The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Are Food Advanced Glycation End Products Toxic in Biological Systems?
Abstract
Model food advanced glycation end products (AGEs) were prepared as glycated casein (GC) and glycated soy protein (GS) by the reaction of casein or soy protein with glucose at 50 degrees C, relative humidity 75% for seven days in a powder state. These browned proteins were used as materials for animal experiments. A mixture of 20% glycated proteins (GC:GS = 1:1) diet was fed to streptozotocin (STZ)-diabetic rats for 11 weeks. The results showed that: (1) fructoselysine was observed in the hepatic portal veins, arteries, and femoral veins of rats fed with glycated proteins after 2 h of feeding; (2) blood sugar of glycated protein-fed rats was lower than that of diabetic rats fed with intact protein, while HbA1C in blood and glucose in urine of both groups were similar; (3) lipid peroxidation status in serum, liver, and kidney of both groups was similar; (4) superoxide dismutase (SOD) and glutathione-S-transferase (GST) enzymatic activity in serum and liver of both groups were also similar; (5) there were no differences in degree of cataract formation and concentration of glucose, fructose, sorbitol, and lipid peroxide in the lenses of both groups. From the above results, it can be estimated that food AGEs are not toxic in biological systems, and reactive oxygen species increase in diabetic rats is not caused by glycated proteins but by other pathways.
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Energy restriction decreases low-grade inflammation.
“One diet-dependent but apparently quite non-specific way of decreasing low-grade inflammation is energy restriction (267) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [267]
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Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,651
Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,509
Uribarri, J., Peppa, Μ., Cai, W., Goldberg, T., Lu, M. M., Baliga, S. K., Vassalotti, J. A., & Vlassara, H. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00779-0 · Cited by 197
Antioxidant and Anti-Cataract Effects of Chlorella on Rats with Streptozotocin-Induced Diabetes
Shibata, S., NATORI, Y., NISHIHARA, T., Tomisaka, K., Matsumoto, K., Sansawa, H., & Nguyễn, V. C. (2003) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.49.334 · Cited by 96
Effect of Maillard reaction products on protein digestion. In vitro studies
Öste, R., Dahlqvist, A., Sjoestroem, H., Norén, O., & Miller, R. (1986) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00068a051 · Cited by 64
Identification of N.epsilon.-carboxymethyllysine: a new Maillard reaction product in rat urine
Liardon, R., Weck-Gaudard, D. D., PHILIPPOSSIAN, G., & Finot, P. A. (1987) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00075a035 · Cited by 60
Metabolism and Physiological Effects of Maillard Reaction Products (MRP)
Finot, P. A. (1990) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9127-1_28 · Cited by 27
Antioxidative Effect of Maillard Reaction Products in Vivo
Chuyên, N. V., Utsunomiya, N., Hidaka, A., & Kato, H. (1990) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9127-1_31 · Cited by 10
Balance Studies with Glycosylated Proteins on Human Volunteers
Erbersdobler, H. F., Buhl, K., & Klusmann, U. (1990) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9127-1_29 · Cited by 4
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Research works printed but not linked: 2
- Habig W.H., 1974, Glutathione‐S‐transferase: the first enzymatic step in mercapturic acid formation, J. Biol. Chem., 249, 7130
- Imajo T., 1977, Improved measurement method of superoxide dismutase, Igaku no Ayumi, 101, 496
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
“a non-modified protein to a basal animal diet and fed to rats for 11 weeks was in fact unable to demonstrate any adverse health effects of the AGE-supplemented diet((548)).”
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751
Baking, Ageing, Diabetes: A Short History of the Maillard Reaction
Hellwig, M., & Henle, T. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308808 · Cited by 477
Nguyen, C. V. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600144 · Cited by 219
Delgado‐Andrade, C., & Fogliano, V. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012441 · Cited by 177
Blocked Lysine in Dairy Products: Formation, Occurrence, Analysis, and Nutritional Implications
Mehta, B. M., & Deeth, H. C. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12178 · Cited by 143
Health effects of dietary Maillard reaction products: the results of ICARE and other studies
Tessier, F. J., & Birlouez‐Aragon, I. (2010) · Amino Acids · doi:10.1007/s00726-010-0776-z · Cited by 136
Effect of Dietary Advanced Glycation End Products on Mouse Liver
Patel, R. A., Baker, S. S., Liu, W., Desai, S. S., Alkhouri, R. H., Kozielski, R., Mastrandrea, L. D., Sarfraz, A., Cai, W., Vlassara, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035143 · Cited by 102
“Chuyen and colleagues examined the effect of dietary AGE on the liver enzymes superoxide dismutase and glutathione-Stransferase in a rat model [39].”
BackgroundFructose-mediated stress signaling in the liver: implications for hepatic insulin resistance
Wei, Y., Wang, D., Topczewski, F., & Pagliassotti, M. J. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.03.013 · Cited by 100
“In addition, recent studies suggest that the relationship between aldehydes, stress signaling and cytotoxicity is highly complex [106,107].”
BackgroundTeodorowicz, M., Hendriks, W. H., Wichers, H. J., & Savelkoul, H. F. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02088 · Cited by 59
“In laboratory animals and humans, consumption of large quantities of such AGEs were shown to induce pathological alterations and therefore AGEs are increasingly subject of safety studies (18).”
