Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis
Open accessAbstract
Background . The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown. We investigated whether serum MGO and sRAGE were related to the presence of disease activity in RA. Methods . 80 patients with RA and 30 control subjects were included in a cross-sectional study. The severity of RA was assessed using the disease activity score for 28 joints (DAS28). Serum MGO and sRAGE were measured by ELISA. Results . Serum MGO levels were significantly higher in patients with RA versus control subjects ( P < 0.001 ) and were increased in RA patients with higher disease activity versus RA patients with moderate disease activity ( P = 0.019 ). Serum sRAGE concentrations were significantly decreased in RA patients with higher disease activity versus RA patients with moderate disease activity and versus control subjects ( P = 0.004 ; P = 0.002 , resp.). A multiple logistic regression analysis demonstrated that MGO was independently associated with the presence of activity disease in RA (OR = 1.17, 95% CI: 1.02–1.31, P = 0.01 ). Conclusion . Serum MGO and sRAGE levels are inversely related to the activity of RA, and MGO is independently associated with a higher disease activity of RA.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Serum pentosidine levels were higher in RA patients (n = 80) than in controls (n = 30), measured by ELISA.
“| RA | Serum | Control subjects (n = 30) vs. RA patients (n = 80) | ELISA | Higher CML and pentosidine levels in RA patients | [237,238] |”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [238]
The Discussion says that CML and pentosidine were increased in RA, citing the authors’ earlier work. This paper studied 80 RA patients and 30 controls, but its Methods specify ELISA measurements of MGO and sRAGE, not pentosidine. It therefore does not establish that pentosidine was measured by ELISA or was higher in this particular cohort. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSerum CML levels were higher in RA patients (n = 80) than in controls (n = 30), measured by ELISA.
“| RA | Serum | Control subjects (n = 30) vs. RA patients (n = 80) | ELISA | Higher CML and pentosidine levels in RA patients | [237,238] |”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [238]
The Discussion reports that CML levels were increased in RA, citing the authors’ earlier work. But this paper’s Methods and Results describe ELISA measurements of MGO and sRAGE—not CML—in its 80 RA patients and 30 controls. It therefore does not establish the claimed CML measurement for that cohort. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310302 · Cited by 19,753 · see citing works
Scott, D. L., Wolfe, F., & Huizinga, T. W. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60826-4 · Cited by 3,019 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114002 · Cited by 1,039 · see citing works
The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
Goh, S.-Y., & Cooper, M. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1817 · Cited by 987 · see citing works
The biology of the receptor for advanced glycation end products and its ligands
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00087-2 · Cited by 687 · see citing works
Thornalley, P. J. (1996) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(95)02054-3 · Cited by 591 · see citing works
Raucci, A., Cugusi, S., Antonelli, A., Barabino, S. M. L., Monti, L. D., Bierhaus, A., Reiß, K., Säftig, P., & Bianchi, M. E. (2008) · The FASEB Journal · doi:10.1096/fj.08-109033 · Cited by 560 · see citing works
Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE
Basta, G., Lazzerini, G., Massaro, M., Simoncini, T., Tanganelli, P., Fu, C., Kislinger, T., Stern, D. M., Schmidt, A. M., & Caterina, R. D. (2002) · Circulation · doi:10.1161/hc0702.104183 · Cited by 544 · see citing works
Thornalley, P. J. (2008) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2008.23.1-2.125 · Cited by 482 · see citing works
Dicarbonyl Intermediates in the Maillard Reaction
THORNALLEY, P. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.014 · Cited by 459 · see citing works
Mortality in rheumatoid arthritis over the last fifty years: Systematic review and meta-analysis
