Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease
Open accessAbstract
Apolipoprotein C-III (apoC-III) is a marker of triglyceride (TG)-rich lipoproteins, which are often increased in metabolic syndrome (MS). The T-455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apoC-III levels. To evaluate the contribution of apoC-III levels and T-455C polymorphisms in the coronary artery disease (CAD) risk of MS patients, we studied 873 patients, 549 with CAD and 251 with normal coronary arteries. Patients were classified also as having or not having MS (MS, n = 270; MS-free, n = 603). Lipids, insulin, apolipoprotein levels, and APOC3 T-455C genotypes were evaluated. ApoC-III levels were significantly increased in MS patients, and the probability of having MS was correlated with increasing quartiles of apoC-III levels. MS patients with CAD had significantly higher apoC-III levels than did CAD-free MS patients. The carriership for the -455C variant multiplied the probability of CAD in MS in an allele-specific way and was associated with increased apoC-III and TG levels. Obesity was less frequent in MS carriers of the -455C allele than in MS noncarriers (21.6% vs. 34.8%, P < 0.05). In conclusion, apoC-III-rich lipoprotein metabolism and the APOC3 polymorphism have relevant impacts on the CAD risk of MS patents.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous studies have suggested that two single-nucleotide polymorphisms in the gene encoding apolipoprotein C3 (APOC3) may be associated with hypertriglyceridemia.
“Previous studies have suggested that two single-nucleotide polymorphisms (SNPs) in the gene encoding apolipoprotein C3 (APOC3) may be associated with hypertriglyceridemia.4–8”
From Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease (2010) · cites this paper as [5]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works
Insulin resistance and cardiovascular disease
Ginsberg, H. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10762 · Cited by 1,358 · see citing works
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921 · see citing works
Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3
Jong, M. C., Hofker, M. H., & Havekes, L. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.3.472 · Cited by 539 · see citing works
Sacks, F. M., Alaupovic, P., Moye, L. A., Cole, T. G., Sussex, B., Stampfer, M. J., Pfeffer, M. A., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.102.16.1886 · Cited by 490 · see citing works
Ginsberg, H. N., Le, N. A., Goldberg, I. J., Gibson, J. C., Rubinstein, A., Wang-Iverson, P., Norum, R., & Brown, W. V. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112713 · Cited by 424 · cited 1× · see citing works
“ApoC-III inhibits the hydrolysis of TG-rich particles by the lipoprotein lipase and their hepatic uptake mediated by apoE (9, 10 ).”
BackgroundObesity, Metabolic Syndrome, and Coronary Atherosclerosis
Grundy, S. M. (2002) · Circulation · doi:10.1161/01.cir.0000020650.86137.84 · Cited by 380 · see citing works
Talmud, P. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.24.3039 · Cited by 365 · see citing works
Hodis, H. N., Mack, W. J., Azen, S. P., Alaupovic, P., Pogoda, J. M., LaBree, L., Hemphill, L., Kramsch, D. M., & Blankenhorn, D. H. (1994) · Circulation · doi:10.1161/01.cir.90.1.42 · Cited by 321 · see citing works
Blankenhorn, D. H., Alaupovic, P., Wickham, E., Chin, H. P., & Azen, S. P. (1990) · Circulation · doi:10.1161/01.cir.81.2.470 · Cited by 278 · see citing works
Li, W. W., Dammerman, M. M., Smith, J. D., Metzger, S., Breslow, J. L., & Leff, T. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118324 · Cited by 278 · see citing works
The Metabolic Syndrome, LDL Particle Size, and Atherosclerosis
Hulthe, J., Bokemark, L., Wikstrand, J., & Fagerberg, B. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2140 · Cited by 249 · see citing works
Zimmet, P., Boyko, E. J., Collier, G. R., & de Courten, M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07783.x · Cited by 233 · see citing works
Groop, L., & Orho‐Melander, M. (2001) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2001.00864.x · Cited by 232 · see citing works
Dammerman, M., Sandkuijl, L. A., Halaas, J. L., Chung, W. K., & Breslow, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4562 · Cited by 227 · see citing works
Chen, M., Breslow, J. L., Li, W., & Leff, T. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39938-7 · Cited by 184 · see citing works
Lipoprotein Subclasses in the Monitored Atherosclerosis Regression Study (MARS)
Mack, W. J., Krauss, R. M., & Hodis, H. N. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.5.697 · Cited by 173 · see citing works
Inhibition of lipoprotein lipase activity by synthetic peptides of apolipoprotein C-III.
