chemical studies on presenile and senile neuropsychiatric diseases” Proc. Fifth Internal. Congr. Neuropathology, Zurich, September 1965. Excerpta Medica Internal. Congr. Series, No. 100, 555.
  7. Larsson, 1963, “Senile dementia”, Acta psychiat. Scand., 39
  8. Rothschild, 1956, Mental Disorders in Late Life
  9. Blocq, 1892, “Sur les lésions et la pathogénie de l'épilepsie dite essentielle”, Sem. med. (Paris), 12, 445

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Metadata

Authors
Blessed, G., Tomlinson, B. E., & Roth, M.
Affiliations
Newcastle University (GB)
ORCID
Roth, Martin
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
1968-07
Volume
114
Issue
512
Pages
797-811
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.114.512.797
OpenAlex
W2159529587
Cited by
4,117
References
22
Citations by year
2026: 39 · 2025: 39 · 2024: 48 · 2023: 43 · 2022: 51 · 2021: 71 · 2020: 73 · 2019: 82 · 2018: 63 · 2017: 62 · 2016: 68 · 2015: 77 · 2014: 79 · 2013: 85 · 2012: 105
FWCI
16.74
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 18109 d)
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords
dementia, senile dementia, brain aging, older adults, central nervous system degeneration, cognitive decline
MeSH terms
Aged, Aging, Cerebral Cortex, Delirium, Dementia, Depression, Female, Humans, Intelligence, Male, Personality, Psychological Tests

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