The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Fear Conditioning and Long‐term Potentiation in the Amygdala: What Really Is the Connection?
Abstract
The cellular mechanisms that underlie learning and memory formation remain one of the most intriguing unknowns about the mammalian brain. A plethora of experimental evidence over the last 30 years has established that long‐term synaptic plasticity at excitatory synapses is the most likely mechanism that underlies learning and memory formation. Experiments done largely in acute brain slices maintained in vitro have revealed many of the molecular mechanisms in the induction and maintenance of long‐term potentiation (LTP). However, evidence directly liking LTP with learning and memory formation has not been established. Pavlovian fear conditioning is a good candidate to provide such evidence. The relations between events that produce fear conditioning are simple; these relations and their fear products involve circuits in the amygdala that are well understood, as are those circuits in the amygdala that underlie LTP. The evidence that links LTP in the amygdala with fear conditioning is reviewed.
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“A large number of studies have provided convincing evidence that associative plasticity in the LA contributes to fear memory formation (4, 6, 7).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [4]
In the citing paper
“Fear conditioning is a simple form of associative learning that provides a powerful model system to study associative plasticity and memory formation (1–4).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [4]
Citations
Cites
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AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
The role of the amygdala in fear and anxiety
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The Emotional Brain, Fear, and the Amygdala
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Research works printed but not linked: 2
- 10.1113/jphysiol.1973.sp010273 · DOI · Paper page
- Rescorla R.A., 1972, Classical Conditioning II, 64
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Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012
Engineering a memory with LTD and LTP
Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. (2014) · Nature · doi:10.1038/nature13294 · Cited by 980
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924
Self-citationMahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 643
Neuronal circuits of fear extinction
Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484
Self-citation
Metadata
- Authors
- Sah, P., Westbrook, R. F., & Lüthi, A.
- Affiliations
- The University of Queensland (AU)
- UNSW Sydney (AU)
- Friedrich Miescher Institute (CH)
- Corresponding author
- Sah, P.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2008-05
- Volume
- 1129
- Issue
- 1
- Pages
- 88-95
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2041442771
- Cited by
- 138
- References
- 75
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 17 · 2013: 8 · 2012: 10
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear conditioning, long-term potentiation, amygdala, synaptic plasticity, learning and memory, excitatory synapses
- MeSH terms
- Amygdala, Animals, Conditioning, Psychological, Fear, Humans, Models, Biological, Long-Term Potentiation
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