ApoC-III gene polymorphisms and risk of coronary artery disease

Olivieri, Oliviero; Stranieri, Chiara; Bassi, Antonella; Zaia, Barbara; Girelli, Domenico; Pizzolo, Francesca; Trabetti, Elisabetta; Cheng, Suzanne; Grow, Michael A.; Pignatti, Pier Franco; Corrocher, Roberto

doi:10.1194/jlr.m200145-jlr200

Cited by 70Lipid metabolism and disordersLipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

ApoC-III gene polymorphisms and risk of coronary artery disease

Open access

Olivieri, Oliviero, Stranieri, Chiara, Bassi, Antonella, Zaia, Barbara, Girelli, Domenico, Pizzolo, Francesca, Trabetti, Elisabetta, Cheng, Suzanne +3 more·2002·Journal of Lipid Research

DOI 10.1194/jlr.m200145-jlr200

Open this paper in CoChat — free account Open PDF

Abstract

Several polymorphisms in the apolipoprotein C-III (apoC-III) gene have been associated with hypertriglyceridemia, but the link with coronary artery disease risk is still controversial. In particular, apoC-III promoter sequence variants in the insulin responsive element (IRE), constitutively resistant to downregulation by insulin, have never been investigated in this connection. We studied a total of 800 patients, 549 of whom had angiographically documented coronary atherosclerosis, whereas 251 had normal coronary arteriograms. We measured plasma lipids, insulin, apoA-I, apoB, and apoC-III and assessed three polymorphisms in the apoC-III gene, namely, T-455C in the IRE promoter region, C1100T in exon 3, and Sst1 polymorphic site (S1/S2) in the 3' untranslated region. Each variant influenced triglyceride levels, but only the T-455C (in homozygosity) and S2 alleles influenced apoC-III levels. In coronary artery disease (CAD) patients, 18.6% were homozygous for the -455C variant compared with only 9.2% in CAD-free group (P < 0.001). In logistic regression models, homozygosity for -455C variant was associated with a significantly increased risk of CAD (OR = 2.5 and 2.18 for unadjusted and adjusted models, respectively) suggesting that it represents an independent genetic susceptibility factor for CAD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1194/jlr.m200145-jlr200

