Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease
Open accessAbstract
Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.
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Fibrates exert lipid-modifying effects by activating peroxisome proliferator-activated receptor alpha, a nuclear receptor that increases expression of LPL, apoAI, and other lipid-related genes.
“Fibrates or fibric acid derivatives exert their lipidmodifying effects by activating the peroxisome proliferator-activated receptor (PPAR)-a, a nuclear receptor that increases expression of LPL, apoAI, and other lipid-related genes”
From The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk (2019) · cites this paper as [13]
TRLs have been implicated in pro-inflammatory signaling pathways, impairment of insulin sensitivity and upregulation of factors promoting thrombosis.
“Specifically, TRLs have been implicated in pro-inflammatory signaling pathways, impairment of insulin sensitivity and upregulation of factors promoting thrombosis.22,23”
From Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?: New Insights From the Framingham Offspring Study (2016) · cites this paper as [23]
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- Authors
- Rosenson, R. S., Davidson, M. H., Hirsh, B. J., Kathiresan, S., & Gaudet, D.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Chicago (US)
- Mount Sinai Hospital (US)
- Harvard University (US)
- Université de Montréal (CA)
- Corresponding author
- Rosenson, Robert S.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 64
- Issue
- 23
- Pages
- 2525-2540
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2005157832
- Cited by
- 260
- References
- 160
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 12 · 2023: 26 · 2022: 27 · 2021: 21 · 2020: 28 · 2019: 23 · 2018: 21 · 2017: 19 · 2016: 26 · 2015: 15
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Regeneron Pharmaceuticals
- Kowa Company
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- triglyceride-rich lipoproteins, atherosclerotic cardiovascular disease, triglycerides, genetic risk factors, causality, cardiovascular risk markers, triglyceride-lowering therapy, lipoprotein metabolism, omics, cardiovascular disease prevention
- MeSH terms
- Cardiovascular Diseases, Fasting, Humans, Inflammation, Intestinal Mucosa, Lipoproteins, Liver, Triglycerides, Genetic Variation, Hypertriglyceridemia, Fatty Acids, Omega-3, Sequence Analysis, DNA, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Postprandial Period, Atherosclerosis
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