A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

Quantifying heterogeneity in a meta‐analysis

Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works

Principal components analysis corrects for stratification in genome-wide association studies

Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248 · see citing works

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928 · see citing works

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416 · see citing works

LocusZoom: regional visualization of genome-wide association scan results

Pruim, R. J., Welch, R. P., Sanna, S., Teslovich, T. M., Chines, P. S., Gliedt, T. P., Boehnke, M., Abecasis, G. R., & Willer, C. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq419 · Cited by 2,707 · see citing works

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Kozlitina, J., Smagris, E., Stender, S., Nordestgaard, B. G., Zhou, H. H., Tybjærg-Hansen, A., Vogt, T. F., Hobbs, H. H., & Cohen, J. C. (2014) · Nature Genetics · doi:10.1038/ng.2901 · Cited by 1,234 · see citing works

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

study, F. T. D., Daly, A. K., Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe’er, I., Floratos, A., Daly, M. J., Goldstein, D. B., John, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.379 · Cited by 1,041 · see citing works

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

Speliotes, E. K., Yerges-Armstrong, L. M., Wu, J., Hernaez, R., Kim, L. J., Palmer, C. D., Gudnason, V., Eiriksdottir, G., Garcia, M. E., Launer, L. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001324 · Cited by 984 · see citing works

Global burden of alcoholic liver diseases

Rehm, J., Samokhvalov, A. V., & Shield, K. D. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.007 · Cited by 740 · see citing works

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

Liu, Y.-L., Reeves, H. L., Burt, A. D., Tiniakos, D., McPherson, S., Leathart, J. B. S., Allison, M. E. D., Alexander, G. J., Piguet, A.-C., Anty, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5309 · Cited by 623 · see citing works

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

He, S., McPhaul, C., Li, J. Z., Garuti, R., Kinch, L. N., Grishin, N. V., Cohen, J. C., & Hobbs, H. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064501 · Cited by 604 · see citing works

Burden of liver disease in the United States: Summary of a workshop

Kim, W. R., Brown, R. S., Terrault, N. A., & El‐Serag, H. B. (2002) · Hepatology · doi:10.1053/jhep.2002.34734 · Cited by 588 · see citing works

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Dongiovanni, P., Petta, S., Maglio, C., Fracanzani, A. L., Pipitone, R., Mozzi, E., Motta, B. M., Kaminska, D., Rametta, R., Grimaudo, S., et al. (2015) · Hepatology · doi:10.1002/hep.27490 · Cited by 533 · see citing works

Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver

Teli, M. R., Day, C., James, O., Burt, A. D., & Bennett, M. K. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91685-7 · Cited by 484 · see citing works

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

The UK PBC Consortium, Mells, G. F., The Wellcome Trust Case Control Consortium 3, Floyd, J. A. B., Morley, K. I., Cordell, H. J., Franklin, C. S., Shin, S.-Y., Heneghan, M. A., Neuberger, J. M., et al. (2011) · Nature Genetics · doi:10.1038/ng.789 · Cited by 464 · see citing works

Evidence of Genetic Predisposition to Alcoholic Cirrhosis and Psychosis: Twin Concordances for Alcoholism and Its Biological End Points by Zygosity among Male Veterans

Hrubec, Z., & Omenn, G. S. (1981) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1981.tb04890.x · Cited by 464 · see citing works

A genome-wide association study of alcohol dependence

Bierut, L. J., Agrawal, A., Bucholz, K. K., Doheny, K. F., Laurie, C., Pugh, E., Fisher, S., Fox, L., Howells, W., Bertelsen, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911109107 · Cited by 457 · see citing works

Variant in PNPLA3 is associated with alcoholic liver disease

Tian, C., Stokowski, R. P., Kershenobich, D., Ballinger, D. G., & Hinds, D. A. (2009) · Nature Genetics · doi:10.1038/ng.488 · Cited by 435 · see citing works

Genome-wide Association Study of Alcohol Dependence

Treutlein, J., Cichon, S., Ridinger, M., Wodarz, N., Soyka, M., Zill, P., Maier, W., Moessner, R., Gäebel, W., Dahmen, N., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.83 · Cited by 380 · see citing works

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

Smagris, E., BasuRay, S., Li, J., Huang, Y., Lai, K. V., Gromada, J., Cohen, J. C., & Hobbs, H. H. (2015) · Hepatology · doi:10.1002/hep.27242 · Cited by 379 · see citing works

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

Pirazzi, C., Valenti, L. V. C., Motta, B. M., Pingitore, P., Hedfalk, K., Mancina, R. M., Burza, M. A., Indiveri, C., Ferro, Y., Montalcini, T., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu121 · Cited by 363 · see citing works

