Cited by 230Advanced Glycation End Products researchGut microbiota and healthPotato Plant Research

Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology

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Snelson, Matthew, Coughlan, Melinda·2019·Nutrients

Abstract

The formation of advanced glycation end products (AGEs) in foods is accelerated with heat treatment, particularly within foods that are cooked at high temperatures for long periods of time using dry heat. The modern processed diet is replete with AGEs, and excessive AGE consumption is thought to be associated with a number of negative health effects. Many dietary AGEs have high molecular weight and are not absorbed in the intestine, and instead pass through to the colon, where they are available for metabolism by the colonic bacteria. Recent studies have been conducted to explore the effects of AGEs on the composition of the gut microbiota as well as the production of beneficial microbial metabolites, in particular, short-chain fatty acids. However, there is conflicting evidence regarding the impact of dietary AGEs on gut microbiota reshaping, which may be due, in part, to the formation of alternate compounds during the thermal treatment of foods. This review summarises the current evidence regarding dietary sources of AGEs, their gastrointestinal absorption and role in gut microbiota reshaping, provides a brief overview of the health implications of dietary AGEs and highlights knowledge gaps and avenues for future study.

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  • Around 10-30% of CML, CEL, pentosidine, and pyrraline are absorbed depending on their chemical characteristics.

    “Nonetheless, the rate and the mechanisms of absorption of CLM, CEL, pentosidine, and pyrraline have been reported with around 10-30% being absorbed depending on their chemical characteristics.[28][29][30]”

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Authors
Snelson, M., & Coughlan, M.
Affiliations
Monash University (AU)
Corresponding author
Snelson, Matthew
Venue
Nutrients
Publisher
MDPI AG
Published
2019-01-22
Volume
11
Issue
2
Pages
215
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2912418879
Cited by
230
References
93
Citations by year
2026: 16 · 2025: 24 · 2024: 35 · 2023: 29 · 2022: 39 · 2021: 33 · 2020: 36 · 2019: 16 · 2018: 2
FWCI
4.04
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Monash University Research Portal (Monash University) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Australian Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
Keywords
advanced glycation end products, gut microbiota, colonic metabolism, short-chain fatty acids, dietary AGEs, heat-treated foods, microbial metabolites, gastrointestinal absorption
MeSH terms
Gastrointestinal Microbiome, Animals, Diet, Digestion, Food, Humans, Glycation End Products, Advanced

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