Moving the Translational Needle in Breast Cancer Survivorship: Connecting Intervention Research to Clinical Practice
Open accessAbstract
Breast cancer is the most common cancer in women worldwide, and advances in its early detection and treatment have yielded large and growing numbers of long-term survivors. 1Since 1989, the death rate for breast cancer has been in decline, and the 5-year and 10-year survival rates for invasive breast cancer have now reached 90% and 84%, respectively. 2Breast cancer has also been one of the most studied cancers with respect to both observational and intervention research, dating back to some of the earliest psychosocial research 50 years ago, first describing the impact of radical mastectomy. 3As a result, there is a large body of published literature that focuses on interventions for the physical and psychosocial outcomes after a breast cancer diagnosis, including pain, fatigue, neuropathy, body image, sexual dysfunction, cognitive impairment, and others.The focus of intervention research has also evolved over time with broader trends in health care delivery, and contemporary topics, such as financial toxicity, have only recently emerged.Many of these studies have also contributed to our understanding of biologic and behavioral mechanisms underlying long-term and late effects in cancer survivors.Importantly, these research advancements are a testament to the accessibility and willingness of survivors of breast cancer to participate in research that might help them or others.Through this historical lens, we consider the findings of the article accompanying this editorial, 4 in which the authors conducted a data synthesis that mapped systematic reviews of interventions for breast cancer survivors onto a contemporary survivorship framework. 5The overall aim of this analysis was to identify key gaps in the intervention research literature and examine the level of connectivity among the framework content elements.Published in 2019, the Cancer Survivorship Care Quality framework consists of five distinct, but inter-related domains of cancer survivorship care (physical effects, psychosocial effects, recurrences and new cancers, health promotion, and chronic conditions), surrounded by four contextual health care delivery domains (clinical structure, communication/decision making, care coordination, and patient/caregiver experience), which are then linked to four health care outcomes (health-related quality of life, emergency services/hospitalizations, costs, and mortality; Fig 1). 5 As one of the few comprehensive frameworks in the field, it provides a useful roadmap and common terminology to guide improvements in cancer survivorship care delivery, research, and policy.
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A comprehensive approach that serves all survivorship domains is insufficiently delivered in clinical practice.
“However, a comprehensive approach that serves all survivorship domains is insufficiently delivered in clinical practice.13,14”
From Implementing a PROACTive Care Pathway to Empower and Support Survivors of Breast Cancer (2023) · cites this paper as [14]
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Cites
Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2022) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21708 · Cited by 17,196 · see citing works
From Cancer Patient to Cancer Survivor: Lost in Transition
(2005) · PsycEXTRA Dataset · doi:10.1037/e720092007-001 · Cited by 2,364 · see citing works
Frailty as a predictor of surgical outcomes in older patients
Makary, M. A., Segev, D. L., Pronovost, P. J., Syin, D., Bandeen-Roche, K., Patel, P., Takenaga, R., Devgan, L., Holzmueller, C. G., Tian, J., et al. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.01.028 · Cited by 2,184 · see citing works
Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis
Levit, L. A., Balogh, E. P., Nass, S. J., & Ganz, P. A. (2014) · Cited by 956 · see citing works
Self-citationNekhlyudov, L., Mollica, M. A., Jacobsen, P. B., Mayer, D. K., Shulman, L. N., & Geiger, A. M. (2019) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djz089 · Cited by 416 · see citing works
Psychosocial correlates of breast cancer and its treatments.
