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Postprandial recruitment of neutrophils may contribute to endothelial dysfunction
Open accessAbstract
Atherosclerosis is a low-grade inflammatory disease involving leukocytes, lipids, and glucose leading to endothelial dysfunction. Since activation of neutrophils by triglycerides and glucose has been described in vitro, we hypothesized that the postprandial phase is an inflammatory state affecting leukocytes, possibly contributing to endothelial dysfunction. We measured postprandial blood leukocyte counts, cytokines, hydroperoxides (HPOs), and flow-mediated vasodilation (FMD) in eight healthy males (age 23 +/- 2 years) after a FAT (50 g/m2) and GLUCOSE challenge (37.5 g/m2), a combination of both (MIXED test), and after WATER. All tests, except WATER, resulted in significantly impaired FMD (10% reduction) between t = 1 h and t = 3 h, accompanied by a significant increase of neutrophils (59% after FAT and 28% after GLUCOSE and MIXED), total plasma HPOs (15 to 31% increase), and plasma interleukin-8 (IL-8) (50-130% increase). WATER did not affect FMD, neutrophils, HPOs, or IL-8. Lymphocytes increased gradually in all tests (40-70% increase at t = 10 h compared with t = 0; P < 0.005), paralleling a gradual 3- to 5-fold interleukin-6 increase. Monocyte and erythrocyte counts did not change in any test. In conclusion, the neutrophil increment during postprandial lipemia and glycemia with concomitant IL-8 and HPO increases may contribute to endothelial dysfunction. Lymphocyte increment is a nonspecific diurnal process. Postprandial intravascular inflammatory changes may be relevant for the pathogenesis of atherosclerosis.
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“The increase in abdominal fat mass is associated with a chronic elevation of the circulating concentrations of inflammatory mediators including several acute-phase inflammatory proteins such as CRP (46,47) , proand anti-inflammatory cytokines, adhesion molecules and pro-thrombotic molecules (22,47 -49) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [47]
In the citing paper
“Organised leisure-time exercise (assessed by a questionnaire) in children has shown negative correlations with serum IL-6 concentrations, independently of adiposity and fat localisation (256) , and in 10-year-old children, a borderline significant negative association was observed between CRP and self-reported physical activity, independently of ponderal index (47) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [47]
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
Burstein, M., Scholnick, H. R., & Morfin, R. F. (1970) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42943-8 · Cited by 2,500
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
Baggiolini, M., Dewald, B., & Moser, B. (1994) · PubMed · Cited by 2,232
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · cited 1×
“Endothelial dysfunction estimated by FMD is clinically significant since it correlates well with coronary artery endothelial function (49), it predicts the presence of CHD (50) and it”
BackgroundSubcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
Danesh, J. (2000) · BMJ · doi:10.1136/bmj.321.7255.199 · Cited by 1,692
lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines
Baggiolini, M., Dewald, B., & Moser, B. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60509-x · Cited by 1,672
Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities
Braunwald, E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,426
(1999) · The Lancet · doi:10.1016/s0140-6736(98)12131-1 · Cited by 1,313
Borch‐Johnsen, K., Neil, A., Balkau, B., Larsen, S. H., Nissinen, A. E. T., Pekkanen, J., Keinanen-Kiukaanniemi, S. M., Hiltunen, L. A., Kivelä, S., Tuomilehto, J. O., et al. (1999) · The Lancet · Cited by 1,272
Neutrophils: Molecules, Functions and Pathophysiological Aspects
Witko‐Sarsat, V., Rieu, P., Descamps‐Latscha, B., Lesavre, P., & Halbwachs‐Mecarelli, L. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780067 · Cited by 1,165
Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state
Patsch, J. R., Miesenböck, G., Hopferwieser, T., Mühlberger, V, Knapp, E., Dunn, J. K., Gotto, A. M., & Patsch, W. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.11.1336 · Cited by 1,122 · cited 1×
“It is generally accepted that postprandial hyperlipidemia may contribute to the development of CHD, because it is frequently present in patients with premature atherosclerosis despite relatively normal fasting lipids (24;25).”
