The DOI matches its Crossref record; 178 of the 181 references it cites were found in a registry or an index.
Bile salt biotransformations by human intestinal bacteria
Open accessAbstract
Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels in the enterohepatic circulation of some individuals and may contribute to the pathogenesis of colon cancer, gallstones, and other gastrointestinal (GI) diseases. Bile salt hydrolysis and hydroxy group dehydrogenation reactions are carried out by a broad spectrum of intestinal anaerobic bacteria, whereas bile acid 7-dehydroxylation appears restricted to a limited number of intestinal anaerobes representing a small fraction of the total colonic flora. Microbial enzymes modifying bile salts differ between species with respect to pH optima, enzyme kinetics, substrate specificity, cellular location, and possibly physiological function. Crystallization, site-directed mutagenesis, and comparisons of protein secondary structure have provided insight into the mechanisms of several bile acid-biotransforming enzymatic reactions. Molecular cloning of genes encoding bile salt-modifying enzymes has facilitated the understanding of the genetic organization of these pathways and is a means of developing probes for the detection of bile salt-modifying bacteria. The potential exists for altering the bile acid pool by targeting key enzymes in the 7alpha/beta-dehydroxylation pathway through the development of pharmaceuticals or sequestering bile acids biologically in probiotic bacteria, which may result in their effective removal from the host after excretion.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Primary conjugated BAs synthesized in the liver, such as the tauro- and glycoconjugates of cholic acid (TCA, GCA), are deconjugated by BSHs to generate cholic acid (CA)”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [11]
In the citing paper
“This vanguard reaction acts as a ‘gatekeeper’ for subsequent BA transformations that turn primary BAs into secondary BAs”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [11]
In the citing paper
“There is an intensive bidirectional interaction between BAs and intestinal microbiota.51”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [51]
In the citing paper
“Primary bile acids are converted to secondary bile acids by the local microbiota, partly in the small intestine and predominantly in the colon. This involves multiple steps and typically begins with the initial deconjugation of glycine or taurine, followed by dehydroxylation (Ridlon et al., 2006).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Ridlon et al., 2006
In the citing paper
“Bile acid activity of commensal bacteria is involved in a complex interplay with host hepatic enzymes, and together they promote digestion and absorption of dietary lipids.42”
From The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids (2015) · cites this paper as [42]
Citations
Cites
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1×
“Bacterial density in the human colon is among the highest found in nature, approaching 10(12) bacteria/ gram wet weight feces (2, 3).”
BackgroundMICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776
Comparative Genomics of Listeria Species
Glaser, P., Frangeul, L., Buchrieser, C., Rusniok, C., Amend, A., Baquero, F., Berche, P., Blöcker, H., Brandt, P., Chakraborty, T., et al. (2001) · Science · doi:10.1126/science.1063447 · Cited by 1,505
Vitamin D Receptor As an Intestinal Bile Acid Sensor
Makishima, M., Lu, T. T., Xie, W., Whitfield, G. K., Domoto, H., Evans, R. M., Haussler, M. R., & Mangelsdorf, D. J. (2002) · Science · doi:10.1126/science.1070477 · Cited by 1,176
The Continuing Importance of Bile Acids in Liver and Intestinal Disease
Hofmann, A. F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.22.2647 · Cited by 972
Wyatt, J. S., Delpy, D. T., Cope, M., Wray, S., & Reynolds, E. O. R. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90467-8 · Cited by 875
Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704
Hepatology. A Textbook of Liver Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-259_2 · Cited by 624
Bile acids as carcinogens in human gastrointestinal cancers
Bernstein, H., Bernstein, C., Payne, C. M., Dvorakova, K., & Garewal, H. (2005) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.08.001 · Cited by 611
Chandramouli, V., Kailasapathy, K., Peiris, P., & Jones, M. (2004) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2003.09.002 · Cited by 475
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Zhang, Y., & Talalay, P. (1994) · PubMed · Cited by 474
