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Levels of anxiety and depression as predictors of mortality: the HUNT study
Open accessAbstract
BACKGROUND: Depression is reported to be associated with increased mortality, although underlying mechanisms are uncertain. Associations between anxiety and mortality are also uncertain. AIMS: To investigate associations between individual and combined anxiety/depression symptom loads (using the Hospital Anxiety and Depression Scale (HADS)) and mortality over a 3-6 year period. METHOD: We utilised a unique link between a large population survey (HUNT-2, n = 61 349) and a comprehensive mortality database. RESULTS: Case-level depression was associated with increased mortality (hazard ratio (HR) = 1.52, 95% CI 1.35-1.72) comparable with that of smoking (HR = 1.59, 95% CI 1.44-1.75), and which was only partly explained by somatic symptoms/conditions. Anxiety comorbid with depression lowered mortality compared with depression alone (anxiety depression interaction P = 0.017). The association between anxiety symptom load and mortality was U-shaped. CONCLUSIONS: Depression as a risk factor for mortality was comparable in strength to smoking. Comorbid anxiety reduced mortality compared with depression alone. The relationship between anxiety symptoms and mortality was more complex with a U-shape and highest mortality in those with the lowest anxiety symptom loads.
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“Anxiety comorbid with depression was found to reduce mortality compared with depression alone in Norwegian adults [25].”
From Adaptive function and correlates of anxiety during a pandemic (2021) · cites this paper as [25]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779
Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis
Barth, J., Schumacher, M., & Herrmann-Lingen, C. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000146332.53619.b2 · Cited by 1,358
van Melle, J. P., de Jonge, P., Spijkerman, T. A., Tijssen, J. G. P., Ormel, J., van Veldhuisen, D. J., van den Brink, R. H. S., & van den Berg, M. P. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000146294.82810.9c · Cited by 1,034
Mykletun, A., Stordal, E., & Dahl, A. A. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.179.6.540 · Cited by 908
Depression as a Risk Factor for Coronary Artery Disease: Evidence, Mechanisms, and Treatment
Lett, H. S., Blumenthal, J. A., Babyak, M. A., Sherwood, A., Strauman, T. J., Robins, C., & Newman, M. F. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000126207.43307.c0 · Cited by 847
Excess mortality in depression: a meta-analysis of community studies
Cuijpers, P. J., & Smit, F. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00413-x · Cited by 798
Depression as a risk factor for cardiac mortality and morbidity
Carney, R. M., Freedland, K. E., Miller, G. E., & Jaffe, A. S. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00311-2 · Cited by 746
A systematic review of the mortality of depression
Wulsin, L. R., Vaillant, G. E., & Wells, V. E. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199901000-00003 · Cited by 703 · cited 2×
“31,33 Despite some controversy over the evidence for this association, potential mechanisms have been suggested.”
