Dietary advanced glycation endproducts (AGEs) and their health effects – PRO
Abstract
Thermal processing of food results in the formation of various novel compounds, among others advanced glycation endproducts (AGEs). AGEs result from nonenzymatic glycation reactions between reducing sugars and free amino groups of proteins, peptides, or amino acids. Due to their potential noxious effects, alimentary AGEs are also called glycotoxins. This review provides a summary of the available evidence on the health effects of exaggerated intake of thermally treated food. Data from experimental studies in rodents and from clinical studies in healthy volunteers and in patients suffering from selected diseases in which AGEs are of pathogenetic importance (diabetes, chronic renal failure) are summarized. It is concluded that, an exaggerated intake of thermally processed foods may exert in vivo diabetogenic and nephrotoxic effects, induce low‐grade inflammation, enhance oxidative stress, and promote atherosclerosis. Introduction: http://dx.doi.org/10.1002/mnfr.200700067 Contra arguments: http://dx.doi.org/10.1002/mnfr.200600304
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Cooking meat (chicken, pork, or beef) by boiling or stewing reduces AGE contents to one-half of that prepared by broiling.
“For example, cooking meat (e.g., chicken, pork, or beef) by boiling or stewing can reduce the AGE contents to one-half of that prepared by broiling1,271.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [271]
Cooking methods regulate the levels of AGE formation, with the order of effect being oven-frying > frying > broiling > roasting > boiling/poaching/stewing/steaming.
“As mentioned above, cooking methods can play a critical role in regulating the levels of AGE formation, with effects ranging from those caused by oven-frying > frying > broiling > roasting > boiling/poaching/stewing/steaming.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [271]
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- Authors
- Šebeková, K., & Somoza, V.
- ORCID
- Somoza, Veronika
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2007-09
- Volume
- 51
- Issue
- 9
- Pages
- 1079-1084
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2100897974
- Cited by
- 148
- References
- 19
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 11 · 2013: 14 · 2012: 14
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- advanced glycation end products, thermal food processing, glycation, dietary AGEs, diabetes mellitus, chronic kidney disease, nephrotoxicity, low-grade inflammation, oxidative stress, atherosclerosis, health effects
- MeSH terms
- Animals, Diabetes Mellitus, Diet, Dietary Proteins, Food Handling, Hot Temperature, Humans, Insulin Resistance, Glycation End Products, Advanced, Mice, Rats, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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