Lengeler, J. W., Drews, G., & Schlegel, H. G. (1998) · Wiley eBooks · doi:10.1002/9781444313314 · Cited by 412
Human Intestinal Microflora in Health and Disease
(1983) · Elsevier eBooks · doi:10.1016/c2012-0-01555-4 · Cited by 395
Armstrong, M., & Carey, M. C. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38175-x · Cited by 371
Magee, E. A., Richardson, C. J., Hughes, R., & Cummings, J. H. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1488 · Cited by 359
Dussurget, O., Cabanes, D., Dehoux, P., Lecuit, M., Buchrieser, C., Glaser, P., & Cossart, P. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03080.x · Cited by 356
Lin, J., Şahin, O., Michel, L. O., & Zhang, Q. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4250-4259.2003 · Cited by 308
Significance of bile salt hydrolytic activities of lactobacilli
Smet, I. D., Hoorde, L. V., Woestyne, M. V., Christiaens, H., & Verstraete, W. (1995) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1995.tb03140.x · Cited by 307
Gibson, G. R., Cummings, J. H., & Macfarlane, G. T. (1991) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1991.tb04799.x · Cited by 301
Bile Salt Hydrolase of Bifidobacterium longum —Biochemical and Genetic Characterization
Tanaka, H., Hashiba, H., Kok, J., & Mierau, I. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.6.2502-2512.2000 · Cited by 285
Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats2
Reddy, B. S., Narasawa, T., Weisburger, J. H., & Wynder, E. L. (1976) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/56.2.441 · Cited by 262
Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature.
McGarr, S. E., Ridlon, J. M., & Hylemon, P. B. (2005) · PubMed · Cited by 259
Self-citationDetoxification of hydrogen sulfide and methanethiol in the cecal mucosa
Levitt, M. D., Furne, J. K., Springfield, J. R., Suarez, F. L., & DeMaster, E. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7712 · Cited by 248
Qiao, L., Studer, E. J., Leach, K., McKinstry, R. P., Gupta, S., Decker, R. H., Kukreja, R. C., Valerie, K. C., Nagarkatti, P. S., El‐Deiry, W. S., et al. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.9.2629 · Cited by 238
Self-citationTanaka, N., Nonaka, T., Tanabe, T., Yoshimoto, T., Tsuru, D., & Mitsui, Y. (1996) · Biochemistry · doi:10.1021/bi951904d · Cited by 235
Increased serum deoxycholic acid levels in men with colorectal adenomas
Bayerdörffer, E., Mannes, G. A., Richter, W. O., Ochsenkühn, T., Wiebecke, B., Köpcke, W., & Paumgartner, G. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90846-5 · Cited by 234
Fecal Hydrogen Sulfide Production in Ulcerative Colitis
Levine, J., Ellis, C. J., Furne, J. K., Springfield, J. R., & Levitt, M. D. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.083_c.x · Cited by 212
Heuman, D. M., Pandak, M. W., Hylemon, P. B., & Vlahčevič, Z. R. (1991) · Hepatology · doi:10.1002/hep.1840140527 · Cited by 208
Self-citationHypocholesterolemic effect of yogurt and milk
Hepner, G., Fried, R., St Jeor, S., Fusetti, L., & Morin, R. (1979) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.1.19 · Cited by 202
Deplancke, B., & Gaskins, H. R. (2003) · The FASEB Journal · doi:10.1096/fj.02-0883fje · Cited by 190
Kitahara, M., Takamine, F., Imamura, T., & Benno, Y. (2001) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-51-1-39 · Cited by 189
Pai, R., Tarnawski, A. S., & Tran, T. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0894 · Cited by 189
Dietary Glycine and Taurine on Bile Acid Conjugation in Man. Bile Acids and Steroids 75
Sjövall, J. (1959) · Experimental Biology and Medicine · doi:10.3181/00379727-100-24741 · Cited by 189
Cowen, A. E., Korman, M. G., Hofmann, A. F., & Cass, O. W. (1975) · PubMed · Cited by 189
Eneroth, P. H. E., Gordon, B. A., Ryhage, R., & Sjövall, J. (1966) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39261-0 · Cited by 183
Guérin, D., Vuillemard, J.-C., & Subirade, M. (2003) · Journal of Food Protection · doi:10.4315/0362-028x-66.11.2076 · Cited by 182
Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity
Smet, I. D., Boever, P. D., & Verstraete, W. (1998) · British Journal Of Nutrition · doi:10.1079/bjn19980030 · Cited by 182
Lactobacilli and bile salt hydrolase in the murine intestinal tract
Tannock, G. W., Dashkevicz, M. P., & Feighner, S. D. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.7.1848-1851.1989 · Cited by 166
Dar, S. A., Kuenen, J. G., & Muyzer, G. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.5.2325-2330.2005 · Cited by 161
7alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum.
