Bioactive products formed in humans from fish oils
Open accessAbstract
Resolvins, maresins, and protectins can be formed from fish oils. These specialized pro-resolving mediators (SPMs) have been implicated in the resolution of inflammation. Synthetic versions of such SPMs exert anti-inflammatory effects in vitro and when administered to animal models. However, their importance as endogenous products formed in sufficient amounts to exert anti-inflammatory actions in vivo remains speculative. We biased our ability to detect SPMs formed in healthy volunteers by supplementing fish oil in doses shown previously to influence blood pressure and platelet aggregation under placebo-controlled conditions. Additionally, we sought to determine the relative formation of SPMs during an acute inflammatory response and its resolution, evoked in healthy volunteers by bacterial lipopolysaccharide (LPS). Bioactive lipids, enzymatic epoxyeicosatrienoic acids (EETs), and free radical-catalyzed prostanoids [isoprostanes (iPs)] formed from arachidonic acid and the fish oils, served as comparators. Despite the clear shift from ω-6 to ω-3 EETs and iPs, we failed to detect a consistent signal, in most cases, of SPM formation in urine or plasma in response to fish oil, and in all cases in response to LPS on a background of fish oil. Our results question the relevance of these SPMs to the putative anti-inflammatory effects of fish oils in humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Another study did not detect consistent plasma levels of SPMs after fish oil dietary supplementation in healthy volunteers.
“another study did not detect consistent plasma levels of SPMs after fish oil dietary supplementation in healthy volunteers127.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [127]
A short term supplementation period of 17.6 g EPA and DHA per day did not result in the detection of inflammatory resolving mediators in plasma or urine.
“A short term supplementation period of 17.6 g EPA and DHA/day did not result in the detection of these inflammatory resolving mediators in plasma or urine [152].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [152]
A recent study has called into question the production of inflammatory resolving molecules and their role in mediating inflammatory challenges in healthy humans.
“a recent study has called into question the production of inflammatory resolving molecules and their role in mediating inflammatory challenges in healthy humans [152].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [152]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Prostaglandins and Inflammation
Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 3,852 · see citing works
Self-citationPro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Itakura, H., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60527-3 · Cited by 2,516 · see citing works
(1999) · PubMed · Cited by 2,062 · see citing works
Psychogios, N., Hau, D., Peng, J., Guo, A. C., Mandal, R., Bouatra, S., Sinelnikov, I. V., Krishnamurthy, R., Eisner, R., Gautam, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016957 · Cited by 1,718 · see citing works
Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189 · see citing works
Resolvin E1 and protectin D1 activate inflammation-resolution programmes
Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works
Fish and Omega-3 Fatty Acid Intake and Risk of Coronary Heart Disease in Women
Hu, F. B. (2002) · JAMA · doi:10.1001/jama.287.14.1815 · Cited by 1,018 · see citing works
Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works
Wang, C., Harris, W. S., Chung, M., Lichtenstein, A. H., Balk, E. M., Kupelnick, B., Jordan, H. S., & Lau, J. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.5 · Cited by 980 · see citing works
Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., & Serhan, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042031 · Cited by 926 · see citing works
Fish consumption and the 30-year risk of fatal myocardial infarction
Daviglus, M. L., Stamler, J., Orencia, A. J., Dyer, A. R., Liu, K., Greenland, P., Walsh, M. K., Morris, D., & Shekelle, R. B. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361502 · Cited by 902 · see citing works
Does fish oil lower blood pressure? A meta-analysis of controlled trials.
Morris, M. C., Sacks, F. M., & ROSNER, B. A. (1993) · Circulation · doi:10.1161/01.cir.88.2.523 · Cited by 688 · see citing works
Hooper, L., Thompson, R. L., Harrison, R. A., Summerbell, C. D., Ness, A. R., Moore, H. J., Worthington, H. V., Durrington, P. N., Higgins, J. P. T., Capps, N. E., et al. (2006) · BMJ · doi:10.1136/bmj.38755.366331.2f · Cited by 676 · see citing works
Arita, M., Ohira, T., Sun, Y., Elangovan, S., Chiang, N., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3912 · Cited by 636 · see citing works
n–3 Fatty Acids in Cardiovascular Disease
Caterina, R. D. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1008153 · Cited by 568 · see citing works
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464 · see citing works
RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis
Hastürk, H., Kantarcı, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Dyke, T. E. V. (2005) · The FASEB Journal · doi:10.1096/fj.05-4724fje · Cited by 437 · see citing works
Colas, R. A., Shinohara, M., Dalli, J., Chiang, N., & Serhan, C. N. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00024.2014 · Cited by 424 · see citing works
Knapp, H. R., Reilly, I. A. G., Alessandrini, P., & FitzGerald, G. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604103141501 · Cited by 415 · see citing works
Self-citationThe Antihypertensive Effects of Fish Oil
Knapp, H. R., & FitzGerald, G. A. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904203201603 · Cited by 405 · see citing works
Self-citationWada, M., DeLong, C. J., Hong, Y. H., Rieke, C. J., Song, I., Sidhu, R. S., Yuan, C., Warnock, M., Schmaier, A. H., Yokoyama, C., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703169200 · Cited by 400 · see citing works
Self-citationIsoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo
Lawson, J. A., FitzGerald, G. A., & Rokach, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24441 · Cited by 381 · see citing works
Self-citationResolution of inflammation is altered in Alzheimer's disease
Wang, X., Zhu, M., Hjorth, E., Cortés‐Toro, V., Eyjolfsdottir, H., Graff, C., Nennesmo, I., Palmblad, J., Eriksdotter, M., Sambamurti, K., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.12.024 · Cited by 301 · see citing works
Oh, S. F., Pillai, P. S., Recchiuti, A., Yang, R., & Serhan, C. N. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42545 · Cited by 292 · see citing works
Fish oil — How does it reduce plasma triglycerides?
