Age‐Dependent Effects on Functional Aspects in Human Satellite Cells
Open accessAbstract
Abstract: In humans aging is a complex process that determines many physical and metabolic alterations correlated to the accumulation of oxidative damage in different tissues. Sarcopenia is an age‐related nonpathological condition that includes a progressive loss of mass and strength in skeletal muscle, associated with a decline in the fibers' functional capability. This condition could be correlated to abnormal reactive oxygen species (ROS) accumulation with consequent fiber oxidative damage. This complex situation is not only evident in mature muscle fibers but also in muscle resident satellite cells (involved in fiber damage repairing) in which some functional parameters, at least for that concerns the Ca 2+ homeostasis, seem to be modified. In fact, our data show that there is an age‐dependent increase of lipid peroxidation, in cultured myotubes (differentiated and fused satellite cells) after 7 days of in vitro differentiation. In these substrates also the capacity of these cells to produce Ca 2+ transient in response to various stimuli (ATP, caffeine, nicotine, KCl) is, sometimes, drastically modified. In particular, the presence of an age‐dependent defective status of excitation–contraction (EC) coupling apparatus is supported by a single cell Ca 2+ analysis obtained from myotubes (derived from aged muscles) in the presence of 40 mM caffeine or 40 mM KCl. The alkaloid presence induces a complete emptying of ryanodine‐dependent calcium stores indicating a probable integrity both of SR‐terminal cisternae and/or the specific Ca 2+ channel known as RyR1. However, if a sarcolemmal depolarization is induced by the addition of 40 mM KCl in the experimental medium then Ca 2+ release RyR1‐dependent can be observed only if Ca 2+ is present in the experimental solution. These results suggest that the EC uncoupling status could be due to the alteration of the interaction between RyR and DHPR. The two receptors are present and functionally active in myotubes from aged donors but they are probably still not in the right localization. These results suggest that during donor's life the satellite cells undergo an aging process similar to the one observed in skeletal muscle tissue, even if they are in a quiescence status for most of the time.
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Increased reactive oxygen species levels and decreased antioxidant activity in satellite cells could dysregulate basal autophagy and impair the removal of misfolded proteins, thereby affecting satellite cell homeostasis.
“The increased ROS levels and decreased antioxidant activity in satellite cells [121, 122] could dysregulate basal autophagy (essential to maintaining the quiescent state of stem cells) and impair the removal of misfolded proteins, thereby affecting satellite cell homeostasis [87, 116].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [121]
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Self-citation
- Authors
- BECCAFICO, S., PUGLIELLI, C., PIETRANGELO, T., BELLOMO, R., FANÒ, G., & FULLE, S.
- Affiliations
- University of Chieti-Pescara (IT)
- Corresponding author
- FULLE, S.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2007-04
- Volume
- 1100
- Issue
- 1
- Pages
- 345-352
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1972882792
- Cited by
- 61
- References
- 16
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- satellite cells, aging, sarcopenia, skeletal muscle, excitation-contraction coupling, ryanodine receptor, calcium homeostasis, lipid peroxidation, reactive oxygen species, oxidative damage, myotubes, caffeine-induced calcium release, sarcoplasmic reticulum
- MeSH terms
- Adenosine Triphosphate, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Caffeine, Calcium, Female, Humans, Male, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Satellite Cells, Skeletal Muscle
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