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Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses
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Background: The efficacy of psychopharmacological treatments has been called into question. Psychiatrists are unfamiliar with the effectiveness of common medical drugs. Aims: To put the efficacy of psychiatric drugs into the perspective of that of major medical drugs. Method: We searched Medline and the Cochrane Library for systematic reviews on the efficacy of drugs compared with placebo for common medical and psychiatric disorders, and systematically presented the effect sizes for primary efficacy outcomes. Results: We included 94 meta-analyses (48 drugs in 20 medical diseases, 16 drugs in 8 psychiatric disorders). There were some general medical drugs with clearly higher effect sizes than the psychotropic agents, but the psychiatric drugs were not generally less efficacious than other drugs. Conclusions: Any comparison of different outcomes in different diseases can only serve the purpose of a qualitative perspective. The increment of improvement by drug over placebo must be viewed in the context of the disease's seriousness, suffering induced, natural course, duration, outcomes, adverse events and societal values.
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“These medications, which are as efficacious, or more efficacious, than many medications used for non-psychiatric disorders (Leucht et al., 2012)”
From The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder (2021) · cites this paper as Leucht et al., 2012
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10 retracted
Metformin monotherapy for type 2 diabetes mellitus
Sáenz, A., Fernandez-Esteban, I., Mataix, A. L., Segura, M. A., Figuls, M. R. I., & Moher, D. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002966.pub3 · Cited by 310
RetractedMedical treatments in the short term management of reflux oesophagitis
Moayyedi, P., Santana, J. O., Khan, M., Preston, C., & Donnellan, C. F. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003244.pub3 · Cited by 239
RetractedPropranolol for migraine prophylaxis
Linde, K., & Rossnagel, K. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003225.pub2 · Cited by 196
RetractedFaris, R. F., Flather, M. D., Purcell, H., Poole-Wilson, P. A., & Coats, A. J. S. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003838.pub4 · Cited by 194
RetractedMedical treatments in the short term management of reflux oesophagitis
Moayyedi, P., Santana, J. O., Khan, M., Preston, C., & Donnellan, C. F. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003244.pub2 · Cited by 173
RetractedDonnellan, C. F., Preston, C., Moayyedi, P., & Sharma, N. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003245.pub3 · Cited by 150
RetractedDonnellan, C. F., Preston, C., Moayyedi, P., & Sharma, N. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003245.pub2 · Cited by 122
RetractedFaris, R. F., Flather, M. D., Purcell, H., Poole-Wilson, P. A., & Coats, A. J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003838.pub2 · Cited by 81
RetractedOral sumatriptan for acute migraine
McCrory, D. C., & Gray, R. N. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002915 · Cited by 73
RetractedCelecoxib for rheumatoid arthritis
Garner, S. E., Fidan, D., Frankish, R. R., Judd, M., Shea, B., Towheed, T., Tugwell, P., & Wells, G. A. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003831 · Cited by 67
RetractedStatistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
Effects of Intensive Glucose Lowering in Type 2 Diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802743 · Cited by 7,888
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., Larrue, V., Lees, K. R., Medeghri, Z., Machnig, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804656 · Cited by 6,684
Villalba, J. B. (1996) · Lung Cancer · doi:10.1016/0169-5002(96)85918-6 · Cited by 2,510
Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442
Selective publication of antidepressant trials and its influence on apparent efficacy
Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., & Rosenthal, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa065779 · Cited by 2,435
British Guideline on the Management of Asthma
British Thoracic Society Scottish Intercollegiate Guidelines Network (2008) · Thorax · doi:10.1136/thx.2008.097741 · Cited by 2,023
Garg, R. (1995) · JAMA · doi:10.1001/jama.273.18.1450 · Cited by 1,993
Cholinesterase inhibitors for Alzheimer's disease
Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906
Levodopa and the Progression of Parkinson's Disease
The Parkinson Study Group (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033447 · Cited by 1,844