BackgroundSchmidt, M. I., Duncan, B. B., Sharrett, A. R., Lindberg, G., Savage, P. J., Offenbacher, S., Azambuja, M. I. R., Tracy, R. P., & HEISS, G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01046-6 · Cited by 1,080
Weitz‐Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J. A., Bruns, C., Cottens, S., Takada, Y., & Hommel, U. (2001) · Nature Medicine · doi:10.1038/89058 · Cited by 1,038
The role of neutrophils in myocardial ischemia–reperfusion injury
Jordan, J. E. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00187-x · Cited by 645
Neutrophil-Derived Proteins: Selling Cytokines by the Pound
Cassatella, M. A. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60791-9 · Cited by 558
Chemokines and atherosclerosis
Reape, T. J., & Groot, P. H. E. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00346-9 · Cited by 508
Fatty acid modulation of endothelial activation
Caterina, R. D., Liao, J. K., & Libby, P. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.213s · Cited by 489
Reddy, K. G., Nair, R., Sheehan, H. M., & Hodgson, J. M. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90627-0 · Cited by 447
Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress
Bae, J.-H., Bassenge, E., Kim, K.-B., Kim, Y.-N., Kim, K.-S., Lee, H.-J., Moon, K.-C., Lee, M.-S., Park, K.-Y., & Schwemmer, M. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00601-8 · Cited by 373
Title, L. M., Cummings, P. M., Giddens, K., & Nassar, B. A. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00980-3 · Cited by 331
The role of inflammation in vascular diseases
Sullivan, G. W., Sarembock, I. J., & Linden, J. M. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.5.591 · Cited by 270
Acute hyperglycemia induces an oxidative stress in healthy subjects
Marfella, R., Quagliaro, L., Nappo, F., Ceriello, A., & Giugliano, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13727 · Cited by 242
Weintraub, M. S., Grosskopf, I., Rassin, T., Miller, H. I., Charach, G., Rotmensch, H. H., Liron, M., Rubinstein, A., & Iaina, A. (1996) · BMJ · doi:10.1136/bmj.312.7036.935 · Cited by 216
Schroeder, S., Enderle, M. D., Ossen, R., Meisner, C., Baumbach, A., Pfohl, M., Herdeg, C., Oberhoff, M., Haering, H. U., & Karsch, K. R. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70189-4 · Cited by 204
Shurtz-Swirski, R., Sela, S., Herskovits, A. T., Shasha, S. M., Shapiro, G., Nasser, L., & Kristal, B. (2001) · Diabetes Care · doi:10.2337/diacare.24.1.104 · Cited by 191
Haught, W. H., Mansour, M., Rothlein, R., Kishimoto, T., Mainolfi, E. A., Hendricks, J. B., Hendricks, C., & Mehta, J. L. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90383-x · Cited by 190
Hiramatsu, K., & ARIMORI, S. (1988) · Diabetes · doi:10.2337/diab.37.6.832 · Cited by 165
C-reactive protein and cardiovascular disease: a review of risk prediction and interventions
de Ferranti, S. D., & Rifai, N. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00797-5 · Cited by 162
Variability of flow mediated dilation: consequences for clinical application
Hijmering, M. L., Stroes, E. S. G., Pasterkamp, G., Sierevogel, M. J., Banga, J. D., & Rabelink, T. J. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00748-6 · Cited by 161
Self-citationInterleukin-6: The Endocrine Cytokine
Papanicolaou, D. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6582 · Cited by 159
Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men
Marchesi, S., Lupattelli, G., Schillaci, G., Pirro, M., Siepi, D., Roscini, A. R., Pasqualini, L., & Mannarino, E. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(00)00415-9 · Cited by 138
Muscari, A. (2000) · European Heart Journal · doi:10.1053/euhj.1999.2013 · Cited by 133
Serum interleukin-8 level is increased in diabetic patients
Available, N. A. N. (1999) · Diabetologia · doi:10.1007/s001250051124 · Cited by 127
Dart, A. M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00150-9 · Cited by 125
Leukocyte Count and Risk of Major Coronary Heart Disease Events
Phillips, A. N., Neaton, J. D., Cook, D. G., Grimm, R. H., & Shaper, A. G. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116421 · Cited by 109
The Relationship of White Blood Cell Count to Other Cardiovascular Risk Factors
Hansen, L. K., Grimm, R. H., & Neaton, J. D. (1990) · International Journal of Epidemiology · doi:10.1093/ije/19.4.881 · Cited by 100
Huang, Z., Chien, K., Yang, C., Tsai, K., & Wang, C. (2001) · Lipids · doi:10.1007/s11745-001-0713-9 · Cited by 76
Prevention of in Vitro Lipolysis by Tetrahydrolipstatin
Krebs, M., Stingl, H., Nowotny, P., Weghuber, D., Bischof, M. G., Waldhäusl, W. K., & Roden, M. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.7.950 · Cited by 71
Huang, Z. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00445-2 · Cited by 64
Polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Role of selectins.
