Sample Size Calculations in Clinical Research

Chow, Shein-Chung; Wang, Hansheng; Shao, Jun

doi:10.1201/9781584889830

Cited by 579Statistical Methods in Clinical TrialsStatistical Methods in EpidemiologyPharmaceutical studies and practices

Sample Size Calculations in Clinical Research

Chow, Shein-Chung, Wang, Hansheng, Shao, Jun·2007·Chapman & Hall/CRC eBooks

DOI 10.1201/9781584889830

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Abstract

Focusing on an integral part of pharmaceutical development, Sample Size Calculations in Clinical Research, Second Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. It provides sample size formulas and procedures for testing equality, noninferiority/supe

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A 48-treatment randomized experiment would require 66 days to detect a 5% effect with p<0.05 and β<0.20.
“In order to detect a 5% effect with p < 0.05 and β < 0.20, we estimate that such an experiment would require 66 days [10].”
From An Efficient Bandit Algorithm for Realtime Multivariate Optimization (2017) · cites this paper as [10]
For the primary clinical outcome of the trial, a total of N = 92 participants were needed to achieve 80% power while expecting an approximate 25% dropout rate.
“Considering the primary clinical outcome of this trial (Depression Anxiety Stress Scale – 21 items), in order to achieve 80% power and expecting an approximate 25% dropout rate, a total of N = 92 participants were needed.”
From Inflammatory markers changes following acceptance-based behavioral psychotherapy in generalized anxiety disorder patients: Evidence from a randomized controlled trial (2024) · cites this paper as Chow et al., 2007

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Authors: Chow, S.-C., Wang, H., & Shao, J.
ORCID: Chow, Shein-Chung
Wang, Hansheng
Shao, Jun
Venue: Chapman & Hall/CRC eBooks
Publisher: Chapman and Hall/CRC
Published: 2007-08-22
DOI: 10.1201/9781584889830
OpenAlex: W4210615620
Cited by: 562
References: 0
Citations by year: 2026: 16 · 2025: 72 · 2024: 57 · 2023: 45 · 2022: 54 · 2021: 56 · 2020: 43 · 2019: 41 · 2018: 41 · 2017: 41 · 2016: 23 · 2015: 28 · 2014: 14 · 2013: 6 · 2012: 8
FWCI: 0.94
Type: book
Language: en
Open access: closed
Locations: Chapman & Hall/CRC eBooks (publishedVersion)
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: sample size determination, clinical trials, drug development, non-inferiority testing, superiority testing, equivalence testing, statistical power

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