Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
Open accessAbstract
The formation of advanced glycation end products (AGEs) in foods is accelerated with heat treatment, particularly within foods that are cooked at high temperatures for long periods of time using dry heat. The modern processed diet is replete with AGEs, and excessive AGE consumption is thought to be associated with a number of negative health effects. Many dietary AGEs have high molecular weight and are not absorbed in the intestine, and instead pass through to the colon, where they are available for metabolism by the colonic bacteria. Recent studies have been conducted to explore the effects of AGEs on the composition of the gut microbiota as well as the production of beneficial microbial metabolites, in particular, short-chain fatty acids. However, there is conflicting evidence regarding the impact of dietary AGEs on gut microbiota reshaping, which may be due, in part, to the formation of alternate compounds during the thermal treatment of foods. This review summarises the current evidence regarding dietary sources of AGEs, their gastrointestinal absorption and role in gut microbiota reshaping, provides a brief overview of the health implications of dietary AGEs and highlights knowledge gaps and avenues for future study.
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Around 10-30% of CML, CEL, pentosidine, and pyrraline are absorbed depending on their chemical characteristics.
“Nonetheless, the rate and the mechanisms of absorption of CLM, CEL, pentosidine, and pyrraline have been reported with around 10-30% being absorbed depending on their chemical characteristics.[28][29][30]”
From The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction (2021) · cites this paper as [29]
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Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives
Khalid, M., Petroianu, G. A., & Adem, A. (2022) · Biomolecules · doi:10.3390/biom12040542 · Cited by 931 · see citing works
Twarda‐Clapa, A., Olczak, A., Białkowska, A. M., & Koziołkiewicz, M. (2022) · Cells · doi:10.3390/cells11081312 · Cited by 792 · see citing works
Molecular mechanisms and therapeutic targets for diabetic kidney disease
Tuttle, K. R., Agarwal, R., Alpers, C. E., Bakris, G. L., Brosius, F. C., Kolkhof, P., & Uribarri, J. (2022) · Kidney International · doi:10.1016/j.kint.2022.05.012 · Cited by 694 · see citing works
Inflammation and Premature Ageing in Chronic Kidney Disease
Ebert, T., Pawelzik, S., Witasp, A., Arefin, S., Hobson, S., Kublickiene, K. R., Shiels, P. G., Bäck, M., & Stenvinkel, P. (2020) · Toxins · doi:10.3390/toxins12040227 · Cited by 242 · see citing works
AGE/RAGE in diabetic kidney disease and ageing kidney
Wu, X., Zhang, D., Wang, Y., Tan, Y.-Q., Yu, X.-Y., & Zhao, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.025 · Cited by 234 · see citing works
Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health
Gill, V., Kumar, V., Singh, K., Kumar, A., & Kim, J.-J. (2019) · Biomolecules · doi:10.3390/biom9120888 · Cited by 232 · see citing works
Zhang, Q., Wang, Y., & Fu, L. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12593 · Cited by 232 · see citing works
The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194 · see citing works
Gut-Derived Protein-Bound Uremic Toxins
Graboski, A. L., & Redinbo, M. R. (2020) · Toxins · doi:10.3390/toxins12090590 · Cited by 137 · see citing works
Bettiga, A., Fiorio, F., Di Marco, F., Trevisani, F., Romani, A., Porrini, E., Salonia, A., Montorsi, F., & Vago, R. (2019) · Nutrients · doi:10.3390/nu11081748 · Cited by 127 · see citing works
Fotheringham, A. K., Gallo, L. A., Borg, D. J., & Forbes, J. M. (2022) · Nutrients · doi:10.3390/nu14132675 · Cited by 112 · see citing works
Zhao, D., Sheng, B., Wu, Y., Li, H., Xu, D., Nian, Y., Mao, S., Li, C., Xu, X., & Zhou, G. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05891 · Cited by 107 · see citing works
Dietary AGEs as Exogenous Boosters of Inflammation
Garay‐Sevilla, M. E., Armando Rojas, R., Portero‐Otín, M., & Uribarri, J. (2021) · Nutrients · doi:10.3390/nu13082802 · Cited by 104 · see citing works
Oxidative stress in metabolic diseases: current scenario and therapeutic relevance
Raut, S. K., & Khullar, M. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04496-z · Cited by 100 · see citing works
Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors
Zheng, W., Li, H., Go, Y., Chan, X. H. F., Huang, Q., & Wu, J. (2022) · Nutrients · doi:10.3390/nu14214588 · Cited by 97 · see citing works
Advanced glycation end products in food and their effects on intestinal tract
Nie, C., Li, Y., Qian, H., Ying, H., & Wang, L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1863904 · Cited by 96 · see citing works
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Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging
Barbu, E., Popescu, M.-R., Popescu, A.-C., & Balanescu, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020963 · Cited by 91 · see citing works
The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease
Huang, Y., Xin, W., Xiong, J., Yao, M., Zhang, B., & Zhao, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.837500 · Cited by 92 · see citing works
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The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
Jennison, E., & Byrne, C. D. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0129 · Cited by 89 · see citing works
Effect of chitooligosaccharides on human gut microbiota and antiglycation
Liu, W., Li, X., Zhao, Z., Pi, X., Meng, Y., Fei, D., Liu, D., & Wang, X. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116413 · Cited by 86 · see citing works
Eroglu, E. I., Ayaz, A., & Büyüktuncer, Z. (2019) · Nutrition Research Reviews · doi:10.1017/s0954422419000209 · Cited by 90 · see citing works
The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies
Wang, L., Jiang, Y., & Zhao, C. (2024) · Experimental Dermatology · doi:10.1111/exd.15065 · Cited by 85 · see citing works
Accumulation of Advanced Glycation End-Products in the Body and Dietary Habits
Zawada, A. E., Machowiak, A., Rychter, A. M., Ratajczak, A. E., Szymczak‐Tomczak, A., Dobrowolska, A., & Krela‐Kaźmierczak, I. (2022) · Nutrients · doi:10.3390/nu14193982 · Cited by 87 · see citing works
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The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders
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The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease
