The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Postprandial recruitment of neutrophils may contribute to endothelial dysfunction
Open accessAbstract
Atherosclerosis is a low-grade inflammatory disease involving leukocytes, lipids, and glucose leading to endothelial dysfunction. Since activation of neutrophils by triglycerides and glucose has been described in vitro, we hypothesized that the postprandial phase is an inflammatory state affecting leukocytes, possibly contributing to endothelial dysfunction. We measured postprandial blood leukocyte counts, cytokines, hydroperoxides (HPOs), and flow-mediated vasodilation (FMD) in eight healthy males (age 23 +/- 2 years) after a FAT (50 g/m2) and GLUCOSE challenge (37.5 g/m2), a combination of both (MIXED test), and after WATER. All tests, except WATER, resulted in significantly impaired FMD (10% reduction) between t = 1 h and t = 3 h, accompanied by a significant increase of neutrophils (59% after FAT and 28% after GLUCOSE and MIXED), total plasma HPOs (15 to 31% increase), and plasma interleukin-8 (IL-8) (50-130% increase). WATER did not affect FMD, neutrophils, HPOs, or IL-8. Lymphocytes increased gradually in all tests (40-70% increase at t = 10 h compared with t = 0; P < 0.005), paralleling a gradual 3- to 5-fold interleukin-6 increase. Monocyte and erythrocyte counts did not change in any test. In conclusion, the neutrophil increment during postprandial lipemia and glycemia with concomitant IL-8 and HPO increases may contribute to endothelial dysfunction. Lymphocyte increment is a nonspecific diurnal process. Postprandial intravascular inflammatory changes may be relevant for the pathogenesis of atherosclerosis.
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“The increase in abdominal fat mass is associated with a chronic elevation of the circulating concentrations of inflammatory mediators including several acute-phase inflammatory proteins such as CRP (46,47) , proand anti-inflammatory cytokines, adhesion molecules and pro-thrombotic molecules (22,47 -49) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [47]
In the citing paper
“Organised leisure-time exercise (assessed by a questionnaire) in children has shown negative correlations with serum IL-6 concentrations, independently of adiposity and fat localisation (256) , and in 10-year-old children, a borderline significant negative association was observed between CRP and self-reported physical activity, independently of ponderal index (47) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [47]
Citations
Cites
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Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
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“Endothelial dysfunction estimated by FMD is clinically significant since it correlates well with coronary artery endothelial function (49), it predicts the presence of CHD (50) and it”
BackgroundSubcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
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Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776
Multiple Roles for Neutrophils in Atherosclerosis
Soehnlein, O. (2012) · Circulation Research · doi:10.1161/circresaha.111.257535 · Cited by 514
Microvascular complications of impaired glucose tolerance
Singleton, J. R., Smith, A. G., Russell, J. W., & Feldman, E. L. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2867 · Cited by 372
Metadata
- Authors
- van Oostrom, A. J. H. H. M., Sijmonsma, T. P., Verseyden, C., Jansen, E. H. J. M., de Koning, E. J. P., Rabelink, T. J., & Castro Cabezas, M.
- Affiliations
- University Medical Center Utrecht (NL)
- National Institute for Public Health and the Environment (NL)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 44
- Issue
- 3
- Pages
- 576-583
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2131142277
- Cited by
- 249
- References
- 54
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 7 · 2017: 13 · 2016: 13 · 2015: 14 · 2014: 23 · 2013: 16 · 2012: 9
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- postprandial lipemia, postprandial blood glucose, neutrophil recruitment, endothelial dysfunction, atherosclerosis, interleukin-8, interleukin-6, hydroperoxides, flow-mediated dilation, lymphocyte count, glucose challenge test, low-grade inflammation
- MeSH terms
- Adult, Arteriosclerosis, Blood Glucose, Dietary Fats, Endothelium, Vascular, Fasting, Fatty Acids, Nonesterified, Glucose, Humans, Hydrogen Peroxide, Inflammation, Insulin, Leukocyte Count, Male, Models, Biological, Neutrophils, Time Factors, Triglycerides, Interleukin-6, Interleukin-8, Postprandial Period
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