BackgroundLiu, X., Zheng, L., Zhang, R., Liu, G., Xiao, S., Qiao, X., Wu, Y., & Gong, Z. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.02.013 · Cited by 43
Gerrard, J. A. (2006) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2005.11.011 · Cited by 36
Short-term effects of dietary advanced glycation end products in rats
Poulsen, M. W., Andersen, J. M., Hedegaard, R. V., Madsen, A. N., Krath, B. N., Monošík, R., Bak, M. J., Nielsen, J., Holst, B., Skibsted, L. H., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004833 · Cited by 35
“Similar to our results, a long-term study in diabetic rats found no adverse effects of dietary AGE on oxidative stress((29)).”
BackgroundMethodResultHighly Heated Food Rich in Maillard Reaction Products Limit an Experimental Colitis in Mice
Anton, P. M., Craus, A., Niquet-Léridon, C., & Tessier, F. J. (2012) · Food & Function · doi:10.1039/c2fo30045a · Cited by 24
Glycated proteins in nutrition: Friend or foe?
Šebeková, K., & Šebeková, K. B. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.11.012 · Cited by 23
Exceptionally versatile – arginine in bacterial post-translational protein modifications
Lassak, J., Koller, F., Krafczyk, R., & Volkwein, W. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0182 · Cited by 22
Mehta, B. M. (2015) · Springer eBooks · doi:10.1007/978-3-642-36605-5_1 · Cited by 18
Backen, Altern, Diabetes: eine kurze Geschichte der Maillard‐Reaktion
Hellwig, M., & Henle, T. (2014) · Angewandte Chemie · doi:10.1002/ange.201308808 · Cited by 18
Dubois, C., Litke, R. R., Rianha, S., Paul-Constant, C., Lo‐Guidice, J., Taront, S., Tessier, F. J., Boulanger, É., & Fradin, C. (2021) · Nutrients · doi:10.3390/nu13124398 · Cited by 19
Acute and sub-chronic toxicity of glucose–cysteine Maillard reaction products in Sprague-Dawley rats
Li, Y., Su, L., Li, F., Wang, C., Yuan, D., Chen, J., Tan, L., Jin, Z., & Ma, W. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.03.021 · Cited by 17
Nutrient and Maillard reaction product concentrations of commercially available pet foods and treats
Oba, P. M., Hwisa, N. T., Huang, X., Cadwallader, K. R., & Swanson, K. S. (2022) · Journal of Animal Science · doi:10.1093/jas/skac305 · Cited by 14
Studies on mechanism of free Nε‐(carboxymethyl)lysine‐induced toxic injury in mice
Wang, Y., Xu, H., Liu, X., Liu, L., Wu, Y., & Gong, Z. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22322 · Cited by 10
Lhommeau, I., Douillard, S., Bigot‐Corbel, E., Benoit, I., Krempf, M., & Patrice, T. (2011) · Metabolism · doi:10.1016/j.metabol.2011.02.004 · Cited by 7
“[39] Chuyen NV, Arai H, Nakanishi T, et al.”
BackgroundResultMehta, B. M. (2014) · Springer eBooks · doi:10.1007/978-3-642-41609-5_1-1 · Cited by 6
“Therefore, the safety of food AGEs is a problem of concern (Chuyen et al. 2005; Sebekova and Somoza 2007).”
BackgroundTayşi, S., Okumuş, S., Ezirmik, S., Uzun, N., Yılmaz, A., Akyüz, M., Tekelioğlu, Ü. Y., Dirier, A., & Al, B. (2011) · Cited by 1
Maillard-Reaktionsprodukte in Lebensmitteln: Mögliche gesundheitliche Bedeutung
Maslo, R. (2006) · Journal of Consumer Protection and Food Safety · doi:10.1007/s00003-006-0021-6 · Cited by 1
“Chuyen et al. (2005) konnten bei diabetischen Nagern mit und ohne AGE-reiche Ernährung in Form von glykiertem Casein und Sojaprotein keine Unterschiede feststellen beim HbA1c, Lipidperoxidationsstatus im Serum, der Leber und den Nieren, der Aktivität bestimmter antioxidativer Enzyme im Serum und…”
BackgroundThe Modulatory Function of Natural Bioactive Compounds in Foodborne Hazard-Induced Immune Imbalance
Wang, J., Zhang, N., Wang, M., Jin, D., Shi, J., Wang, J., Li, N., Yang, W., Chen, X., & Gong, P. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2587829
Metadata
- Authors
- CHUYEN, N. V., ARAI, H., NAKANISHI, T., & UTSUNOMIYA, N.
- Affiliations
- Japan Women's University (JP)
- Kyoritsu Women's University (JP)
- Corresponding author
- UTSUNOMIYA, N.
- ORCID
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2005-06
- Volume
- 1043
- Issue
- 1
- Pages
- 467-473
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1998753026
- Cited by
- 27
- References
- 9
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- advanced glycation end products, glycated proteins, casein, soy protein, fructoselysine, streptozotocin-induced diabetes, lipid peroxidation, superoxide dismutase, glutathione S-transferase, cataract, reactive oxygen species, blood glucose, HbA1c, dietary toxicity
- MeSH terms
- Animals, Animal Feed, Diabetes Mellitus, Experimental, Glycosylation, Lysine, Male, Portal System, Maillard Reaction, Glycation End Products, Advanced, Rats, Wistar, Soybean Proteins, Rats
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