Cited by 335Schizophrenia research and treatmentMental Health Treatment and AccessMental Health and Patient Involvement

Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies

Open access
Lally, John, Ajnakina, Olesya, Stubbs, Brendon, Cullinane, Michael, Murphy, Kieran C., Gaughran, Fiona, Murray, Robin M.·2017·British Journal of Psychiatry

Abstract

Background: Remission and recovery rates for people with first-episode psychosis (FEP) remain uncertain. Aims: To assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators. Method: We conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies with more than 1 year of follow-up data, and conducted meta-regression analyses to investigate potential moderators. Results: Seventy-nine studies were included representing 19072 patients with FEP. The pooled rate of remission among 12301 individuals with FEP was 58% (60 studies, mean follow-up 5.5 years). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 38% (35 studies, mean follow-up 7.2 years). Recovery rates were higher in North America than in other regions. Conclusions: Remission and recovery rates in FEP may be more favourable than previously thought. We observed stability of recovery rates after the first 2 years, suggesting that a progressive deteriorating course of illness is not typical. Although remission rates have improved over time recovery rates have not, raising questions about the effectiveness of services in achieving improved recovery.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1192/bjp.bp.117.201475

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Part of this paper’s reference list could not be split into single entries.

Flagged first, then by citations

2 of the 107 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Lally, J., Ajnakina, O., Stubbs, B., Cullinane, M., Murphy, K. C., Gaughran, F., & Murray, R. M.
Affiliations
University College Dublin (IE)
Corresponding author
Lally, John
Venue
British Journal of Psychiatry
Published
2017-12
Volume
211
Issue
6
Pages
350-358
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2761844088
Cited by
335
References
107
Citations by year
2026: 27 · 2025: 37 · 2024: 41 · 2023: 39 · 2022: 37 · 2021: 51 · 2020: 36 · 2019: 39 · 2018: 26 · 2017: 2
FWCI
4.28
Type
journal article
Language
en
Open access
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion, other-oa)
Funders
  • Eli Lilly and Company
  • Sunovion
  • National Institute for Health and Care Research (NF-SI-0512-10110, RP-PG-0606-1049)
  • H. Lundbeck A/S
  • Medical Research Council (MR/K004867/1, MR/K013807/1)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Health Professions › General Health Professions › Mental Health and Patient Involvement
Keywords
first-episode psychosis, remission, recovery, long-term outcomes, prevalence rates, clinical course
MeSH terms
Adult, Humans, Psychotic Disorders, Outcome Assessment, Health Care

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review