Shea, B. J., Hamel, C., Wells, G. A., Bouter, L. M., Kristjansson, E., Grimshaw, J., Henry, D. A., & Boers, M. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2008.10.009 · Cited by 1,755
Law, M. R., Wald, N. J., & Rudnicka, A. R. (2003) · BMJ · doi:10.1136/bmj.326.7404.1423 · Cited by 1,720
Flather, M. D., Yusuf, S., Køber, L., Pfeffer, M. A., Hall, A. S., Murray, G. D., Torp-Pedersen, C. T., Ball, S. G., Pogue, J. M., Moyé, L. A., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02212-1 · Cited by 1,585
Thrombolysis for acute ischaemic stroke
Wardlaw, J. M., Murray, V., Berge, E., & del Zoppo, G. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000213.pub3 · Cited by 1,460
The Salmeterol Multicenter Asthma Research Trial
Nelson, H. S., Weiss, S. T., Bleecker, E. R., Yancey, S. W., & Dorinsky, P. (2006) · CHEST Journal · doi:10.1378/chest.129.1.15 · Cited by 1,112
Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
Walsh, B. T., Seidman, S. N., Sysko, R., & Gould, M. (2002) · JAMA · doi:10.1001/jama.287.14.1840 · Cited by 1,109
Health Outcomes Associated With Various Antihypertensive Therapies Used as First-Line Agents
Psaty, B. M., Lumley, T., Furberg, C. D., Lovasi, G. S., Pahor, M., Alderman, M. H., & Weiss, N. S. (2003) · JAMA · doi:10.1001/jama.289.19.2534 · Cited by 1,096
Ferrari, M. D., Roon, K. I., Lipton, R. B., & Goadsby, P. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06711-3 · Cited by 993
Should β blockers remain first choice in the treatment of primary hypertension? A meta-analysis
Lindholm, L. H., Carlberg, B., & Samuelsson, O. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67573-3 · Cited by 990
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
Geddes, J. R., Carney, S. M., Davies, C., Furukawa, T. A., Kupfer, D. J., Frank, E., & Goodwin, G. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12599-8 · Cited by 945
Wald, D. S., Law, M., Morris, J. K., Bestwick, J. P., & Wald, N. J. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.09.038 · Cited by 938
Aspirin for the Primary Prevention of Cardiovascular Events in Women and Men
Berger, J. S., Roncaglioni, M. C., Avanzini, F., Pangrazzi, I., Tognoni, G., & Brown, D. (2006) · JAMA · doi:10.1001/jama.295.3.306 · Cited by 782
Raina, P., Santaguida, P., Ismaila, A., Patterson, C., Cowan, D., Levine, M., Booker, L., & Oremus, M. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-5-200803040-00009 · Cited by 771
Blood Pressure Lowering Treatment Trialists’ Collaboration (2008) · BMJ · doi:10.1136/bmj.39548.738368.be · Cited by 739
BTS guideline for emergency oxygen use in adult patients
O’Driscoll, B. R., Howard, L., Davison, A. G., & on behalf of the British Thoracic Society (2008) · Thorax · doi:10.1136/thx.2008.102947 · Cited by 727
Geddes, J. R., Burgess, S., Hawton, K., Jamison, K., & Goodwin, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.217 · Cited by 661
Antibiotics for acute otitis media in children
Venekamp, R. P., Sanders, S., Glasziou, P., Mar, C. D., & Rovers, M. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000219.pub4 · Cited by 619
Cipriani, A., Pretty, H., Hawton, K., & Geddes, J. R. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.10.1805 · Cited by 617
Antidepressants for Bipolar Depression: A Systematic Review of Randomized, Controlled Trials
Gijsman, H. J., Geddes, J. R., Rendell, J. M., Nolen, W. A., & Goodwin, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1537 · Cited by 567
Clinical Effects of β-Adrenergic Blockade in Chronic Heart Failure
Lechat, P. P., Packer, M., Chalon, S., Cucherat, M., Arab, T., & Boissel, J. (1998) · Circulation · doi:10.1161/01.cir.98.12.1184 · Cited by 558
A systematic review and economic evaluation of statins for the prevention of coronary events
Ward, S., Lloyd Jones, M., Pandor, A., Holmes, M., Ara, R., Ryan, A., Yeo, W., & Payne, N. (2007) · Health Technology Assessment · doi:10.3310/hta11140 · Cited by 556
Inhaled corticosteroids for stable chronic obstructive pulmonary disease
Yang, I. A., Clarke, M., Sim, E., & Fong, K. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002991.pub3 · Cited by 530
Hansen, R. A., Webb, A. P., Moore, C. G., Gartlehner, G., Jonas, D. E., & Morgan, L. C. (2020) · PubMed Central · doi:10.17615/ae8c-2p76 · Cited by 523
Kaduszkiewicz, H., Zimmermann, T., Beck-Bornholdt, H.-P., & van den Bussche, H. (2005) · BMJ · doi:10.1136/bmj.331.7512.321 · Cited by 522
Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis
Wang, Y., Parker, C. E., Bhanji, T., Feagan, B. G., & MacDonald, J. K. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000543.pub4 · Cited by 500
Abramowitz, J. S. (1997) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.65.1.44 · Cited by 490
Leucht, S., Arbter, D., Engel, R. R., Kissling, W., & Davis, J. M. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002136 · Cited by 489