Shearer, G. C., Savinova, O. V., & Harris, W. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.011 · Cited by 285 · see citing works
Mas, E., Croft, K. D., Zahra, P., Barden, A., & Mori, T. A. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.190199 · Cited by 270 · see citing works
Tjonahen, E., Oh, S. F., Siegelman, J. N., Elangovan, S., Percarpio, K. B., Hong, S., Arita, M., & Serhan, C. N. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.011 · Cited by 241 · see citing works
Isobe, Y., Arita, M., Matsueda, S., Iwamoto, R., Fujihara, T., Nakanishi, H., Taguchi, R., Masuda, K., Sasaki, K. A., Urabe, D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340612 · Cited by 235 · see citing works
Seki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901809 · Cited by 221 · see citing works
Fischer, R., Konkel, A., Mehling, H., Blossey, K., Gapelyuk, A., Wessel, N., von Schacky, C., Dechend, R., Müller, D. N., Rothe, M., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m047357 · Cited by 214 · see citing works
Giera, M. A., Ioan‐Facsinay, A., Toes, R. E. M., Gao, F., Dalli, J., Deelder, A. M., Serhan, C. N., & Mayboroda, O. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.011 · Cited by 210 · see citing works
Ho, K. J., Spite, M., Owens, C. D., Lancero, H., Kroemer, A. H. K., Pande, R., Creager, M. A., Serhan, C. N., & Conte, M. S. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091082 · Cited by 204 · see citing works
Otto, M. C. D. O., Wu, J. H. Y., Baylín, A., Vaidya, D. M., Rich, S. S., Tsai, M. Y., Jacobs, D. R., & Mozaffarian, D. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000506 · Cited by 178 · see citing works
Resolvin E1 protects the rat heart against reperfusion injury
Keyes, K. T., Ye, Y., Lin, Y., Zhang, C., Perez-Polo, J. R., Gjorstrup, P., & Birnbaum, Y. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01057.2009 · Cited by 166 · see citing works
Liao, Z., Dong, J., Wu, W., Yang, T., Wang, T., Guo, L., Chen, L., Xu, D., & Wen, F. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-110 · Cited by 149 · see citing works
Miyahara, T., Runge, S. J., Chatterjee, A., Chen, M., Mottola, G., Fitzgerald, J. M., Serhan, C. N., & Conte, M. S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225615 · Cited by 134 · see citing works
Diversity of lipid mediators in human adipose tissue depots
Clària, J., Nguyen, B. T., Madenci, A. L., Ozaki, C. K., & Serhan, C. N. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00351.2012 · Cited by 130 · see citing works
Moertl, D., Hammer, A., Steiner, S., Hutuleac, R., Vonbank, K., & Berger, R. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.02.011 · Cited by 124 · see citing works
Weiss, G. A., Troxler, H., Klinke, G., Rogler, D., Braegger, C., & Hersberger, M. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-89 · Cited by 120 · see citing works
Wang, Q., Zheng, X., Yang, C. H., Zhang, Y.-L., Wen, H.-X., Tao, Z., Li, H., Yu, H., Gao, Y., Yang, L.-M., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302421 · Cited by 113 · see citing works
Prüß, H., Rosche, B., Sullivan, A. B., Brommer, B., Wengert, O., Gronert, K., & Schwab, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055859 · Cited by 103 · see citing works
Keelan, J. A., Mas, E., D’Vaz, N., Dunstan, J. A., Li, S., Barden, A. E., Mark, P. J., Waddell, B. J., Prescott, S. L., & Mori, T. A. (2014) · Reproduction · doi:10.1530/rep-14-0549 · Cited by 100 · see citing works
Amano, T., Matsubara, T., Uetani, T., Kato, M., Kato, B., Yoshida, T., Harada, K., Kumagai, S., Kunimura, A., Shinbo, Y., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.05.030 · Cited by 83 · see citing works
Dawczynski, C., Massey, K. A., Ness, C., Kiehntopf, M., Stepanow, S., Platzer, M., Grün, M., Nicolaou, A., & Jahreis, G. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.12.010 · Cited by 77 · see citing works