Stellwag, E. J., & Hylemon, P. B. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40615-7 · Cited by 161
Self-citationSelective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative
Adachi, R., Honma, Y., Masuno, H., Kawana, K., Shimomura, I., Yamada, S., & Makishima, M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400294-jlr200 · Cited by 157
Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems
Hylemon, P. B., & Harder, J. (1998) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1998.tb00382.x · Cited by 156
Self-citationMetabolism of Lithocholate in Healthy Man
Cowen, A. E., Korman, M. G., Hofmann, A. F., Cass, O. W., & Coffin, S. B. (1975) · Gastroenterology · doi:10.1016/s0016-5085(19)32637-x · Cited by 155
Im, E., & Martinez, J. D. (2004) · Journal of Nutrition · doi:10.1093/jn/134.2.483 · Cited by 154
Wells, J. E., & Hylemon, P. B. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.3.1107-1113.2000 · Cited by 154
Self-citationMetabolism of lithocholate in healthy man. II. Enterohepatic circulation.
Cowen, A. E., Korman, M. G., Af, H., Cass, O., & Coffin, S. B. (1975) · PubMed · Cited by 153
Berr, F., Kullak‐Ublick, G., Paumgartner, G., Münzing, W., & Hylemon, P. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70024-0 · Cited by 149
Self-citationHardison, W. G. M. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)93767-8 · Cited by 147
Colonic Bacterial Flora: Changing Understandings in the Molecular Age
Mai, V., & Morris, J. G. (2004) · Journal of Nutrition · doi:10.1093/jn/134.2.459 · Cited by 147
Unconjugated secondary bile acids in the serum of patients with colorectal adenomas.
Bayerdörffer, E., Mannes, G. A., Ochsenkühn, T., Dirschedl, P., Wiebecke, B., & Paumgartner, G. (1995) · Gut · doi:10.1136/gut.36.2.268 · Cited by 146
Kitahara, M., Takamine, F., Imamura, T., & Benno, Y. (2000) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-50-3-971 · Cited by 146
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis
Stellwag, E. J., & Hylemon, P. B. (1976) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(76)90068-1 · Cited by 145
Self-citationA new family of CoA‐transferases
Heider, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03178-7 · Cited by 143
Antagonistic effects of sulfide and butyrate on proliferation of colonic mucosa
Christl, S. U., Eisner, H.-D., Dusel, G., Kasper, H., & Scheppach, W. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02100146 · Cited by 142
Elkins, C. A., Moser, S. A., & Savage, D. C. (2001) · Microbiology · doi:10.1099/00221287-147-12-3403 · Cited by 142
Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens
Coleman, J. P., & Hudson, L. L. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.7.2514-2520.1995 · Cited by 140
Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.
Salen, G., Tint, G. S., Eliav, B. B., DEERING, N. G., & Mosbach, E. H. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107596 · Cited by 139
Rossocha, M., Schultz‐Heienbrok, R., von Moeller, H., Coleman, J. P., & Saenger, W. (2005) · Biochemistry · doi:10.1021/bi0473206 · Cited by 138
Christiaens, H., Leer, R. J., Pouwels, P. H., & Verstraete, W. (1992) · Applied and Environmental Microbiology · doi:10.1128/aem.58.12.3792-3798.1992 · Cited by 128
Hlivák, P., Odraska, J., Ferencĭk, M., Ebringer, L., Jahnova, E., & Mikeś, Z. (2005) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656709 · Cited by 126
Bile acid induction specificity of 7α-dehydroxylase activity in an intestinal Eubacterium species
A, B., Lipsky, W. R. L., Fricke, R. J., & Hylemon, P. B. (1980) · Steroids · doi:10.1016/0039-128x(80)90115-4 · Cited by 125
Self-citationDietary fat and its relationship to large bowel cancer.