Sharma, A., Kaur, S., Sarkar, M. S., Sarin, B., & Changotra, H. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08815-4 · Cited by 71 · see citing works
Skin AGEs and diabetic neuropathy
Papachristou, S., Pafili, K., & Παπάνας, Ν. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00697-7 · Cited by 67 · see citing works
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Metaproteomics of the human gut microbiota: Challenges and contributions to other OMICS
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The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes
Snelson, M., Lucut, E., & Coughlan, M. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031766 · Cited by 60 · see citing works
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The association between dietary and skin advanced glycation end products: the Rotterdam Study
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Dietary Antioxidant Capacity and Skin Photoaging: A 15-Year Longitudinal Study
Hughes, M. C. B., Williams, G. M., Pageon, H., Fourtanier, A. M., & Green, A. C. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.06.026 · Cited by 47 · see citing works
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Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging
Portero‐Otín, M., de la Maza, M. P., & Uribarri, J. (2023) · Cells · doi:10.3390/cells12131684 · Cited by 45 · see citing works
Advanced Glycation End Products and Inflammation in Type 1 Diabetes Development
Du, C., Whiddett, R. O., Buckle, I., Chen, C., Forbes, J. M., & Fotheringham, A. K. (2022) · Cells · doi:10.3390/cells11213503 · Cited by 47 · see citing works
Glycation of LDL: AGEs, impact on lipoprotein function, and involvement in atherosclerosis
Poznyak, A. V., Sukhorukov, V. N., Surkova, R., Orekhov, N. A., & Orekhov, A. N. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1094188 · Cited by 43 · see citing works
Vijaykrishnaraj, M., & Wang, K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112336 · Cited by 42 · see citing works
Bacterial processing of glucose modulates C. elegans lifespan and healthspan
Kingsley, S. F., Seo, Y., Allen, C., Ghanta, K. S., Finkel, S. E., & Tissenbaum, H. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-85046-3 · Cited by 37 · see citing works
Wang, S., Zheng, X., Zheng, L., Yang, Y., Xiao, D., Zhang, H., Ai, B., & Sheng, Z. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136583 · Cited by 41 · see citing works
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The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD
Reynaert, N. L., Vanfleteren, L. E. G. W., & Perkins, T. N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103366 · Cited by 39 · see citing works
Designing healthier and more sustainable ultraprocessed foods
McClements, D. J. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13331 · Cited by 43 · see citing works
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The antiglycative effect of apple flowers in fructose/glucose-BSA models and cookies
Gao, J., Sun, Y., Li, L., Zhou, Q., & Wang, M. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127170 · Cited by 39 · see citing works
Chen, Y., & Guo, T. L. (2021) · Journal of Immunotoxicology · doi:10.1080/1547691x.2021.1959677 · Cited by 40 · see citing works
Barley Melanoidins: Key Dietary Compounds With Potential Health Benefits
Sharma, J. K., Sihmar, M., Santal, A. R., Prager, L., Carbonero, F. G., & Singh, N. P. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.708194 · Cited by 38 · see citing works
Taguchi, K., Fukami, K., Elias, B. C., & Brooks, C. R. (2021) · Toxins · doi:10.3390/toxins13050361 · Cited by 39 · see citing works
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Advanced Glycation End Products and Health: A Systematic Review
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Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract
van der Lugt, T., Opperhuizen, A., Bast, A., & Vrolijk, M. F. (2020) · Nutrients · doi:10.3390/nu12092814 · Cited by 35 · see citing works
Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease
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Modulating Digestibility and Mitigating Beany Flavor of Pea Protein
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Dietary N‐epsilon‐carboxymethyllysine as for a major glycotoxin in foods: A review
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Dietary advanced glycation end products and cancer risk in Japan: From the Takayama study
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Derivation and elimination of uremic toxins from kidney-gut axis
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Aging and “Age-Related” Diseases - What Is the Relation?
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Target Metabolites to Slow Down Progression of Amyotrophic Lateral Sclerosis in Mice
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Elucidating the structure of melanoidins derived from biscuits: A preliminary study
Patrignani, M., Forte, L. D. S. G., Rufián‐Henares, J. Á., & Conforti, P. A. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136082 · Cited by 17 · see citing works
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Thermal processed Crassostrea gigas impact the mouse gut microbiota
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Does Gut Microbial Methylglyoxal Metabolism Impact Human Physiology?
Akinrimisi, O. I., Maasen, K., Scheijen, J. L. J. M., Nemet, I., Nieuwdorp, M., Schalkwijk, C. G., & Hanssen, N. M. J. (2025) · Antioxidants · doi:10.3390/antiox14070763 · Cited by 14 · see citing works
- Authors
- Snelson, M., & Coughlan, M.
- Affiliations
- Monash University (AU)
- Corresponding author
- Snelson, Matthew
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-01-22
- Volume
- 11
- Issue
- 2
- Pages
- 215
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6413015
- OpenAlex
- W2912418879
- Cited by
- 230
- References
- 93
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 35 · 2023: 29 · 2022: 39 · 2021: 33 · 2020: 36 · 2019: 16 · 2018: 2
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Australian Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Keywords
- advanced glycation end products, gut microbiota, colonic metabolism, short-chain fatty acids, dietary AGEs, heat-treated foods, microbial metabolites, gastrointestinal absorption
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diet, Digestion, Food, Humans, Glycation End Products, Advanced
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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