(2012) · Europe PMC (PubMed Central) · Cited by 75 · see citing works
Balas, L., Guichardant, M., Durand, T., & Lagarde, M. (2013) · Biochimie · doi:10.1016/j.biochi.2013.11.006 · Cited by 68 · see citing works
Song, W., Lawson, J. A., Wang, M., Zou, H. Y., & FitzGerald, G. A. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)33003-6 · Cited by 65 · see citing works
Self-citationDetermination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS
Sasaki, A., Fukuda, H., Shiida, N., Tanaka, N. K., Furugen, A., Ogura, J., Shuto, S., Mano, N., & Yamaguchi, H. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8412-5 · Cited by 58 · see citing works
Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis
Settimio, R., Filippo, C. D., Ferraraccio, F., Simonelli, F., & D'AMICO, M. (2012) · Mediators of Inflammation · doi:10.1155/2012/318621 · Cited by 56 · see citing works
Pedersen, A. K., & FitzGerald, G. A. (1985) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1985.8 · Cited by 53 · see citing works
Self-citationOmega‐3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers
Ferguson, J. F., Mulvey, C. K., Patel, P., Shah, R. Y., Doveikis, J., Zhang, W., Tabita‐Martinez, J., Terembula, K., Eiden, M. J., Koulman, A., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300368 · Cited by 48 · see citing works
Self-citationRecchiuti, A., Codagnone, M., Pierdomenico, A. M., Rossi, C., Mari, V. C., Cianci, E., Simiele, F., Gatta, V., & Romano, M. (2014) · The FASEB Journal · doi:10.1096/fj.13-248393 · Cited by 47 · see citing works
Kalish, B. T., Le, H. D., Fitzgerald, J. M., Wang, S., Seamon, K. J., Gura, K. M., Gronert, K., & Puder, M. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00106.2013 · Cited by 47 · see citing works
Total synthesis of the macrophage derived anti-inflammatory lipid mediator Maresin 1
Rodrı́guez, A. R., & Spur, B. W. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.05.143 · Cited by 37 · see citing works
Jacobo, S. H., Chang, C.-T., Lee, G., Lawson, J. A., Powell, W. S., Praticò, D., FitzGerald, G. A., & Rokach, J. (2006) · The Journal of Organic Chemistry · doi:10.1021/jo051916x · Cited by 35 · see citing works
Self-citationCell-Cell Interaction in the Transcellular Biosynthesis of Novel ω-3-Derived Lipid Mediators
Chiang, N., & Serhan, C. N. (2006) · Humana Press eBooks · doi:10.1385/1-59745-113-4:227 · Cited by 28 · see citing works
Hu (2012) · doi:10.1001/archinternmed.2012.463 · Cited by 26 · see citing works
Total synthesis of Resolvin D1, a potent anti-inflammatory lipid mediator
Rodrı́guez, A. R., & Spur, B. W. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.10.059 · Cited by 19 · see citing works
Eicosapentaenoic-acid-derived isoprostanes: Synthesis and discovery of two major isoprostanes
Chang, C.-T., Patel, P., Kang, N., Lawson, J. A., Song, W., Powell, W. S., FitzGerald, G. A., & Rokach, J. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.09.008 · Cited by 14 · see citing works
Self-citationA comparison between the concentration of prostaglandin F in human plasma and serum
Challis, J. R. G., & Tulchinsky, D. (1974) · Prostaglandins · doi:10.1016/s0090-6980(74)80127-9 · Cited by 12 · see citing works
iPF2α-III-17,18,19,20-d4: Total synthesis and metabolism
Kim, S., Powell, W. S., Lawson, J. A., Jacobo, S. H., Praticò, D., FitzGerald, G. A., Maxey, K. M., & Rokach, J. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.01.062 · Cited by 8 · see citing works
Self-citationChang, C.-T., Patel, P., Gore, V., Song, W., Lawson, J. A., Powell, W. S., FitzGerald, G. A., & Rokach, J. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.09.099 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
1 of the 66 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation
