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Cited by 326Alcohol Consumption and Health EffectsLiver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

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Alcohol effects on hepatic lipid metabolism

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Jeon, Sookyoung, Carr, Rotonya·2020·Journal of Lipid Research
DOI 10.1194/jlr.r119000547PMC PMC7112138
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Abstract

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.

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Metadata

Authors
Jeon, S., & Carr, R.
Affiliations
University of Pennsylvania (US)
Corresponding author
Carr, Rotonya
ORCID
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2020-04
Volume
61
Issue
4
Pages
470-479
ISSN
0022-2275 (ISSN-L)
DOI
10.1194/jlr.r119000547
PMC
PMC7112138
OpenAlex
W3005408539
Cited by
326
References
161
Citations by year
2026: 58 · 2025: 78 · 2024: 76 · 2023: 49 · 2022: 45 · 2021: 13 · 2020: 7
FWCI
4.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R01 AA026302-02, P30 DK0503060)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
alcoholic liver disease, hepatic lipid metabolism, hepatic steatosis, alcoholic steatohepatitis, fatty acid oxidation, de novo lipogenesis, lipid export, lipid droplet formation, genetic susceptibility, bioactive lipids, liver fibrosis
MeSH terms
Ethanol, Animals, Humans, Liver, Lipogenesis, Lipid Metabolism

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