Liver Transplantation for Alcoholic Liver Disease in Europe: A Study from the ELTR (European Liver Transplant Registry)

Burra, P., Senzolo, M., Adam, R. A., Delvart, V., Karam, V. H., Germani, G., & Neuberger, J. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02869.x · Cited by 332 · see citing works

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease

Buch, S., Schafmayer, C., Völzke, H., Becker, C., Franke, A., von Eberstein, H., Kluck, C., Baessmann, I., Brosch, M., Lammert, F., et al. (2007) · Nature Genetics · doi:10.1038/ng2101 · Cited by 332 · see citing works

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

Stickel, F., Buch, S., Lau, K., zu Schwabedissen, H. E. M., Berg, T., Ridinger, M., Rietschel, M., Schafmayer, C., Braun, F., Hinrichsen, H. M., et al. (2010) · Hepatology · doi:10.1002/hep.24017 · Cited by 291 · see citing works

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Melum, E., Franke, A., Schramm, C., Weismüller, T. J., Gotthardt, D. N., Offner, F. A., Juran, B. D., Laerdahl, J. K., Labi, V., Bjornsson, E. S., et al. (2010) · Nature Genetics · doi:10.1038/ng.728 · Cited by 255 · see citing works

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

Gijón, M. A., Riekhof, W. R., Zarini, S., Murphy, R. C., & Voelker, D. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806194200 · Cited by 228 · see citing works

Alcoholic Liver Disease: Pathologic, Pathogenetic and Clinical Aspects

Ishak, K. G., Zimmerman, H. J., & Ray, M. B. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00518.x · Cited by 225 · see citing works

Simultaneous Genotype Calling and Haplotype Phasing Improves Genotype Accuracy and Reduces False-Positive Associations for Genome-wide Association Studies

Browning, B. L., & Yu, Z. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.11.004 · Cited by 212 · see citing works

Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non‐invasive laboratory tests

Nguyen-Khac, É., Chatelain, D., Tramier, B., Decrombecque, C., Robert, B., Joly, J., Brevet, M., Grignon, P., LION, S., Page, L. L., et al. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03831.x · Cited by 211 · see citing works

Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

Innocenti, F., Cooper, G. M., Stanaway, I. B., Gamazon, E. R., Smith, J. D., Mirkov, S., Ramı́rez, J., Liu, W., Lin, Y. S., Moloney, C., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002078 · Cited by 205 · see citing works

Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?

Zintzaras, E., Stefanidis, I., Mauro Santos, A., & Vidal, F. (2006) · Hepatology · doi:10.1002/hep.21023 · Cited by 201 · see citing works

Endocannabinoids in liver disease

Tam, J., Liu, J., Mukhopadhyay, B., Çınar, R., Godlewski, G., & Kunos, G. (2010) · Hepatology · doi:10.1002/hep.24077 · Cited by 196 · see citing works

Genetics and alcoholism

Edenberg, H. J., & Foroud, T. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.86 · Cited by 195 · see citing works

Genome-Wide Association Study Identifies Variants Associated With Progression of Liver Fibrosis From HCV Infection

Patin, É., Kutalik, Z., Guergnon, J., Bibert, S., Nalpas, B., Jouanguy, E., Munteanu, M., Bousquet, L., Argiro, L., Halfon, P., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.097 · Cited by 176 · see citing works

Genetic Predisposition to Organ‐Specific Endpoints of Alcoholism

Reed, T., Page, W. F., Viken, R. J., & Christian, J. C. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01695.x · Cited by 171 · see citing works

The l -α-Lysophosphatidylinositol/ GPR55 System and Its Potential Role in Human Obesity

Moreno‐Navarrete, J. M., Catalán, V., Whyte, L. S., Díaz–Arteaga, A., Vázquez‐Martínez, R., Rotellar, F., Guzmán‐Ruiz, R., Gómez‐Ambrosi, J., Pulido, M. R., Russell, W. R., et al. (2011) · Diabetes · doi:10.2337/db11-0649 · Cited by 160 · see citing works

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease

Salameh, H. M., Raff, E., Erwin, A., Seth, D., Nischalke, H. D., Falleti, E., Burza, M. A., Leathert, J., Romeo, S., Molinaro, A., et al. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.137 · Cited by 156 · see citing works

Marked 25-hydroxyvitamin D deficiency is associated with poor prognosis in patients with alcoholic liver disease

Trépo, E., Ouziel, R., Pradat, P., Momozawa, Y., Quertinmont, E., Gervy, C., Gustot, T., Degré, D., Vercruysse, V., Deltenre, P., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.024 · Cited by 134 · see citing works

Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis

Patsenker, E., Stoll, M., Millonig, G., Agaimy, A., Wissniowski, T., Schneider, V., Mueller, S., Brenneisen, R., Seitz, H. K., Ocker, M., et al. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00149 · Cited by 78 · see citing works

Systematic review with meta‐analysis: the I148M variant of patatin‐like phospholipase domain‐containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis

Chamorro, A. ‐., Torres, J. L., Mirón‐Canelo, J. ‐., González‐Sarmiento, R., Laso, F. J., & Marcos, M. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12890 · Cited by 73 · see citing works

Immediate Listing for Liver Transplantation Versus Standard Care for Child–Pugh Stage B Alcoholic Cirrhosis

Vanlemmens, C., Martino, V. D., Milan, C., Messner, M., Minello, A., Duvoux, C., Poynard, T., Perarnau, J., Piquet, M.-A. A., Pageaux, G., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-3-200902030-00004 · Cited by 71 · see citing works

Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence

Han, S., Yang, B., Kranzler, H. R., Liu, X., Zhao, H., Farrer, L. A., Boerwinkle, E., Potash, J. B., & Gelernter, J. E. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.10.021 · Cited by 66 · see citing works

fcGENE: A Versatile Tool for Processing and Transforming SNP Datasets

Roshyara, N. R., & Scholz, M. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097589 · Cited by 48 · see citing works

A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease

Nischalke, H. D., Lutz, P. L., Krämer, B., Söhne, J., Müller, T., Rosendahl, J., Fischer, J., Berg, T., Hittatiya, K., Fischer, H., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.06.006 · Cited by 46 · see citing works

Artifact due to differential error when cases and controls are imputed from different platforms

Sinnott, J. A., & Kraft, P. (2011) · Human Genetics · doi:10.1007/s00439-011-1054-1 · Cited by 34 · see citing works

Genetic variants in or nearADH1BandADH1Caffect susceptibility to alcohol dependence in a British and Irish population

Way, M. J., McQuillin, A., Saini, J., Ruparelia, K., Lydall, G. J., Guerrini, I., Ball, D., Smith, I. D., Quadri, G., Thomson, A. D., et al. (2014) · Addiction Biology · doi:10.1111/adb.12141 · Cited by 27 · see citing works

Reverse Reaction of Lysophosphatidylinositol Acyltransferase

Yamashita, A., Watanabe, M., Sato, K., Miyashita, T., Nagatsuka, T., Kondo, H., Norikazu, K., Nakanishi, H., Kamata, R., Sugiura, T., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303391200 · Cited by 20 · see citing works

Early Liver Transplantation for Severe Alcoholic Hepatitis

Tamura, S., Sugawara, Y., & Kukudo, N. (2012) · New England Journal of Medicine · doi:10.1056/nejmc1114241 · Cited by 19 · see citing works

Hepatocellular carcinoma

Llovet, J. M., Kelley, R. K., Villanueva, A., Singal, A. G., Pikarsky, E., Roayaie, S., Lencioni, R., Koike, K., Zucman-Rossi, J., & Finn, R. S. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00240-3 · Cited by 7,055 · see citing works

FinnGen provides genetic insights from a well-phenotyped isolated population

Kurki, M. I., Karjalainen, J., Palta, P., Sipilä, T. P., Kristiansson, K., Donner, K. M., Reeve, M. P., Laivuori, H., Aavikko, M., Kaunisto, M. A., et al. (2023) · Nature · doi:10.1038/s41586-022-05473-8 · Cited by 4,233 · see citing works

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002 · see citing works

Alcoholic liver disease

Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0014-7 · Cited by 1,271 · see citing works

Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases

Crabb, D. W., Im, G. Y., Szabó, G., Mellinger, J. L., & Lucey, M. R. (2019) · Hepatology · doi:10.1002/hep.30866 · Cited by 938 · see citing works

Genetics and epigenetics of NAFLD and NASH: Clinical impact

Eslam, M., Valenti, L., & Romeo, S. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.09.003 · Cited by 971 · see citing works

A Protein-Truncating <i>HSD17B13</i> Variant and Protection from Chronic Liver Disease

Abul-Husn, N. S., Cheng, X., Li, A. H., Xin, Y., Schurmann, C., Stevis, P., Liu, Y., Kozlitina, J., Stender, S., Wood, G. C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1712191 · Cited by 827 · see citing works

Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases

Samuel, V. T., & Shulman, G. I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.002 · Cited by 745 · see citing works

