Cited by 148Advanced Glycation End Products researchPotato Plant ResearchDiet, Metabolism, and Disease

Dietary advanced glycation endproducts (AGEs) and their health effects – PRO

Šebeková, Katarína, Somoza, Veronika·2007·Molecular Nutrition & Food Research

Abstract

Thermal processing of food results in the formation of various novel compounds, among others advanced glycation endproducts (AGEs). AGEs result from nonenzymatic glycation reactions between reducing sugars and free amino groups of proteins, peptides, or amino acids. Due to their potential noxious effects, alimentary AGEs are also called glycotoxins. This review provides a summary of the available evidence on the health effects of exaggerated intake of thermally treated food. Data from experimental studies in rodents and from clinical studies in healthy volunteers and in patients suffering from selected diseases in which AGEs are of pathogenetic importance (diabetes, chronic renal failure) are summarized. It is concluded that, an exaggerated intake of thermally processed foods may exert in vivo diabetogenic and nephrotoxic effects, induce low‐grade inflammation, enhance oxidative stress, and promote atherosclerosis. Introduction: http://dx.doi.org/10.1002/mnfr.200700067 Contra arguments: http://dx.doi.org/10.1002/mnfr.200600304

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Crossref · 10.1002/mnfr.200700035

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Authors
Šebeková, K., & Somoza, V.
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2007-09
Volume
51
Issue
9
Pages
1079-1084
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2100897974
Cited by
148
References
19
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 11 · 2013: 14 · 2012: 14
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
advanced glycation end products, thermal food processing, glycation, dietary AGEs, diabetes mellitus, chronic kidney disease, nephrotoxicity, low-grade inflammation, oxidative stress, atherosclerosis, health effects
MeSH terms
Animals, Diabetes Mellitus, Diet, Dietary Proteins, Food Handling, Hot Temperature, Humans, Insulin Resistance, Glycation End Products, Advanced, Mice, Rats, Renal Insufficiency, Chronic

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