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Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation

Nguyen, Tam M., Sawyer, Janet K., Kelley, Kathryn L., Davis, Matthew A., Rudel, Lawrence L.·2012·Journal of Lipid Research
DOI 10.1194/jlr.m018820
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Crossref · 10.1194/jlr.m018820

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  • Free cholesterol deposited into the inner leaflet of the apical plasma membrane by NPC1L1 must subsequently move to the endoplasmic reticulum to be esterified by ACAT2.

    “Free cholesterol deposited into the inner leaflet of the apical PM by NPC1L1 must subsequently move to the ER to be esterified by ACAT2 (3–5).”

    From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [4]

    The Discussion (page unavailable) identifies ACAT2 as the major enzyme esterifying cholesterol in enterocytes and says lower NPC1L1 expression could limit cholesterol uptake. The paper does not establish that NPC1L1 deposits cholesterol in the inner leaflet of the apical membrane or that cholesterol must then move to the ER for esterification. (LLM, conf=0.86)

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Research works printed but not linked: 46

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Metadata

Authors
Nguyen, T. M., Sawyer, J. K., Kelley, K. L., Davis, M. A., & Rudel, L. L.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2012-01
Volume
53
Issue
1
Pages
95-104
ISSN
0022-2275
DOI
10.1194/jlr.m018820
Cited by
90
References
1
Language
en
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