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Previous studies have suggested that two single-nucleotide polymorphisms in the gene encoding apolipoprotein C3 (APOC3) may be associated with hypertriglyceridemia.
“Previous studies have suggested that two single-nucleotide polymorphisms (SNPs) in the gene encoding apolipoprotein C3 (APOC3) may be associated with hypertriglyceridemia.4–8”
From Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease (2010) · cites this paper as [6]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Handbook of Human Genetic Linkage.
Edwards, A. W. F., Terwilliger, J. D., & Ott, J. (1996) · Biometrics · doi:10.2307/2533082 · Cited by 873 · see citing works
Handbook of human genetic linkage
Petty, E. M. (1995) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(95)90062-4 · Cited by 563 · see citing works
Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3
Jong, M. C., Hofker, M. H., & Havekes, L. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.3.472 · Cited by 539 · see citing works
VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial
Sacks, F. M., Alaupovic, P., Moye, L. A., Cole, T. G., Sussex, B., Stampfer, M. J., Pfeffer, M. A., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.102.16.1886 · Cited by 490 · see citing works
Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI: evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo
Ginsberg, H. N., Le, N. A., Goldberg, I. J., Gibson, J. C., Rubinstein, A., Wang-Iverson, P., Norum, R., & Brown, W. V. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112713 · Cited by 424 · cited 1× · see citing works
“ApoC-III inhibits the hydrolysis of TG-rich particles by lipoprotein lipase and their apoE–mediated hepatic uptake (10, 11).”
Background
Triglyceride- and cholesterol-rich lipoproteins have a differential effect on mild/moderate and severe lesion progression as assessed by quantitative coronary angiography in a controlled trial of lovastatin.
Hodis, H. N., Mack, W. J., Azen, S. P., Alaupovic, P., Pogoda, J. M., LaBree, L., Hemphill, L., Kramsch, D. M., & Blankenhorn, D. H. (1994) · Circulation · doi:10.1161/01.cir.90.1.42 · Cited by 321 · see citing works
Remnant Lipoprotein Levels in Fasting Serum Predict Coronary Events in Patients With Coronary Artery Disease
Kugiyama, K., Doi, H., Takazoe, K., Kawano, H., Soejima, H., Mizuno, Y., Tsunoda, R., Sakamoto, T., Nakano, T., Nakajima, K., et al. (1999) · Circulation · doi:10.1161/01.cir.99.22.2858 · Cited by 284 · see citing works
Prediction of angiographic change in native human coronary arteries and aortocoronary bypass grafts. Lipid and nonlipid factors.
Blankenhorn, D. H., Alaupovic, P., Wickham, E., Chin, H. P., & Azen, S. P. (1990) · Circulation · doi:10.1161/01.cir.81.2.470 · Cited by 278 · see citing works
Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.
Li, W. W., Dammerman, M. M., Smith, J. D., Metzger, S., Breslow, J. L., & Leff, T. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118324 · Cited by 278 · see citing works
An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.
Dammerman, M., Sandkuijl, L. A., Halaas, J. L., Chung, W. K., & Breslow, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4562 · Cited by 227 · see citing works
A multilocus genotyping assay for candidate markers of cardiovascular disease risk.Preprint
Cheng, S., Grow, M., Pallaud, C., Klitz, W., Erlich, H. A., Visvikis, S., Chen, J. J., Pullinger, C., Malloy, M., Siest, G., et al. (1999) · Genome Research · doi:10.1101/gr.9.10.936 · Cited by 224 · see citing works
Self-citation
Polymorphisms in the Factor VII Gene and the Risk of Myocardial Infarction in Patients with Coronary Artery Disease
Girelli, D., Russo, C. A., Ferraresi, P., Olivieri, O., Pinotti, M., Friso, S., Manzato, F., Mazzucco, A., Bernardi, F., & Corrocher, R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009143431104 · Cited by 220 · see citing works
Self-citation
Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.
Chen, M., Breslow, J. L., Li, W., & Leff, T. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39938-7 · Cited by 184 · see citing works
Lipoprotein Subclasses in the Monitored Atherosclerosis Regression Study (MARS)
Mack, W. J., Krauss, R. M., & Hodis, H. N. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.5.697 · Cited by 173 · see citing works
Inhibition of lipoprotein lipase activity by synthetic peptides of apolipoprotein C-III.
Wj, M., Gesquière, J. C., Bass, H. B., Tartar, A. L., Fruchart, J., & Wang, C. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41415-4 · Cited by 173 · see citing works
Triglyceride-Rich Lipoprotein Remnant Particles and Risk of Atherosclerosis
Hodis, H. N. (1999) · Circulation · doi:10.1161/01.cir.99.22.2852 · Cited by 149 · see citing works
Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus Relationships with lipids, apolipoproteins, and premature coronary artery disease
Ordovás, J. M., Civeira, F., Genest, J. J., Craig, S., Robbins, A. H., MEADE, T., Pocovı́, M., Frossard, P. M., Masharan, U., Wilson, P. W. F., et al. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90234-t · Cited by 145 · see citing works
Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study
Russo, G. T., Meigs, J. B., Cupples, L. A., Demissie, S., Otvos, J. D., Wilson, P. W. F., Lahoz, C., Cucinotta, D., Couture, P., Mallory, T., et al. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00409-9 · Cited by 123 · see citing works
