Utero‐Tubal Sperm Transport and Its Impairment in Endometriosis and Adenomyosis
Abstract
Abstract: The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, sperm is transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80–90% of subjects with adenomyosis and our data clearly indicate that sperm transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in sperm transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
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Uterine function of rapid and directed sperm transport into the dominant tube is dysfunctional in women with endometriosis and is characterized by hyper- and dysperistalsis.
“The uterine function of rapid and directed sperm transport into the ‘dominant tube’ is dysfunctional in women with endometriosis and is characterized by hyper- and dysperistalsis [27–32].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [32]
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- Authors
- KISSLER, S., ZANGOS, S., WIEGRATZ, I., KOHL, J., RODY, A., GAETJE, R., DOEBERT, N., WILDT, L., KUNZ, G., LEYENDECKER, G., & KAUFMANN, M.
- Affiliations
- Goethe University Frankfurt (DE)
- Innsbruck Medical University (AT)
- St.-Johannes-Hospital Dortmund (DE)
- Corresponding author
- KISSLER, STEFAN
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2007-04
- Volume
- 1101
- Issue
- 1
- Pages
- 38-48
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2091245029
- Cited by
- 89
- References
- 26
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 1 · 2013: 6 · 2012: 1
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, adenomyosis, uterine contractility, female infertility, spontaneous pregnancy rate, dysmenorrhea
- MeSH terms
- Endometriosis, Fallopian Tubes, Female, Humans, Male, Myometrium, Sperm Transport, Spermatozoa, Uterus
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