Dicarbonyl Intermediates in the Maillard Reaction

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

Thornalley, P. J., LANGBORG, A., & Minhas, H. S. (1999) · Biochemical Journal · doi:10.1042/bj3440109 · Cited by 1,209 · see citing works

Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

Thornalley, P. J., Battah, S., Ahmed, N., Karachalias, N., Agalou, S., Babaei‐Jadidi, R., & Dawnay, A. (2003) · Biochemical Journal · doi:10.1042/bj20030763 · Cited by 659 · see citing works

Glyoxalase I – structure, function and a critical role in the enzymatic defence against glycation

Thornalley, P. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311343 · Cited by 615 · see citing works

The formation of methylglyoxal from triose phosphates

Phillips, S. A., & Thornalley, P. J. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17638.x · Cited by 565 · see citing works

Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

Babaei‐Jadidi, R., Karachalias, N., Ahmed, N., Battah, S., & Thornalley, P. J. (2003) · Diabetes · doi:10.2337/diabetes.52.8.2110 · Cited by 372 · see citing works

Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to N∊-carboxymethyl-lysine- and N∊-(1-carboxyethyl)lysine-modified albumin

Ahmed, N., Argirov, O. K., Minhas, H. S., CORDEIRO, C. A., & Thornalley, P. J. (2002) · Biochemical Journal · doi:10.1042/bj3640001 · Cited by 336 · see citing works

Methylglyoxal-Derived Hydroimidazolone Advanced Glycation End-Products of Human Lens Proteins

Ahmed, N., Thornalley, P. J., Dawczynski, J., Franke, S., Strobel, J., Stein, G., & HAIK, G. M. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0573 · Cited by 282 · see citing works

Protein Modification by Methylglyoxal: Chemical Nature and Synthetic Mechanism of a Major Fluorescent Adduct

Shipanova, I. N., Glomb, M. A., & Nagaraj, R. H. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0195 · Cited by 279 · see citing works

Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment

Ahmed, N., Ahmed, U., Thornalley, P. J., Häger, K., Fleischer, G., & Münch, G. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02864.x · Cited by 238 · see citing works

A fast method to predict protein interaction sites from sequences

Gallet, X., Charloteaux, B., Thomas, A., & Brasseur, R. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4092 · Cited by 212 · see citing works

The metabolism of aminoacetone to methylglyoxal by semicarbazide-sensitive amine oxidase in human umbilical artery

Lyles, G. A., & Chalmers, J. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90196-p · Cited by 197 · see citing works

Heat Sterilization of Fluids for Peritoneal Dialysis Gives Rise to Aldehydes

Thorell, C. B. N., Muscalu, N., Andrén, A. H. G., et al. (1993) · Peritoneal Dialysis International · doi:10.1177/089686089301300309 · Cited by 192 · see citing works

Acetone Metabolism in Humans During Diabetic Ketoacidosis

Reichard, G., Skutches, C. L., Hoeldtke, R. D., & Owen, O. E. (1986) · Diabetes · doi:10.2337/diab.35.6.668 · Cited by 177 · see citing works

Pathways of Formation of Glycoxidation Products during Glycation of Collagen

Wells-Knecht, M. C., Thorpe, S. R., & Baynes, J. (1995) · Biochemistry · doi:10.1021/bi00046a020 · Cited by 155 · see citing works

Are predictors of coronary heart disease and lower-extremity arterial disease in type 1 diabetes the same?

Forrest, K. Y. Z., BECKER, D. J., Kuller, L. H., Wolfson, S. K., & Orchard, T. J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00217-8 · Cited by 147 · see citing works

3,4-Dideoxyglucosone-3-ene (3,4-DGE): A cytotoxic glucose degradation product in fluids for peritoneal dialysis

Lindén, T., Cohen, A. S., Deppisch, R. M., Kjellstrand, P. T. T., & Wieslander, A. P. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00490.x · Cited by 143 · see citing works

α-Hydroxyaldehydes, products of lipid peroxidation

Loidl‐Stahlhofen, A., & Spitelier, G. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90264-x · Cited by 136 · see citing works

α-Oxoaldehyde metabolism and diabetic complications

Beisswenger, P. J., Howell, S. K., Nelson, R. G., Mauer, M. S., & Szwergold, B. S. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311358 · Cited by 121 · see citing works

Detection and identification of a protein-bound imidazolone resulting from the reaction of arginine residues and methylglyoxal

Henle, T., Walter, A. W., Hae�ner, R., & Klostermeyer, H. (1994) · European Food Research and Technology · doi:10.1007/bf01192954 · Cited by 107 · see citing works

Glucose degradation products (GDP) retard remesothelialization independently of d-glucose concentration

Morgan, L. W., Wieslander, A. P., Davies, M., et al. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00265.x · Cited by 106 · see citing works

The reaction of methylglyoxal with aminoguanidine under physiological conditions and prevention of methylglyoxal binding to plasma proteins

Lo, T. W. C., Selwood, T., & Thornalley, P. J. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90584-3 · Cited by 103 · see citing works

High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats

Babaei‐Jadidi, R., Karachalias, N., Kupich, C., Ahmed, N., & Thornalley, P. J. (2004) · Diabetologia · doi:10.1007/s00125-004-1582-5 · Cited by 98 · see citing works

Determination of α-dicarbonyl compounds in cigarette smoke

Morée-Testa, P., & Saint-Jalm, Y. (1981) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)88074-7 · Cited by 75 · see citing works

Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis

Ahmed, N., Thornalley, P. J., Luthen, R. E., Häussinger, D., Šebeková, K., Schinzel, R., Voelker, W., & Heidland, A. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.08.007 · Cited by 67 · see citing works

