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The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Resveratrol alleviates alcoholic fatty liver in mice

Ajmo, Joanne M., Liang, Xiaomei, Rogers, Christopher Q., Pennock, Brandi, You, Min·2008·American Journal of Physiology-Gastrointestinal and Liver Physiology
DOI 10.1152/ajpgi.90358.2008
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Abstract

Alcoholic fatty liver is associated with inhibition of sirtuin 1 (SIRT1) and AMP-activated kinase (AMPK), two critical signaling molecules regulating the pathways of hepatic lipid metabolism in animals. Resveratrol, a dietary polyphenol, has been identified as a potent activator for both SIRT1 and AMPK. In the present study, we have carried out in vivo animal experiments that test the ability of resveratrol to reverse the inhibitory effects of chronic ethanol feeding on hepatic SIRT1-AMPK signaling system and to prevent the development of alcoholic liver steatosis. Resveratrol treatment increased SIRT1 expression levels and stimulated AMPK activity in livers of ethanol-fed mice. The resveratrol-mediated increase in activities of SIRT1 and AMPK was associated with suppression of sterol regulatory element binding protein 1 (SREBP-1) and activation of peroxisome proliferator-activated receptor γ coactivator α (PGC-1α). In parallel, in ethanol-fed mice, resveratrol administration markedly increased circulating adiponectin levels and enhanced mRNA expression of hepatic adiponectin receptors (AdipoR1/R2). In conclusion, resveratrol treatment led to reduced lipid synthesis and increased rates of fatty acid oxidation and prevented alcoholic liver steatosis. The protective action of resveratrol is in whole or in part mediated through the upregulation of a SIRT1-AMPK signaling system in the livers of ethanol-fed mice. Our study suggests that resveratrol may serve as a promising agent for preventing or treating human alcoholic fatty liver disease.

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Crossref · 10.1152/ajpgi.90358.2008

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11 of 11 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 49

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Metadata

Authors
Ajmo, J. M., Liang, X., Rogers, C. Q., Pennock, B., & You, M.
Venue
American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher
American Physiological Society
Published
2008-10
Volume
295
Issue
4
Pages
G833-G842
ISSN
  • 0193-1857
  • 1522-1547
DOI
10.1152/ajpgi.90358.2008
Cited by
314
References
11
Language
en

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