Zabetakis, I., Lordan, R., Norton, C., & Τσούπρας, Α. (2020) · Nutrients · doi:10.3390/nu12051466 · Cited by 535 · see citing works
Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works
Inflammation and resolution in obesity
Soták, M., Clark, M., Suur, B. E., & Börgeson, E. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01047-y · Cited by 234 · see citing works
Omega-3 Fatty Acids and Skeletal Muscle Health
Jeromson, S., Gallagher, I., Galloway, S., & Hamilton, D. (2015) · Marine Drugs · doi:10.3390/md13116977 · Cited by 203 · see citing works
Schebb, N. H., Kühn, H., Kahnt, A. S., Rund, K. M., O’Donnell, V. B., Flamand, N., Peters-Golden, M. L., Jakobsson, P., Weylandt, K. H., Rohwer, N., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.838782 · Cited by 202 · see citing works
Self-citationSchunck, W., Konkel, A., Fischer, R., & Weylandt, K. H. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.016 · Cited by 196 · see citing works
Lordan, R., Τσούπρας, Α., & Zabetakis, I. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100694 · Cited by 179 · see citing works
Desai, B. N., Singhal, G., Watanabe, M., Stevanovic, D., Lundasen, T., Fisher, F. M., Mather, M. L., Vardeh, H. G., Douris, N., Adams, A. C., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.08.004 · Cited by 150 · see citing works
Self-citationN-3 Polyunsaturated Fatty Acids and the Resolution of Neuroinflammation
Joffre, C., Rey, C., & Layé, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01022 · Cited by 146 · see citing works
Phospholipid signaling in innate immune cells
O’Donnell, V. B., Rossjohn, J., & Wakelam, M. J. O. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97944 · Cited by 143 · see citing works
Kosaraju, R., Guesdon, W., Crouch, M. J., Teague, H., Sullivan, E. M., Karlsson, E. A., Schultz‐Cherry, S., Gowdy, K. M., Bridges, L. C., Reese, L., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601031 · Cited by 136 · see citing works
Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment
Lordan, R., Rando, H. M., & Greene, C. S. (2021) · mSystems · doi:10.1128/msystems.00122-21 · Cited by 130 · see citing works
Kutzner, L., Rund, K. M., Ostermann, A. I., Hartung, N. M., Galano, J., Balas, L., Durand, T., Balzer, M. S., David, S., & Schebb, N. H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00169 · Cited by 106 · see citing works
Inflammation and cardiovascular disease: are marine phospholipids the answer?
Lordan, R., Redfern, S., Τσούπρας, Α., & Zabetakis, I. (2020) · Food & Function · doi:10.1039/c9fo01742a · Cited by 103 · see citing works
Markworth, J. F., Kaur, G., Miller, E. G., Larsen, A., Sinclair, A. J., Maddipati, K. R., & Cameron‐Smith, D. (2016) · The FASEB Journal · doi:10.1096/fj.201600360r · Cited by 90 · see citing works
The roles of lipids in SARS-CoV-2 viral replication and the host immune response
Theken, K. N., Tang, S. Y., Sengupta, S., & FitzGerald, G. A. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100129 · Cited by 89 · see citing works
Self-citationBioactive Compounds in Edible Oils and Their Role in Oxidative Stress and Inflammation
Mazzocchi, A., Cosmi, V. D., Risé, P., Milani, G. P., Turolo, S., Syrén, M., Sala, A., & Agostoni, C. V. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.659551 · Cited by 92 · see citing works
Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis
Brouwers, H., von Hegedus, J., Toes, R. E. M., Kloppenburg, M., & Ioan‐Facsinay, A. (2015) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2016.02.003 · Cited by 87 · see citing works
Omega-3 fatty acids, membrane remodeling and cancer prevention
Fuentes, N. R., Kim, E., Fan, Y., & Chapkin, R. S. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.04.001 · Cited by 80 · see citing works
n-3 Fatty acid supplementation and proresolving mediators of inflammation