Dadoun, S., Zeboulon, N., Combescure, C., Elhaï, M., Rozenberg, S., Gossec, L., & Fautrel, B. (2012) · Joint Bone Spine · doi:10.1016/j.jbspin.2012.02.005 · Cited by 293 · see citing works
Lapolla, A., Flamini, R., Vedova, A. D., Senesi, A., Reitano, R., Fedele, D., Basso, E., Seraglia, R., & Traldi, P. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.180 · Cited by 288 · see citing works
Evidence of Oxidative Stress in the Neocortex in Incidental Lewy Body Disease
Dalfó, E., Portero-Otín, M., Ayala, V., Martínez, A., Pamplona, R., & Ferrer, I. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000179050.54522.5a · Cited by 261 · see citing works
Geroldi, D., Falcone, C., & Emanuele, E. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706777585013 · Cited by 249 · see citing works
Prevalence of rheumatoid arthritis in France: 2001
Guillemin, F., Saraux, A., Guggenbuhl, P., Roux, C. H., Fardellone, P., Bihan, E. L., Cantagrel, A. G., Chary-Valckenaere, I., Euller-Ziegler, L., Flipo, R.-M., et al. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.029199 · Cited by 243 · see citing works
Ahmed, N., Ahmed, U., Thornalley, P. J., Häger, K., Fleischer, G., & Münch, G. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02864.x · Cited by 238 · see citing works
Hanford, L. E., Enghild, J. J., Valnickova, Z., Petersen, S. V., Schaefer, L. M., Schaefer, T. M., Reinhart, T. A., & Oury, T. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409782200 · Cited by 217 · see citing works
The Disease Activity Score and the EULAR Response Criteria
Fransen, J., & van Riel, P. L. C. M. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.10.001 · Cited by 207 · see citing works
Hanssen, N. M. J., Wouters, K., Huijberts, M. S., Gijbels, M. J., Sluimer, J. C., Scheijen, J. L. J. M., Heeneman, S., Biessen, E. A. L., Daemen, M. J. A. P., Brownlee, M., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht402 · Cited by 175 · see citing works
Pullerits, R., Bokarewa, M. I., Dahlberg, L., & Tarkowski, A. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1749 · Cited by 166 · see citing works
Shiraki, M., Kuroda, T., Tanaka, S., Saito, M., Fukunaga, M., & Nakamura, T. (2007) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0784-6 · Cited by 150 · see citing works
Vascular methylglyoxal metabolism and the development of hypertension
Wang, X., Desai, K. M., Chang, T., & Wu, L. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000173778.85233.1b · Cited by 131 · see citing works
Fosmark, D. S., Torjesen, P. A., Kilhovd, B. K., Berg, T. J., Sandvik, L., Hanssen, K. F., Agardh, C., & Agardh, E. (2006) · Metabolism · doi:10.1016/j.metabol.2005.08.017 · Cited by 122 · see citing works
FitzGerald, O., Soden, M., Yanni, G., Robinson, R., & Bresnihan, B. (1991) · Annals of the Rheumatic Diseases · doi:10.1136/ard.50.11.792 · Cited by 121 · see citing works
Minaur, N., Jacoby, R. K., Cosh, J., Taylor, G. J., & Rasker, J. J. (2004) · PubMed · Cited by 114 · see citing works
Gaens, K. H. J., Niessen, P. M. G., Rensen, S. S., Buurman, W. A., Greve, J. W. M., Driessen, A., Wolfs, M. G. M., Hofker, M. H., Bloemen, J. G., Dejong, C. H., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.028 · Cited by 109 · see citing works
Iguchi, T., & Ziff, M. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112312 · Cited by 106 · see citing works
Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients
Kerkeni, M., Saïdi, A., Bouzidi, H., Letaief, A., Yahia, S. B., & Hammami, M. (2012) · Diabetes and Vascular Disease Research · doi:10.1177/1479164112460253 · Cited by 93 · see citing works
Self-citationMethylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells
Yamawaki, H., Saito, K., Okada, M., & Hara, Y. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00252.2008 · Cited by 90 · see citing works
Kumar, A. (2002) · British journal of rheumatology · doi:10.1093/rheumatology/41.12.1457 · Cited by 83 · see citing works
van Eupen, M. G. A., Schram, M. T., Colhoun, H. M., Hanssen, N. M. J., Niessen, H. W. M., Tarnow, L., Parving, H. H., Rossing, P., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013) · Diabetologia · doi:10.1007/s00125-013-2919-8 · Cited by 60 · see citing works