Reddy, B. S. (1981) · PubMed · Cited by 122
Comparison of the bile salts and sodium dodecyl sulfate stress responses in Enterococcus faecalis
Flahaut, S., Frère, J., Boutibonnes, P., & Auffray, Y. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.7.2416-2420.1996 · Cited by 120
Purification and characterization of bile salt hydrolase from Clostridium perfringens.
Gopal-Srivastava, R., & Hylemon, P. B. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38464-9 · Cited by 117
Self-citationSide chain conjugation prevents bacterial 7-dehydroxylation of bile acids.
Batta, A. K., Salen, G., Arora, R., Shefer, S., Batta, M., & Person, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38535-7 · Cited by 116
Hirano, S., Nakama, R., Tamaki, M., Masuda, N., & Oda, H. (1981) · Applied and Environmental Microbiology · doi:10.1128/aem.41.3.737-745.1981 · Cited by 115
Deoxycholic acid and the pathogenesis of gall stones.
Marcus, S. N., & Heaton, K. W. (1988) · Gut · doi:10.1136/gut.29.4.522 · Cited by 111
Rarity of Colon Cancer in Africans Is Associated With Low Animal Product Consumption, Not Fiber
O’Keefe, S. J., Kidd, M. S., Espitalier-Noël, G., & Owira, P. M. O. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01089.x · Cited by 109
Kim, G., Miyamoto, C. M., Meighen, E. A., & Lee, B. H. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.9.5603-5612.2004 · Cited by 105
Grill, J., Schneider, F., Crociani, J., & Ballongue, J. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.7.2577-2582.1995 · Cited by 105 · cited 2×
“shown the importance of this residue in catalysis (10, 12, 13).”
BackgroundRose, P. E. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i26.3990 · Cited by 104
Rao, Y.-P., Studer, E. J., Stravitz, R. T., Gupta, S., Qiao, L., Dent, P., & Hylemon, P. B. (2002) · Hepatology · doi:10.1053/jhep.2002.31104 · Cited by 104
Self-citationYoshimoto, T., Higashi, H., Kanatani, A., Lin, X.-S., Nagai, H., Ōyama, H., Kurazono, K., & Tsuru, D. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.7.2173-2179.1991 · Cited by 102
Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708
Mallonee, D. H., White, W. B., & Hylemon, P. B. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.12.7011-7019.1990 · Cited by 102
Self-citationMallonee, D. H., & Hylemon, P. B. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.24.7053-7058.1996 · Cited by 97
Self-citationSue, D., Boor, K. J., & Wiedmann, M. (2003) · Microbiology · doi:10.1099/mic.0.26526-0 · Cited by 96
Gupta, S., Natarajan, R., Payne, S. G., Studer, E. J., Spiegel, S., Dent, P., & Hylemon, P. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310979200 · Cited by 90
Self-citationWells, J. E., Berr, F., Thomas, L. A., Dowling, R. H., & Hylemon, P. B. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80183-x · Cited by 90
Self-citationDissimilation of the C2 sulfonates
Cook, A. M., & Denger, K. (2002) · Archives of Microbiology · doi:10.1007/s00203-002-0497-0 · Cited by 90
Grill, J.-P., Cayuela, C., Antoine, J., & Schneider, F. (2000) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.01147.x · Cited by 88
Laue, H., Friedrich, M., Ruff, J., & Cook, A. M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.5.1727-1733.2001 · Cited by 87
Hussaini, S. H., Pereira, S. P., Murphy, G. M., & Dowling, R. H. (1995) · Hepatology · doi:10.1002/hep.1840220619 · Cited by 87
Tauroconjugation of cholic acid stimulates 7 alpha-dehydroxylation by fecal bacteria
Eldere, J. V., Celis, P., Pauw, G. D., Lesaffre, E., & Eyssen, H. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.2.656-661.1996 · Cited by 86
Hirano, S., & Masuda, N. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40663-7 · Cited by 85
Mallonee, D. H., Adams, J. L., & Hylemon, P. B. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.7.2065-2071.1992 · Cited by 84
Self-citationBile salt deconjugation by Lactobacillus plantarum 80 and its implication for bacterial toxicity
Boever, P. D., & Verstraete, W. (1999) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1999.00019.x · Cited by 83
Kawamoto, K., Horibe, I., & Uchida, K. (1989) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122962 · Cited by 83
A proposed nomenclature for bile acids.