Barden, A. E., Mas, E., & Mori, T. A. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000262 · Cited by 77 · see citing works
Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation
Kilburg-Basnyat, B. J., Reece, S. W., Crouch, M. J., Luo, B., Boone, A. D., Yaeger, M. J., Hodge, M. X., Psaltis, C. E., Hannan, J. L., Manke, J., et al. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy040 · Cited by 71 · see citing works
Ostermann, A. I., & Schebb, N. H. (2017) · Food & Function · doi:10.1039/c7fo00403f · Cited by 69 · see citing works
Omega-3 Fatty Acids in Atherosclerosis and Coronary Artery Disease
Bäck, M. (2017) · Future Science OA · doi:10.4155/fsoa-2017-0067 · Cited by 69 · see citing works
Emerging Roles and Therapeutic Applications of Arachidonic Acid Pathways in Cardiometabolic Diseases
Hu, Y., Li, W., Cheng, X., Yang, H., She, Z., Cai, J., Li, H., & Zhang, X.-J. (2024) · Circulation Research · doi:10.1161/circresaha.124.324383 · Cited by 60 · see citing works
Oxylipin profiling for clinical research: Current status and future perspectives
Parchem, K., Letsiou, S., Petan, T., Oskolkova, O., Medina, I., Kuda, O., O’Donnell, V. B., Nicolaou, A., Fedorova, M., Bochkov, V., et al. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101276 · Cited by 55 · see citing works
Alnouri, M. W., Roquid, K. A., Bonnavion, R., Cho, H., Heering, J., Kwon, J., Jäger, Y., Wang, S., Günther, S., Wettschureck, N., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407130121 · Cited by 54 · see citing works
Remodelling of primary human CD4+T cell plasma membrane order byn-3 PUFA
Fan, Y.-Y., Fuentes, N. R., Hou, T. Y., Barhoumi, R., Li, X. C., Deutz, N. E. P., ENGELEN, M. P. K. J., McMurray, D. N., & Chapkin, R. S. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517003385 · Cited by 51 · see citing works
Self-citationPrentice, K. J., Wendell, S. G., Liu, Y., Eversley, J. A., Salvatore, S. R., Mohan, H., Brandt, S. L., Adams, A. C., Wang, X. S., Wei, D., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.019 · Cited by 48 · see citing works
Self-citationLiu, G., Gong, Y., Zhang, R., Piao, L., Li, X., Liu, Q., Yan, S., Shen, Y., Guo, S., Zhu, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800173r · Cited by 46 · see citing works
Self-citationMozurkewich, E., Greenwood, M., Clinton, C. M., Berman, D. R., Romero, V., Djurić, Z., Qualls, C., & Gronert, K. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00274 · Cited by 45 · see citing works
Jung, T. W., Kyung, E. J., Kim, H., Shin, Y. K., Lee, S. H., Park, E. S., Hacımüftüoğlu, A., El‐Aty, A. M. A., & Jeong, J. H. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.246686 · Cited by 42 · see citing works
Watanabe, Y., & Tatsuno, I. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2021.1863784 · Cited by 42 · see citing works
Liu, W., Yang, Y.-H., Wang, Y.-C., Chang, W., & Wang, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311012 · Cited by 39 · see citing works
Robinson, D. T., Palac, H., Baillif, V., Goethem, E. V., Dubourdeau, M., Horn, L. V., & Martin, C. R. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.05.003 · Cited by 38 · see citing works
Al‐Shaer, A. E., Regan, J., Buddenbaum, N., Tharwani, S. D., Drawdy, C., Behee, M., Sergin, S., Fenton, J. I., Maddipati, K. R., Kane, S. F., et al. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac075 · Cited by 36 · see citing works
Fuentes, N. R., Mlih, M., Barhoumi, R., Fan, Y., Hardin, P. E., Steele, T. J., Behmer, S. T., Prior, I. A., Karpac, J., & Chapkin, R. S. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0324 · Cited by 34 · see citing works
Rund, K. M., Peng, S., Greite, R., Claaßen, C., Nolte, F., Oger, C., Galano, J., Balas, L., Durand, T., Chen, R., et al. (2019) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2019.106386 · Cited by 34 · see citing works
Pro-Resolving Molecules—New Approaches to Treat Sepsis?