Martens, H., Nienhuis, H. L. A., Gross, S., van der Steege, G., Brouwer, E., Berden, J., de Sévaux, R. G. L., Derksen, R. H. W. M., Voskuyl, A. E., Berger, S., et al. (2012) · Lupus · doi:10.1177/0961203312444495 · Cited by 56 · see citing works
Haddad, M., Knani, I., Bouzidi, H., Berriche, O., Hammami, M., & Kerkeni, M. (2016) · Disease Markers · doi:10.1155/2016/6248264 · Cited by 55 · see citing works
Self-citationKerkeni, M., Saïdi, A., Bouzidi, H., Yahya, S. B., & Hammami, M. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.07.006 · Cited by 50 · see citing works
Self-citationWu, L. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-137 · Cited by 48 · see citing works
Kerkeni, M., dos Santos-Weiss, I. C. R., Jaisson, S., Dandana, A., Addad, F., Gillery, P., & Hammami, M. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.07.008 · Cited by 47 · see citing works
Self-citationMa, C. ‐., Ma, J. ‐., Jiao, Y. ‐., Li, J. ‐., Wang, L., Yang, Q. ‐., You, L., Cui, B., Chen, Z., & Zhao, Y. (2012) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2012.02691.x · Cited by 43 · see citing works
Park, M.-J., Lee, S. H., Moon, S., Lee, J.-A., Lee, E., Kim, E., Park, J., Lee, J. J., Min, J., Kim, S. J., et al. (2016) · Scientific Reports · doi:10.1038/srep35933 · Cited by 36 · see citing works
Lin, C.-C., Chan, C.-M., Huang, Y., Hsu, S.-H., Huang, C., & Tsai, S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.060 · Cited by 33 · see citing works
Ishibashi, Y., Matsui, T., Nakamura, N., Sotokawauchi, A., Higashimoto, Y., & Yamagishi, S. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117715855 · Cited by 29 · see citing works
Knani, I., Bouzidi, H., Zrour, S., Bergaoui, N., Hammami, M., & Kerkeni, M. (2018) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563217733500 · Cited by 23 · see citing works
Self-citationSerum levels of soluble receptor for advanced glycation end products (sRAGE) in Takayasu's arteritis
Mahajan, N., Dhawan, V., Malik, S., & Jain, S. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.05.075 · Cited by 23 · see citing works
Comparative DFT Study To Determine if α-Oxoaldehydes are Precursors for Pentosidine Formation
Nasiri, R., Field, M. J., Zahedi, M., & Moosavi‐Movahedi, A. A. (2012) · The Journal of Physical Chemistry A · doi:10.1021/jp2104165 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases
Kehm, R., Baldensperger, T., Raupbach, J., & Höhn, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101901 · Cited by 348 · see citing works
Methylglyoxal and Its Adducts: Induction, Repair, and Association with Disease
Lai, S. W. T., Gonzalez, E. D. J. L., Zoukari, T., Ki, P., & Shuck, S. C. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00160 · Cited by 154 · see citing works
Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases
Yue, Q., Song, Y., Liu, Z., Zhang, L., Yang, L., & Li, J. (2022) · Molecules · doi:10.3390/molecules27154922 · Cited by 109 · see citing works
Sialylated Immunoglobulins for the Treatment of Immuno-Inflammatory Diseases
Markina, Y. V., Владимировна, Г. Е., Markin, A. M., Glanz, V. Y., Wu, W., Sobenin, I. A., & Orekhov, A. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155472 · Cited by 34 · see citing works
AGE/Non-AGE Glycation: An Important Event in Rheumatoid Arthritis Pathophysiology
Monu, M., Agnihotri, P., & Biswas, S. (2021) · Inflammation · doi:10.1007/s10753-021-01589-7 · Cited by 27 · see citing works
The Potential Influence of Advanced Glycation End Products and (s)RAGE in Rheumatic Diseases
Delrue, C., Speeckaert, R., Delanghe, J., & Speeckaert, M. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032894 · Cited by 22 · see citing works
Methylglyoxal suppresses microglia inflammatory response through NRF2-IκBζ pathway
Wei, S.-L., Yang, Y., Si, W.-Y., Zhou, Y., Li, T., Du, T., Zhang, P., Li, X.-L., Duan, R.-N., Duan, R., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102843 · Cited by 21 · see citing works
Cruz, N., Flores, M., Urquiaga, I., & Ávila, F. (2022) · Antioxidants · doi:10.3390/antiox11081513 · Cited by 15 · see citing works
