The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Long-Term Follow-Up of a Randomized Trial Comparing Concurrent Single Agent Cisplatin, Cisplatin-Based Combination Chemotherapy, or Hydroxyurea During Pelvic Irradiation for Locally Advanced Cervical Cancer: A Gynecologic Oncology Group Study
Open accessAbstract
Purpose: We report the long-term survival and toxicity of a randomized phase III study comparing cisplatin alone with cisplatin, flurouracil, and hydroxyurea versus hydroxyurea concurrent with pelvic irradiation for patients with locally advanced cervical cancer with pathologically negative para-aortic nodes. Patients and Methods: Comparisons of progression-free (PFS) and overall survival (OS) between treatment arms utilized Kaplan-Meier and log-rank statistics. Relative risk estimates adjusting for prognostic factors were determined using the Cox proportional hazards regression model. Pearson's χ 2 test was used to assess differences in adverse events. Results: The analysis included 526 patients. The median follow-up among surviving patients was 106 months. Consistent with the original report, improvement in PFS and OS was evident for both cisplatin-containing arms compared with hydroxyurea (P < .001). Analogous results were seen for stage IIB and for stage III disease (each P < .025). The relative risk of progression of disease or death was 0.57 (95% CI, 0.43 to 0.75) with cisplatin and 0.51 (95% CI, 0.38 to 0.67) with cisplatin-based combination chemotherapy compared with hydroxyurea. Among 518 patients who received radiation, acute (grade 3 or 4) gastrointestinal or urologic toxicities occurred in 66 with cisplatin (19.1%) and 29 with hydroxyurea (16.8%). Delayed radiation toxicity occurred in six patients who received cisplatin (1.7%) and two who received hydroxyurea (1.2%; P = .680). Conclusion: Cisplatin-based chemotherapy during pelvic radiation therapy improves long-term PFS and OS among locally advanced cervical cancer patients collectively and for stage IIB and III disease, individually. There was no observed increase in late toxicity with cisplatin-based chemoradiotherapy.
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Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,181
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
Rose, P. G., Bundy, B. N., Watkins, E. B., Thigpen, J. T., Deppe, G., Maiman, M. A., Clarke-Pearson, D. L., & Insalaco, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904153401502 · Cited by 2,658
Self-citationMorris, M., Eifel, P. J., Lu, J., Grigsby, P. W., Levenback, C., Stevens, R. E., Rotman, M., Gershenson, D. M., & Mutch, D. G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904153401501 · Cited by 2,299
Peters, W. A., Liu, P. Y., Barrett, R. J., Stock, R. J., Monk, B. J., Berek, J. S., Souhami, L., Grigsby, P., Gordon, W., & Alberts, D. S. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.8.1606 · Cited by 2,284
Keys, H. M., Bundy, B. N., Stehman, F. B., Muderspach, L. I., Chafe, W. E., Suggs, C. L., Walker, J. L., & Gersell, D. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904153401503 · Cited by 1,923
Whitney, C. W., Sause, W., Bundy, B. N., Malfetano, J. H., Hannigan, E. V., Fowler, Jr., Clarke-Pearson, D. L., & Liao, S.-Y. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.5.1339 · Cited by 1,524
Self-citationEifel, P. J., Winter, K., Morris, M., Levenback, C., Grigsby, P. W., Cooper, J., Rotman, M., Gershenson, D., & Mutch, D. G. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.07.197 · Cited by 1,018
Cited by
Kim, T. H., Kim, M.-H., Kim, B.-J., Park, S.-I., Ryu, S.-Y., & Cho, C.-K. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.03.029 · Cited by 67
Cancer of the cervix uteri: 2025 update
Bhatla, N., Aoki, D., Sharma, D. N., & Sankaranarayanan, R. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70277 · Cited by 58
Metadata
- Authors
- Rose, P. G., Ali, S., Watkins, E., Thigpen, J. T., Deppe, G., Clarke-Pearson, D. L., & Insalaco, S.
- Venue
- Journal of Clinical Oncology
- Published
- 2007-07-01
- Volume
- 25
- Issue
- 19
- Pages
- 2804-2810
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2156281133
- Cited by
- 284
- References
- 13
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rose, P. G., Ali, S., Watkins, E., Thigpen, J. T., Deppe, G., Clarke-Pearson, D. L., & Insalaco, S. (2007). Long-Term Follow-Up of a Randomized Trial Comparing Concurrent Single Agent Cisplatin, Cisplatin-Based Combination Chemotherapy, or Hydroxyurea During Pelvic Irradiation for Locally Advanced Cervical Cancer: A Gynecologic Oncology Group Study. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2006.09.4532
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