Beta-blockers for hypertension
Wiysonge, C. S., Bradley, H., Volmink, J. A., Mayosi, B. M., & Opie, L. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002003.pub5 · Cited by 488
Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis
Faraone, S. V., & Buitelaar, J. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0054-3 · Cited by 485
Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis
Wang, Y., Parker, C. E., Feagan, B. G., & MacDonald, J. K. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000544.pub4 · Cited by 482
Salpeter, S. R., Buckley, N. S., Ormiston, T. M., & Salpeter, E. E. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-12-200606200-00126 · Cited by 461
Benzodiazepines and Zolpidem for Chronic Insomnia: A Meta-analysis of Treatment Efficacy
Nowell, P. D. (1997) · JAMA · doi:10.1001/jama.1997.03550240060035 · Cited by 451
Neuroleptic Withdrawal in Schizophrenic Patients
Gilbert, P. L. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950150005001 · Cited by 434
Antimicrobial prophylaxis for colorectal surgery
Nelson, R. L., Gladman, E., & Barbateskovic, M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001181.pub4 · Cited by 426
Overview: maintenance therapy in psychiatry: I. Schizophrenia
Davis, J. M. (1975) · American Journal of Psychiatry · doi:10.1176/ajp.132.12.1237 · Cited by 410
Self-citationBousquet, J., Cabrera, P., Berkman, N., Buhl, R., Holgate, S., Wenzel, S., Fox, H., Hedgecock, S., Blogg, M., & Cioppa, G. D. (2005) · Allergy · doi:10.1111/j.1398-9995.2004.00770.x · Cited by 401
Contemporary Management of Chronic Obstructive Pulmonary Disease
Sin, D. D., McAlister, F. A., Man, S. F. P., & Anthonisen, N. R. (2003) · JAMA · doi:10.1001/jama.290.17.2301 · Cited by 401
(2001) · Europe PMC (PubMed Central) · Cited by 393
β-Blockers in Congestive Heart Failure: A Bayesian Meta-Analysis
Brophy, J. M., Joseph, L., & Rouleau, J. L. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-7-200104030-00008 · Cited by 389
Willsie, S. K. (2007) · Yearbook of Pulmonary Disease · doi:10.1016/s8756-3452(08)70262-7 · Cited by 385
Clomipramine in the Treatment of Patients With Obsessive-Compulsive Disorder
(1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320054008 · Cited by 384
Anticoagulants for acute ischaemic stroke
Sandercock, P. A., Counsell, C. E., & Kamal, A. K. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000024.pub3 · Cited by 373
Inhaled Corticosteroids in Patients With Stable Chronic Obstructive Pulmonary Disease
Drummond, M., Dasenbrook, E. C., Pitz, M. W., Murphy, D. J., & Fan, E. (2008) · JAMA · doi:10.1001/jama.2008.717 · Cited by 362
Heidenreich, P. A., Lee, T. T., & Massie, B. M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00104-6 · Cited by 357
Methotrexate in Rheumatoid Arthritis
Świerkot, J., & Szechiński, J. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-418 · Cited by 347
Soomro, G. M., Altman, D. G., Rajagopal, S., & Oakley Browne, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001765.pub3 · Cited by 342
Phenothiazine Treatment in Acute Schizophrenia
(1964) · Archives of General Psychiatry · doi:10.1001/archpsyc.1964.01720210028005 · Cited by 336
Alpha-glucosidase inhibitors for type 2 diabetes mellitus
Van de Laar, F. A., Lucassen, P. L., Akkermans, R. P., Van de Lisdonk, E. H., Rutten, G. E., & Van Weel, C. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003639.pub2 · Cited by 335
Rising, K., Bacchetti, P., & Bero, L. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050217 · Cited by 328
Antibiotics for acute otitis media: a meta-analysis with individual patient data
Rovers, M. M., Glasziou, P., Appelman, C. L., Burke, P., McCormick, D. P., Damoiseaux, R. A. M. J., Gaboury, I., Little, P. S., & Hoes, A. W. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69606-2 · Cited by 328
Mitte, K. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.05.003 · Cited by 324
Guttmacher, M. S. (1964) · PubMed · Cited by 310
Cheung, B. M. Y., Lauder, I. J., Lau, C., & Kumana, C. R. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2003.02060.x · Cited by 303
Interferons in relapsing remitting multiple sclerosis: a systematic review
Filippini, G., Munari, L., Incorvaia, B., Ebers, G. C., Polman, C. H., D’Amico, R., & Rice, G. P. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12512-3 · Cited by 299
Maintenance treatment with antipsychotic drugs for schizophrenia
Leucht, S., Tardy, M., Komossa, K., Heres, S., Kissling, W., & Davis, J. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008016.pub2 · Cited by 293
Self-citationMAOIs in the Contemporary Treatment of Depression
Thase, M. E. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00058-8 · Cited by 292