Hofmann, A., Sjövall, J., Kurz, G., Radominska-p, A., Schteingart, C. D., Tint, G., Vlahcevic, Z. R., & Setchell, K. D. R. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41624-4 · Cited by 82
Baron, S. F., Franklund, C. V., & Hylemon, P. B. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.15.4558-4569.1991 · Cited by 80
Self-citationMacdonald, I. A., Rochon, Y. P., Hutchison, D. M., & Holdeman, L. V. (1982) · Applied and Environmental Microbiology · doi:10.1128/aem.44.5.1187-1195.1982 · Cited by 80
Bile acid metabolism by fresh human colonic contents: a comparison of caecal versus faecal samples
Thomas, L. A., Veysey, M. J., French, G., Hylemon, P. B., Murphy, G. M., & Dowling, R. H. (2001) · Gut · doi:10.1136/gut.49.6.835 · Cited by 80
Self-citationElkins, C. A., & Savage, D. C. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.17.4344-4349.1998 · Cited by 79
Biotransformation of Bile Acids and Cholesterol by the Intestinal Microflora
Hylemon, P. B., & Glass, T. L. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-341280-5.50015-x · Cited by 78
Self-citationFormation of urso- and ursodeoxy-cholic acids from primary bile acids by Clostridium absonum
Macdonald, I. A., Hutchison, D. M., & Forrest, T. P. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34960-9 · Cited by 76
Corzo, G., & Gilliland, S. E. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75255-0 · Cited by 76
3α-, 7α- And 12α-hydroxysteroid dehydrogenase activities from Clostridium perfringens
Macdonald, I. A., Meier, E. C., Mahony, D. E., & Costain, G. A. (1976) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(76)90086-2 · Cited by 75
Lie, T. J., Clawson, M. L., Godchaux, W., & Leadbetter, E. R. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.8.3328-3334.1999 · Cited by 75
Samuelsson, B. O. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69529-8 · Cited by 74
Multiple forms of 7-alpha-hydroxysteroid dehydrogenase in selected strains of Bacteroides fragilis
Hylemon, P. B., & Sherrod, J. A. (1975) · Journal of Bacteriology · doi:10.1128/jb.122.2.418-424.1975 · Cited by 74
Self-citationBile Salt 3α- and 12α-Hydroxysteroid Dehydrogenases from Eubacterium lentum and Related Organisms
MacDonald, I. A., Jellett, J. F., Mahony, D. E., & Holdeman, L. V. (1979) · Applied and Environmental Microbiology · doi:10.1128/aem.37.5.992-1000.1979 · Cited by 73
Cholic acid accumulation and its diminution by short-chain fatty acids in bifidobacteria
Kurdi, P., Tanaka, H., van Veen, H. W., Asano, K., Tomita, F., & Yokota, A. (2003) · Microbiology · doi:10.1099/mic.0.26376-0 · Cited by 70
Franklund, C. V., Baron, S. F., & Hylemon, P. B. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.10.3002-3012.1993 · Cited by 67
Self-citationWells, J. E., Williams, K. B., Whitehead, T. R., Heuman, D. M., & Hylemon, P. B. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00115-3 · Cited by 65
Self-citationBergström, S., Danielsson, H., & Kazuno, T. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69464-5 · Cited by 65
Huijghebaert, S., & Hofmann, A. F. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38791-5 · Cited by 65
Hylemon, P., Melone, P., Franklund, C. V., Lund, E. G., & Björkhem, I. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42247-3 · Cited by 64
Self-citationCOLONIC BACTERIAL ACTIVITY, BILIARY CHOLESTEROL SATURATION, AND PATHOGENESIS OF GALLSTONES
Low-Beer, T. S., & Nutter, S. (1978) · The Lancet · doi:10.1016/s0140-6736(78)91800-7 · Cited by 63
Bile salt induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum
Macdonald, I. A., & Roach, P. D. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90011-4 · Cited by 63
Bennett, M. J., McKnight, S. L., & Coleman, J. P. (2003) · Current Microbiology · doi:10.1007/s00284-003-4079-4 · Cited by 63
Cholic Acid Is Accumulated Spontaneously, Driven by Membrane ΔpH, in Many Lactobacilli
Kurdi, P., van Veen, H. W., Tanaka, H., Mierau, I., Konings, W. N., Tannock, G. W., Tomita, F., & Yokota, A. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.22.6525-6528.2000 · Cited by 63
Hirano, S., & Masuda, N. (1982) · Applied and Environmental Microbiology · doi:10.1128/aem.43.5.1057-1063.1982 · Cited by 62
The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum.