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Research works printed but not linked: 5
- 1980, Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III)
- 1967, International Statistical Classification of Diseases and Related Health Problems (ICD–8)
- 10.1016/S0895-4356(03)00254-3 · DOI
- 10.1176/ajp.2006.163.8.1412 · DOI · Paper page
- 1978, International Statistical Classification of Diseases and Related Health Problems (ICD–9)
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Churchill, R. C., Moore, T. H., Davies, P. A., Caldwell, D. M., Jones, H. F., Lewis, G., & Hunot, V. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008706 · Cited by 4
Underlying domains of anxiety trait in a Costa Rican sample: Preliminary results
Ugalde‐Araya, D., Coto-Vílchez, C., Ávila-Aguirre, A., Chavarría‐Soley, G., Raventós, H., & Rojas, J. C. (2020) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2020.01.001 · Cited by 4
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Apsari, R. A., & Wijaya, S. K. (2020) · doi:10.1109/ibiomed50285.2020.9487614 · Cited by 4
Abu‐Zaid, A., Gari, A. M., Alsharif, S. A., Alshahrani, M. S., Khadawardi, K. A., Ahmed, A. M., Baradwan, A., Bukhari, I. A., Alyousef, A., Alharbi, F. S., et al. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.08.011 · Cited by 5
Eyre, H. A. (2014) · Journal of Yoga & Physical Therapy · doi:10.4172/2157-7595.1000165 · Cited by 4
Studies of Depression and Illness Representations in End-Stage Renal Disease
Chilcot, J. (2010) · University of Hertfordshire Research Archive (University of Hertfordshire) · Cited by 4
Kantola, K. G., Wynn, R., Johnsen, J.-A. K., & Hadler‐Olsen, E. (2025) · Acta Odontologica Scandinavica · doi:10.2340/aos.v84.45205 · Cited by 3
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Bitsika, V., Elmose, M., Mertika, A., Sharpley, C. F., Ladopoulou, K., Kampakos, C., & Syriopoulou–Delli, C. K. (2023) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2023.2196469 · Cited by 4
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(2013) · Perspectives in Public Health · doi:10.1177/1757913913476631 · Cited by 3
Grygiel, P., Świtaj, P., Anczewska, M., Sikorska, J., Humenny, G., & Rębisz, S. (2013) · doi:10.13140/rg.2.1.4507.0803 · Cited by 5
Anxiety and dementia: cause or effect?
Stewart, R. J. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12992 · Cited by 3
Inflammatory potential of diet in mental disorders and psychosocial stress
Davis, J. A., Aslam, H., Jacka, F. N., & Marx, W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822130-3.00010-7 · Cited by 2
Grant, S., Azhar, G. S., Han, E., Booth, M. S., Motala, A., Larkin, J., & Hempel, S. (2020) · RAND Corporation eBooks · doi:10.7249/rr2452 · Cited by 2
Campetti, P. H. D. M. (2019) · Jornal Brasileiro de Economia da Saúde · doi:10.21115/jbes.v11.n3.p263-70 · Cited by 2
Mykletun, A., & Øverland, S. N. (2010) · Norsk Epidemiologi · doi:10.5324/nje.v19i2.582 · Cited by 3
Psychodynamic therapies versus treatment as usual for depression
Moore, T. H., Hunot, V., Davies, P. A., Caldwell, D. M., Jones, H. F., Lewis, G., & Churchill, R. C. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008707 · Cited by 2
Prevalence and structure of anxiety-depression in an Australian community sample
Sharpley, C. F., Bitsika, V., Jesulola, E., & Agnew, L. L. (2016) · Archives of Psychiatry and Psychotherapy · doi:10.12740/app/62976 · Cited by 2
Bitsika, V., & Sharpley, C. F. (2012) · e-publications@bond (Bond University) · Cited by 2
Nyrønning, L. Å., Hultgren, R., Albrektsen, G., Mattsson, E. J. R., & Stenman, M. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-049055 · Cited by 2
Bitsika, V., & Sharpley, C. F. (2022) · Journal of Developmental and Physical Disabilities · doi:10.1007/s10882-021-09832-7 · Cited by 2
Prevalence and Coping Strategies of Postnatal Depression among Women in Bayelsa State, Nigeria