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2008) · The Lancet · doi:10.1016/s0140-6736(08)60069-0 · Cited by 283
Efficacy of Drug Treatment in Obsessive–Compulsive Disorder: a Meta-Analytic Review
Piccinelli, M. P., Pini, S., Bellantuono, C., & Wilkinson, G. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.166.4.424 · Cited by 282
Antiplatelet therapy for acute ischaemic stroke
Sandercock, P. A., Counsell, C. E., Gubitz, G. J., & Tseng, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000029.pub2 · Cited by 271
Griebsch, I., Coast, J., & Brown, J. (2005) · PEDIATRICS · doi:10.1542/peds.2004-2127 · Cited by 270
Smith, L. A., Cornelius, V. R., Warnock, A., Tacchi, M. J., & Taylor, D. M. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00468.x · Cited by 269
Thrombolysis for acute ischaemic stroke
Wardlaw, J. M., Murray, V., Berge, E., & del Zoppo, G. J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000213.pub2 · Cited by 267
Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder
Macritchie, K., Geddes, J., Scott, J., Haslam, D. R., & Goodwin, G. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003196 · Cited by 263
Hansen, R. A., Gartlehner, G., Lohr, K. N., Gaynes, B. N., & Carey, T. S. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-6-200509200-00006 · Cited by 260
Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder
Cipriani, A., Reid, K. S., Young, A. H., Macritchie, K., & Geddes, J. R. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003196.pub2 · Cited by 248
Scherk, H., Pajonk, F. G., & Leucht, S. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.442 · Cited by 243
Self-citationTiotropium for stable chronic obstructive pulmonary disease: a meta-analysis
Barr, R. G. (2006) · Thorax · doi:10.1136/thx.2006.063271 · Cited by 236
Lithium for maintenance treatment of mood disorders
Burgess, S., Geddes, J. R., Hawton, K. K., Taylor, M. J., Townsend, E., Jamison, K. R., & Goodwin, G. M. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003013 · Cited by 231
A meta-analysis of treatments for panic disorder.
Clum, G. A., Clum, G. A., & Surls, R. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.2.317 · Cited by 221
Young, J., Sutter, A. D., Merenstein, D., van Essen, G. A., Kaiser, L., Varonen, H., Williamson, I. G., & Bucher, H. C. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60416-x · Cited by 221
Leucht, S., Davis, J. M., Engel, R. R., Kane, J. M., & Wagenpfeil, S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301325 · Cited by 220
Self-citationA Meta-analysis of the Effects of Presenting Treatment Benefits in Different Formats
Covey, J. A. (2007) · Medical Decision Making · doi:10.1177/0272989x07306783 · Cited by 218
Lee, V. C., Rhew, D. C., Dylan, M. L., Badamgarav, E., Braunstein, G. D., & Weingarten, S. R. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-9-200411020-00011 · Cited by 210
Vogelmeier, C. F., Buhl, R., Criée, C., Gillissen, A., Kardos, P., Köhler, D., MAGNUSSEN, H., Morr, H., Nowak, D., Pfeiffer-Kascha, D., et al. (2007) · Pneumologie · doi:10.1055/s-2007-959200 · Cited by 208
(2003) · PubMed · Cited by 203
Corticosteroids or ACTH for acute exacerbations in multiple sclerosis
Citterio, A., Mantia, L. L., Ciucci, G., Candelise, L., Brusaferri, F., Midgard, R., & Filippini, G. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001331 · Cited by 203
Multivariate Meta-Analysis of Controlled Drug Studies for Obsessive-Compulsive Disorder
Ackerman, D. L., & Greenland, S. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200206000-00012 · Cited by 202
Anand, S. S. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm518xx · Cited by 201
Neuroleptic Withdrawal in Schizophrenic Patients
Baldessarini, R. J. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950150021002 · Cited by 194
Barton, R. (2007) · Thorax · doi:10.1136/thx.2007.086215 · Cited by 194
Antibiotics for acute otitis media in children
Sanders, S., Glasziou, P., Mar, C. D., & Rovers, M. M. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000219.pub2 · Cited by 194
Cheng, J. Y. W., Chen, R. Y. L., Ko, J. S. N., & Ng, E. M. L. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0840-x · Cited by 185
Statin Therapy in Stroke Prevention: A Meta-analysis Involving 121,000 Patients
O’Regan, C., Wu, P., Arora, P., Perri, D., & Mills, E. J. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.06.033 · Cited by 182
Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis
Sutherland, L. R., & MacDonald, J. K. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000544.pub2 · Cited by 178
Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time
Trikalinos, T. A., Churchill, R., Ferri, M., Leucht, S., Tuunainen, A., Wahlbeck, K., & Ioannidis, J. P. A. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.02.018 · Cited by 177