Murohara, T., Buerke, M., & Lefer, A. M. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.9.1509 · Cited by 64
Systemic immune changes following meal intake in humans
Hansen, K. S., Sickelmann, F., Pietrowsky, R., Fehm, H., & Jan Born, A. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.2.r548 · Cited by 60
Mohrschladt, M. F., Weverling‐Rijnsburger, A. W. E., de Man, F. H. A. F., Stoeken, D.-J., Sturk, A., Smelt, A. H. M., & Westendorp, R. G. J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00316-0 · Cited by 52
Did grandma give you heart disease? The new battle against coronary artery disease
Superko, H. R. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00771-1 · Cited by 49
Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain‐length
Wanten, G. J. A., Janssen, F., & Naber, A. H. J. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00959.x · Cited by 48
Berliner, S., Rogowski, O., Rotstein, R., Fusman, R., Shapira, I., Bornstein, N. M., Prochorov, V., Roth, A., Keren, G., Eldor, A., et al. (2000) · Cardiology · doi:10.1159/000007041 · Cited by 39
Schratzberger, P. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00014-5 · Cited by 33
The IL-8 Production in Endothelial Cells is Stimulated by High Glucose
Urakaze, M., Temaru, R., Satou, A., Yamazaki, K., Hamazaki, T., & Kobayashi, M. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979825 · Cited by 22
Takeshita, S. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00463-4 · Cited by 7
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776
Multiple Roles for Neutrophils in Atherosclerosis
Soehnlein, O. (2012) · Circulation Research · doi:10.1161/circresaha.111.257535 · Cited by 514
Microvascular complications of impaired glucose tolerance
Singleton, J. R., Smith, A. G., Russell, J. W., & Feldman, E. L. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2867 · Cited by 372
Metadata
- Authors
- van Oostrom, A. J. H. H. M., Sijmonsma, T. P., Verseyden, C., Jansen, E. H. J. M., de Koning, E. J. P., Rabelink, T. J., & Castro Cabezas, M.
- Affiliations
- University Medical Center Utrecht (NL)
- National Institute for Public Health and the Environment (NL)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 44
- Issue
- 3
- Pages
- 576-583
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2131142277
- Cited by
- 249
- References
- 54
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 7 · 2017: 13 · 2016: 13 · 2015: 14 · 2014: 23 · 2013: 16 · 2012: 9
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- postprandial lipemia, postprandial blood glucose, neutrophil recruitment, endothelial dysfunction, atherosclerosis, interleukin-8, interleukin-6, hydroperoxides, flow-mediated dilation, lymphocyte count, glucose challenge test, low-grade inflammation
- MeSH terms
- Adult, Arteriosclerosis, Blood Glucose, Dietary Fats, Endothelium, Vascular, Fasting, Fatty Acids, Nonesterified, Glucose, Humans, Hydrogen Peroxide, Inflammation, Insulin, Leukocyte Count, Male, Models, Biological, Neutrophils, Time Factors, Triglycerides, Interleukin-6, Interleukin-8, Postprandial Period
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