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Cited by 578Microbial metabolism and enzyme functionAnaerobic Digestion and Biogas ProductionMicrobial Fuel Cells and Bioremediation

The DOI matches its Crossref record; 255 of the 255 references it cites were found in a registry or an index.

Old Acetogens, New Light

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Drake, Harold L., Gößner, Anita S., Daniel, Steven L.·2008·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1419.016
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Abstract

Acetogens utilize the acetyl-CoA Wood-Ljungdahl pathway as a terminal electron-accepting, energy-conserving, CO(2)-fixing process. The decades of research to resolve the enzymology of this pathway (1) preceded studies demonstrating that acetogens not only harbor a novel CO(2)-fixing pathway, but are also ecologically important, and (2) overshadowed the novel microbiological discoveries of acetogens and acetogenesis. The first acetogen to be isolated, Clostridium aceticum, was reported by Klaas Tammo Wieringa in 1936, but was subsequently lost. The second acetogen to be isolated, Clostridium thermoaceticum, was isolated by Francis Ephraim Fontaine and co-workers in 1942. C. thermoaceticum became the most extensively studied acetogen and was used to resolve the enzymology of the acetyl-CoA pathway in the laboratories of Harland Goff Wood and Lars Gerhard Ljungdahl. Although acetogenesis initially intrigued few scientists, this novel process fostered several scientific milestones, including the first (14)C-tracer studies in biology and the discovery that tungsten is a biologically active metal. The acetyl-CoA pathway is now recognized as a fundamental component of the global carbon cycle and essential to the metabolic potentials of many different prokaryotes. The acetyl-CoA pathway and variants thereof appear to be important to primary production in certain habitats and may have been the first autotrophic process on earth and important to the evolution of life. The purpose of this article is to (1) pay tribute to those who discovered acetogens and acetogenesis, and to those who resolved the acetyl-CoA pathway, and (2) highlight the ecology and physiology of acetogens within the framework of their scientific roots.

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Research works printed but not linked: 13

  1. Fischer F., 1932, Biologische Gasreaktionen. II. Über die Bildung von Essigsäure bei der biologischen Umsetzung von Kohlenoxyd und Kohlensäure mit Wasserstoff zu Methan, Biochem. Z., 245, 2
  2. Wieringa K.T., 1941, Über die Bildung von Essigsäure aus Kohlensäure und Wasserstoff durch anaerobe Bazillen, Brennstoff-Chemie, 22, 161
  3. Fontaine F.E.1941.The fermentation of cellulose and glucose by thermophilic bacteria.Ph.D. dissertation. University of Wisconsin‐Madison .
  4. Drake H.L., 2005, Handbook on Clostridia, 719
  5. Drake H.L., 2004, The Prokaryotes An Evolving Electronic Resource for the Microbiological Community
  6. 10.1021/bi015604 · DOI
  7. 10.1021/bi015932 · DOI
  8. Das A., 1995, Bioenergetics of acetogenic thermophilic clostridia, the homoacetogens—An overview, Biochem. (Life Sci. Adv.), 14, 33
  9. Müller V., 2004, Strict and Facultative Anaerobes: Medical and Environmental Aspects, 251
  10. Ljungdahl L.G., 1985, Comparison of three thermophilic acetogenic bacteria for production of calcium magnesium acetate, Biotechnol. Bioeng. Symp., 15, 207
  11. Wiegel J., 1990, Calcium Magnesium Acetate, 359
  12. Davydova‐Charakhchyan I.A., 1992, Acetogenic bacteria from oil fields of Tataria and western Siberia, Mikrobiologiya, 61, 306
  13. Ragsdale S.W., 1985, Acetate biosynthesis by acetogenic bacteria, J. Biol. Chem., 260, 3970

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Metadata

Authors
Drake, H. L., Gößner, A. S., & Daniel, S. L.
Affiliations
  • University of Bayreuth (DE)
  • Eastern Illinois University (US)
Corresponding author
Drake, Harold L.
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2008-03
Volume
1125
Issue
1
Pages
100-128
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1419.016
OpenAlex
W2077787127
Cited by
578
References
255
Citations by year
2026: 26 · 2025: 21 · 2024: 37 · 2023: 42 · 2022: 54 · 2021: 43 · 2020: 42 · 2019: 38 · 2018: 35 · 2017: 38 · 2016: 28 · 2015: 38 · 2014: 27 · 2013: 16 · 2012: 25
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 25 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • The Keep (Eastern Illinois University) (submittedVersion)
  • Journal of Collective Bargaining in the Academy (submittedVersion)
Funders
Wageningen University and Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Anaerobic Digestion and Biogas Production
  • Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
Keywords
acetogenic bacteria, acetogenesis, CO2 fixation, Clostridium thermoaceticum, Clostridium aceticum, tungsten enzymes, carbon cycle, autotrophic metabolism, origin of life
MeSH terms
Acetyl Coenzyme A, Carbon Dioxide, Carbon Radioisotopes, Clostridium, Energy Metabolism, Oxidation-Reduction, Phylogeny, Wood, Evolution, Molecular

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