Wj, M., Gesquière, J. C., Bass, H. B., Tartar, A. L., Fruchart, J., & Wang, C. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41415-4 · Cited by 173 · see citing works
Chan, D. C., Watts, G. F., Redgrave, T. G., Mori, T. A., & Barrett, P. H. R. (2002) · Metabolism · doi:10.1053/meta.2002.33339 · Cited by 133 · see citing works
Markers of triglyceride-rich lipoprotein remnant metabolism in visceral obesity
Chan, D. C., Watts, G. F., Barrett, P. H., Mamo, J. C., & Redgrave, T. G. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.2.278 · Cited by 117 · see citing works
Luc, G., Fievet, C., Arveiler, D., Evans, A. E., Bard, J. M., Cambien, F., Fruchart, J. C., & Ducimetiere, P. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37594-5 · Cited by 114 · see citing works
Polymorphic Markers in Apolipoprotein C-III Gene Flanking Regions and Hypertriglyceridemia
Surguchov, A. P., Page, G. P., Smith, L. C., Patsch, W., & Boerwinkle, E. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.941 · Cited by 108 · see citing works
Triglycerides, apo C3 and Lp B:C3 and cardiovascular risk in Type II diabetes
Gervaise, N., Garrigue, M. A., Lasfargues, G., & Lecomte, P. (2000) · Diabetologia · doi:10.1007/s001250051366 · Cited by 82 · see citing works
Wong, W.-M. R., Hawe, E., Li, L. K., Miller, G. J., Nicaud, V., Pennacchio, L. A., Humphries, S. E., & Talmud, P. J. (2003) · Circulation Research · doi:10.1161/01.res.0000069688.94567.7a · Cited by 81 · see citing works
Common Genomic Variation in theAPOC3Promoter Associated With Variation in Plasma Lipoproteins
Hegele, R. A., Connelly, P. W., Hanley, A. J., Sun, F. Y., Harris, S. B., & Zinman, B. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2753 · Cited by 74 · see citing works
ApoC-III gene polymorphisms and risk of coronary artery disease
Olivieri, O., Stranieri, C., Bassi, A., Zaia, B., Girelli, D., Pizzolo, F., Trabetti, E., Cheng, S., Grow, M. A., Pignatti, P. F., et al. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200145-jlr200 · Cited by 70 · see citing works
Self-citationShoulders, C. C., Grantham, T. T., North, J. D., Gaspardone, A., Tomai, F., de Fazio, A., Versaci, F., Gioffrè, P. A., & Cox, N. J. (1996) · Human Genetics · doi:10.1007/s004390050259 · Cited by 59 · see citing works
Accumulation of Triglyceride-Rich Lipoprotein in Subjects With Abdominal Obesity
Bard, J., Charles, M.-A. A., Juhan-Vague, I., Vague, P., André, P., Safar, M. E., Fruchart, J., & Eschwège, É. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.3.407 · Cited by 39 · see citing works
Tilly, P., Sass, C., Vincent‐Viry, M., Aguillon, D., Siest, G., & Visvikis‐Siest, S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200006-jlr200 · Cited by 34 · see citing works
Jamshidi, Y., Flavell, D. M., Hawe, E., MacCallum, P. K., Meade, T. W., & Humphries, S. E. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00002-3 · Cited by 24 · see citing works
Gr, T. (1998) · PubMed · Cited by 17 · see citing works
Attia, N., Durlach, V., Cambilleau, M., Roche, D., & Girard-Globa, A. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00337-8 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119 · see citing works
Progress and Challenges in Metabolic Syndrome in Children and Adolescents
Steinberger, J., Daniels, S. R., Eckel, R. H., Hayman, L. L., Lustig, R. H., McCrindle, B. W., & Mietus‐Snyder, M. (2009) · Circulation · doi:10.1161/circulationaha.108.191394 · Cited by 713 · see citing works
Pathophysiology of diabetic dyslipidaemia: where are we?
