Cited by 163Lipid metabolism and disordersLipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study

Open access
Lai, Chao-Qiang, Demissie, Serkalem, Cupples, L. Adrienne, Zhu, Yueping, Adiconis, Xian, Parnell, Laurence D., Corella, Dolores, Ordovas, Jose M.·2004·Journal of Lipid Research

Abstract

Several polymorphisms in the APOA5 gene have been associated with increased plasma triglyceride (TG) concentrations. However, associations between APOA5 and lipoprotein subclasses, remnant-like particles (RLPs), and cardiovascular disease (CVD) risk have been less explored. We investigated associations of five APOA5 single-nucleotide polymorphisms (SNPs; -1131T>C, -3A>G, 56C>G IVS3+ 476G>A, and 1259T>C) with lipoprotein subfractions and CVD risk in 1,129 men and 1,262 women participating in the Framingham Heart Study. Except for the 56C>G SNP, the other SNPs were in significant linkage disequilibria, resulting in three haplotypes (11111, 22122, and 11211) representing 98% of the population. SNP analyses revealed that the -1131T>C and 56C>G SNPs were significantly associated with higher plasma TG concentrations in both men and women. For RLP and lipoprotein subclasses, we observed gender-specific association for the -1131T>C and 56C>G SNPs. Female carriers of the -1131C allele had higher RLP concentrations, whereas in males, significant associations for RLPs were observed for the 56G allele. Moreover, haplotype analyses confirmed these findings and revealed that the 22122 and 11211 haplotypes exhibited different associations with HDL cholesterol concentrations. In women, the -1131C allele was associated with a higher hazard ratio for CVD (1.85; 95% confidence interval, 1.03-3.34; P = 0.04), in agreement with the association of this SNP with higher RLPs.

Integrity signals

Registry

Crossref · 10.1194/jlr.m400192-jlr200

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The minor allele of rs3135506 (minor allele frequency about 6% in whites) has been repeatedly associated with increased plasma triglyceride concentrations.

    “The minor allele of rs3135506 (minor allele frequency (MAF) of about 6% in whites) has been repeatedly associated with increased plasma TG concentrations [96–99].”

    From Fenofibrate and metabolic syndrome (2010) · cites this paper as [97]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lai, C.-Q., Demissie, S., Cupples, L. A., Zhu, Y., Adiconis, X., Parnell, L. D., Corella, D., & Ordovas, J. M.
Affiliations
  • Tufts University (US)
  • Boston University (US)
Corresponding author
Lai, Chao-Qiang
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2004-11
Volume
45
Issue
11
Pages
2096-2105
ISSN
0022-2275 (ISSN-L)
OpenAlex
W2154292243
Cited by
163
References
59
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 1 · 2012: 11
FWCI
9.82
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Heart, Lung, and Blood Institute (HL54776, R01HL054776)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
APOA5, apolipoprotein A-I, single nucleotide polymorphisms, plasma triglycerides, remnant-like particles, lipoprotein subclasses, cardiovascular risk, HDL cholesterol, haplotypes, linkage disequilibrium, sex differences, Framingham Heart Study
MeSH terms
Apolipoprotein A-V, Adult, Aged, Alleles, Apolipoproteins, Apolipoproteins A, Cardiovascular Diseases, Cardiovascular System, Cholesterol, Coronary Disease, Female, Genotype, Haplotypes, Humans, Lipoproteins, Male, Middle Aged, Polymorphism, Genetic, Risk, Sex Factors, Triglycerides, Genetic Variation, Linkage Disequilibrium, Polymorphism, Single Nucleotide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review