Meyerowitz, B. E. (1980) · Psychological Bulletin · doi:10.1037/0033-2909.87.1.108 · Cited by 324 · see citing works
Nekhlyudov, L., O'malley, D. M., & Hudson, S. V. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30570-8 · Cited by 249 · see citing works
Leach, C. R., Weaver, K. E., Aziz, N. M., Alfano, C. M., Bellizzi, K. M., Kent, E. E., Forsythe, L. P., & Rowland, J. H. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-014-0403-1 · Cited by 240 · see citing works
Alfano, C. M., Leach, C. R., Smith, T. G., Miller, K. D., Alcaraz, K. I., Cannady, R. S., Wender, R. C., & Brawley, O. W. (2019) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21548 · Cited by 179 · see citing works
Jefford, M., Rowland, J. H., Grunfeld, E., Richards, M., Maher, J., & Glaser, A. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.554 · Cited by 159 · see citing works
Risk-Based Health Care, the Cancer Survivor, the Oncologist, and the Primary Care Physician
McCabe, M. S., Partridge, A. H., Grunfeld, E., & Hudson, M. M. (2013) · Seminars in Oncology · doi:10.1053/j.seminoncol.2013.09.004 · Cited by 150 · see citing works
Bjerkeset, E., Röhrl, K., & Schou‐Bredal, I. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05522-8 · Cited by 146 · see citing works
Mayer, D. K., & Alfano, C. M. (2019) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djy232 · Cited by 127 · see citing works
Gallicchio, L. M., Tonorezos, E. S., de Moor, J. S., Elena, J. W., Farrell, M. M., Green, P. A., Mitchell, S. A., Mollica, M. A., Perna, F. M., Saiontz, N. G., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab049 · Cited by 119 · see citing works
Alfano, C., Mayer, D., Bhatia, S., Maher, J., Scott, J. M., Nekhlyudov, L., Merrill, J. K., & Henderson, T. (2019) · Ca · doi:10.3322/caac.21558 · Cited by 106 · see citing works
Cancer care coordination: opportunities for healthcare delivery research
Weaver, S. J., & Jacobsen, P. B. (2018) · Translational Behavioral Medicine · doi:10.1093/tbm/ibx079 · Cited by 93 · see citing works
Nekhlyudov, L., Campbell, G. B., Schmitz, K. H., Brooks, G. A., Kumar, A. J., Ganz, P. A., & Ah, D. M. V. (2021) · Cancer · doi:10.1002/cncr.33913 · Cited by 88 · see citing works
Self-citationThe Effectiveness of Shared Care in Cancer Survivors—A Systematic Review
Zhao, Y., Brettle, A., & Qiu, L. (2018) · International Journal of Integrated Care · doi:10.5334/ijic.3954 · Cited by 86 · see citing works
Young, R. C. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1508387 · Cited by 83 · see citing works
Facilitators and barriers to shared primary and specialist cancer care: a systematic review
Lisy, K., Kent, J., Piper, A., & Jefford, M. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05624-5 · Cited by 80 · see citing works
Symptom Clusters in Breast Cancer Survivors: A Latent Class Profile Analysis
Lee, L., Ross, A. C., Griffith, K. A., Jensen, R. E., & Wallen, G. R. (2019) · Oncology nursing forum · doi:10.1188/20.onf.89-100 · Cited by 67 · see citing works
New Frameworks to Assess Value of Cancer Care: Strengths and Limitations
Schnipper, L. E., & Bastian, A. (2016) · The Oncologist · doi:10.1634/theoncologist.2016-0177 · Cited by 52 · see citing works
Assuring Quality Cancer Survivorship Care: We've Only Just Begun
Mayer, D. K., Shapiro, C. L., Jacobson, P., & McCabe, M. S. (2015) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2015.35.e583 · Cited by 36 · see citing works
Lisy, K., Kent, J., Dumbrell, J., Kelly, H., Piper, A., & Jefford, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092991 · Cited by 29 · see citing works
Mapping Systematic Reviews of Breast Cancer Survivorship Interventions: A Network Analysis
Kemp, E., Geerse, O. P., Knowles, R., Woodman, R. J., Mohammadi, L., Nekhlyudov, L., & Koczwara, B. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02015 · Cited by 15 · see citing works