Sutherland, J. D., & Macdonald, I. A. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38105-0 · Cited by 62
Dawson, J. A., Mallonee, D. H., Björkhem, I., & Hylemon, P. B. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39155-0 · Cited by 60
Self-citationWhite, B. A., Fricke, R. J., & Hylemon, P. B. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38183-9 · Cited by 60
Self-citationNAD- and NADP-dependent 7α-hydroxysteroid dehydrogenases from Bacteroides fragilis
MacDonald, I. A., Williams, C. N., Mahony, D. E., & Christie, W. M. (1975) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(75)90091-1 · Cited by 59
Physiological and molecular aspects of bile salt response in Enterococcus faecalis
Rincé, A., Breton, Y. S. L., Verneuil, N., Giárd, J.-C., Hartke, A., & Auffray, Y. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(03)00182-x · Cited by 58
Purification and Properties of a 3α-Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni*
Boyer, J., Baron, D. N., & Talalay, P. (1965) · Biochemistry · doi:10.1021/bi00885a020 · Cited by 58
Edenharder, R., & Knaflic, T. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37375-2 · Cited by 57
Macdonald, I. A., White, B. A., & Hylemon, P. B. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37894-9 · Cited by 56
Self-citationColeman, J. P., Hudson, L. L., & Adams, M. J. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.16.4865-4874.1994 · Cited by 55
Tanabe, T., Tanaka, N., UCHIKAWA, K.-I., Kabashima, T., Ito, K., Nonaka, T., Mitsui, Y., Tsuru, M., & Yoshimoto, T. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022159 · Cited by 54
Coleman, J. P., White, W. B., Lijewski, M. A., & Hylemon, P. B. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.5.2070-2077.1988 · Cited by 53
Self-citationEXCRETION OF BILE ACIDS BY THREE MEN ON A FAT-FREE DIET
Ali, S. S., Kuksis, A., & Beveridge, J. M. R. (1966) · Canadian Journal of Biochemistry · doi:10.1139/o66-112 · Cited by 53
Sherrod, J. A., & Hylemon, P. B. (1977) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(77)90031-5 · Cited by 52
Self-citationMallonee, D. H., Lijewski, M. A., & Hylemon, P. B. (1995) · Current Microbiology · doi:10.1007/bf00295498 · Cited by 52
Self-citationMacDonald, I. A., Jellett, J. F., & Mahony, D. E. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40635-2 · Cited by 51
White, B. A., Cacciapuoti, A. F., Fricke, R. J., Whitehead, T. R., Mosbach, E. H., & Hylemon, P. B. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37326-0 · Cited by 51
Self-citationDetergent (sodium dodecyl sulfate) shock proteins in Escherichia coli
Adamowicz, M., Kelley, P. M., & Nickerson, K. W. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.1.229-233.1991 · Cited by 49
Björkhem, I., Einarsson, K., Melone, P. D., & Hylemon, P. B. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38290-0 · Cited by 48
Self-citationMacdonald, I. A., Mahony, D. E., Jellet, J. F., & Meier, C. E. (1977) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(77)90167-9 · Cited by 46
Role of Intestinal Transit in the Pathogenesis of Gallbladder Stones
Dowling, R. H., Veysey, M. J., Pereira, S. P., Hussaini, S. H., Thomas, L. A., Wass, J. A. H., & Murphy, G. M. (1997) · Canadian Journal of Gastroenterology · doi:10.1155/1997/532036 · Cited by 45
On the 3α‐Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni
SKÅLHEGG, B. A. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03603.x · Cited by 45
DNA hypomethylation induced by non-genotoxic carcinogens in mouse and rat colon
Pereira, M. A., Wang, W., Kramer, P. M., & Tao, L. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.03.024 · Cited by 43
Cholylsarcosine, a new bile acid analogue: Metabolism and effect on biliary secretion in humans
Schmassmann, A., Fehr, H. F., Locher, J., Lillienau, J., Schteingart, C. D., Rossi, S. S., & Hofmann, A. F. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90289-o · Cited by 42
Edenharder, R., & Schneider, J. S. (1985) · Applied and Environmental Microbiology · doi:10.1128/aem.49.4.964-968.1985 · Cited by 42
Zhu, Y., Hua, P., Rafiq, S. A., Waffner, E. J., Duffey, M. E., & Lance, P. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00525.2001 · Cited by 42