Buechler, C., Pohl, R., & Aslanidis, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030476 · Cited by 34 · see citing works
Arnardottir, H. H., Pawelzik, S., Sarajlic, P., Quaranta, A., Kolmert, J., Religa, D., Wheelock, C. E., & Bäck, M. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.895 · Cited by 33 · see citing works
Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis
Lin, N., Shay, J. E. S., Xie, H. J., Lee, D. S. M., Skuli, N., Tang, Q., Zhou, Z., Azzam, A., Meng, H., Wang, H., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02565 · Cited by 30 · see citing works
Self-citationDecreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer
Tian, M., Huang, B., He, N., Sun, L., Du, G., Gong, X., Xu, Y., Zheng, Y., Zheng, H., & Qu, H. (2020) · Mediators of Inflammation · doi:10.1155/2020/4539035 · Cited by 31 · see citing works
A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood
Mazaleuskaya, L. L., Lawson, J. A., Li, X., Grant, G. R., Mesaros, C., Großer, T., Blair, I. A., Ricciotti, E., & FitzGerald, G. A. (2016) · JCI Insight · doi:10.1172/jci.insight.87031 · Cited by 31 · see citing works
Self-citationTsai, W.-C., Kalyanaraman, C., Yamaguchi, A. A., Holinstat, M. A., Jacobson, M. P., & Holman, T. R. (2021) · Biochemistry · doi:10.1021/acs.biochem.0c00931 · Cited by 29 · see citing works
Ma, Y., Jiang, J., Zhao, C., Wei, B., & Gao, J. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000802 · Cited by 28 · see citing works
Shoieb, S. M., El‐Ghiaty, M. A., & El‐Kadi, A. O. S. (2020) · Emergent Materials · doi:10.1007/s42247-020-00136-8 · Cited by 27 · see citing works
Rapid Metabolization of Protectin D1 by β-Oxidation of Its Polar Head Chain
Balas, L., Risé, P., Dayaker, G., Rovati, G. E., Bolego, C., Stellari, F. F., Trenti, A., Buccellati, C., Durand, T., & Sala, A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01463 · Cited by 27 · see citing works
Li, X., Mazaleuskaya, L. L., Ballantyne, L. L., Meng, H., FitzGerald, G. A., & Funk, C. D. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m080028 · Cited by 26 · see citing works
Self-citationOxidative stress in relation to diet and physical activity among premenopausal women
Anderson, C., Milne, G. L., Sandler, D. P., & Nichols, H. B. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516003226 · Cited by 25 · see citing works
Omega-3 fatty acid supplement use and oxidative stress levels in pregnancy
Sley, E. G., Rosen, E. M., Erve, T. J. V. ‘., Sathyanarayana, S., Barrett, E. S., Nguyen, R. H. N., Bush, N. R., Milne, G. L., Swan, S. H., & Ferguson, K. K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240244 · Cited by 30 · see citing works
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis
Salazar, J. J., Pírela, D., Nava, M., Castro, A. V., Angarita, L., Parra, H., Durán‐Agüero, S., Rojas-Gómez, D. M., Galbán, N., Áñez, R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063133 · Cited by 26 · see citing works
Marchand, N. E., Choi, M. Y., Oakes, E. G., Cook, N. R., Stevens, E. F., Gomelskaya, N., Kotler, G., Manson, J. E., Lasky-Su, J. A., Mora, S., et al. (2023) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2023.102542 · Cited by 25 · see citing works
Molecular signature of complex regional pain syndrome (CRPS) and its analysis
König, S., Schlereth, T., & Birklein, F. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1366859 · Cited by 24 · see citing works
Teopompi, E., Risé, P., Pisi, R., Buccellati, C., Aiello, M., Pisi, G., Tripodi, M. C., Fainardi, V., Clini, E. M., Chetta, A. A., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00938 · Cited by 24 · see citing works
Kim, J., Joshi, H. P., Sheen, S. H., Kim, K., Kyung, J. W., Choi, H., Kim, Y. W., Kwon, S. Y., Roh, E. J., Choi, U. Y., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02118-7 · Cited by 24 · see citing works
Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization
Fuentes, N. R., Salinas, M. L., Kim, E., & Chapkin, R. S. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.03.014 · Cited by 22 · see citing works
Role for phospholipid acyl chains and cholesterol in pulmonary infections and inflammation
Shaikh, S. R., Fessler, M. B., & Gowdy, K. M. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4vmr0316-103r · Cited by 22 · see citing works
Kutzner, L., Goloshchapova, K., Rund, K. M., Jübermann, M., Blum, M., Rothe, M., Kirsch, S. F., Schunck, W., Kühn, H., & Schebb, N. H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158806 · Cited by 22 · see citing works
Caffrey, C., Leamy, A., O’Sullivan, E., Zabetakis, I., Lordan, R., & Nasopoulou, C. (2023) · Marine Drugs · doi:10.3390/md21110549 · Cited by 20 · see citing works
Zulyniak, M. A., Roke, K., Gerling, C., Logan, S. L., Spriet, L. L., & Mutch, D. M. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500830 · Cited by 21 · see citing works
Specialized pro-resolving mediators: do they circulate in plasma?
