The Role of NFAT in Osteoclast Formation

Osteoclast differentiation and activation

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

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Genetic regulation of osteoclast development and function

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RANK is essential for osteoclast and lymph node development.

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c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

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Skeletal remodeling in health and disease

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TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells

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Requirement for NF-κB in osteoclast and B-cell development

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Osteopetrosis in mice lacking NF-κB1 and NF-κB2

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DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells

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Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

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Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

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Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

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The transcription factor NF-ATc is essential for cardiac valve formation

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Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

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v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation

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Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

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The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

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Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1

Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H., Tsujimoto, M., Katayama, S., Hisatake, K., & Nogi, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408795200 · Cited by 436

Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator

Ishida, N., Hayashi, K., Hoshijima, M., Ogawa, T., Koga, S., Miyatake, Y., Kumegawa, M., Kimura, T., & Takeya, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205063200 · Cited by 377

Calcineurin/NFAT Signaling in Osteoblasts Regulates Bone Mass

Winslow, M. M., Pan, M., Starbuck, M. W., Gallo, E. M., Deng, L., Karsenty, G., & Crabtree, G. R. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.006 · Cited by 355

Regulation of osteoclast differentiation and function by the CaMK-CREB pathway

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A Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation

Kim, N., Takami, M., Rho, J., Josien, R., & Choi, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011681 · Cited by 278

Nuclear Factor of Activated T Cells c1 Induces Osteoclast-associated Receptor Gene Expression during Tumor Necrosis Factor-related Activation-induced Cytokine-mediated Osteoclastogenesis

Kim, K., Kim, J. H., Lee, J., Jin, H., Lee, S., Fisher, D. E., Kook, H. Y., Kim, K. K., Choi, Y., & Kim, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505815200 · Cited by 247

RANK‐mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis

Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., & Inoue, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600564 · Cited by 233

PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2

Mao, D., Epple, H., Uthgenannt, B., Novack, D. V., & Faccio, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28775 · Cited by 214

Contribution of Nuclear Factor of Activated T Cells c1 to the Transcriptional Control of Immunoreceptor Osteoclast-associated Receptor but Not Triggering Receptor Expressed by Myeloid Cells-2 during Osteoclastogenesis

Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K., & Takayanagi, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505820200 · Cited by 199

NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation

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Osteoblast–osteoclast interactions

Chen, X., Wang, Z., Duan, N., Zhu, G., Schwarz, E. M., & Xie, C. L. (2017) · Connective Tissue Research · doi:10.1080/03008207.2017.1290085 · Cited by 905

Regulation of NFATc1 in Osteoclast Differentiation

Kim, J. H., & Kim, N. (2014) · Journal of Bone Metabolism · doi:10.11005/jbm.2014.21.4.233 · Cited by 570

The RANKL‐OPG system in clinical periodontology

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The Molecular Pathogenesis of Osteosarcoma: A Review

Broadhead, M. L., Clark, J. C. M., Myers, D. E., Dass, C. R., & Choong, P. (2011) · Sarcoma · doi:10.1155/2011/959248 · Cited by 355

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

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Novel osteoclast signaling mechanisms

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The molecular understanding of osteoclast differentiation

Asagiri, M., & Takayanagi, H. (2007) · Bone · doi:10.1016/j.bone.2006.09.023 · Cited by 1,363

Mechanistic insight into osteoclast differentiation in osteoimmunology

Takayanagi, H. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0612-6 · Cited by 413

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701

Ca 2+ ‐NFATc1 signaling is an essential axis of osteoclast differentiation

Negishi‐Koga, T., & Takayanagi, H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00821.x · Cited by 415