White, W. B., Franklund, C. V., Coleman, J. P., & Hylemon, P. B. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.10.4555-4561.1988 · Cited by 41
Self-citationCharacterization of 7-α-dehydroxylase in Clostridium leptum
Stellwag, E., & Hylemon, P. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.10.s243 · Cited by 40
Self-citationTransformation of bile acids by Clostridium perfringens
Hirano, S., Masuda, N., Oda, H., & Mukai, H. (1981) · Applied and Environmental Microbiology · doi:10.1128/aem.42.3.394-399.1981 · Cited by 39
Cloning and characterization of a bile salt hydrolase (bsh) from Bifidobacterium adolescentis
Kim, G., Brochet, M., & Lee, B. H. (2005) · Biotechnology Letters · doi:10.1007/s10529-005-6717-3 · Cited by 39
Ye, H.-Q., Mallonee, D. H., Wells, J. E., Björkhem, I., & Hylemon, P. B. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33335-6 · Cited by 38
Self-citationSkålhegg, B. A. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb09901.x · Cited by 37
Bile acid induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium limosum.
Sutherland, J. D., & Williams, C. N. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34377-7 · Cited by 36
Hussaini, S. H. (1995) · Hepatology · doi:10.1016/0270-9139(95)90199-x · Cited by 36
Harris, J., & Hylemon, P. B. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90060-7 · Cited by 35
Self-citationMultiple copies of a bile acid-inducible gene in Eubacterium sp. strain VPI 12708
Gopal-Srivastava, R., Mallonee, D. H., White, W. B., & Hylemon, P. B. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.8.4420-4426.1990 · Cited by 34
Self-citationMetabolism of primary bile acids by Clostridium perfringens
Macdonald, I. A., Hutchison, D. M., Forrest, T. P., Bokkenheuser, V. D., Winter, J., & Holdeman, L. V. (1983) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(83)90336-9 · Cited by 34
Lindstedt, S., & Samuelsson, B. O. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69861-8 · Cited by 34
Edenharder, R., Pfützner, A., & Hammann, R. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90272-5 · Cited by 31
Multiple forms of bile salt hydrolase from Lactobacillus sp. strain 100-100
Lundeen, S. G., & Savage, D. C. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.22.7217-7220.1992 · Cited by 31
Franklund, C. V., de Prada, P., & Hylemon, P. B. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38748-4 · Cited by 30
Self-citationActivity on bile acids of a Clostridium bifermentans cell‐free extract
Ferrari, A., & Beretta, L. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80076-8 · Cited by 30
7α-OH epimerisation of bile acids via oxido-reduction with Xanthomonas maltophilia
Medici, A., Pedrini, P., Bianchini, E., Fantin, G., Guerrini, A., Natalini, B., & Pellicciari, R. (2002) · Steroids · doi:10.1016/s0039-128x(01)00136-2 · Cited by 29
On the mechanism of cholic acid 7α‐dehydroxylation by a Clostridium bifermentans cell‐free extract
Ferrari, A., Scolastico, C., & Beretta, L. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80077-x · Cited by 26
Bergström, S., Lindstedt, S., & Samuelsson, B. O. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69860-6 · Cited by 25
White, W. B., Coleman, J. P., & Hylemon, P. B. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.2.611-616.1988 · Cited by 25
Self-citationKishinaka, M., Umeda, A., & Kuroki, S. (1994) · Steroids · doi:10.1016/0039-128x(94)90062-0 · Cited by 25
Molecular cloning of bile acid 7-dehydroxylase from Eubacterium sp. strain VPI 12708
Coleman, J. P., White, W. B., & Hylemon, P. B. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.4.1516-1521.1987 · Cited by 24
Self-citationCharacterization of NADP-dependent 12β-hydroxysteroid dehydrogenase from Clostridium paraputrificum
Edenharder, R., & Pfützner, A. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90266-4 · Cited by 22
Edenharder, R., Pfützner, M., & Hammann, R. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90061-1 · Cited by 22
Sutherland, J. D., Holdeman, L. V., Williams, C. N., & Macdonald, I. A. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37716-6 · Cited by 21
Bile acids as drugs: principles, mechanisms of action and formulations.