Self-citationHansen, R., Gaynes, B., Thieda, P., Gartlehner, G., Deveaugh-Geiss, A., Krebs, E., & Lohr, K. (2008) · Psychiatric Services · doi:10.1176/ps.2008.59.10.1121 · Cited by 172
Pharmacological Management to Reduce Exacerbations in Adults With Asthma
Sin, D. D., Man, J., Sharpe, H. M., Gan, W., & Man, S. F. P. (2004) · JAMA · doi:10.1001/jama.292.3.367 · Cited by 168
Chlorpromazine versus placebo for schizophrenia
Adams, C. E., Awad, G. A., Rathbone, J., Thornley, B., & Soares‐Weiser, K. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000284.pub3 · Cited by 167
Otto, M. W., Tuby, K. S., Gould, R. A., McLean, R. Y. S., & Pollack, M. H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.1989 · Cited by 166
Bech, P., Cialdella, P., Haugh, M., Birkett, M. A., Hours, A. T., Boissel, J., & Tollefson, G. D. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.176.5.421 · Cited by 157
Haloperidol versus placebo for schizophrenia
Adams, C. E., Bergman, H., Irving, C. B., & Lawrie, S. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003082.pub3 · Cited by 157
Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis
Sutherland, L. R., & MacDonald, J. K. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000543.pub2 · Cited by 157
Antimicrobial prophylaxis for colorectal surgery
Nelson, R. L., Glenny, A., & Song, F. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001181.pub3 · Cited by 156
Inhaled corticosteroids for stable chronic obstructive pulmonary disease
Yang, I. A., Fong, K. M., Sim, E., Black, P., & Lasserson, T. J. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002991.pub2 · Cited by 153
Shibata, M. C., Flather, M. D., & Wang, D. (2001) · European Journal of Heart Failure · doi:10.1016/s1388-9842(01)00144-1 · Cited by 150
Meglitinide analogues for type 2 diabetes mellitus
Black, C., Donnelly, P., McIntyre, L., Royle, P., Shepherd, J., & Thomas, S. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004654.pub2 · Cited by 147
Interferon in relapsing-remitting multiple sclerosis
Rice, G. P., Incorvaia, B., Munari, L., Ebers, G. C., Polman, C. H., D’Amico, R., Parmelli, E., & Filippini, G. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002002 · Cited by 146
Adalimumab for treating rheumatoid arthritis
Navarro-Sarabia, F., Ariza‐Ariza, R., Hernández‐Cruz, B., & Villanueva, I. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005113.pub2 · Cited by 140
Inhaled beclomethasone versus placebo for chronic asthma
Adams, N. P., Bestall, J., & Jones, P. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002738 · Cited by 139
Falagas, M. E., Kotsantis, I., Vouloumanou, E. K., & Rafailidis, P. I. (2009) · Journal of Infection · doi:10.1016/j.jinf.2008.12.009 · Cited by 138
Meta-analysis of pharmacotherapy trials for obsessive-compulsive disorder
Stein, D. J., Spadaccini, E., & Hollander, E. (1995) · International Clinical Psychopharmacology · doi:10.1097/00004850-199503000-00002 · Cited by 136
Gartlehner, G., Hansen, R., Carson, S., & Lohr, K. (2006) · Annals of Family Medicine · doi:10.1370/afm.517 · Cited by 136
A meta-analysis of methylprednisolone in recovery from multiple sclerosis exacerbations
Miller, D. M., Weinstock‐Guttman, B., Béthoux, F., Lee, J.-C., Beck, G. J., Block, V., Durelli, L., LaMantia, L., Barnes, D., Sellebjerg, F. T., et al. (2000) · Multiple Sclerosis Journal · doi:10.1177/135245850000600408 · Cited by 130
Chróinín, M. N., Greenstone, I. I., Ducharme, F. M., Masse, V., & Danish, A. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005535 · Cited by 128
Infliximab for the treatment of rheumatoid arthritis
Blumenauer, B. B., Judd, M., Wells, G. A., Burls, A., Cranney, A., Hochberg, M. C., Tugwell, P., & Lopez-Olivo, M. A. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003785 · Cited by 128
Holgate, S. T., Bousquet, J., Wenzel, S. E., Fox, H., Liu, J., & Castellsagué, J. (2001) · Current Medical Research and Opinion · doi:10.1185/0300799019117010 · Cited by 125
Fluticasone versus placebo for chronic asthma in adults and children
Adams, N. P., Bestall, J., Lasserson, T. J., Jones, P., & Cates, C. J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003135.pub4 · Cited by 121
Mood stabilizers in the prevention of recurrent affective disorders: a meta‐analysis
Davis, J. M., Janicak, P. G., & Hogan, D. M. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb10890.x · Cited by 120
Self-citationBarbui, C., Furukawa, T. A., & Cipriani, A. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.070693 · Cited by 120
Kaplan, A. G. (2006) · Primary Care Respiratory Journal · doi:10.1016/j.pcrj.2006.08.002 · Cited by 118
Steinbrueck, S. M., Maxwell, S. E., & Howard, G. S. (1983) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.51.6.856 · Cited by 117
Association Between Unreported Outcomes and Effect Size Estimates in Cochrane Meta-analyses