Murphy, R. C. (2015) · Journal of Lipid Research · doi:10.1194/jlr.c062356 · Cited by 21 · see citing works
Resolution pharmacology and the treatment of infectious diseases
Costa, V. V., Resende, F., Melo, E. M., & Teixeira, M. M. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16323 · Cited by 20 · see citing works
Kampschulte, N., Kirchhoff, R., Löwen, A., & Schebb, N. H. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100694 · Cited by 20 · see citing works
Schwarzkopf, K. M., Queck, A., Thomas, D., Angioni, C., Cai, C., Freygang, Y., Rüschenbaum, S., Geißlinger, G., Zeuzem, S., Welsch, C., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211537 · Cited by 20 · see citing works
Dietary fats and F2-isoprostanes: A review of the clinical evidence
Silva, M. S. D., Bilodeau, J., Julien, P., & Rudkowska, I. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1196646 · Cited by 19 · see citing works
Identification of novel F2-isoprostane metabolites by specific UDP-glucuronosyltransferases
Milne, G. L., Nogueira, M. S., Gao, B., Sanchez, S. C., Amin, W., Thomas, S., Oger, C., Galano, J., Murff, H. J., Yang, G., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2023.103020 · Cited by 16 · see citing works
Wu, J. T., Li, X., Xia, F., Teng, F., & Xu, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.759825 · Cited by 15 · see citing works
Self-citationBenefit–Risk Assessment of Fish Oil in Preventing Cardiovascular Disease
Lands, B. (2016) · Drug Safety · doi:10.1007/s40264-016-0438-5 · Cited by 15 · see citing works
Dubé, L., Spahis, S., Lachaîne, K., Lemieux, A., Monhem, H., Poulin, S.-M., Randoll, C., Travaillaud, E., Ould-Chikh, N.-E.-H., Marcil, V., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0156 · Cited by 14 · see citing works
Koudelka, A., Buchan, G. J., Cechova, V., O’Brien, J. P., Stevenson, E. R., Uvalle, C. E., Liu, H., Woodcock, S. R., Mullett, S. J., Zhang, C., et al. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100705 · Cited by 13 · see citing works
Combinations of bio-active dietary constituents affect human white adipocyte function in-vitro
Warnke, I., Jocken, J. W. E., Schoop, R., Toepfer, C., Góralczyk, R., & Schwager, J. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0143-5 · Cited by 13 · see citing works
Thomas, C. P., Tyrrell, V. J., Burston, J. J., Johnson, S. R. C., Aldrovandi, M., Álvarez-Jarreta, J., Inglis, R., Leonard, A., Fice, L., Costales, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2502640122 · Cited by 12 · see citing works
Blood Fatty Acids Profile in MIS-C Children
Verduci, E., Risé, P., Profio, E. D., Fiori, L., Vizzuso, S., Dilillo, D., Mannarino, S., Zoia, E., Calcaterra, V., Pinna, C., et al. (2021) · Metabolites · doi:10.3390/metabo11110721 · Cited by 11 · see citing works
Souza, L. C., Moris, J. M., Gordon, P. M., Heileson, J. L., & Funderburk, L. (2025) · Nutrients · doi:10.3390/nu17122014 · Cited by 10 · see citing works
Nutraceuticals: Potential prospect for COVID-19 management
Mehrotra, N., & Jadhav, K. (2021) · Annals of Phytomedicine An International Journal · doi:10.21276/ap.covid19.2021.10.1.9 · Cited by 9 · see citing works
EPA, DHA, and resolvin effects on cancer risk: The underexplored mechanisms
Kiyasu, Y., Zuo, X., Liu, Y., Yao, J. C., & Shureiqi, I. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106854 · Cited by 9 · see citing works
Sottero, B., Testa, G., Gamba, P., Staurenghi, E., Giannelli, S., & Leonarduzzi, G. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.010 · Cited by 9 · see citing works
Teague, H., Harris, M., Whelan, J. T., Comstock, S. S., Fenton, J. I., & Shaikh, S. R. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.012 · Cited by 9 · see citing works
Understanding the Role of Polyunsaturated Fatty Acids in the Development and Prevention of Cancer
Akbar, S., Rahman, A., Aḥmad, N., Imran, M., & Hafeez, Z. (2024) · Cancer treatment and research · doi:10.1007/978-3-031-55622-7_3 · Cited by 8 · see citing works
Lagarde, M., Calzada, C., Jouvene, C. C., Bernoud‐Hubac, N., Létisse, M., Guichardant, M., & Véricel, E. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.10.001 · Cited by 8 · see citing works
Berrocal-Navarrete, F., Marín-Sanhueza, P., Norambuena-González, R., Martin, M. Q. S., Vielma, F. H., González, D. R., & Zúñiga‐Hernández, J. (2026) · Biomolecules · doi:10.3390/biom16010139 · Cited by 7 · see citing works
Khabir, Z., Abdelhafez, A., Camponovo, F. F., Joyce, P., & Garcia‐Bennett, A. E. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2615693 · Cited by 8 · see citing works
Kim, E.-J., Wright, G. A., Zoh, R. S., Patil, B. S., Jayaprakasha, G. K., Callaway, E. S., Ivanov, I. V., Turner, N. D., & Chapkin, R. S. (2018) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000465 · Cited by 7 · see citing works
Naicker, B., Ramanayake-Mudiyanselage, V., Maxey, T., Tyrrell, V. J., Horn, J., Kennedy, P. D., Tew, D. J., Johnson, J., FitzGerald, G. A., Murphy, R. C., et al. (2026) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2026.102731 · Cited by 6 · see citing works
Self-citationEffects of forages, dust exposure and proresolving lipids on airway inflammation in horses
Olave, C. J., Ivester, K. M., Couëtil, L. L., Franco, J., Mukhopadhyay, A., Robinson, J. P., & Park, J. H. (2022) · American Journal of Veterinary Research · doi:10.2460/ajvr.21.08.0126 · Cited by 6 · see citing works
Molfino, A., Amabile, M. I., Lionetto, L., Spagnoli, A., Ramaccini, C., Luca, A. D., Simmaco, M., Monti, M., & Muscaritoli, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1280987 · Cited by 5 · see citing works
Quantitation of Oxylipins in Biological Samples, Focusing on Plasma, and Urine
O’Donnell, V. B., Milne, G. L., Nogueira, M. S., Giera, M. A., & Schebb, N. H. (2023) · doi:10.1002/9783527836512.ch12 · Cited by 5 · see citing works
Zahoor, I., Waters, J., Ata, N., Datta, I., Pedersen, T. L., Cerghet, M., Poisson, L., Markovic‐Plese, S., Rattan, R., Taha, A. Y., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.04.574253 · Cited by 5 · see citing works
Resolving lipoxin A4: Endogenous mediator or exogenous anti-inflammatory agent?