Apolipoproteins C–III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: the ECTIM study. Etude Cas Temoins sur 'Infarctus du Myocarde
Luc, G., Fievet, C., Arveiler, D., Evans, A. E., Bard, J. M., Cambien, F., Fruchart, J. C., & Ducimetiere, P. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37594-5 · Cited by 114 · see citing works
Polymorphic Markers in Apolipoprotein C-III Gene Flanking Regions and Hypertriglyceridemia
Surguchov, A. P., Page, G. P., Smith, L. C., Patsch, W., & Boerwinkle, E. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.941 · Cited by 108 · see citing works
Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: A randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris
* (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80133-7 · Cited by 96 · see citing works
ApoCIII Gene Variants Modulate Postprandial Response to Both Glucose and Fat Tolerance Tests
Waterworth, D. M., Ribalta, J., Nicaud, V., Dallongeville, J., Humphries, S. E., & Talmud, P. J. (1999) · Circulation · doi:10.1161/01.cir.99.14.1872 · Cited by 85 · see citing works
Association between genetic variation at the APO AI‐CIII‐AIV gene cluster and familial combined hyperlipidaemia
Xu, C., Talmud, P. J., Schuster, H., Houlston, R. S., Miller, G. J., & Humphries, S. E. (1994) · Clinical Genetics · doi:10.1111/j.1399-0004.1994.tb04404.x · Cited by 77 · see citing works
Common Genomic Variation in theAPOC3Promoter Associated With Variation in Plasma Lipoproteins
Hegele, R. A., Connelly, P. W., Hanley, A. J., Sun, F. Y., Harris, S. B., & Zinman, B. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2753 · Cited by 74 · see citing works
Polymorphisms of the apolipoprotein and angiotensin converting enzyme genes in young North Karelian patients with coronary heart disease
Miettinen, H. E., Korpela, K., H�m�l�inen, L., & KONTULA, K. K. (1994) · Human Genetics · doi:10.1007/bf00202868 · Cited by 68 · see citing works
Secondary Prevention of Coronary Heart Disease
Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.2 · Cited by 65 · see citing works
Hypertriglyceridemia and the apolipoprotein CIII gene locus: lack of association with the variant insulin response element in Italian school children
Shoulders, C. C., Grantham, T. T., North, J. D., Gaspardone, A., Tomai, F., de Fazio, A., Versaci, F., Gioffrè, P. A., & Cox, N. J. (1996) · Human Genetics · doi:10.1007/s004390050259 · Cited by 60 · see citing works
Apolipoprotein C-lll gene variation and dyslipidaemia
Talmud, P. J., & Humphries, S. E. (1997) · Current Opinion in Lipidology · doi:10.1097/00041433-199706000-00005 · Cited by 60 · see citing works
Associations of genotypes at the apolipoprotein AI‐CIII‐AIV, apolipoprotein B and lipoprotein lipase gene loci with coronary atherosclerosis and high density lipoprotein subclasses
Peacock, R. E., Hamsten, A., Johansson, J., Nilsson‐Ehle, P., & Humphries, S. E. (1994) · Clinical Genetics · doi:10.1111/j.1399-0004.1994.tb04159.x · Cited by 51 · see citing works
Overview of fenofibrate.
Cj, P. (1998) · PubMed · Cited by 46 · see citing works
A variation in the apolipoprotein C-III gene is associated with an increased number of circulating VLDL and IDL particles in familial combined hyperlipidemia
Ribalta, J., Ville, A. E. L., Vallvé, J.-C., Humphries, S. E., Turner, P. R., & Masana, L. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37189-3 · Cited by 41 · see citing works
Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese
Ko, Y.-L., Ko, Y.-S., Wu, S.-M., Teng, M., Chen, F.-R., Hsu, T., Chiang, C.-W., & Lee, Y. (1997) · Human Genetics · doi:10.1007/s004390050511 · Cited by 39 · see citing works
The SsíI polymorphism of the apolipoprotein C-III gene determines the insulinresponse to an oral-glucose-tolerance test after consumption of a diet rich in saturated fats
Salas-Coronas, J., Jansen, S., López‐Miranda, J., Ordovás, J. M., Castro, P., Marin, C., Ostos, M. A., Bravo, M. D., Jiménez-Perepérez, J., Blanco, A., et al. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.396 · Cited by 39 · see citing works
Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI–APOE cluster
Waterworth, D. M., Hubacek, J. A., Pitha, J. V., Kovář, J., Poledne, R., Humphries, S. E., & Talmud, P. J. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32016-2 · Cited by 38 · see citing works
Lack of association between genetic variations of apo A-I–C-III–A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study
Kee, F., Amouyel, P., Fumeron, F., Arveiler, D., Cambou, J., Evans, A., Cambien, F., Fruchart, J., Ducimetière, P., & Dallongeville, J. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00066-0 · Cited by 34 · see citing works
Angiographic evidence for the role of triglyceride-rich lipoproteins in progression of coronary artery disease.
Gr, T. (1998) · PubMed · Cited by 17 · see citing works
RFLP studies in different ethnic groups
Humphries, S. E., Talmud, P. J., Monsalve, V., et al. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90183-4 · Cited by 16 · see citing works
Small genetic effects in complex diseases: A review of regulatory sequence variants in dyslipoproteinemia and atherosclerosis
Hegele, R. A. (1997) · Clinical Biochemistry · doi:10.1016/s0009-9120(96)00167-1 · Cited by 15 · see citing works
The Trouble With Triglycerides
Bloomfield, H. E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.13.1903 · Cited by 12 · see citing works