Furukawa, T. A., Watanabe, N., Omori, I. M., Montori, V. M., & Guyatt, G. H. (2007) · JAMA · doi:10.1001/jama.297.5.468-b · Cited by 115
Anticonvulsants in Migraine Prophylaxis: A Cochrane Review
Mulleners, W., & Chronicle, E. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01571.x · Cited by 113
Oral theophylline for chronic obstructive pulmonary disease
Ram, F. S., Jones, P., Jardim, J. R., Castro, A. A., Atallah, Á. N., Lacasse, Y., Goldstein, R. S., & Cendon, S. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003902 · Cited by 112
Bateman, E. D., Nelson, H. S., Bousquet, J. J., Kral, K. M., Sutton, L., Ortega, H. G., & Yancey, S. W. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-1-200807010-00229 · Cited by 108
Salpeter, S. R., Buckley, N. S., & Salpeter, E. E. (2006) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2006.00507.x · Cited by 105
Methotrexate for treating rheumatoid arthritis
Suarez-Almazor, M. E., Belseck, E. M., Shea, B., Tugwell, P., & Wells, G. A. (1998) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000957 · Cited by 104
Short-acting beta2-agonists for stable chronic obstructive pulmonary disease
Sestini, P., Renzoni, E. A., Robinson, S. M., Poole, P., & Ram, F. S. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001495 · Cited by 103
Antimalarials for treating rheumatoid arthritis
Suarez-Almazor, M. E., Belseck, E. M., Shea, B., Homik, J., Wells, G. A., & Tugwell, P. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000959 · Cited by 102
Gøtzsche, P. C., & Johansen, H. K. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000189.pub2 · Cited by 99
Leflunomide for the treatment of rheumatoid arthritis
Osiri, M., Shea, B., Welch, V. A., Suarez-Almazor, M. E., Strand, V., Tugwell, P., & Wells, G. A. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002047 · Cited by 98
β-blockers in congestive heart failure
Moskowitz, R. M., & Kukin, M. L. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.11.1795 · Cited by 96
Moncrieff, J. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.167.5.569 · Cited by 93
(2009) · Clinical Governance An International Journal · doi:10.1108/cgij.2009.24814dae.004 · Cited by 91
Headaches and the Treatment of Blood Pressure
Law, M., Morris, J. K., Jordan, R. E., & Wald, N. (2005) · Circulation · doi:10.1161/circulationaha.104.529628 · Cited by 82
Interferon for interferon naive patients with chronic hepatitis C
Myers, R. P., Regimbeau, C., Thévenot, T., Leroy, V., Mathurin, P., Opolon, P., Zarski, J., & Poynard, T. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000370 · Cited by 81
Azathioprine for treating rheumatoid arthritis
Suarez-Almazor, M. E., Spooner, C., & Belseck, E. M. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001461 · Cited by 79
Addition of anti-leukotriene agents to inhaled corticosteroids for chronic asthma
Ducharme, F. M. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003133.pub2 · Cited by 79
Lampl, C., Voelker, M., & Diener, H. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0547-2 · Cited by 75
Pitchforth, J., & Mengersen, K. L. (2012) · Wiley series in probability and statistics · doi:10.1002/9781118394472.ch7 · Cited by 74
Low dosage tricyclic antidepressants for depression
Furukawa, T. A., McGuire, H., & Barbui, C. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003197 · Cited by 74
Sulfasalazine for treating rheumatoid arthritis
Suarez-Almazor, M. E., Belseck, E. M., Shea, B., Tugwell, P., & Wells, G. A. (1998) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000958 · Cited by 74
Short-term efficacy of tricyclic antidepressants revisited: a meta-analytic study
Storosum, J. G., Elferink, A. J. A., van Zwieten, B. J., van den Brink, W., Gersons, B. P. R., STRIK, R. V., & Broekmans, A. W. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00083-9 · Cited by 73
Ribavirin plus interferon versus interferon for chronic hepatitis C
Brok, J. S., Gluud, L. L., & Gluud, C. N. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005445.pub2 · Cited by 73
Moderate-term, low-dose corticosteroids for rheumatoid arthritis
Criswell, L. A., Saag, K. G., Sems, K. M., Welch, V. A., Shea, B., Wells, G. A., & Suarez-Almazor, M. E. (1998) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001158 · Cited by 73
Alpha-glucosidase inhibitors for type 2 diabetes mellitus (Review)
de Laar, F. A. V., Lucassen, P. L., Akkermans, R., van de Lisdonk, E. H., Rutten, G. E. H. M., & van Weel, C. (2005) · Cochrane Database of Systematic Reviews · Cited by 66
Wilkinson, G., Balestrieri, M., Ruggeri, M., & Bellantuono, C. (1991) · Psychological Medicine · doi:10.1017/s0033291700029986 · Cited by 63
A quantitative analysis of clinical drug trials for the treatment of affective disorders.