Uzobo, E., Teibowei, B. J., & Ogeh, V. I. (2022) · Africa Journal of Nursing and Midwifery · doi:10.25159/2520-5293/9457 · Cited by 2
Snodgrass, R., Carnell, J., & Chapman, T. (2022) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.2203035 · Cited by 3
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Layard, R., Chisholm, D., Patel, V., & Saxena, S. (2013) · SSRN Electronic Journal · doi:10.2139/ssrn.2336397 · Cited by 3
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Salalι, G. D., Uysal, M. S., & Bevan, A. (2021) · Research Square · doi:10.21203/rs.3.rs-271498/v1 · Cited by 3
Fränz, K. (1986) · University of Regensburg Publication Server (University of Regensburg) · Cited by 2
The Origins of Anxiety, Panic and Rage Attacks
Janov, A. (2013) · Activitas Nervosa Superior · doi:10.1007/bf03379596 · Cited by 1
Researching Depression in Prostate Cancer Patients: Factors, Timing, and Measures
Sharpley, C. F., Bitsika, V., Christie, D., Denham, J. W., Duchesne, G. M., & Couper, J. W. (2014) · Journal of Men s Health · doi:10.1089/jomh.2014.0036 · Cited by 1
Medical illness in psychiatric patients in the emergency department
Stiebel, V. G., & Nightengale, B. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139088077.022 · Cited by 1
Antidepressants are an Important Part of Treating Depression
Sareen, J., & Enns, M. W. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00240 · Cited by 1
Jellesma, F. C. (2013) · Cited by 1
Psykisk helse som global utfordring
Siem, H. (2016) · Tidsskrift for psykisk helsearbeid · doi:10.18261/issn.1504-3010-2016-04-06 · Cited by 1
Zhang, Y., Chen, J., Tang, R., Deng, J., Guo, H., Wu, X., & Xu, Q. (2023) · BMC Nephrology · doi:10.1186/s12882-023-03291-2 · Cited by 1
Spécificités et approche préventive du suicide chez le sujet âgé
Limosin, F. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2014.09.264 · Cited by 1
Söderberg, M., Schiöler, L., Stattin, M., Burdorf, A., & Järvholm, B. (2019) · Scandinavian Journal of Public Health · doi:10.1177/1403494819884440 · Cited by 1
(2023) · Cambridge University Press eBooks · doi:10.1017/9781009298957.026
Epidemiology of anxiolytic and hypnotic drug use in the general population in Norway
Hausken, A. M. (2010) · NORA - Norwegian Open Research Archives · Cited by 1
Uncertainty in economic evaluations: implications for healthcare decisions
Mohseninejad, L. (2013) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 1
Temporal and population dynamics of depressive symptoms : empirical and modeling approaches
Rosenström, T. H. (2013) · Työväentutkimus Vuosikirja · Cited by 1
Naicker, K. (2018) · uO Research (University of Ottawa) · doi:10.20381/ruor-21599 · Cited by 1
Knaus, Y. C. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.47.2021.tde-09112021-154824 · Cited by 3
Miloyan, B. H., & Bulley, A. (2015) · Springer eBooks · doi:10.1007/978-981-287-080-3_259-1 · Cited by 1
Knudsen, A. K. (2013) · NORA - Norwegian Open Research Archives · Cited by 1
Chepenik, L. G., & Mallory, M. N. S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139088077.012
Psychiatric symptoms and disorders in old age: prevalence, course and diagnostic thresholds
Sigström, R. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Antidepressants in counselling psychology: Relevance, effectiveness and implications for practice
Sharpley, C. F. (2011) · Counselling Psychology Quarterly · doi:10.1080/09515070.2011.589245
[The screening test for mitochondrial disease].
Oguro, N., & Momoi, M. Y. (2002) · PubMed
Psychosomatik und Psychotherapie der koronaren Herzerkrankung
Michal, M., Münzel, T. F., & Beutel, M. E. (2011) · Psychiatrie und Psychotherapie up2date · doi:10.1055/s-0031-1276852
Drinking and depression in Norwegian doctors : a 15-year longitudinal study
Grotmol, K. S. (2012) · NORA - Norwegian Open Research Archives
Bei, H. (2011) · NORA - Norwegian Open Research Archives
Panic Disorder and Cardiovascular Death: What Is Beneath?