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Pimentel-Parra, G. A., García‐Vivar, C., Escalada‐Hernández, P., Martín‐Rodríguez, L. S., & Soto‐Ruiz, N. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03059-5 · Cited by 32 · see citing works
Implementing a PROACTive Care Pathway to Empower and Support Survivors of Breast Cancer
Franzoi, M. A., Degousée, L., Martin, E., Semedo, P. M., Aupomerol, M., Soldato, D., Di Meglio, A., Chiodi, C., Barbier, A., Chaouachi, H., et al. (2023) · JCO Oncology Practice · doi:10.1200/op.23.00016 · Cited by 18 · see citing works
Breast cancer treatment and recovery: pets’ roles as emotional buffers and stressors
Kogan, L. R., Currin-McCulloch, J. A., & Cook, L. S. (2023) · BMC Women s Health · doi:10.1186/s12905-023-02662-z · Cited by 17 · see citing works
He, Q., Wan, S., Jiang, M., Li, W., Zhang, Y., Zhang, L., Wu, M., Lin, J., Zou, L., & Hu, Y. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118144 · Cited by 12 · see citing works
Long-Term Follow-Up Care After Treatment for Primary Breast Cancer: Strategies and Considerations
Franzoi, M. A., Janni, W. J., Erdmann-Sager, J., Kline‐Quiroz, C. M., Schäffler, H., Pfister, K., Fazzalari, A., & Vaz-Luís, I. (2025) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk-25-473472 · Cited by 10 · see citing works
Machine Learning Risk Stratification for Older Breast Cancer Survivors: Clinical Care Implications
Wheeler, S. B., Rotter, J., Spees, L. P., Biddell, C. B., Trogdon, J. G., Alfano, C. M., Mayer, D. K., Dinan, M. A., Nekhlyudov, L., & Birken, S. A. (2025) · Health Services Research · doi:10.1111/1475-6773.70005 · Cited by 5 · see citing works
Sohl, S. J., Duncan, P. W., Thakur, E. R., Puccinelli‐Ortega, N., Salsman, J. M., Russell, G. B., Pasche, B., Wentworth, S., MILLER, D. P., Wagner, L. I., et al. (2022) · JMIR Formative Research · doi:10.2196/41354 · Cited by 2 · see citing works
Franzoi, M. A., Martin, É., Ferreira, A. R., Jacq, F., Gillanders, E., Meglio, A. D., & Vaz-Luís, I. (2025) · ESMO Real World Data and Digital Oncology · doi:10.1016/j.esmorw.2025.100173 · Cited by 1 · see citing works
Sohl, S. J., Duncan, P. W., Thakur, E. R., Puccinelli‐Ortega, N., Salsman, J. M., Russell, G. B., Pasche, B., Wentworth, S., MILLER, D. P., Wagner, L. I., et al. (2022) · doi:10.2196/preprints.41354
Soto‐Ruiz, N., Escalada‐Hernández, P., de Murieta, A. B.-S., Leite, A. C. A. B., Pimentel-Parra, G. A., & García‐Vivar, C. (2025) · doi:10.2196/preprints.72654
Kukuz, I. K., Stipčić, A., Grančić, J., Aljinović, J., Barun, B., Pivalica, D., & Poljičanin, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15020465
Design and usability of the CUMACA-M mobile app for long-term breast cancer survivors
Soto‐Ruiz, N., Escalada‐Hernández, P., de Murieta, A. B.-S., Leite, A. C. A. B., Pimentel-Parra, G. A., & García‐Vivar, C. (2026) · Health Policy and Technology · doi:10.1016/j.hlpt.2026.101313
- Authors
- Brauer, E. R., & Ganz, P. A.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Journal of Clinical Oncology
- Published
- 2022-07-01
- Volume
- 40
- Issue
- 19
- Pages
- 2069-2073
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC9242407
- OpenAlex
- W4224210016
- Cited by
- 12
- References
- 25
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Breast Cancer Research Foundation
- National Cancer Institute (K08CA252615)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- breast cancer survivorship, survivorship care, intervention research, research-to-practice translation, psychosocial outcomes, late effects of cancer treatment, financial toxicity, health care delivery, research gaps
- MeSH terms
- Cancer Survivors, Survivorship, Breast, Breast Neoplasms, Female, Humans
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