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In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis

Zhu, Yuyan, Chen, Chih-Yu, Li, Junjie, Cheng, Ji-Xin, Jang, Miran, Kim, Kee-Hong·2018·Journal of Lipid Research
DOI 10.1194/jlr.m081745
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  • Interventions that promote cholesterol-regulating processes reduce Aβ pathology, including increasing ER-free cholesterol via inhibiting cholesteryl ester formation by ACAT1 inhibition.

    “Interestingly, interventions that promote these processes reduce Aβ pathology, including increasing ER-FC via inhibiting CE formation by ACAT1 inhibition [74, 75, 103, 111].”

    From Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation (2023) · cites this paper as [103]

    The Discussion reports that ACAT1 inhibition suppresses cholesteryl ester synthesis in neurons and that cholesteryl ester forms on the ER membrane. It does not report increased ER free cholesterol or reduced Aβ pathology; its own adipocyte results instead show decreased intracellular free cholesterol. The References list a separate work on ACAT inhibition and amyloid-beta reduction, but that title does not establish the claimed outcome in this paper. (LLM, conf=0.86)

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Research works printed but not linked: 47

  1. Farkas, 1973, Studies on the compartmentation of lipid in adipose cells. II. Cholesterol accumulation and distribution in adipose tissue components, J. Lipid Res., 14, 344, 10.1016/S0022-2275(20)36894-2 · DOI
  2. Prattes, 2000, Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures, J. Cell Sci., 113, 2977, 10.1242/jcs.113.17.2977 · DOI
  3. Le Lay, 2001, Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes, J. Biol. Chem., 276, 16904, 10.1074/jbc.M010955200 · DOI
  4. Kovanen, 1975, Regulation of cholesterol synthesis and storage in fat cells, J. Lipid Res., 16, 211, 10.1016/S0022-2275(20)36728-6 · DOI
  5. Schreibman, 1975, Human adipocyte cholesterol. Concentration, localization, synthesis, and turnover, J. Clin. Invest., 55, 986, 10.1172/JCI108028 · DOI
  6. Vroegrijk, 2013, CD36 is important for adipocyte recruitment and affects lipolysis, Obesity (Silver Spring)., 21, 2037, 10.1002/oby.20354 · DOI
  7. Jelinek, 2015, The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage is susceptible to increased weight gain when fed a high-fat diet: Confirmation of a gene-diet interaction, Gene., 568, 112, 10.1016/j.gene.2015.05.025 · DOI
  8. Tilvis, 1978, Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins, Scand. J. Clin. Lab. Invest., 38, 83, 10.3109/00365517809108407 · DOI
  9. Chang, 1998, Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner, J. Biol. Chem., 273, 35132, 10.1074/jbc.273.52.35132 · DOI
  10. Chang, 2001, Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2, Curr. Opin. Lipidol., 12, 289, 10.1097/00041433-200106000-00008 · DOI
  11. Fazio, 2001, Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages, J. Clin. Invest., 107, 163, 10.1172/JCI10310 · DOI
  12. Su, 2005, Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1, Circulation., 111, 2373, 10.1161/01.CIR.0000164236.19860.13 · DOI
  13. Huang, 2016, Myeloid acyl-CoA:cholesterol acyltransferase 1 deficiency reduces lesion macrophage content and Suppresses atherosclerosis progression, J. Biol. Chem., 291, 6232, 10.1074/jbc.M116.713818 · DOI
  14. Buhman, 2000, Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice, Nat. Med., 6, 1341, 10.1038/82153 · DOI · Paper page
  15. Yue, 2014, Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness, Cell Metab., 19, 393, 10.1016/j.cmet.2014.01.019 · DOI
  16. Shibuya, 2015, ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease, Future Med. Chem., 7, 2451, 10.4155/fmc.15.161 · DOI · Paper page
  17. Bhattacharyya, 2010, ACAT inhibition and amyloid beta reduction, Biochim. Biophys. Acta., 1801, 960, 10.1016/j.bbalip.2010.04.003 · DOI · Paper page
  18. Petschnigg, 2009, Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast, J. Biol. Chem., 284, 30981, 10.1074/jbc.M109.024752 · DOI
  19. Sandager, 2002, Storage lipid synthesis is non-essential in yeast, J. Biol. Chem., 277, 6478, 10.1074/jbc.M109109200 · DOI
  20. Oelkers, 2002, The DGA1 gene determines a second triglyceride synthetic pathway in yeast, J. Biol. Chem., 277, 8877, 10.1074/jbc.M111646200 · DOI