Vergès, B. (2015) · Diabetologia · doi:10.1007/s00125-015-3525-8 · Cited by 708 · see citing works
Fruchart, J.-C., Sacks, F., Hermans, M. P., Assmann, G., Brown, W. V., Ceska, R., Chapman, M. J., Dodson, P. M., Fioretto, P., Ginsberg, H. N., et al. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.10.002 · Cited by 463 · see citing works
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
Petersen, K. F., Dufour, S., Hariri, A., Nelson-Williams, C., Foo, J. N., Zhang, X.-M., Dziura, J., Lifton, R. P., & Shulman, G. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907295 · Cited by 428 · see citing works
Riwanto, M., Rohrer, L., Roschitzki, B., Besler, C., Mocharla, P., Mueller, M., Perisa, D., Heinrich, K., Altwegg, L., von Eckardstein, A., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.108753 · Cited by 337 · see citing works
The Human Obesity Gene Map: The 2004 Update
Përusse, L., Rankinen, T., Zuberi, A. R., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G. A., Walts, B., Snyder, E. E., & Bouchard, C. (2005) · Obesity Research · doi:10.1038/oby.2005.50 · Cited by 326 · see citing works
Fruchart, J.-C., Sacks, F. M., Hermans, M. P., Assmann, G., Brown, W. V., Ceska, R., Chapman, M. J., Dodson, P. M., Fioretto, P., Ginsberg, H. N., et al. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.046 · Cited by 260 · see citing works
Prevalence of Body Iron Excess in the Metabolic Syndrome
Bozzini, C., Girelli, D., Olivieri, O., Martinelli, N., Bassi, A., De Matteis, G., Tenuti, I., Lotto, V., Friso, S., Pizzolo, F., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.8.2061 · Cited by 224 · see citing works
Self-citationLipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans
Atzmon, G., Rincon, M., Schechter, C. B., Shuldiner, A. R., Lipton, R. B., Bergman, A., & Barzilai, N. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040113 · Cited by 222 · see citing works
Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular risk.
Pacifico, L., Nobili, V., Anania, C., Verdecchia, P., & Chiesa, C. (2011) · Europe PMC (PubMed Central) · doi:10.3748/wjg.v17.i26.3082 · Cited by 198 · see citing works
Genetic variants and the metabolic syndrome: a systematic review
Povel, C. M., Boer, J. M. A., Reiling, E., & Feskens, E. J. M. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00907.x · Cited by 170 · see citing works
Willems van Dijk, K., Rensen, P. C., Voshol, P. J., & Havekes, L. M. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200406000-00002 · Cited by 154 · see citing works
Wyler von Ballmoos, M. C., Haring, B., & Sacks, F. M. (2015) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.05.002 · Cited by 134 · see citing works
McCrindle, B. W., Mietus‐Snyder, M., Steinberger, J., Daniels, S. R., Eckel, R. H., & Hayman, L. L. (2009) · Cited by 138 · see citing works
The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk
Lai, C., Parnell, L. D., & Ordovás, J. M. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000162320.54795.68 · Cited by 137 · see citing works
Seaweed Lipids as Nutraceuticals
Mišurcová, L., Ambrožová, J. V., & Samek, D. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00027-2 · Cited by 120 · see citing works
Guettier, J.-M., Georgopoulos, A., Tsai, M. Y., Radha, V., Shanthirani, S., Deepa, R., Gross, M., Rao, G., & Mohan, V. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1338 · Cited by 108 · see citing works
Khetarpal, S. A., Zeng, X., Millar, J. S., Vitali, C., Somasundara, A. V. H., Zanoni, P., Landro, J. A., Barucci, N., Zavadoski, W. J., Sun, Z., et al. (2017) · Nature Medicine · doi:10.1038/nm.4390 · Cited by 109 · see citing works
Kawakami, A., Aikawa, M., Nitta, N., Yoshida, M., Libby, P., & Sacks, F. M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000249620.68705.0d · Cited by 99 · see citing works
Apolipoprotein CIII links dyslipidemia with atherosclerosis
Kawakami, A., & Yoshida, M. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e607 · Cited by 98 · see citing works
Genetics of familial combined hyperlipidemia and risk of coronary heart disease
Shoulders, C. C. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh069 · Cited by 96 · see citing works
An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?
