Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 184

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Alberta Physical Activity and Breast Cancer Prevention Trial: Sex Hormone Changes in a Year-Long Exercise Intervention Among Postmenopausal Women

Friedenreich, Christine M., Woolcott, Christy G., McTiernan, Anne, Ballard-Barbash, Rachel, Brant, Rollin F., Stanczyk, Frank Z., Terry, Tim, Boyd, Norman F., Yaffe, Martin J., Irwin, Melinda L., Jones, Charlotte A., Yasui, Yutaka, Campbell, Kristin L., McNeely, Margaret L., Karvinen, Kristina H., Wang, Qinggang, Courneya, Kerry S.·2010·Journal of Clinical Oncology
DOI 10.1200/jco.2009.24.9557
Open this paper in CoChat — free account

Abstract

Purpose: We examined how an aerobic exercise intervention influenced circulating estradiol, estrone, sex hormone–binding globulin (SHBG), androstenedione, and testosterone levels, which may be involved in the association between physical activity and breast cancer risk. Methods: A two-center, two-arm randomized controlled trial of exercise was conducted in 320 postmenopausal, sedentary women age 50 to 74 years. Participants were randomly assigned to a 1-year aerobic exercise intervention of 225 min/wk (n = 160) or to a control group who maintained their usual level of activity (n = 160). Baseline, 6-month, and 12-month assessments of estrone, estradiol, androstenedione, and testosterone were quantified by radioimmunoassay after extraction, and SHBG was quantified by an immunometric assay. Intent-to-treat analyses were performed using linear mixed models. Results: Blood data were available on 309 women (96.6%) at 12 months. Women in the intervention group exercised an average of 3.6 d/wk for 178 min/wk. At 12 months, statistically significant reductions in estradiol (treatment effect ratio [TER] = 0.93; 95% CI, 0.88 to 0.98) and free estradiol (TER = 0.91; 95% CI, 0.87 to 0.96) and increases in SHBG (TER = 1.04; 95% CI, 1.02 to 1.07) were observed in the exercise group compared with the control group. No significant differences in estrone, androstenedione, and testosterone levels were observed between exercisers and controls at 12 months. Conclusion: This trial found that previously sedentary postmenopausal women can adhere to a moderate- to vigorous-intensity exercise program that results in changes in estradiol and SHBG concentrations that are consistent with a lower risk for postmenopausal breast cancer.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1200/jco.2009.24.9557

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 33

  1. 10.1136/bjsm.2006.029132 · DOI · Paper page
  2. 10.1097/00003677-200410000-00010 · DOI
  3. 10.1038/nrc2325 · DOI · Paper page
  4. 10.1289/ehp.97105s3587 · DOI
  5. 10.1016/S0140-6736(97)10384-1 · DOI · Paper page
  6. 10.1097/00008469-200102000-00003 · DOI · Paper page
  7. 10.1249/00003677-199500230-00009 · DOI
  8. 10.1093/jnci/djj376 · DOI · Paper page
  9. 10.1677/erc.1.01038 · DOI · Paper page
  10. 10.1093/jnci/94.8.606 · DOI · Paper page
  11. 10.1158/1055-9965.EPI-06-0745 · DOI
  12. 10.1158/0008-5472.CAN-03-3393 · DOI · Paper page
  13. McTiernan A, 2004, Cancer Epidemiol Biomarkers Prev, 13, 1099, 10.1158/1055-9965.1099.13.7 · DOI
  14. 10.1023/A:1008929714862 · DOI · Paper page
  15. 10.1158/1055-9965.EPI-08-0823 · DOI
  16. 10.1200/JCO.2008.19.7459 · DOI
  17. 10.1046/j.1365-2265.2001.01183.x · DOI
  18. 10.1023/A:1008838412423 · DOI
  19. 10.1158/1055-9965.EPI-07-0061 · DOI
  20. Borg G, 1998, Borg's Perceived Exertion and Pain Scales
  21. 10.1017/S1368980007184287 · DOI
  22. 10.1093/aje/kwj112 · DOI
  23. American College of Sports Medicine, 2000, ACSM's Guidelines for Exercise Testing and Prescription
  24. 10.1210/jcem-36-5-867 · DOI
  25. Goebelsmann U, 1979, Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man, 165
  26. 10.1677/erc.0.0060165 · DOI
  27. Rinaldi S, 2002, Cancer Epidemiol Biomarkers Prev, 11, 1065
  28. Rosner B, 1986, Fundamentals of Biostatistics
  29. Warburton DE, 2007, Can J Public Health, 98, S16
  30. 10.1097/00005768-200009001-00009 · DOI · Paper page
  31. 10.1200/JCO.2005.11.027 · DOI
  32. 10.1111/j.1749-6632.2009.03688.x · DOI
  33. 10.1200/JCO.2008.20.5179 · DOI · Paper page

Cited by

See all 184

Metadata

Authors
Friedenreich, C. M., Woolcott, C. G., McTiernan, A., Ballard-Barbash, R., Brant, R. F., Stanczyk, F. Z., Terry, T., Boyd, N. F., Yaffe, M. J., Irwin, M. L., Jones, C. A., Yasui, Y., Campbell, K. L., McNeely, M. L., Karvinen, K. H., Wang, Q., & Courneya, K. S.
Affiliations
From Alberta Health Services; Department of Medicine, University of Calgary, Calgary; Cross Cancer Institute, Alberta Health Services; Departments of Public Health Sciences, Physical Therapy, and Oncology and Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta; Departments of Statistics and Physical Therapy, University of British Columbia, Vancouver, British Columbia; Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute; Sunnybrook Research...
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2010-03-20
Volume
28
Issue
9
Pages
1458-1466
ISSN
  • 0732-183X
  • 1527-7755
DOI
10.1200/jco.2009.24.9557
Cited by
184
References
8
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.