The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial
Open accessAbstract
PURPOSE: Preoperative chemoradiotherapy may improve the radical resection rate for resectable or borderline resectable pancreatic cancer, but the overall benefit is unproven. PATIENTS AND METHODS: In this randomized phase III trial in 16 centers, patients with resectable or borderline resectable pancreatic cancer were randomly assigned to receive preoperative chemoradiotherapy, which consisted of 3 courses of gemcitabine, the second combined with 15 × 2.4 Gy radiotherapy, followed by surgery and 4 courses of adjuvant gemcitabine or to immediate surgery and 6 courses of adjuvant gemcitabine. The primary end point was overall survival by intention to treat. RESULTS: Between April 2013 and July 2017, 246 eligible patients were randomly assigned; 119 were assigned to preoperative chemoradiotherapy and 127 to immediate surgery. Median overall survival by intention to treat was 16.0 months with preoperative chemoradiotherapy and 14.3 months with immediate surgery (hazard ratio, 0.78; 95% CI, 0.58 to 1.05; P = .096). The resection rate was 61% and 72% ( P = .058). The R0 resection rate was 71% (51 of 72) in patients who received preoperative chemoradiotherapy and 40% (37 of 92) in patients assigned to immediate surgery ( P < .001). Preoperative chemoradiotherapy was associated with significantly better disease-free survival and locoregional failure-free interval as well as with significantly lower rates of pathologic lymph nodes, perineural invasion, and venous invasion. Survival analysis of patients who underwent tumor resection and started adjuvant chemotherapy showed improved survival with preoperative chemoradiotherapy (35.2 v 19.8 months; P = .029). The proportion of patients who suffered serious adverse events was 52% versus 41% ( P = .096). CONCLUSION: Preoperative chemoradiotherapy for resectable or borderline resectable pancreatic cancer did not show a significant overall survival benefit. Although the outcomes of the secondary end points and predefined subgroup analyses suggest an advantage of the neoadjuvant approach, additional evidence is required.
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Cites
Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer
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Self-citationFOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer
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Redefining the R1 resection in pancreatic cancer
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Cited by
Mizrahi, J. D., Surana, R., Valle, J. W., & Shroff, R. T. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30974-0 · Cited by 2,559
Versteijne, E., van Dam, J. L., Suker, M., Janssen, Q. P., Groothuis, K., Akkermans-Vogelaar, J. M., Besselink, M. G., Bonsing, B. A., Buijsen, J., Busch, O. R., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02233 · Cited by 786
Self-citationContemporary radiotherapy: present and future
Chandra, R. A., Keane, F. K., Voncken, F. E. M., & Thomas, C. R. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00233-6 · Cited by 380
Neoadjuvant therapy for pancreatic cancer
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Metadata
- Authors
- Versteijne, E., Suker, M., Groothuis, K., Akkermans-Vogelaar, J. M., Besselink, M. G., Bonsing, B. A., Buijsen, J., Busch, O. R., Creemers, G.-J. M., van Dam, R. M., Eskens, F. A. L. M., Festen, S., de Groot, J. W. B., Groot Koerkamp, B., de Hingh, I. H., Homs, M. Y. V., van Hooft, J. E., Kerver, E. D., Luelmo, S. A. C., Neelis, K. J., Nuyttens, J., Paardekooper, G. M. R. M., Patijn, G. A., van der Sangen, M. J. C., de Vos-Geelen, J., Wilmink, J. W., Zwinderman, A. H., Punt, C. J., van Eijck, C. H., van Tienhoven, G., & for the Dutch Pancreatic Cancer Group
- Venue
- Journal of Clinical Oncology
- Published
- 2020-06-01
- Volume
- 38
- Issue
- 16
- Pages
- 1763-1773
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W3008190574
- Cited by
- 1,082
- References
- 29
- FWCI
- 56.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Versteijne, E., Suker, M., Groothuis, K., Akkermans-Vogelaar, J. M., Besselink, M. G., Bonsing, B. A., Buijsen, J., Busch, O. R., Creemers, G.-J. M., van Dam, R. M., Eskens, F. A. L. M., Festen, S., de Groot, J. W. B., Groot Koerkamp, B., de Hingh, I. H., Homs, M. Y. V., van Hooft, J. E., Kerver, E. D., Luelmo, S. A. C., . . . for the Dutch Pancreatic Cancer Group. (2020). Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial. Journal of Clinical Oncology. https://doi.org/10.1200/jco.19.02274
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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