AMPK and SIRT1: a long-standing partnership?
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AMP-activated protein kinase (AMPK) and the histone/protein deacetylase SIRT1 are fuel-sensing molecules that have coexisted in cells throughout evolution. When a cell's energy state is diminished, AMPK activation restores energy balance by stimulating catabolic processes that generate ATP and downregulating anabolic processes that consume ATP but are not acutely needed for survival. SIRT1 in turn is best known historically for producing genetic changes that mediate the increase in longevity caused by calorie restriction. Although the two molecules have been studied intensively for many years, only recently has it become apparent that they have similar effects on diverse processes such as cellular fuel metabolism, inflammation, and mitochondrial function. In this review we will examine the evidence that these similarities occur because AMPK and SIRT1 both regulate each other and share many common target molecules. In addition, we will discuss the clinical relevance of these interactions and in particular the possibility that their dysregulation predisposes to disorders such as type 2 diabetes and atherosclerotic cardiovascular disease and is a target for their therapy.
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Once activated, SIRT1 and AMPK positively affect glucose homeostasis and improve insulin sensitivity.
“Once activated, SIRT1 and AMPK positively affect glucose homeostasis and improve insulin sensitivity [21, 22].”
From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [22]
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Glucose Autoregulates Its Uptake in Skeletal Muscle
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- Authors
- Ruderman, N. B., Julia Xu, X., Nelson, L., Cacicedo, J. M., Saha, A. K., Lan, F., & Ido, Y.
- Affiliations
- Boston University (US)
- Diabetes Research Unit, Section of Endocrinology, Departments of Medicine, Physiology, and Biophysics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts
- Corresponding author
- Ruderman, Neil B.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2010-04
- Volume
- 298
- Issue
- 4
- Pages
- E751-E760
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC2853213
- OpenAlex
- W2140406095
- Cited by
- 903
- References
- 112
- Citations by year
- 2026: 52 · 2025: 57 · 2024: 56 · 2023: 59 · 2022: 84 · 2021: 80 · 2020: 75 · 2019: 53 · 2018: 53 · 2017: 54 · 2016: 46 · 2015: 50 · 2014: 53 · 2013: 45 · 2012: 39
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (5r01dk019514-35)
- National Heart, Lung, and Blood Institute (P01HL068758)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007201, R01DK067509, R01-DK-019514)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- AMPK, SIRT1, energy sensing, fuel metabolism, caloric restriction, longevity, inflammation, mitochondrial function, type 2 diabetes, atherosclerotic cardiovascular disease, therapeutic target
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Energy Metabolism, Enzyme Activation, Humans, Gene Expression Regulation, Enzymologic, Cyclic AMP-Dependent Protein Kinases, Sirtuin 1
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