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Cited by 75Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular Health

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Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells

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Desrumaux, Catherine M., Mak, Puiying A., Boisvert, William A., Masson, David, Stupack, Dwayne, Jauhiainen, Matti, Ehnholm, Christian, Curtiss, Linda K.·2003·Journal of Lipid Research
DOI 10.1194/jlr.m200281-jlr200
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Abstract

Phospholipid transfer protein (PLTP) in plasma promotes phospholipid transfer from triglyceride-rich lipoproteins to HDL and plays a major role in HDL remodeling. Recent in vivo observations also support a key role for PLTP in cholesterol metabolism. Our immunohistochemical analysis of human carotid endarterectomy samples identified immunoreactive PLTP in areas that colocalized with CD68-positive macrophages, suggesting that PLTP could be produced locally by intimal macrophages. Using RT-PCR, Western blot analysis with a monoclonal anti-PLTP antibody, and a PLTP activity assay, we observed PLTP mRNA and protein expression in human macrophages. In adherent peripheral blood human macrophages, this PLTP expression was increased by culture with granulocyte macrophage colony-stimulating factor. Incubation of macrophages with acetylated-LDL induced an increase in PLTP mRNA and protein expression that paralleled cholesterol loading. PLTP expression was observed in elicited mouse peritoneal macrophages and in cultured Raw264.7 cells as well. Thus, this study demonstrates that PLTP is expressed by macrophages, is regulated by cholesterol loading, and is present in atherosclerotic lesions.

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Metadata

Authors
Desrumaux, C. M., Mak, P. A., Boisvert, W. A., Masson, D., Stupack, D., Jauhiainen, M., Ehnholm, C., & Curtiss, L. K.
Affiliations
  • Scripps Research Institute (US)
  • University of California, Los Angeles (US)
  • Inserm (FR)
  • Finnish Institute for Health and Welfare (FI)
Corresponding author
Curtiss, Linda K.
ORCID
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2003-08
Volume
44
Issue
8
Pages
1453-1461
ISSN
0022-2275 (ISSN-L)
DOI
10.1194/jlr.m200281-jlr200
OpenAlex
W2066601467
Cited by
75
References
3
Citations by year
2025: 3 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
7.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
National Heart, Lung, and Blood Institute (HL43815, R01HL043815)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
phospholipid transfer protein, atherosclerosis, macrophages, foam cells, HDL remodeling, cholesterol loading, acetylated LDL, macrophage gene expression, GM-CSF, carotid endarterectomy, peritoneal macrophages, RAW 264.7 macrophages
MeSH terms
Animals, Arteriosclerosis, Carotid Arteries, Carrier Proteins, Cell Line, Cells, Cultured, Cholesterol, Foam Cells, Gene Expression Regulation, Humans, Immunohistochemistry, Lung, Macrophages, Membrane Proteins, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Phospholipid Transfer Proteins, Mice

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