The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. The Japan Lung Cancer Photodynamic Therapy Study Group.
Abstract
PURPOSE: A phase II study was conducted between June 1989 and February 1992 to evaluate the activity and toxicity of photodynamic therapy (PDT) with photofrin II in centrally located early-stage lung cancer and to determine the complete response (CR) rate as the primary end point. PATIENTS AND METHODS: Patients had histologically proven lung cancer and endoscopically superficial thickening or small protrusions. All lesions were located in subsegmental or larger bronchi. All patients had a performance status (PS) of 0 to 2 and arterial oxygen pressure tension (PaO2) > or = 60 mm Hg. No lymph node or distant metastases were present. All patients received photofrin II (2 mg/kg) intravenously 48 hours before PDT. Tumor lesions were superficially photoradiated by an argon dye laser or an excimer dye laser. RESULTS: Of 54 patients with 64 carcinomas, 51 with 61 carcinomas were eligible for toxicity evaluation and 49 with 59 carcinomas were assessable for response. Of the 59 assessable carcinomas, 50 (84.8%; 95% confidence interval, 73.0% to 92.8%) showed a CR after initial PDT. The median duration of CR was 14.0+ months (range, 2.0+ to 32.4+). The multiple regression model indicates that estimated length of longitudinal tumor extent was the only independent prognostic factor for CR (P = .002). Five carcinomas that had a CR had a local recurrence at 6, 10, 12, 16, and 18 months after initial PDT, respectively. Toxicity assessment (World Health Organization [WHO] grade 2) showed transient elevation of ALT (1.9%), pulmonary toxicity (7.7%), and allergic reaction (7.7%), as well as sunburn (1.9%). CONCLUSION: PDT with photofrin II has an excellent effect on patients with centrally located early-stage lung cancer who have limited tumor invasion extending over a small area (< or = 1 cm).
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Cites
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Self-citationFive-year Disease-free Survival of a Lung Cancer Patient Treated Only by Photodynamic Therapy
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Clinical development and potential of photothermal and photodynamic therapies for cancer
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Self-citation
Metadata
- Authors
- Furuse, K., Fukuoka, M., Kato, H., Horai, T., Kubota, K., Kodama, N., Kusunoki, Y., Takifuji, N., Okunaka, T., & Konaka, C.
- Venue
- Journal of Clinical Oncology
- Published
- 1993-10
- Volume
- 11
- Issue
- 10
- Pages
- 1852-1857
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2225649561
- Cited by
- 283
- References
- 11
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Furuse, K., Fukuoka, M., Kato, H., Horai, T., Kubota, K., Kodama, N., Kusunoki, Y., Takifuji, N., Okunaka, T., & Konaka, C. (1993). A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. The Japan Lung Cancer Photodynamic Therapy Study Group. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1993.11.10.1852
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