Chan, D. C., Chen, M. M., Ooi, E. M. M., & Watts, G. F. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01678.x · Cited by 85 · see citing works
Apolipoprotein CIII Links Hyperlipidemia With Vascular Endothelial Cell Dysfunction
Kawakami, A., Osaka, M., Tani, M., Azuma, H., Sacks, F. M., Shimokado, K., & Yoshida, M. (2008) · Circulation · doi:10.1161/circulationaha.108.784785 · Cited by 92 · see citing works
RetractedAPOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome
Miller, M., Rhyne, J., Chen, H., Beach, V., Ericson, R., Luthra, K., Dwivedi, M., & Misra, A. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.013 · Cited by 89 · see citing works
Grundy, S. M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000253905.13219.4b · Cited by 71 · see citing works
Martinelli, N., Trabetti, E., Bassi, A., Girelli, D., Friso, S., Pizzolo, F., Sandri, M. F., Malerba, G., Pignatti, P. F., Corrocher, R., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.04.009 · Cited by 68 · see citing works
Self-citationQi, L., Liu, S., Rifai, N., Hunter, D., & Hu, F. B. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.006 · Cited by 67 · see citing works
Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation
Li, J., Li, L., Guo, D., Li, S., Zeng, Y., Liu, C., Fu, R., Huang, M., & Xie, W. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.12.029 · Cited by 66 · see citing works
Olivieri, O., Martinelli, N., Girelli, D., Pizzolo, F., Friso, S., Beltrame, F., Lotto, V., Annarumma, L., & Corrocher, R. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03720.x · Cited by 64 · see citing works
Self-citationJian, W., Edom, R. W., Wang, D., Weng, N., & Zhang, S. (2013) · Analytical Chemistry · doi:10.1021/ac3034757 · Cited by 61 · see citing works
Wu, Y., Yu, Y., Zhao, T., Wang, S., Fu, Y., Qi, Y., Yang, G., Yao, W., Su, Y., Ma, Y., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147946 · Cited by 59 · see citing works
ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
Luo, M., Liu, A., Wang, S., Wang, T., Hu, D., Wu, S., & Peng, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-02601-7 · Cited by 58 · see citing works
Rasouli, B. S., Grill, V., Midthjell, K., Ahlbom, A., Andersson, T., & Carlsson, S. (2012) · Diabetes Care · doi:10.2337/dc12-0913 · Cited by 58 · see citing works
New Era of Lipid-Lowering Drugs
Barter, P. J., & Rye, K. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012203 · Cited by 59 · see citing works
Ruiz-Narváez, E., Yang, Y., Nakanishi, Y., Kirchdorfer, J., & Campos, H. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500040-jlr200 · Cited by 57 · see citing works
Serum apolipoprotein C‐III in high‐density lipoprotein: a key diabetogenic risk factor in Turks
Onat, A., Hergenç, G., Ayhan, E., Uğur, M., Kaya, H., Tuncer, M., & Can, G. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02814.x · Cited by 55 · see citing works
Poma, B. Z., Riva, A., Nasi, M., Cicconi, P., Broggini, V., Cozzi‐Lepri, A., Mologni, D., Mazzotta, F., Monforte, A. D., Mussini, C., et al. (2008) · AIDS · doi:10.1097/qad.0b013e32830b3a96 · Cited by 54 · see citing works
Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor RORα
Genoux, A., Dehondt, H., Helleboid‐Chapman, A., Duhem, C., Hum, D. W., Martin, G., Pennacchio, L. A., Staels, B., Fruchart‐Najib, J., & Fruchart, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000163841.85333.83 · Cited by 54 · see citing works