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Mancina, R. M., Dongiovanni, P., Petta, S., Pingitore, P., Meroni, M., Rametta, R., Borén, J., Montalcini, T., Pujia, A., Wiklund, O., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.032 · Cited by 676 · see citing works

Lipid droplets and liver disease: from basic biology to clinical implications

Gluchowski, N. L., Becuwe, M., Walther, T. C., & Farese, R. V. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.32 · Cited by 675 · see citing works

Global Epidemiology and Genetics of Hepatocellular Carcinoma

Toh, M. R., Wong, E. Y. T., Wong, S. H., Ng, A. W. T., Loo, L., Chow, P. K.-H., & Ngeow, J. Y. Y. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.01.033 · Cited by 600 · see citing works

Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors

Huang, D. Q., Mathurin, P., Cortez-Pinto, H., & Loomba, R. (2023) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-022-00688-6 · Cited by 553 · see citing works

Role of Insulin Resistance in MAFLD

Sakurai, Y., Kubota, N., Yamauchi, T., & Kadowaki, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084156 · Cited by 448 · see citing works

Update on NAFLD genetics: From new variants to the clinic

Trépo, E., & Valenti, L. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.02.020 · Cited by 393 · see citing works

FinnGen: Unique genetic insights from combining isolated population and national health register dataPreprint

Kurki, M., Karjalainen, J. M., Palta, P., Sipila, T. P., Kristiansson, K., Donner, K. M., Reeve, M. P., Laivuori, H. M., Aavikko, M., Kaunisto, M. A., et al. (2022) · medRxiv · doi:10.1101/2022.03.03.22271360 · Cited by 405 · see citing works

Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review

Singal, A. K., & Mathurin, P. (2021) · JAMA · doi:10.1001/jama.2021.7683 · Cited by 398 · see citing works

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

Fang, Y., Chen, H., Wang, C., & Liang, L. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i27.2974 · Cited by 390 · see citing works

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

Dongiovanni, P., Stender, S., Pietrelli, A., Mancina, R. M., Cespiati, A., Petta, S., Pelusi, S., Pingitore, P., Badiali, S., Maggioni, M., et al. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12719 · Cited by 367 · see citing works

Alcohol-associated liver disease

Mackowiak, B., Fu, Y., Maccioni, L., & Gao, B. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176345 · Cited by 359 · see citing works

Changing epidemiology of hepatocellular carcinoma in Asia

Zhang, C., Cheng, Y., Zhang, S., Fan, J., & Gao, Q. (2022) · Liver International · doi:10.1111/liv.15251 · Cited by 340 · see citing works

Fibrosis and alcohol-related liver disease

Lackner, C., & TINIAKOS, D. G. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.12.003 · Cited by 326 · see citing works

Alcohol effects on hepatic lipid metabolism

Jeon, S., & Carr, R. (2020) · Journal of Lipid Research · doi:10.1194/jlr.r119000547 · Cited by 326 · see citing works

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

Tacke, F., Puengel, T., Loomba, R., & Friedman, S. L. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.038 · Cited by 321 · see citing works

17‐Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease

Ma, Y., Belyaeva, O. V., Brown, P. M., Fujita, K., Valles, K., Karki, S., de Boer, Y. S., Koh, C., Chen, Y., Du, X., et al. (2018) · Hepatology · doi:10.1002/hep.30350 · Cited by 310 · see citing works

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

Eslam, M., & George, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0212-0 · Cited by 310 · see citing works

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Juanola, O., Martínez‐López, S., Francés, R., & Gómez‐Hurtado, I. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18105227 · Cited by 310 · see citing works

Metabolic dysfunction-associated steatotic liver disease in adults

Huang, D. Q., Wong, V. W., Rinella, M. E., Boursier, J., Lazarus, J. V., Yki‐Järvinen, H., & Loomba, R. S. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00599-1 · Cited by 336 · see citing works

ACG Clinical Guideline: Alcohol-Associated Liver Disease

Jophlin, L., Singal, A. K., Bataller, R. A., Wong, R. J., Sauer, B. G., Terrault, N. A., & Shah, V. H. (2023) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002572 · Cited by 319 · see citing works

PNPLA3 gene in liver diseases

Trépo, E., Romeo, S., Zucman‐Rossi, J., & Nahon, P. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.03.011 · Cited by 293 · see citing works

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

BasuRay, S., Wang, Y., Šmagris, Ē., Cohen, J. C., & Hobbs, H. H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901974116 · Cited by 285 · see citing works

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

Liu, Y., Basty, N., Whitcher, B. J., Bell, J. D., Sorokin, E. P., van Bruggen, N., Thomas, E. L., & Cule, M. (2021) · eLife · doi:10.7554/elife.65554 · Cited by 267 · see citing works

