The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
Open accessAbstract
Background: Two recent clinical studies support the feasibility of trials to evaluate the disease-modifying properties of lithium in Alzheimer's disease, although no benefits were obtained from short-term treatment. Aims: To evaluate the effect of long-term lithium treatment on cognitive and biological outcomes in people with amnestic mild cognitive impairment (aMCI). Method: Forty-five participants with aMCI were randomised to receive lithium (0.25–0.5 mmol/l) ( n = 24) or placebo ( n = 21) in a 12-month, double-blind trial. Primary outcome measures were the modification of cognitive and functional test scores, and concentrations of cerebrospinal fluid (CSF) biomarkers (amyloid-beta peptide (Aβ 42 ), total tau (T-tau), phosphorylated-tau) (P-tau). Trial registration: NCT01055392. Results: Lithium treatment was associated with a significant decrease in CSF concentrations of P-tau ( P = 0.03) and better perform-ance on the cognitive subscale of the Alzheimer's Disease Assessment Scale and in attention tasks. Overall tolerability of lithium was good and the adherence rate was 91%. Conclusions: The present data support the notion that lithium has disease-modifying properties with potential clinical implications in the prevention of Alzheimer's disease.
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Lithium Treatment and Risk of Dementia
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Cited by
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Current and future treatments for Alzheimer's disease
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Schneider, L. S., Mangialasche, F., Andreasen, N., Feldman, H., Giacobini, E., Jones, R., Mantua, V., Mecocci, P., Pani, L., Winblad, B., et al. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12191 · Cited by 651
Alzheimer’s disease: Recent treatment strategies
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The importance of tau phosphorylation for neurodegenerative diseases
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Metadata
- Authors
- Forlenza, O. V., Diniz, B. S., Radanovic, M., Santos, F. S., Talib, L. L., & Gattaz, W. F.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2011-05
- Volume
- 198
- Issue
- 5
- Pages
- 351-356
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2037053607
- Cited by
- 402
- References
- 8
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Forlenza, O. V., Diniz, B. S., Radanovic, M., Santos, F. S., Talib, L. L., & Gattaz, W. F. (2011). Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. British Journal of Psychiatry. https://doi.org/10.1192/bjp.bp.110.080044
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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