da Silva, C. T. B., & Manfro, G. G. (2016) · Springer eBooks · doi:10.1007/978-3-319-12538-1_12
Risk Factors and Disease Correlates
Taylor, R. B. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7874-5_5
Relationship between Anxiety and Burning Mouth Syndrome of Psychiatric Outpatients
Putri, A., Nurdiana, N., & Darwis, A. F. (2018) · International Dental Conference of Sumatera Utara (IDCSU) · doi:10.2991/idcsu-17.2018.6
Mental health care use in medically unexplained and explained physical symptoms
van der Sluijs, J. F. V. E., Have, M. T., Rijnders, C. A. T., van Marwijk, H., de Graaf, R., & Feltz-Cornelis, C. M. V. D. (2016)
Winter, G., Hart, R. A. D. J., Charlesworth, R. P. G., & Sharpley, C. F. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.6
Medical Illness in Psychiatric Disease
Stiebel, V. G., & Nightingale, B. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-52520-0_17
Biased Survival Expectations and Behaviours: Does Domain Specific Information Matter?Preprint
Costa‐Font, J., & Vilaplana‐Prieto, C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4114395
Pop, M., & Tarba, C. (1988) · PubMed
Miloyan, B. H., & Bulley, A. (2017) · Springer eBooks · doi:10.1007/978-981-287-082-7_259
Petterson, L. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-16999-6_692-1
Petterson, L. J. (2021) · Springer eBooks · doi:10.1007/978-3-319-19650-3_692
WITHDRAWNPreprint
Matar, M., Heeren, A., & 2023, C. G. (2024) · doi:10.31234/osf.io/gv7am
Kuutti, M. A., Kärkkäinen, M., Aukee, P., & Laakkonen, E. K. (2024) · JYU Reports · doi:10.17011/jyureports/2024/36
Liu, C., Yu, H., Sun, X., Xu, Q., Wang, X., Huang, Y., Sun, P., & zhang, X. (2023) · Research Square · doi:10.21203/rs.3.rs-3391103/v1
Kaiser, M. (2015) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4912
Steffen, A., Nübel, J., Jacobi, F., Bätzing, J., & Holstiege, J. (2020) · Figshare · doi:10.6084/m9.figshare.12050313
Steffen, A., Nübel, J., Jacobi, F., Bätzing, J., & Holstiege, J. (2020) · Figshare · doi:10.6084/m9.figshare.12050316
Wu, K., Lu, L. Z.-B., Chen, Y., Dai, C., Tian, H., Wu, Y., Liu, Y., Duan, A., Guo, K., Huang, L., et al. (2026) · Pulmonology · doi:10.1080/25310429.2026.2703419
The HPA axis and GABA-Glutamate Systems as Potential Antidepressant Targets in Prostate Cancer
Sharpley, C. F. (2011) · The Open Prostate Cancer Journal · doi:10.2174/1876822901104010001 · Cited by 1
Metadata
- Authors
- Mykletun, A., Bjerkeset, O., øverland, S., Prince, M., Dewey, M., & Stewart, R.
- Affiliations
- Norwegian Institute of Public Health (NO)
- Norwegian University of Science and Technology (NO)
- University of Bergen (NO)
- King's College London (GB)
- Corresponding author
- Mykletun, Arnstein
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2009-08
- Volume
- 195
- Issue
- 2
- Pages
- 118-125
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2147161932
- Cited by
- 279
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 13 · 2022: 14 · 2021: 22 · 2020: 19 · 2019: 14 · 2018: 15 · 2017: 12 · 2016: 20 · 2015: 11 · 2014: 22 · 2013: 35 · 2012: 17
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- National Institute for Health and Care Research
- King's College London
- Norges Forskningsråd
- Norwegian Institute of Public Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, anxiety, mortality, comorbid depression and anxiety, Hospital Anxiety and Depression Scale, smoking, somatic symptoms, U-shaped relationship, HUNT study, risk factors
- MeSH terms
- Adult, Aged, Anxiety Disorders, Cause of Death, Depressive Disorder, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Norway, Comorbidity, Confounding Factors, Epidemiologic, Young Adult
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