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

Donati, B., Dongiovanni, P., Romeo, S., Meroni, M., McCain, M. V., Miele, L., Petta, S., Maier, S., Rosso, C., Luca, L. D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04991-0 · Cited by 262 · see citing works

Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease

Anstee, Q. M., Seth, D., & Day, C. P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.037 · Cited by 252 · see citing works

Pathophysiology and Management of Alcoholic Liver Disease: Update 2016

Stickel, F., Datz, C., Hampe, J., & Bataller, R. A. (2017) · Gut and Liver · doi:10.5009/gnl16477 · Cited by 253 · see citing works

Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins

Smagris, E., Gilyard, S., BasuRay, S., Cohen, J. C., & Hobbs, H. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719955 · Cited by 226 · see citing works

Impact of non-invasive biomarkers on hepatology practice: past, present and future

Anstee, Q. M., Castera, L., & Loomba, R. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.026 · Cited by 224 · see citing works

Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study

Krawczyk, M. J., Rau, M., Schattenberg, J. M., Bantel, H., Pathil, A., Demir, M., Kluwe, J., Boettler, T., Lammert, F., & Geier, A. (2016) · Journal of Lipid Research · doi:10.1194/jlr.p067454 · Cited by 204 · see citing works

Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease

Romeo, S., Sanyal, A. J., & Valenti, L. V. C. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.12.002 · Cited by 203 · see citing works

The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease

Díaz, L. A., Arab, J. P., Louvet, A., Bataller, R., & Arrese, M. (2023) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-023-00822-y · Cited by 207 · see citing works

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Argemí, J., Latasa, M. U., Atkinson, S. R., Blokhin, I. O., Massey, V. L., Gue, J. P., Cabezas, J., Lozano, J. J., Booven, D. V., Bell, A. W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11004-3 · Cited by 195 · see citing works

Ethyl glucuronide in hair detects a high rate of harmful alcohol consumption in presumed non-alcoholic fatty liver disease

Staufer, K., Huber-Schönauer, U., Strebinger, G., Pimingstorfer, P., Suesse, S., Scherzer, T. M., Paulweber, B., Ferenci, P., Stimpfl, T., Yegles, M., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.04.040 · Cited by 190 · see citing works

Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives

Liu, S.-Y., Tsai, I., & Hsu, Y.-C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105170 · Cited by 186 · see citing works

Alcoholic Liver Disease in Asia, Europe, and North America

Liangpunsakul, S., Haber, P., & McCaughan, G. W. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.043 · Cited by 181 · see citing works

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

Luukkonen, P. K., Zhou, Y., Hyötyläinen, T., Leivonen, M., Arola, J. T., Orho‐Melander, M., Orešič, M., & Yki‐Järvinen, H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.07.045 · Cited by 178 · see citing works

Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis

Carlsson, B., Lindén, D., Brolén, G., Liljeblad, M., Bjursell, M., Romeo, S., & Loomba, R. (2020) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.15738 · Cited by 169 · see citing works

The genetics of alcohol dependence and alcohol-related liver disease

Stickel, F., Moreno, C., Hampe, J., & Morgan, M. Y. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.08.011 · Cited by 165 · see citing works

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

Emdin, C. A., Haas, M. E., Khera, A. V., Aragam, K. G., Chaffin, M. D., Klarin, D. M., Hindy, G., Jiang, L., Wei, W., Feng, Q., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008629 · Cited by 162 · see citing works

Global Epidemiology of Hepatocellular Carcinoma

Singh, S. P., Madke, T., & Chand, P. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.102446 · Cited by 178 · see citing works

The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease

Boyle, M., Masson, S., & Anstee, Q. M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.006 · Cited by 159 · see citing works

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158 · see citing works

Genetic and epigenetic factors determining NAFLD risk

Jonas, W., & Schürmann, A. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101111 · Cited by 157 · see citing works

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

Teo, K., Abeysekera, K. W. M., Adams, L. A., Aigner, E. S., Anstee, Q. M., Bañales, J. M., Banerjee, R., Basu, P., Berg, T., Bhatnagar, P., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.08.027 · Cited by 154 · see citing works

Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients With Nonalcoholic Fatty Liver Disease

Grimaudo, S., Pipitone, R. M., Pennisi, G., Celsa, C., Cammà, C., Marco, V. D., Barcellona, M. R., Boemi, R., Enea, M., Giannetti, A., et al. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.08.011 · Cited by 152 · see citing works

TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease

Luo, F., Oldoni, F., & Das, A. (2021) · Hepatology Communications · doi:10.1002/hep4.1822 · Cited by 148 · see citing works