Pavlic, M., Valéro, R., Duez, H., Xiao, C., Szeto, L., Patterson, B. W., & Lewis, G. F. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.169383 · Cited by 52 · see citing works
Olivieri, O., Martinelli, N., Sandri, M., Bassi, A., Guarini, P., Trabetti, E., Pizzolo, F., Girelli, D., Friso, S., Pignatti, P. F., et al. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.040477 · Cited by 50 · see citing works
Self-citationFlorez, H. J., Mendez, A. J., Casanova-Romero, P. Y., Larreal, C., Castillo-Florez, S., Lee, D. J., & Goldberg, R. B. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.013 · Cited by 46 · see citing works
Pollex, R. L., Ban, M. R., Young, T. K., Bjerregaard, P., Anand, S. S., Yusuf, S., Zinman, B., Harris, S. B., Hanley, A. J., Connelly, P. W., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-80 · Cited by 45 · see citing works
ApoE ε2/ε3/ε4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome
Olivieri, O., Martinelli, N., Bassi, A., Trabetti, E., Girelli, D., Pizzolo, F., Friso, S., Pignatti, P. F., & Corrocher, R. (2007) · Clinical and Experimental Medicine · doi:10.1007/s10238-007-0142-y · Cited by 45 · see citing works
Self-citationRosenthal, E. A., Ranchalis, J., Crosslin, D. R., Burt, A., Brunzell, J. D., Motulsky, A. G., Nickerson, D. A., Wijsman, E. M., & Jarvik, G. P. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.10.019 · Cited by 42 · see citing works
Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M. J., Kontush, A., & Feldman, D. (2022) · Metabolites · doi:10.3390/metabo12050460 · Cited by 41 · see citing works
Hosseini‐Esfahani, F., Mirmiran, P., DANESHPOUR, M. S., Mehrabi, Y., Hedayati, M., Soheilian‐Khorzoghi, M., & Azizi, F. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003687 · Cited by 38 · see citing works
Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content
Peter, A., Kantartzis, K., Machicao, F. E., Machann, J., Wagner, S., Templin, S., Königsrainer, I., Königsrainer, A., Schick, F., Fritsche, A., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.154 · Cited by 36 · see citing works
Aroner, S. A., Yang, M., Li, J., Furtado, J. D., Sacks, F. M., Tjønneland, A. M., Overvad, K., Cai, T., & Jensen, M. K. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx143 · Cited by 33 · see citing works
Olivieri, O., Martinelli, N., Baroni, M., Branchini, A., Girelli, D., Friso, S., Pizzolo, F., & Bernardi, F. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000440 · Cited by 32 · see citing works
Self-citationLow High-Density Lipoprotein and Risk of Myocardial Infarction
Ramirez, A., & Hu, P. P. (2015) · Clinical Medicine Insights Cardiology · doi:10.4137/cmc.s26624 · Cited by 31 · see citing works
Liu, X. F., Yu, J. Q., Dalan, R., Liu, A. Q., & Luo, K. Q. (2014) · Integrative Biology · doi:10.1039/c3ib40265g · Cited by 31 · see citing works
Lipid Biomarkers and Atherosclerosis—Old and New in Cardiovascular Risk in Childhood
Močnik, M., & Varda, N. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032237 · Cited by 30 · see citing works
Albreiki, M. S., Middleton, B., & Hampton, S. M. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12770 · Cited by 29 · see citing works
Hopkins, P. N., Nanjee, M. N., Wu, L. L., McGinty, M. G., Brinton, E. A., Hunt, S. C., & Anderson, J. L. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.016 · Cited by 29 · see citing works
Determinants of VLDL composition and apo B-containing particles in familial combined hyperlipidemia