Identification of Nω-Carboxymethylarginine, a New Advanced Glycation Endproduct in Serum Proteins of Diabetic Patients: Possibility of a New Marker of Aging and Diabetes

Odani, H., Iijima, K., Nakata, M., Miyata, S., Kusunoki, H., Yasuda, Y., Hiki, Y., Irie, S., Maeda, K., & Fujimoto, D. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5322 · Cited by 56 · see citing works

Isolation and characterization of advanced glycation end products derived from the in vitro reaction of ribose and collagen

Paul, R. G., AVERY, C. N., SLATTER, A. D., et al. (1998) · Biochemical Journal · doi:10.1042/bj3301241 · Cited by 49 · see citing works

Control of Maillard Reactions in Foods: Strategies and Chemical Mechanisms

Lund, M. N., & Ray, C. A. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00882 · Cited by 871 · see citing works

The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194 · see citing works

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

Xue, J., Ray, R., Singer, D., Böhme, D., Burz, D. S., Rai, V., Hoffmann, R., & Shekhtman, A. (2014) · Biochemistry · doi:10.1021/bi500046t · Cited by 186 · see citing works

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

Rabbani, N., Xue, M., & Thornalley, P. J. (2016) · Glycoconjugate Journal · doi:10.1007/s10719-016-9705-z · Cited by 169 · see citing works

Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity

Gaens, K. H., Stehouwer, C. D., & Schalkwijk, C. G. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835aea13 · Cited by 166 · see citing works

Impact of advanced glycation end products (AGEs) signaling in coronary artery disease

Kosmopoulos, M., Drekolias, D., Zavras, P. D., Piperi, C., & Papavassiliou, A. G. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.006 · Cited by 136 · see citing works

Glyoxalase 1 Modulation in Obesity and Diabetes

Rabbani, N., & Thornalley, P. J. (2019) · Antioxidants & Redox Signaling · doi:10.1089/ars.2017.7424 · Cited by 102 · see citing works

Oxidation, glycation and glycoxidation—The vicious cycle and lung cancer

Ahmad, S., Khan, M. Y., Rafi, Z., Khan, H., Siddiqui, Z., Rehman, S., Shahab, U., Khan, M. S., Saeed, M., Alouffi, S., et al. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.10.005 · Cited by 91 · see citing works

Kidney, heart and brain: three organs targeted by ageing and glycation

Frimat, M., Daroux, M., Litke, R., Nevière, R., Tessier, F. J., & Boulanger, E. (2017) · Clinical Science · doi:10.1042/cs20160823 · Cited by 88 · see citing works

Glycation affects fibril formation of Aβ peptides

Emendato, A., Milordini, G., Zacco, E., Sicorello, A., Dal Piaz, F., Guerrini, R., Thorogate, R., Picone, D., & Pastore, A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002275 · Cited by 65 · see citing works

1,3-Diene Probes for Detection of Triplet Carbonyls in Biological Systems

Velosa, A. C., Baader, W. J., Stevani, C. V., Mano, C. M., & Bechara, E. J. H. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700074n · Cited by 51 · see citing works

Glycation free adduct accumulation in renal disease: the new AGE

Thornalley, P. J. (2005) · Pediatric Nephrology · doi:10.1007/s00467-005-2011-9 · Cited by 53 · see citing works

Metformin: Repurposing Opportunities for Cognitive and Mood Dysfunction

Ying, M., Maruschak, N., Mansur, R., Carvalho, A., Cha, D., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130205514 · Cited by 29 · see citing works

Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis

Knani, I., Bouzidi, H., Zrour, S., Bergaoui, N., Hammami, M., & Kerkeni, M. (2018) · Disease Markers · doi:10.1155/2018/8735926 · Cited by 25 · see citing works

Exploring the composition and properties of Centella asiatica metabolites and investigating their impact on BSA glycation, LDL oxidation and α-amylase inhibition

Borges, A. L. S., Bittar, V. P., Justino, A. B., Carrillo, M. S. P., Duarte, R. F. M., Silva, N. B. S., Gonçalves, D. S., Prado, D. G., Araújo, I. A. C., Martins, M. M., et al. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116143 · Cited by 6 · see citing works

Glyoxal Derivatives as Ozonation Products: The Biodegradation, DNA Lesion in Rat Hepatocytes and the Occurrence in Water Purification Process.

Ueno, H., Nakamuro, K., & Sayato, Y. (1995) · Journal of Japan Society on Water Environment · doi:10.2965/jswe.18.961 · Cited by 2 · see citing works

Investigation of formation of well-known AGEs precursors in cookies using an in vitro simulated gastrointestinal digestive system

Yaman, M., Demirci, M., ÇİNTESUN, E. E., Kurt, E., & Mızrak, Ö. F. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131451 · Cited by 20 · see citing works

Primary emissions of glyoxal and methylglyoxal from laboratory measurements of open biomass burningPreprint

Zarzana, K. J., Selimovic, V., Koss, A. R., et al. (2018) · doi:10.5194/acp-2018-521 · Cited by 7 · see citing works

Mechanism of Carbon Skeleton Formation of 2,3,5-Trimethylpyrazine via a Conversion Reaction between Methylglyoxal and Glyoxal

Jiang, W., Wang, X., Ma, Y., Du, M., Wu, C., & Xu, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08745 · Cited by 20 · see citing works

Comparison of Gas–Particle Partitioning of Glyoxal and Methylglyoxal in the Summertime Atmosphere at the Foot and Top of Mount Hua

Qi, W., Zhang, Y., Shen, M., et al. (2023) · Molecules · doi:10.3390/molecules28135276 · Cited by 10 · see citing works