History of Nonalcoholic Fatty Liver Disease

Lonardo, A., Leoni, S., Alswat, K., & Fouad, Y. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165888 · Cited by 148 · see citing works

Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers

Kawaguchi, T., Shima, T., Mizuno, M., Mitsumoto, Y., Umemura, A., Kanbara, Y., Tanaka, S., Sumida, Y., Yasui, K., Takahashi, M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0185490 · Cited by 144 · see citing works

Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review

Ajmera, V. H., Terrault, N. A., & Harrison, S. A. (2017) · Hepatology · doi:10.1002/hep.29055 · Cited by 137 · see citing works

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis

Strnad, P., Buch, S., Hamesch, K., Fischer, J., Rosendahl, J., Schmelz, R., Brueckner, S., Brosch, M., Heimes, C. V., Woditsch, V., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-316228 · Cited by 137 · see citing works

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Cherubini, A., Ostadreza, M., Jamialahmadi, O., Pelusi, S., Rrapaj, E., Casirati, E., Passignani, G., Norouziesfahani, M., Sinopoli, E., Baselli, G., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02553-8 · Cited by 136 · see citing works

PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases

Yang, J., Trépo, E., Nahon, P., Cao, Q., Moreno, C., Letouzé, É., Imbeaud, S., Gustot, T., Deviere, J. M. E., Debette, S., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31910 · Cited by 132 · see citing works

Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

Helsley, R. N., Varadharajan, V., Brown, A. L., Gromovsky, A. D., Schugar, R. C., Ramachandiran, I., Fung, K., Kabbany, M. N., Banerjee, R., Neumann, C. K. A., et al. (2019) · eLife · doi:10.7554/elife.49882 · Cited by 132 · see citing works

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

Thabet, K., Asimakopoulos, A., Shojaei, M., Romero‐Gómez, M., Mangia, A., Irving, W. L., Berg, T., Dore, G. J., Grønbæk, H., Sheridan, D. A., et al. (2016) · Nature Communications · doi:10.1038/ncomms12757 · Cited by 130 · see citing works

Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study

Silva, N. M. G. D., Borges, M. C., Hingorani, A. D., Engmann, J., Shah, T., Zhang, X., Luan, J., Langenberg, C., Wong, A., Kuh, D. J., et al. (2019) · Diabetes · doi:10.2337/db18-1048 · Cited by 129 · see citing works

Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology

Sookoian, S. C., Pirola, C. J., Valenti, L. V. C., & Davidson, N. O. (2020) · Hepatology · doi:10.1002/hep.31229 · Cited by 129 · see citing works

Association of Genetic Variation With Cirrhosis: A Multi-Trait Genome-Wide Association and Gene–Environment Interaction Study

Emdin, C. A., Haas, M., Ajmera, V. H., Simon, T. G., Homburger, J. R., Neben, C. L., Jiang, L., Wei, W., Feng, Q., Zhou, A. Y., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.12.011 · Cited by 129 · see citing works

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

Chen, V. L., Du, X., Chen, Y., Kuppa, A., Handelman, S. K., Vohnoutka, R. B., Peyser, P. A., Palmer, N. D., Bielak, L. F., Halligan, B. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20870-1 · Cited by 129 · see citing works

Alcoholic liver disease: A current molecular and clinical perspective

Ohashi, K., Pimienta, M., & Seki, E. (2018) · Liver Research · doi:10.1016/j.livres.2018.11.002 · Cited by 129 · see citing works

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

Schafmayer, C., Harrison, J., Buch, S., Lange, C., Reichert, M., Hofer, P., Cossais, F., Kupčinskas, J., Schönfels, W. V., Schniewind, B., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317619 · Cited by 127 · see citing works

Loss of hepatic Mboat7 leads to liver fibrosis

Thangapandi, V. R., Knittelfelder, O., Brosch, M., Patsenker, E., Vvedenskaya, O., Buch, S., Hinz, S., Hendricks, A., Nati, M., Herrmann, A., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-320853 · Cited by 125 · see citing works

Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity

Valentine, W. J., Yanagida, K., Kawana, H., Kono, N., Noda, N. N., Aoki, J., & Shindou, H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101470 · Cited by 125 · see citing works

Nutrition and Genetics in NAFLD: The Perfect Binomium

Meroni, M., Longo, M., Rustichelli, A., & Dongiovanni, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082986 · Cited by 122 · see citing works

Non-alcoholic Fatty Liver Disease (NAFLD) as a Neglected Metabolic Companion of Psychiatric Disorders: Common Pathways and Future Approaches