Cruz‐Bautista, I., Mehta, R., Cabiedes, J., García-Ulloa, A. C., Guillén-Pineda, L. E., Almeda‐Valdés, P., Ramos, D. C., & Aguilar-Salinas, C. A. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.08.018 · Cited by 28 · see citing works
Abe, Y., Kawakami, A., Osaka, M., Uematsu, S., Akira, S., Shimokado, K., Sacks, F. M., & Yoshida, M. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210427 · Cited by 26 · see citing works
RetractedAlmofti, M. R., Huang, Z., Yang, P., Rui, Y., & Yang, P. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04366.x · Cited by 26 · see citing works
Martinelli, N., Olivieri, O., Shen, G.-Q., Trabetti, E., Pizzolo, F., Busti, F., Friso, S., Bassi, A., Li, L., Hu, Y., et al. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-41 · Cited by 25 · see citing works
Self-citationLin, B., Huang, Y., Zhang, M., Wang, J., & Wu, Y. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-004156 · Cited by 25 · see citing works
Zhang, R.-N., Zheng, R.-D., Mi, Y., Zhou, D., Shen, F., Chen, G., Zhu, C., Pan, Q., & Fan, J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4120-7 · Cited by 25 · see citing works
Sahebkar, A., Simental‐Mendía, L. E., Mikhailidis, D. P., Pirro, M., Banach, M., Sirtori, C. R., Ruscica, M., & Reiner, Ž. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.01.008 · Cited by 25 · see citing works
ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
Gerritsen, G., Rensen, P. C. N., Kypreos, K. E., Zannis, V. I., Havekes, L. M., & van Dijk, K. W. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400479-jlr200 · Cited by 24 · see citing works
Mass spectral analysis of urine proteomic profiles of dairy cows suffering from clinical ketosis
Xu, C., Shu, S., Xia, C., PengXian, W., Sun, Y., Xu, C., & Li, C. (2015) · Veterinary Quarterly · doi:10.1080/01652176.2015.1055352 · Cited by 23 · see citing works
Martinelli, N., Girelli, D., Olivieri, O., Cavallari, U., Biscuola, M., Trabetti, E., Friso, S., Pizzolo, F., Tenuti, I., Bozzini, C., et al. (2005) · Clinical and Experimental Medicine · doi:10.1007/s10238-005-0060-9 · Cited by 22 · see citing works
Self-citationLamon‐Fava, S., Herrington, D. M., Horvath, K. V., Schaefer, E. J., & Asztalos, B. F. (2010) · Metabolism · doi:10.1016/j.metabol.2010.05.012 · Cited by 22 · see citing works
Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks
Basavaraju, P., Balasubramani, R., Kathiresan, D. S., Devaraj, I., Babu, K., Vasanthakumar, A., & Moorthi, P. V. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.788852 · Cited by 21 · see citing works
Hosseini‐Esfahani, F., Mirmiran, P., DANESHPOUR, M. S., Mehrabi, Y., Hedayati, M., Zarkesh, M., & Azizi, F. (2014) · Lifestyle Genomics · doi:10.1159/000365445 · Cited by 21 · see citing works
Consistency between cross-sectional and longitudinal SNP: blood lipid associations
Costanza, M. C., Beer‐Borst, S., James, R. W., Gaspoz, J., & Morabia, A. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9670-1 · Cited by 20 · see citing works
Influence of Apolipoproteins on the Association Between Lipids and Insulin Sensitivity
Baldi, S., Bonnet, F., Laville, M., Morgantini, C., Monti, L. D., Højlund, K., Ferrannini, E., Natali, A., & on behalf of the RISC Investigators (2013) · Diabetes Care · doi:10.2337/dc13-0682 · Cited by 20 · see citing works
Ruiz-Narváez, E., Sacks, F. M., & Campos, H. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1932 · Cited by 20 · see citing works
Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy
Bonnet, É., Genoux, A., Bernard, J., Fauvel, J., Massip, P., & Perret, B. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.140 · Cited by 19 · see citing works
Krishnan, S., Copeland, K. C., Bright, B. C., Gardner, A. W., Blackett, P. R., & Fields, D. A. (2010) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2010.00395.x · Cited by 19 · see citing works
Graded Effects of Proteinuria on HDL Structure in Nephrotic Rats
Shearer, G. C., Newman, J. W. I., Hammock, B. D., & Kaysen, G. A. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080644 · Cited by 19 · see citing works
Lü, H., Lei, X., Winkler, R., John, S., Kumar, D., Li, W., & Alnouti, Y. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01654-6 · Cited by 18 · see citing works
Ceppa, F., Mérens, A., Burnat, P., Mayaudon, H., & Bauduceau, B. (2008) · Military Medicine · doi:10.7205/milmed.173.10.960 · Cited by 17 · see citing works
Review: Genetics of the cardiometabolic syndrome: new insights and therapeutic implications
Sookoian, S. C., & Pirola, C. J. (2007) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944707082702 · Cited by 16 · see citing works
Xia, L., Alqahtani, S., Ferreira, C. R., Aryal, U. K., Biggs, K., & Shannahan, J. H. (2022) · Nanomaterials · doi:10.3390/nano12122022 · Cited by 16 · see citing works
Kim, Y., Seo, H. S., Lee, E. M., Na, J. O., Choi, C. U., Lim, H. E., Kim, E. J., Rha, S., Park, C. G., & Oh, D. J. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.86 · Cited by 15 · see citing works
Onat, A., Erginel‐Ünaltuna, N., Çoban, N., Çiçek, G., & Yüksel, H. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.12.009 · Cited by 15 · see citing works
Filippatos, T. D., Tsimihodimos, V., Kostapanos, M. S., Kostara, C. E., Bairaktari, E. T., Kiortsis, D. N., Tselepis, A. D., & Elisaf, M. (2008) · Cited by 14 · see citing works
Metabolic syndrome in children (Review)
Wu, Y., Zhang, C.-L., & Zhen, Q. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3632 · Cited by 14 · see citing works
Bard, J., Lassalle, R., Capeau, J., Bach‐Ngohou, K., Nazih‐Sanderson, F., Rémy, G., Reynes, J., Ecobichon, J.-L., Savès, M., & Raffi, F. (2006) · Antiviral Therapy · doi:10.1177/135965350601100310 · Cited by 14 · see citing works
FXR crosstalk with other nuclear receptors
Mohammed, T. A., & Zalzala, M. H. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01118-2 · Cited by 14 · see citing works
Apolipoprotein C3 Gene Variants and Risk of Developing Type 2 Diabetes in Saudi Subjects
Alharbi, K. K., Hussain, T., Alharbi, F. K., Tabassum, S. N., Mohammed, A. A., Gambhir, D., & Khan, I. A. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0022 · Cited by 12 · see citing works
Pizzolo, F., Pavan, C., Guarini, P., Trabetti, E., Girelli, D., Corrocher, R., & Olivieri, O. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000187260.32567.75 · Cited by 12 · see citing works
Self-citationOlivieri, O., Chiariello, C., Martinelli, N., Castagna, A., Speziali, G., Girelli, D., Pizzolo, F., Bassi, A., Cecconi, D., Robotti, E., et al. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1099 · Cited by 12 · see citing works
Self-citationGarenc, C., Couillard, C., Laflamme, N., Cadelis, F., Gagné, C., Couture, P., Julien, P., & Bergeron, J. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201469 · Cited by 12 · see citing works
Characterization of the Metabolic Syndrome by Apolipoproteins in the Oklahoma Cherokee
