Studies on Absorption and Elimination of Dietary Maillard Reaction Products
Abstract
A bstract: A nine‐day dietary study involving 18 healthy volunteers was performed in order to investigate the influence of nutrition on the urinary excretion of the Maillard reaction products (MRPs) fructoselysine, pyrraline, and pentosidine. From day two through day eight, most types of Maillard product‐containing food had to be avoided. On day five, participants were divided into four groups, three of them receiving a test meal (pretzel sticks, brewed coffee, or custard) containing defined amounts of MRPs. The fourth group served as a control. Urine samples taken over a 24‐h period were analyzed for MRPs using chromatographic means. As a result of the MRP‐free diet, urinary excretion of free pyrraline and fructoselysine, which was calculated from furosine analysis, were lowered about 90%. Excretion of pentosidine decreased about 40%. Consumption of pretzel sticks and coffee on day five resulted in increased amounts of pyrraline and pentosidine in urine samples on days five to seven. Related to the supplied amounts of pyrraline, about 50% were recovered in the urine samples after ingestion of the pretzel sticks. For pentosidine, 60% of the ingested free derivative from coffee brew and 2% of the peptide‐bound amino acid ingested with the bakery product were recovered in the urine samples, indicating a better bioavailability for free pentosidine compared to the protein‐bound form. For peptide‐bound Amadori products, no influence on the excretion was observed after ingestion of the test foods, indicating degradation in the intestine or plasma to yet‐unknown metabolites. In conclusion, differences concerning the excretion rate of individual MRPs point to individual resorption and metabolic pathways. These results are of importance for the discussion of a possible (patho)physiological role of dietary advanced glycation end products (AGEs).
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Pentosidine absorption is greater from brewed coffee (free-form) than from bakery products where pentosidine occurs as a protein-bound AGE.
“The same is true for the AGE pentosidine the absorption of which is greater when derived from brewed coffee (free-form) compared to bakery products where pentosidine occurs as a protein-bound AGE.[37]”
From The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction (2021) · cites this paper as [37]
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- Authors
- FÖRSTER, A., KÜHNE, Y., & HENLE, T. O.
- Affiliations
- Technische Universität Dresden (DE)
- Corresponding author
- HENLE, T.OMAS
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2005-06
- Volume
- 1043
- Issue
- 1
- Pages
- 474-481
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2004771015
- Cited by
- 180
- References
- 18
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 16 · 2021: 7 · 2020: 10 · 2019: 15 · 2018: 13 · 2017: 5 · 2016: 8 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 7
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- Maillard reaction products, advanced glycation end products, fructoselysine, pyrraline, pentosidine, urinary excretion, elimination diet, bioavailability, coffee, furosine, Amadori products
- MeSH terms
- Adult, Diet, Female, Humans, Intestinal Absorption, Lysine, Male, Reference Values, Maillard Reaction
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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