Implementing a Geriatric Assessment in Cooperative Group Clinical Cancer Trials: CALGB 360401
Open accessAbstract
Purpose: Factors captured in a geriatric assessment can predict morbidity and mortality in older adults, but are not routinely measured in cancer clinical trials. This study evaluated the implementation of a geriatric assessment tool in the cooperative group setting. Patients and Methods: Patients age ≥ 65 with cancer, who enrolled on cooperative group cancer trials, were eligible to enroll on Cancer and Leukemia Group B (CALGB) 360401. They completed a geriatric assessment tool before initiation of protocol therapy, consisting of valid and reliable geriatric assessment measures which are primarily self-administered and require minimal resources and time by healthcare providers. The assessment measures functional status, comorbidity, cognitive function, psychological state, social support, and nutritional status. The protocol specified criteria for incorporation of the tool in future cooperative group trials was based on the time to completion and percent of patients who could complete their portion without assistance. Patient satisfaction with the tool was captured. Results: Of the 93 patients who enrolled in this study, five (5%) met criteria for cognitive impairment and three did not complete the cognitive screen, leaving 85 assessable patients (median age, 72 years). The median time to complete the geriatric assessment tool was 22 minutes, 87% of patients (n = 74) completed their portion without assistance, 92% (n = 78) were satisfied with the questionnaire length, 95% (n = 81) reported no difficult questions, and 96% (n = 82) reported no upsetting questions. One hundred percent of health care professionals completed their portion. Conclusion: This brief, primarily self-administered geriatric assessment tool met the protocol specified criteria for inclusion in future cooperative group clinical trials.
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The self-administered CGA has been shown to be feasible, taking less than 30 minutes with all but 5 minutes patient self-reported.
“since the self-administered CGA has been shown to be feasible (less than 30 minutes, of which all but 5 minutes are patient self-reported) (9,10)”
From Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy (2016) · cites this paper as [10]
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- Authors
- Hurria, A., Cirrincione, C. T., Muss, H. B., Kornblith, A. B., Barry, W., Artz, A. S., Schmieder, L., Ansari, R., Tew, W. P., Weckstein, D., Kirshner, J., Togawa, K., Hansen, K., Katheria, V., Stone, R., Galinsky, I., Postiglione, J., & Cohen, H. J.
- Affiliations
- University of Vermont (US)
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2011-04-01
- Volume
- 29
- Issue
- 10
- Pages
- 1290-1296
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC3083997
- OpenAlex
- W2156402672
- Cited by
- 350
- References
- 54
- Citations by year
- 2026: 13 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 31 · 2021: 28 · 2020: 31 · 2019: 25 · 2018: 31 · 2017: 25 · 2016: 25 · 2015: 28 · 2014: 21 · 2013: 22 · 2012: 24
- FWCI
- 11.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Pfizer
- American Society of Clinical Oncology
- Celgene
- Genentech
- National Institute on Aging (K23AG026749)
- National Cancer Institute (CA-41287, U10CA077440, U10CA077651, CA 77651, CA 47577, CA59518, CA86726, CA-33601, U10CA033601, U10CA045808, U10CA059518, CA45389, U10CA032291, U10CA047577, U10CA086726, U10CA031946, CA-77406, U10CA077406, U10CA045389, CA 32291, U10CA041287, U10CA077658, U10CA035421, CA-31946)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- geriatric assessment, elderly cancer patients, functional status, comorbidities, cognitive screening, patient satisfaction, nutritional status, social support
- MeSH terms
- Aged, Attention, Cognition, Feasibility Studies, Humans, Memory, Neoplasms, Neuropsychological Tests, Predictive Value of Tests, Surveys and Questionnaires, Time Factors, United States, Reproducibility of Results, Geriatric Assessment, Patient Satisfaction, Karnofsky Performance Status, Patient Selection
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