Flagged first, then by citations

Sorted by citations

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
Petersen, K. F., Dufour, S., Hariri, A., Nelson-Williams, C., Foo, J. N., Zhang, X.-M., Dziura, J., Lifton, R. P., & Shulman, G. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907295 · Cited by 428 · see citing works
Apolipoprotein C-III: understanding an emerging cardiovascular risk factor
Ooi, E. M. M., Barrett, P. H. R., Chan, D. C., & Watts, G. F. (2008) · Clinical Science · doi:10.1042/cs20070308 · Cited by 282 · see citing works
Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity.
Cohn, J. S., Patterson, B. W., Uffelman, K. D., Davignon, J., & Steiner, G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032056 · Cited by 170 · see citing works
Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease
Olivieri, O., Bassi, A., Stranieri, C., Trabetti, E., Martinelli, N., Pizzolo, F., Girelli, D., Friso, S., Pignatti, P. F., & Corrocher, R. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300253-jlr200 · Cited by 139 · see citing works
Self-citation
FoxO1 integrates insulin signaling to VLDL production.
Kamagate, A., & Dong, H. H. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6882 · Cited by 127 · see citing works
Polymorphisms in the Fatty Acid-Binding Protein 2 and Apolipoprotein C-III Genes Are Associated with the Metabolic Syndrome and Dyslipidemia in a South Indian Population
Guettier, J.-M., Georgopoulos, A., Tsai, M. Y., Radha, V., Shanthirani, S., Deepa, R., Gross, M., Rao, G., & Mohan, V. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1338 · Cited by 108 · see citing works
Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and “insulin-resistant” T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction
Olivieri, O., Martinelli, N., Sandri, M., Bassi, A., Guarini, P., Trabetti, E., Pizzolo, F., Girelli, D., Friso, S., Pignatti, P. F., et al. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.040477 · Cited by 50 · see citing works
Self-citation

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019
Promising biomarkers in patients with advanced coronary artery disease
(2020) · doi:10.1016/j.atherosclerosis.2020.10.787
Adaptation to Coronary Artery Disease: First Pilot Study in the Military
(1997) · doi:10.1093/milmed/162.12.792 · Cited by 2 · see citing works
Diagnosing and Characterizing Coronary Artery Disease in Women: Developments in Noninvasive and Invasive Imaging Techniques
Ng, V. G., Meller, S. M., Shetty, S. S., & Lansky, A. J. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9500-1 · Cited by 6 · see citing works
EFFECT OF PROLONGED AND INTENSE EXERCISE TRAINING ON PATIENTS WITH CORONARY ARTERY DISEASE (CAD)
(1983) · doi:10.1249/00005768-198315020-00050

Authors: Olivieri, O., Stranieri, C., Bassi, A., Zaia, B., Girelli, D., Pizzolo, F., Trabetti, E., Cheng, S., Grow, M. A., Pignatti, P. F., & Corrocher, R.
Affiliations: University of Verona (IT)
Corresponding author: Olivieri, Oliviero
ORCID: Olivieri, Oliviero
Stranieri, Chiara
Bassi, Antonella
Girelli, Domenico
Pizzolo, Francesca
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2002-09
Volume: 43
Issue: 9
Pages: 1450-1457
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.m200145-jlr200
OpenAlex: W2144970509
Cited by: 70
References: 39
Citations by year: 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 2
FWCI: 2.84
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6574 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
INFM-OAR (INFN Catania) (submittedVersion, cc-by)
Funders: Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona
Regione del Veneto
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: apolipoprotein C-III, genetic polymorphism, coronary artery disease, genetic susceptibility, promoter, 3' untranslated region, hypertriglyceridemia, triglyceride levels
MeSH terms: Adult, Apolipoproteins B, Apolipoproteins C, Coronary Artery Disease, Female, Genotype, Humans, Insulin, Male, Middle Aged, Polymorphism, Genetic, Biomarkers, Odds Ratio, Apolipoprotein A-I, Genetic Predisposition to Disease, Apolipoprotein C-III

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ApoC-III gene polymorphisms and risk of coronary artery disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks