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Fear Conditioning and Long‐term Potentiation in the Amygdala: What Really Is the Connection?

Sah, P., Westbrook, R. F., Lüthi, A.·2008·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1417.020

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Abstract

The cellular mechanisms that underlie learning and memory formation remain one of the most intriguing unknowns about the mammalian brain. A plethora of experimental evidence over the last 30 years has established that long‐term synaptic plasticity at excitatory synapses is the most likely mechanism that underlies learning and memory formation. Experiments done largely in acute brain slices maintained in vitro have revealed many of the molecular mechanisms in the induction and maintenance of long‐term potentiation (LTP). However, evidence directly liking LTP with learning and memory formation has not been established. Pavlovian fear conditioning is a good candidate to provide such evidence. The relations between events that produce fear conditioning are simple; these relations and their fear products involve circuits in the amygdala that are well understood, as are those circuits in the amygdala that underlie LTP. The evidence that links LTP in the amygdala with fear conditioning is reviewed.

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Authors: Sah, P., Westbrook, R. F., & Lüthi, A.
Affiliations: The University of Queensland (AU)
UNSW Sydney (AU)
Friedrich Miescher Institute (CH)
Corresponding author: Sah, P.
ORCID: Sah, P.
Westbrook, R. F.
Lüthi, A.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2008-05
Volume: 1129
Issue: 1
Pages: 88-95
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1417.020
OpenAlex: W2041442771
Cited by: 138
References: 75
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 17 · 2013: 8 · 2012: 10
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 58 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: fear conditioning, long-term potentiation, amygdala, synaptic plasticity, learning and memory, excitatory synapses
MeSH terms: Amygdala, Animals, Conditioning, Psychological, Fear, Humans, Models, Biological, Long-Term Potentiation

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Fear Conditioning and Long‐term Potentiation in the Amygdala: What Really Is the Connection?

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