Soto-Angona, Ó., Anmella, G., Valdés-Florido, M. J., De Uribe-Viloria, N., Carvalho, A. F., Penninx, B. W. J. H., & Berk, M. (2020) · BMC Medicine · doi:10.1186/s12916-020-01713-8 · Cited by 122 · see citing works

Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH)

Arab, J. P., Roblero, J. P., Altamirano, J., Bessone, F., Araújo, R. C., la Tijera, F. H., Restrepo, J. C., Torre, A., Urzua, A. M., Simonetto, D. A., et al. (2019) · Annals of Hepatology · doi:10.1016/j.aohep.2019.04.005 · Cited by 122 · see citing works

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Pazoki, R., Vujković, M., Elliott, J., Εvangelou, Ε., Gill, D., Ghanbari, M., van der Most, P. J., Pinto, R. C., Wielscher, M., Farlik, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22338-2 · Cited by 115 · see citing works

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis

Stickel, F., Buch, S., Nischalke, H. D., Weiss, K. H., Gotthardt, D. N., Fischer, J., Rosendahl, J., Marot, A., Elamly, M., Casper, M., et al. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0041-8 · Cited by 119 · see citing works

NAFLD and Atherosclerosis: Two Sides of the Same Dysmetabolic Coin?

Stols‐Gonçalves, D., Hovingh, G. K., Nieuwdorp, M., & Holleboom, A. G. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.008 · Cited by 118 · see citing works

Machine learning enables new insights into genetic contributions to liver fat accumulation

Haas, M. E., Pirruccello, J. P., Friedman, S. N., Wang, M., Emdin, C. A., Ajmera, V. H., Simon, T. G., Homburger, J. R., Guo, X., Budoff, M., et al. (2021) · Cell Genomics · doi:10.1016/j.xgen.2021.100066 · Cited by 118 · see citing works

The role of PNPLA3 in health and disease

Pingitore, P., & Romeo, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.06.018 · Cited by 115 · see citing works

TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

Longo, M., Meroni, M., Paolini, E., Erconi, V., Carli, F., Fortunato, F., Ronchi, D., Piciotti, R., Sabatini, S., Macchi, C., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.11.007 · Cited by 114 · see citing works

Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study

Thursz, M. R., Kamath, P. S., Mathurin, P., Szabó, G., & Shah, V. H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.041 · Cited by 112 · see citing works

Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers

Stickel, F., Lutz, P. L., Buch, S., Nischalke, H. D., da Silva, I. P., Rausch, V., Fischer, J., Weiss, K. H., Gotthardt, D. N., Rosendahl, J., et al. (2019) · Hepatology · doi:10.1002/hep.30996 · Cited by 110 · see citing works

Toward Genetic Prediction of Nonalcoholic Fatty Liver Disease Trajectories: PNPLA3 and Beyond

Krawczyk, M. J., Liebe, R., & Lammert, F. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.053 · Cited by 110 · see citing works

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

Mitsche, M. A., Hobbs, H. H., & Cohen, J. C. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002333 · Cited by 109 · see citing works

Alcohol‐Related Liver Disease

Szabó, G., Kamath, P. S., Shah, V. H., Thursz, M. R., Mathurin, P., Addolorato, G., Bataller, R. A., Burra, P., Castéra, L., Cortez‐Pinto, H., et al. (2019) · Hepatology · doi:10.1002/hep.30369 · Cited by 108 · see citing works

Diagnosis and management of secondary causes of steatohepatitis

Liebe, R., Esposito, I., Bock, H. H., Dahl, S. V., Stindt, J., Baumann, U., Luedde, T., & Keitel, V. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.01.045 · Cited by 108 · see citing works

PNPLA3 genotype and diabetes identify patients with nonalcoholic fatty liver disease at high risk of incident cirrhosis

Chen, V. L., Oliveri, A., Miller, M. J., Wijarnpreecha, K., Du, X., Chen, Y., Cushing, K. C., Lok, A. S., & Speliotes, E. K. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.01.040 · Cited by 108 · see citing works

Genetic and Epigenetic Modifiers of Alcoholic Liver Disease

Meroni, M., Longo, M., Rametta, R., & Dongiovanni, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123857 · Cited by 106 · see citing works

A 17‐Beta‐Hydroxysteroid Dehydrogenase 13 Variant Protects From Hepatocellular Carcinoma Development in Alcoholic Liver Disease

Yang, J., Trépo, E., Nahon, P., Cao, Q., Moreno, C., Letouzé, É., Imbeaud, S., Bayard, Q., Gustot, T., Deviere, J. M. E., et al. (2019) · Hepatology · doi:10.1002/hep.30623 · Cited by 107 · see citing works

MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy

Xian, Y., Weng, J., & Xu, F. L. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001263 · Cited by 106 · see citing works

The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From Molecular Mechanisms to Clinical Implications

Palma, R., Pronio, A., Romeo, M., Scognamiglio, F., Ventriglia, L., Ormando, V. M., Lamazza, A., Pontone, S., Federico, A., & Dallio, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133649 · Cited by 111 · see citing works

Cytosolic phospholipase A2 and lysophospholipid acyltransferases

Kita, Y., Shindou, H., & Shimizu, T. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.08.006 · Cited by 105 · see citing works

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study

Trépo, E., Caruso, S., Yang, J., Imbeaud, S., Couchy, G., Bayard, Q., Letouzé, É., Ganne‐Carrié, N., Moreno, C., Oussalah, A., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00603-3 · Cited by 102 · see citing works

Genome‐wide Association Study and Meta‐analysis on Alcohol‐Associated Liver Cirrhosis Identifies Genetic Risk Factors

Schwantes-An, T.-H. L., Darlay, R., Mathurin, P., Masson, S., Liangpunsakul, S., Mueller, S., Aithal, G. P., Eyer, F., Gleeson, D. C., Thompson, A., et al. (2020) · Hepatology · doi:10.1002/hep.31535 · Cited by 99 · see citing works

Metabolic and Genetic Risk Factors Are the Strongest Predictors of Severity of Alcohol-Related Liver Fibrosis

Israelsen, M. E., Juel, H. B., Detlefsen, S., Madsen, B. S., Rasmussen, D. N., Larsen, T. R., Kjærgaard, M., Jensen, M. J. F., Stender, S., Hansen, T. F., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.11.038 · Cited by 99 · see citing works

Microbiota, a key player in alcoholic liver disease

Cassard, A.-M., & Ciocan, D. (2018) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2017.0067 · Cited by 100 · see citing works

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats

Luo, F., Šmagris, Ē., Martin, S. A., do Vale, G. D., McDonald, J. G., Fletcher, J. A., Burgess, S. C., Hobbs, H. H., & Cohen, J. C. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.12.008 · Cited by 98 · see citing works

The Impact of Macronutrient Intake on Non-alcoholic Fatty Liver Disease (NAFLD): Too Much Fat, Too Much Carbohydrate, or Just Too Many Calories?

Hydes, T., Alam, U., & Cuthbertson, D. J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.640557 · Cited by 94 · see citing works

Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice

Fan, Y., Lu, H., Guo, Y., Zhu, T., Garcia-Barrio, M. T., Jiang, Z., Willer, C. J., Zhang, J., & Chen, Y. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.005 · Cited by 92 · see citing works

Pathogenesis of Alcohol-Associated Liver Disease

Osna, N. A., Rasineni, K., Ganesan, M., Donohue, T. M., & Kharbanda, K. K. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.05.004 · Cited by 92 · see citing works

Genetics of Hepatocellular Carcinoma: Approaches to Explore Molecular Diversity

Caruso, S., O’Brien, D. R., Cleary, S. P., Roberts, L. R., & Zucman‐Rossi, J. (2020) · Hepatology · doi:10.1002/hep.31394 · Cited by 94 · see citing works

New genetic insights into the development of alcohol-related cirrhosis

Weber, C. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.190 · Cited by 1 · see citing works

The genetics of alcohol-related liver disease

Way, M. J. (2017) · UCL Discovery (University College London)

OWE-016 Genetic variants in PNPLA3 and TM6SF2 predispose to hepatocellular carcinoma in patients with alcohol-related cirrhosis

Stickel, F., Buch, S., Rosendahl, J., Nischalke, H. D., Lammert, F., Casper, M., Vogel, A., Deltenre, P., Eyer, F., Gotthardt, D. N., et al. (2018) · doi:10.1136/gutjnl-2018-bsgabstracts.209 · Cited by 6 · see citing works

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis

Stickel, F., Buch, S., Nischalke, H. D., Weiss, K. H., Gotthardt, D. N., Fischer, J., Rosendahl, J., Marot, A., Elamly, M., Casper, M., et al. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0041-8 · Cited by 119 · see citing works

Genetic risk of alcohol-related liver cirrhosis: Associations of PNPLA3, TM6SF2, and a two-variant polygenic risk score

Nesic, B., Jelovac, M., Karan-Djurašević, T., Kalem, D. V., Svorcan, P., Zukić, B., & Grubiša, I. (2025) · Biomolecules and Biomedicine · doi:10.17305/bb.2025.13261 · Cited by 1 · see citing works