Nakhjavani, M. R. J., Jafarpour, M., Ghorbanihaghjo, A., Azar, S. A., & Mahdavi, A. M. (2018) · Modern Rheumatology · doi:10.1080/14397595.2018.1551107 · Cited by 14 · see citing works
Tarannum, A., Arif, Z., Alam, K., & Moinuddin, M. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.127991 · Cited by 13 · see citing works
Michel, M. S., Heß, C., Kaps, L., Kremer, W. M., Hilscher, M., Galle, P. R., Moehler, M. H., Schattenberg, J. M., Wörns, M., Labenz, C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00119-7 · Cited by 13 · see citing works
Fallico, B., Grasso, A., & Arena, E. (2022) · Foods · doi:10.3390/foods11244066 · Cited by 6 · see citing works
Taïbi, N., Taïbi, A., Ameraoui, R., Aboumustapha, M., Hadjadj, M., Boutaiba, Z. M., Kaced, A., Djema, S., Al-Balas, Q. A., Jabal, G. A. A., et al. (2019) · Biochimie · doi:10.1016/j.biochi.2019.11.002 · Cited by 5 · see citing works
Tarannum, A., Arif, Z., Mustafa, M., Alam, K., Moinuddin, & Habib, S. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2283153 · Cited by 4 · see citing works
Low Serum Methylglyoxal Levels Correlate with Psoriasis Severity and Inflammatory Response Indices
Damasiewicz-Bodzek, A., Nowak, A. J., Maciejczyk, M., Waligóra, S., & Przywara-Chowaniec, B. (2025) · Pathophysiology · doi:10.3390/pathophysiology32010008 · Cited by 3 · see citing works
Nowak, A. J., Przywara-Chowaniec, B., Damasiewicz-Bodzek, A., Janoszka, B., Szumska, M., Waligóra, S., & Tyrpień-Golder, K. (2024) · Archives of Medical Science · doi:10.5114/aoms/176941 · Cited by 3 · see citing works
Tarannum, A., Arif, Z., Mustafa, M., Qais, F. A., Habib, S., Uddin, M., & Alam, K. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.2003865 · Cited by 3 · see citing works
Hussein, R., & Aboukhamis, I. (2023) · The Open Rheumatology Journal · doi:10.2174/0118743129257178231005074615 · Cited by 2 · see citing works
Delcheva, G. T., Stefanova, K. I., Stankova, T. R., & Maneva, A. I. (2024) · Journal of Medical Biochemistry · doi:10.5937/jomb0-44758 · Cited by 2 · see citing works
Delcheva, G. T., Stefanova, K. I., & Stankova, T. R. (2023) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2023.2256428 · Cited by 2 · see citing works
Onmaz, D. E., Sivrikaya, A., Abuşoğlu, S., Yi̇lmaz, S., Abuşoğlu, G., Tutkun, L., & Ünlü, A. (2020) · Harran Üniversitesi Tıp Fakültesi Dergisi · doi:10.35440/hutfd.672393 · Cited by 1 · see citing works
Knani, I., Bouzidi, H., Lecube, A., Gharbi, J., & Kerkeni, M. (2019) · Journal of Biology and Life Science · doi:10.5296/jbls.v10i2.14967
Self-citationMethylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues
Betting, F., Schlunck, G., Agostini, H. T., & Martin, G. (2022) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2022-0033
Pérez-Linaza, A., Díaz, S. P., Serrano-García, I., Yi, W., Lores, Á. G., González, J. M. A., Garcia-Cozar, F. J., Fernandez-Ponce, C., & Fernández-Cisnal, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1876035
Antiglycation approach in selected autoimmune diseases: Where do we stand?
Drygała, S., Cemaga, R., & Maciejczyk, M. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104410
- Authors
- Knani, I., Bouzidi, H., Zrour, S., Bergaoui, N., Hammami, M., & Kerkeni, M.
- Affiliations
- University of Monastir (TN)
- Laboratory of Biochemistry, University Hospital Tahar Sfar, Mahdia, Tunisia
- Hospital Fatuma Bourguiba Monastir (TN)
- Corresponding author
- Kerkeni, Mohsen
- Venue
- Disease Markers
- Publisher
- Wiley
- Published
- 2018
- Volume
- 2018
- Pages
- 1-6
- ISSN
- 0278-0240 (ISSN-L)
- 1875-8630
- PMC
- PMC5828101
- OpenAlex
- W2788508712
- Cited by
- 25
- References
- 43
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 1
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Disease Markers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Monastir
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Keywords
- methylglyoxal, rheumatoid arthritis, disease activity, soluble receptor for advanced glycation end products, serum biomarkers, DAS28, advanced glycation end products
- MeSH terms
- Adult, Arthritis, Rheumatoid, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Pyruvaldehyde, Severity of Illness Index, Biomarkers, Logistic Models, Glycation End Products, Advanced
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