Alaupovic, P., Blackett, P. R., Wang, W., & Lee, E. T. (2008) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.00022.x · Cited by 11 · see citing works
Obesity: pathophysiology and treatment
Banning, M. (2005) · The Journal of the Royal Society for the Promotion of Health · doi:10.1177/146642400512500408 · Cited by 11 · see citing works
Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics
Larach, D. B., Cuchel, M., & Rader, D. J. (2013) · Clinical Lipidology · doi:10.2217/clp.13.73 · Cited by 10 · see citing works
Clemente‐Postigo, M., Queipo‐Ortuño, M. I., Valdivielso, P., Tinahones, F. J., & Cardona, F. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.08.014 · Cited by 10 · see citing works
Transactivation of the human apical sodium-dependent bile acid transporter gene by human serum
Duane, W. C., Xiong, W., & Lofgren, J. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.07.005 · Cited by 10 · see citing works
Wybrańska, I., Malczewska-Malec, M., Partyka, Ł., Kieć‐Wilk, B., Kosno, K., Leszczynska-Golabek, I., Zdzienicka, A., Gruca, A., Kwaśniak, M., & Dembinska-Kiec, A. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.142 · Cited by 10 · see citing works
Luo, M., Su, X., Yi, Y., Yang, Y., & Peng, D. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0777-6 · Cited by 10 · see citing works
Metabolic syndrome in children and adolescents
Hong, Y. M. (2009) · Korean Journal of Pediatrics · doi:10.3345/kjp.2009.52.7.737 · Cited by 8 · see citing works
Bashir, B., Adam, S., Ho, J. H., Linn, Z., Durrington, P. N., & Soran, H. (2023) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000889 · Cited by 7 · see citing works
Yu, J., Wang, H., Yang, S.-M., Yuan, J., Chen, L., Chen, C. L., Huang, D. F., Wang, Y., Ju, S.-Q., & ZHU, J.-Y. (2009) · Laboratory Medicine · doi:10.1309/lmubypdivgqwoy2u · Cited by 7 · see citing works
Homocysteine, traditional risk factors and impaired renal function in coronary artery disease
Pizzolo, F., Friso, S., Olivieri, O., Martinelli, N., Bozzini, C., Guarini, P., Trabetti, E., Faccini, G., Corrocher, R., & Girelli, D. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01714.x · Cited by 7 · see citing works
Self-citationNishikai, K., Hirose, H., Ishii, T., Hayashi, M., Saito, I., & Saruta, T. (2004) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11.73 · Cited by 4 · see citing works
- Authors
- Olivieri, O., Bassi, A., Stranieri, C., Trabetti, E., Martinelli, N., Pizzolo, F., Girelli, D., Friso, S., Pignatti, P. F., & Corrocher, R.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Olivieri, Oliviero
- ORCID
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 44
- Issue
- 12
- Pages
- 2374-2381
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2125644926
- Cited by
- 139
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 10 · 2021: 2 · 2020: 1 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 11 · 2012: 2
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein C-III, metabolic syndrome, coronary artery disease, triglyceride-rich lipoproteins, triglycerides, genetic susceptibility, obesity
- MeSH terms
- Adult, Alleles, Apolipoproteins C, Coronary Artery Disease, Data Interpretation, Statistical, Female, Genotype, Humans, Lipids, Male, Middle Aged, Polymorphism, Genetic, Substrate Specificity, Biomarkers, Odds Ratio, Genetic Predisposition to Disease, Metabolic Syndrome, Apolipoprotein C-III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review