Hofmann, A. F. (1995) · PubMed · Cited by 20
Kinetic properties of 7α-hydroxysteroid dehydrogenase from Escherichia coli 080
Prabha, V., Gupta, M., & Gupta, K. G. (1989) · Canadian Journal of Microbiology · doi:10.1139/m89-180 · Cited by 18
Paone, D. A. M., & Hylemon, P. B. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34451-5 · Cited by 18
Self-citationElkins, C. A., & Savage, D. C. (2003) · Microbial Physiology · doi:10.1159/000076738 · Cited by 16
Akao, T., Taiko, A., Hattori, M., Namba, T., & Kobashi, K. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90028-2 · Cited by 16
Baron, S. F., & Hylemon, P. B. (1995) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(95)00034-r · Cited by 15
Self-citationMasuda, N., Oda, H., & Tanaka, H. (1983) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(83)90273-8 · Cited by 13
On the Mechanism of Deoxycholic Acid Formation.
Bergström, S., Lindstedt, S., Samuelsson, B., Hartiala, K., Veige, S., & Diczfalusy, E. R. (1958) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.12-1350a · Cited by 11
Sutherland, J. D., Williams, C. N., Hutchison, D. M., & Holdeman, L. V. (1987) · Canadian Journal of Microbiology · doi:10.1139/m87-116 · Cited by 9
Edenharder, R., & Pfützner, M. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.6.1656-1659.1989 · Cited by 8
Zusman, I., Chevion, M., & Kitrossky, N. (1992) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(11)80205-8 · Cited by 6
Warchol, M., Car, L., Grill, J.-P., & Schneider, F. (2003) · Current Microbiology · doi:10.1007/s00284-003-3998-4 · Cited by 3
Use of a short A/T-rich cassette for enhanced expression of cloned genes inEscherichia coli
Mallonee, D. H., & Hylemon, P. B. (1999) · Molecular Biotechnology · doi:10.1007/bf02789174 · Cited by 3
Self-citationBILE ACID AND CHOLESTEROL METABOLISM.
Shamma'a, M. H., & Somerville, I. F. (1963) · PubMed · Cited by 3
Cited by
Sorted by citations
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Gut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
Wahlstrom, A. M., Sayin, S. I., Marschall, H., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,969
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
Metadata
- Authors
- Ridlon, J. M., Kang, D.-J., & Hylemon, P. B.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 47
- Issue
- 2
- Pages
- 241-259
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2071273298
- Cited by
- 2,829
- References
- 181
- Citations by year
- 2026: 202 · 2025: 220 · 2024: 211 · 2023: 245 · 2022: 263 · 2021: 252 · 2020: 238 · 2019: 200 · 2018: 191 · 2017: 161 · 2016: 130 · 2015: 119 · 2014: 87 · 2013: 91 · 2012: 51
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK038030, P01 DK 38030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- secondary bile acids, enterohepatic circulation, enzyme kinetics, enzyme structure, gene cloning, probiotics, bile acid sequestration, colon cancer, gallstones
- MeSH terms
- Amidohydrolases, Amino Acid Sequence, Bacteria, Bile Acids and Salts, Biotransformation, Cholic Acids, Colonic Neoplasms, Humans, Hydrogen Sulfide, Hydroxysteroid Dehydrogenases, Intestinal Mucosa, Intestines, Models, Molecular, Molecular Sequence Data, Taurine, Molecular Structure, Sequence Homology, Amino Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