McGuffee, R. M., Luetzen, M. A., & Ford, D. A. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100734 · Cited by 4 · see citing works
Human Platelet Lipidomics: Variance, Visualization, Flux, and Fuel
FitzGerald, G. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.025 · Cited by 4 · see citing works
Self-citationBiosynthesis and analytics of specialized pro-resolving mediators: facts and faults
Schebb, N. H., Kühn, H., Kampschulte, N., Flamand, N., Peters-Golden, M. L., Jakobsson, P., Claesson, H., Weylandt, K. H., Rohwer, N., Saul, M. J., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101133 · Cited by 3 · see citing works
Self-citationKorpak, K., Rossi, M., MEERHAEGHE, A. V., Boudjeltia, K. Z., & Compagnie, M. (2024) · Nutrition and Healthy Aging · doi:10.3233/nha-220184 · Cited by 3 · see citing works
Aspirin-triggered DHA metabolites inhibit angiogenesis
Vara-Messler, M., Trevisi, L., Zulato, E., Ramaschi, G. E., Risé, P., Pinna, C., Indraccolo, S., Sala, A., & Bolego, C. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1524980 · Cited by 2 · see citing works
Chiral clues to lipid identity
Das, U. S., & FitzGerald, G. A. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100710 · Cited by 2 · see citing works
Self-citationSetty, Y. B. N., Maddipati, K. R., Keith, S. W., Shimada, A., Sheerer, P., & Miller, R. E. (2025) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2025.102670 · Cited by 2 · see citing works
Unsaturated fatty acids, omega-3 index and hospitalization in MISC
Profio, E. D., Risé, P., Orlandi, L., Zoia, E., Pinna, C., Sala, A., Zuccotti, G., & Verduci, E. (2024) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2024.102627 · Cited by 2 · see citing works
Kuksis, A., & Pruzanski, W. (2022) · Lipids · doi:10.1002/lipd.12359 · Cited by 1 · see citing works
Rescue of Neurons by Resolving Inflammation
Hjorth, E., & Schultzberg, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00009-0 · Cited by 1 · see citing works
- Authors
- Skarke, C., Alamuddin, N., Lawson, J. A., Li, X., Ferguson, J. F., Reilly, M. P., & FitzGerald, G. A.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Skarke, Carsten
- FitzGerald, Garret A.
- ORCID
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 56
- Issue
- 9
- Pages
- 1808-1820
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC4548785
- OpenAlex
- W2270563637
- Cited by
- 109
- References
- 66
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 15 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 7
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (KL2TR000139, UL1TR000003, 2kl2rr024132-06)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK058404)
- National Institute of Environmental Health Sciences (P30ES013508)
- National Center for Research Resources (KL2-RR024132, UL1RR024134)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- fish oil, resolvins, maresins, protectins, specialized pro-resolving mediators, inflammation resolution, anti-inflammatory activity, omega-3 fatty acids, omega-6 fatty acids, epoxyeicosatrienoic acids, isoprostanes, lipopolysaccharide, acute inflammation, urinary biomarkers, plasma biomarkers, dietary supplementation
- MeSH terms
- Adult, Anti-Inflammatory Agents, Female, Fish Oils, Humans, Inflammation, Lipopolysaccharides, Male, Fatty Acids, Omega-3, Inflammation Mediators, CD59 Antigens, Dietary Supplements, Lipid Metabolism, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