  21. Zweytick, 2000, Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae, Eur. J. Biochem., 267, 1075, 10.1046/j.1432-1327.2000.01103.x · DOI
  22. Kawamura, 1981, Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase, Proc. Natl. Acad. Sci. USA., 78, 732, 10.1073/pnas.78.2.732 · DOI
  23. Keay, 1980, Interferon inhibits the conversion of 3T3-L1 mouse fibroblasts into adipocytes, Proc. Natl. Acad. Sci. USA., 77, 4099, 10.1073/pnas.77.7.4099 · DOI
  24. Khan, 2009, Impact of simvastatin on adipose tissue: pleiotropic effects in vivo, Endocrinology., 150, 5262, 10.1210/en.2009-0603 · DOI
  25. Maeda, 2009, Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation, J. Biochem., 145, 771, 10.1093/jb/mvp035 · DOI
  26. Cuffe, 2018, Targeted deletion of adipocyte Abca1 (ATP-binding cassette transporter A1) impairs diet-induced obesity, Epub ahead of print., 22, 910
  27. Kim, 2011, Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion, J. Nutr. Biochem., 22, 910, 10.1016/j.jnutbio.2010.08.003 · DOI
  28. Kwon, 2012, An inhibitory effect of resveratrol in the mitotic clonal expansion and insulin signaling pathway in the early phase of adipogenesis, Nutr. Res., 32, 607, 10.1016/j.nutres.2012.06.014 · DOI
  29. Uchida, 2011, Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, alters triglyceride metabolism in enterocytes of mice, Biochim. Biophys. Acta., 1811, 170, 10.1016/j.bbalip.2010.12.011 · DOI
  30. Li, 2014, Direct visualization of de novo lipogenesis in single living cells, Sci. Rep., 4, 6807, 10.1038/srep06807 · DOI
  31. Tiscornia, 2006, Production and purification of lentiviral vectors, Nat. Protoc., 1, 241, 10.1038/nprot.2006.37 · DOI
  32. Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 · DOI · Paper page
  33. Lee, 1996, Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets, J. Med. Chem., 39, 5031, 10.1021/jm960674d · DOI
  34. Bocan, 1991, Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation, Arterioscler. Thromb., 11, 1830, 10.1161/01.ATV.11.6.1830 · DOI
  35. Repa, 2004, ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis, Hepatology., 40, 1088, 10.1002/hep.20439 · DOI
  36. Miyazaki, 2005, Inhibitors of acyl-coenzyme a: cholesterol acyltransferase, Curr. Drug Targets Cardiovasc. Haematol. Disord., 5, 463, 10.2174/156800605774962040 · DOI
  37. Mukherjee, 1998, Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog, Biophys. J., 75, 1915, 10.1016/S0006-3495(98)77632-5 · DOI · Paper page
  38. Goldstein, 2006, Protein sensors for membrane sterols, Cell., 124, 35, 10.1016/j.cell.2005.12.022 · DOI · Paper page
  39. Borradaile, 2002, Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms, Biochem. J., 366, 531, 10.1042/bj20020046 · DOI
  40. Taghibiglou, 2002, Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe (CI-1011), a novel acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, Biochem. Pharmacol., 63, 349, 10.1016/S0006-2952(01)00918-2 · DOI
  41. Sahlin, 1994, Hepatic esterification rate of cholesterol and biliary lipids in human obesity, J. Lipid Res., 35, 484, 10.1016/S0022-2275(20)41199-X · DOI
  42. Sandager, 2000, An acyl-CoA:cholesterol acyltransferase (ACAT)-related gene is involved in the accumulation of triacylglycerols in Saccharomyces cerevisiae, Biochem. Soc. Trans., 28, 700, 10.1042/bst0280700 · DOI
  43. Brown, 1997, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell., 89, 331, 10.1016/S0092-8674(00)80213-5 · DOI · Paper page
  44. An, 2008, Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes, Exp. Mol. Med., 40, 407, 10.3858/emm.2008.40.4.407 · DOI · Paper page
  45. Chui, 2005, PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1, J. Clin. Invest., 115, 2244, 10.1172/JCI24130 · DOI
  46. Guo, 2016, Niemann-Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes, J. Lipid Res., 57, 1644, 10.1194/jlr.M066522 · DOI
  47. Frisdal, 2015, Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity, Diabetes., 64, 840, 10.2337/db14-0245 · DOI

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Metadata

Authors
Zhu, Y., Chen, C.-Y., Li, J., Cheng, J.-X., Jang, M., & Kim, K.-H.
ORCID
Kim, Kee-Hong
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2018
Volume
59
Issue
5
Pages
820-829
ISSN
0022-2275
DOI
10.1194/jlr.m081745
Cited by
43
References
0
Language
en
Licence
Funders
Purdue Research Foundation

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