Davis, J. M., Wang, Z., & Janicak, P. G. (1993) · PubMed · Cited by 60
Self-citationBeynon, S., Soares‐Weiser, K., Woolacott, N. F., Duffy, S., & Geddes, J. R. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108093885 · Cited by 60
Rodrigo, G. J., & Nannini, L. J. (2006) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2006.02.003 · Cited by 58
Vouloumanou, E. K., Karageorgopoulos, D. E., Kazantzi, M. S., Kapaskelis, A. M., & Falagas, M. E. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp166 · Cited by 58
Meta-Analysis of Rizatriptan Efficacy in Randomized Controlled Clinical Trials
Ferrari, M. D., Loder, E., McCarroll, K., & Lines, C. R. (2001) · Cephalalgia · doi:10.1046/j.1468-2982.2001.00169.x · Cited by 58
Cyclosporine for treating rheumatoid arthritis
Wells, G. A., Haguenauer, D., Shea, B., Suarez-Almazor, M. E., Welch, V. A., Tugwell, P., & Peterson, J. (1998) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001083 · Cited by 56
Ribavirin plus interferon versus interferon for chronic hepatitis C
Brok, J. S., Gluud, L. L., & Gluud, C. N. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005445 · Cited by 55
Cyclophosphamide for treating rheumatoid arthritis
Suarez-Almazor, M. E., Belseck, E. M., Shea, B., Tugwell, P., & Wells, G. A. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001157 · Cited by 53
Digitalis for treatment of congestive heart failure in patients in sinus rhythm
Hood, W. B., Dans, A., Guyatt, G., Jaeschke, R., & McMurray, J. J. V. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002901 · Cited by 53
Efficacy of Adderall® for Attention-Deficit/Hyperactivity Disorder: A meta-analysis
Faraone, S., & Biederman, J. (2002) · Journal of Attention Disorders · doi:10.1177/108705470200600203 · Cited by 53
Inhaled short acting beta2-agonist use in chronic asthma: regular versus as needed treatment
Walters, E. H., Walters, J. A., Gibson, P. G., & Jones, P. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001285 · Cited by 49
Ribavirin monotherapy for chronic hepatitis C
Brok, J. S., Gluud, L. L., & Gluud, C. N. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005527.pub2 · Cited by 49
Magnitude of effect of lithium in short‐term efficacy studies of moderate to severe manic episode
Storosum, J. G., Wohlfarth, T. D., Schene, A. H., Elferink, A. J. A., van Zwieten, B. J., & van den Brink, W. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00445.x · Cited by 47
Bria, E., Gralla, R. J., Raftopoulos, H., Cuppone, F., Milella, M., Sperduti, I., Carlini, P., Terzoli, E., Cognetti, F., & Giannarelli, D. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.05.002 · Cited by 47
Sulfasalazine treatment for rheumatoid arthritis: a metaanalysis of 15 randomized trials.
Weinblatt, M. E., Reda, D. J., Henderson, W., Giobbie‐Hurder, A., Williams, D., Diani, A., & Docsa, S. (1999) · PubMed · Cited by 46
Auranofin versus placebo in rheumatoid arthritis
Suarez-Almazor, M. E., Spooner, C., Belseck, E. M., & Shea, B. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002048 · Cited by 46
Penicillamine for treating rheumatoid arthritis
Suarez-Almazor, M. E., Belseck, E., & Spooner, C. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001460 · Cited by 43
Beta‐blocker treatment in heart failure
Bouzamondo, A., Hulot, J., Sanchez-Peña, P., Cucherat, M., & Lechat, P. P. (2001) · Fundamental and Clinical Pharmacology · doi:10.1046/j.1472-8206.2001.00019.x · Cited by 40
Antiplatelet Therapy for Acute Ischaemic Stroke
Nie, Z. (2008) · Chinese Journal of Stroke · Cited by 35
Measures of efficiency in healthcare: QALMs about QALYs?
