The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The challenge of lipid rafts
Open accessAbstract
The Singer-Nicholson model of membranes postulated a uniform lipid bilayer randomly studded with floating proteins. However, it became clear almost immediately that membranes were not uniform and that clusters of lipids in a more ordered state existed within the generally disorder lipid milieu of the membrane. These clusters of ordered lipids are now referred to as lipid rafts. This review summarizes current thinking on the nature of lipid rafts focusing on the role of proteomics and lipidomics in understanding the structure of these domains. It also outlines the contribution of single-molecule methods in defining the forces that drive the formation and dynamics of these membrane domains.
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Cites
Singer, S. J., & Nicolson, G. L. (1972) · Science · doi:10.1126/science.175.4023.720 · Cited by 9,154
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
Zacharias, D. A., Violin, J. D., Newton, A. C., & Tsien, R. Y. (2002) · Science · doi:10.1126/science.1068539 · Cited by 2,235
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension
Baumgart, T., Hess, S. T., & Webb, W. W. (2003) · Nature · doi:10.1038/nature02013 · Cited by 1,590
Rafts defined: a report on the Keystone symposium on lipid rafts and cell function
Pike, L. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.e600002-jlr200 · Cited by 1,500
Self-citationLipid sorting in epithelial cells
Simons, K., & Van Meer, G. (1988) · Biochemistry · doi:10.1021/bi00417a001 · Cited by 1,371
A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains
Anderson, R. G. W., & Jacobson, K. (2002) · Science · doi:10.1126/science.1068886 · Cited by 1,125
Caveolins, Liquid-Ordered Domains, and Signal Transduction
Smart, E. J., Graf, G. A., McNiven, M. A., Sessa, W. C., Engelman, J. A., Scherer, P. E., Okamoto, T., & Lisanti, M. P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7289 · Cited by 1,006
Structure and Origin of Ordered Lipid Domains in Biological Membranes
Brown, D. A., & London, E. (1998) · Journal of Membrane Biology · doi:10.1007/s002329900397 · Cited by 963
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Lu, S., Jang, H., Muratcioglu, S., Gursoy, A., Keskin, O., Nussinov, R., & Zhang, J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00542 · Cited by 355
Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis
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Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308
Glycosphingolipids—Nature, Function, and Pharmacological Modulation
Wennekes, T., van den Berg, R. J. B. H. N., Boot, R. G., van der Marel, G. A., Overkleeft, H. S., & Aerts, J. M. F. G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200902620 · Cited by 288
Metadata
- Authors
- Pike, L. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S323-S328
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1973006797
- Cited by
- 493
- References
- 44
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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