Schlander, M. (2010) · Zeitschrift für Evidenz Fortbildung und Qualität im Gesundheitswesen · doi:10.1016/j.zefq.2010.03.012 · Cited by 32
Rofecoxib for rheumatoid arthritis
Garner, S., Fidan, D., Frankish, R. R., Judd, M., Towheed, T., Wells, G. A., & Tugwell, P. (2002) · doi:10.1002/14651858.cd003685 · Cited by 30
Prognostic benefit of beta-blockers in patients not receiving ACE-Inhibitors
Krum, H., Haas, S. J., Eichhorn, E. J., Ghali, J. K., Gilbert, E. M., Lechat, P. P., Packer, M., Roecker, E. B., Verkenne, P., Wedel, H., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi409 · Cited by 27
Methotrexate in rheumatoid arthritis
Alarcón, G. S., & Morgan, S. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8452-5_6 · Cited by 26
Paroxetine Versus Placebo and Other Agents for Depressive Disorders
Katzman, M. A., & Tricco, A. C. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n1204 · Cited by 24
Saha, S. A., Molnár, J., & Arora, R. R. (2007) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248407304791 · Cited by 23
Awad, T., Brok, J. S., Thorlund, K., Hauser, G., Štimac, D., Mabrouk, M., Gluud, C. N., & Gluud, L. L. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005441.pub2 · Cited by 18
Digitalis for treatment of heart failure in patients in sinus rhythm
Hood, W. B., Dans, A. L., Guyatt, G. H., Jaeschke, R., & McMurray, J. J. V. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002901.pub2 · Cited by 18
Megatrials are subordinate to medical science
Charlton, B. G. (1995) · BMJ · doi:10.1136/bmj.311.6999.257b · Cited by 14
Efficacy and Safety of Incretin Therapy in Type 2 Diabetes: Systematic Review and Meta-analysis
Amori, R. E., Lau, J., & Pittas, A. G. (2007) · JAMA · doi:10.1001/jama.298.2.194 · Cited by 12
Folate has potential to cause harm
Reynolds, E. H. (1995) · BMJ · doi:10.1136/bmj.311.6999.257 · Cited by 10
Salpeter, S., Buckley, N., & Salpeter, E. (2006) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2006.00607.x · Cited by 4
A simple method for converting an odds ratio to effect size for use in meta-analysis
Chinn, S. (2000) · Statistics in Medicine · doi:10.1002/1097-0258(20001130)19:22
Flagged first, then by citations
7 of the 202 references couldn’t be matched to a known paper.
Research works printed but not linked: 9
- 2006, Parkinson's Disease. National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care
- 2008, Review Manager (RevMan) [Computer program] Version 5.0
- Leucht M , Komossa K , Heres S , Kissling W , Davis JM. An update on relapse prevention with antipsychotic drugs compared to placebo (abstract). Schizophr Res, in press.
- Kirsch, 2010, The Emperor's New Drugs: Exploring the Antidepressant Myth
- Möller, 2009, Duale Reihe Psychiatrie und Psychotherapie
- Borenstein, 2006, Comprehensive Meta-analysis Version 2
- Herold, 2009, Innere Medizin
- 10.1001/jama.1995.03520420066040 · DOI
- Breggin, 2008, Medication Madness: The Role of Psychiatric Drugs in Cases of Violence, Suicide, and Crime
Cited by
Sorted by citations
The Lancet Commission on global mental health and sustainable development
Patel, V., Saxena, S., Lund, C., Thornicroft, G., Baingana, F., Bolton, P., Chisholm, D., Collins, P. Y., Cooper, J. L., Eaton, J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31612-x · Cited by 3,692
Faraone, S. V., Banaschewski, T., Coghill, D., Zheng, Y., Biederman, J., Bellgrove, M. A., Newcorn, J. H., Gignac, M., Al Saud, N. M., Manor, I., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.022 · Cited by 1,545
“These medications, which are as efficacious, or more efficacious, than many medications used for non-psychiatric disorders (Leucht et al., 2012), are classified as either stimulants (methylphenidate and amphetamine) or non-stimulants (atom-oxetine, extended release guanfacine, and extended release…”
Goodwin, G., Haddad, P. M., Ferrier, I. N., Aronson, J., Barnes, T., Cipriani, A., Coghill, D., Fazel, S., Geddes, J. R., Grunze, H., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636545 · Cited by 1,350
“Effect sizes in psychiatry, in common with the rest of medicine, are moderate (Leucht et al., 2012) but deliver worthwhile patient benefit.”
Time for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104
Cleare, A., Pariante, C., Young, A., Anderson, I., Christmas, D., Cowen, P., Dickens, C., Ferrier, I., Geddes, J., Gilbody, S., et al. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115581093 · Cited by 759
“It is important to place the effect sizes of antidepressants into context as being similar to those seen for treatments used in medicine as a whole (Leucht et al., 2012).”
Background
Metadata
- Authors
- Leucht, S., Hierl, S., Kissling, W., Dold, M., & Davis, J. M.
- Affiliations
- TUM Klinikum (DE)
- University of Illinois Chicago (US)
- Corresponding author
- Leucht, Stefan
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2012-02
- Volume
- 200
- Issue
- 2
- Pages
- 97-106
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2101652281
- Semantic Scholar
- 68218f1e65e6903db144e3aec0175e90671d7c26
- Cited by
- 451
- References
- 202
- Citations by year
- 2026: 22 · 2025: 30 · 2024: 31 · 2023: 21 · 2022: 28 · 2021: 33 · 2020: 38 · 2019: 40 · 2018: 28 · 2017: 30 · 2016: 23 · 2015: 41 · 2014: 39 · 2013: 28 · 2012: 16
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- psychotropic drugs, placebo response, effect size, adverse drug reactions
- MeSH terms
- Mental Disorders, Pharmaceutical Preparations, Humans, Placebos, Psychiatry, Psychotropic Drugs, Review Literature as Topic, Meta-Analysis as Topic, Bias, Databases, Bibliographic, Outcome Assessment, Health Care
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